Protein Alignment YME1L1 and kat-60L1

DIOPT Version :9

• Sequence 1: NP_647473.1
• Gene: YME1L1 / 10730
• HGNCID: 12843
• Length: 773
• Species: Homo sapiens
• Sequence 2: NP_001163523.1
• Gene: kat-60L1 / 40715
• FlyBaseID: FBgn0037375
• Length: 673
• Species: Drosophila melanogaster
• Alignment Length: 594
• Identity: 154/594 - (25%)
• Similarity: 249/594 - (41%)
• Gaps: 142/594 - (23%)

Human    20 INAFHTP-KNTSVSLS---GVSVSQNQHRDVVPEHEAPSSECMFSDFLTKLNIVSIGKGKIFEGY 80
            |.|...| :|.|:..|   |.|.:..:||.|                   .|:.|...|.:..|
  Fly   136 ITATSRPSRNASLKKSSEGGHSSTAERHRPV-------------------NNLGSNAPGGLGIG- 180

Human    81 RSMFMEPAKRMKKSLDTTDNWHIRPEP---FSLSIP-PSLNLRDLGLSELKIGQIDQLVENLLPG 141
            .|:.:...:|:...:...:   :.|:|   .:..:| ||....:..:|.|:  :.|..::..||.
  Fly   181 GSVPLRSKQRLPTQVSAAE---VAPQPRASQTAQMPFPSQQQDNRWVSSLR--RRDPELQPTLPS 240

Human   142 FCKGKNISSHWHTSHVSAQSFFENKYGNLDI-----------FSTLRSSCLYRHHSRALQSICSD 195
            .....|.||...:.|.||        ||:.:           ..|:|..    ..:|| .::.:.
  Fly   241 INSNANSSSLSQSHHGSA--------GNVGLAGAGAPTPAASMGTMRLG----RPARA-SAMTAA 292

Human   196 LQYWPVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLMKTKNI 260
            |:      :||..:.|  |.|:| ||:.:|    |:....||          ..|||     :|.
  Fly   293 LR------KSRSVERL--RARKL-STNTQL----NLKHKPVK----------KNSLD-----ENS 329

Human   261 PEAHQDAFKTGFAEGFLKAQAL--TQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTG 323
            ....|||  |...|....||:|  :..|.....:|:...|..|.:.::
  Fly   330 NSDDQDA--TTSLEDNSHAQSLATSHNTPKCSPKTKAKHFSPLGYEVH----------------- 375

Human   324 LDSAVDPVQMKNVTFEH-------VKGVEEAKQELQEVV-------EFLKNPQKFTILGGKLP-K 373
               .||.:: |::...|       |.|:.|||..|||.|       ||.|        |.:.| :
  Fly   376 ---LVDTLE-KDILQRHPCIKWTDVAGLNEAKTILQEAVVLPVIMPEFFK--------GIRRPWR 428

Human   374 GILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFID 438
            |:|:|||||||||:||:|||.|....|:..|.|.....:.|.....:|.||..|:..||..||||
  Fly   429 GVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPSTIFID 493

Human   439 ELDSVGGKRIESPMHPYSRQTINQLLAEMDG----FKPNEGVIIIGATNFPEALDNALIRPGRFD 499
            |:|::...|.....|..||:...:||.:|||    .:..:.::::.|||.|..:|.|..|  ||:
  Fly   494 EIDALCASRGSDSEHEASRRFKAELLIQMDGLNASMQEEKVIMVLAATNHPWDIDEAFRR--RFE 556

Human   500 MQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQA---ALKAAVDG 561
            .::.:|.|:...|:.:||..|..:....|::..||.....|:||:::.|:...|   |::..:.|
  Fly   557 KRIYIPLPNEGTRSALLKLCLKDVCLSPSLNTGIIGDELQGYSGSDISNVCRDASMMAMRRLISG 621

Human   562 KEMVTMKEL 570
            :....:|::
  Fly   622 RTPDQIKQI 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YME1L1	NP_647473.1	P-loop_NTPase	331..>395	CDD:304359	32/78 (41%)
		FtsH_fam	333..766	CDD:273520	84/260 (32%)
		AAA	375..506	CDD:278434	50/134 (37%)
		Peptidase_M41	586..764	CDD:279742
kat-60L1	NP_001163523.1	AAA	426..565	CDD:214640	53/140 (38%)
		AAA	430..563	CDD:278434	50/134 (37%)
		Vps4_C	<638..671	CDD:286426

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910