DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment YME1L1 and pch2

DIOPT Version :9

Sequence 1:	NP_647473.1	Gene:	YME1L1 / 10730	HGNCID:	12843	Length:	773	Species:	Homo sapiens
Sequence 2:	NP_001287235.1	Gene:	pch2 / 41013	FlyBaseID:	FBgn0051453	Length:	421	Species:	Drosophila melanogaster

Alignment Length:	205	Identity:	55/205 - (26%)
Similarity:	94/205 - (45%)	Gaps:	33/205 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   375 ILLVGPPGTGKTLLARAVAGEADV----PFYYA------SGSEFDEMFVGVG--ASRIRNLFREA 427
            |||.||||||||.|.:|:|.:..:    .:.|.      |.|.|.:.|...|  .:::.|...|.
  Fly   169 ILLHGPPGTGKTSLCKALAQKLSIRTQGSYAYTHLVEINSHSLFSKWFSESGKLVAQLFNKIAEL 233

Human   428 KA---NAPCVIFIDELDSVGGKR--IESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEA 487
            .:   |..||: |||::|:...|  :.|.....:.:.:|.:|.::|..|....|:|:..:|..::
  Fly   234 VSDPNNLVCVL-IDEVESLAYARSAMSSNEPRDAMRVVNAVLTQLDSLKTCPNVLILATSNLAQS 297

Human   488 LDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEI-------------IARGTV 539
            :|.|.:  .|.|:::.:..|.:....||.|..|.::.....:..|:             :|..:|
  Fly   298 IDLAFV--DRADIRLFIGYPGISAIREIYKGMLAELMSAGVLQREVLESEDAEEGLLTQLAERSV 360

Human   540 GFSGAELENL 549
            |.||..|..|
  Fly   361 GLSGRTLRKL 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L1	NP_647473.1	P-loop_NTPase	331..>395	CDD:304359	14/19 (74%)
		FtsH_fam	333..766	CDD:273520	55/205 (27%)
		AAA	375..506	CDD:278434	42/147 (29%)
		Peptidase_M41	586..764	CDD:279742
pch2	NP_001287235.1	AAA	166..315	CDD:214640	42/148 (28%)
pch2	NP_001287235.1	AAA	169..314	CDD:278434	42/147 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910