Protein Alignment YME1L1 and CG14183

DIOPT Version :9

• Sequence 1: NP_647473.1
• Gene: YME1L1 / 10730
• HGNCID: 12843
• Length: 773
• Species: Homo sapiens
• Sequence 2: NP_649172.3
• Gene: CG14183 / 40192
• FlyBaseID: FBgn0036931
• Length: 872
• Species: Drosophila melanogaster
• Alignment Length: 669
• Identity: 125/669 - (18%)
• Similarity: 226/669 - (33%)
• Gaps: 244/669 - (36%)

Human    48 PEHEAPSSECMFSDFLTK-------LNIVSIGKGKIFEGYRSMFMEPAKR-----MKKSLDTTDN 100
            |...|.|...|:.:.:.|       :|:::..:.::.:......||....     .|:..|.|.|
  Fly   296 PNQTANSIMEMYKNEMLKKKLDEDFINLINDERTRLLQFRSPWMMEDISDHIRAWFKEFYDATGN 360

Human   101 WHIRPEPFS--------------LSIPPSLNLRDLGLSELK------------------------ 127
            :|..|:|..              :....||..:.|..:|||
  Fly   361 FHPYPDPVKQGTVLVVIDETMTPMEFQESLGKKPLSKAELKKLRDKEKKEKRKKKEKLKQLKMKE 425

Human   128 ---------IGQID--------QLVENLLPGFCKGKNISSHWHTSHVSAQSFFENKYGNLDIFST 175
                     .|.||        :.:||:....   |..|..|.               |:|.:
  Fly   426 AKRRKKLRDAGVIDIGYELTASKAIENIEETM---KKYSKDWR---------------NVDEY-- 470

Human   176 LRSSCLYRHHSRALQSICSDLQYWPVFIQSRGFKTLKSRTRRLQSTSERLA----ETQNIAPSF- 235
                 |.::|        ..::.|                    .|.|:||    |.:.:...:
  Fly   471 -----LNKNH--------DPIKEW--------------------VTEEQLAKIHQEVRGLVDEYM 502

Human   236 -VKGFLLRDR-GSDVESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALT-QKTNDSLRRTRLIL 297
             |:..|||:. ..|.:...|.:|.| .|:..::..|.       |.:.:| .:|.:||
  Fly   503 RVEYELLREALAKDNDEKYKALKVK-YPKKKKEKRKK-------KPKDMTGDRTLESL------- 552

Human   298 FVLLLFGIYGLLKNP-------------------FLSVRFRTTTGLDSAVDPVQMKNVTFEHVKG 343
                    |..||:.                   |::...|...||           .|....||
  Fly   553 --------YNELKDAGIIEEIGHRDFDEFITDFNFVADDTRDEDGL-----------TTLGPAKG 598

Human   344 VEEAKQELQEVVEFLKNPQKFTILG-GKL----PKGILLVGPPGTGKTLLARAVAGEADVPFY-- 401
              :.|..:||           ::|| |:.    ||.:||:||..:||.||...:|.|.|..|.
  Fly   599 --DIKMVIQE-----------SMLGMGEFDVPKPKSLLLIGPLNSGKRLLCEIIASELDAVFMNL 650

Human   402 -------YASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQT 459
                   ||...::   |:.|       :.:.|||..|.:::|:|...:..|::.......:.:.
  Fly   651 SPENTYKYAKDLKY---FLHV-------ILKVAKAFQPTIMYIEEAHRLFWKKVPPEAVEINPRL 705

Human   460 INQLLAE--MDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNK 522
            :...||.  :...|.|:.::::|.:|.|.|.:..:.|  .|...:.:|:.|.  .|..|.|.  :
  Fly   706 LGTSLASKILKPLKKNDKIVLVGTSNMPWAANGGIKR--AFQKVLLIPKCDY--GTSFLLWL--E 764

Human   523 IKFDQSVDP------EIIARGTVGFSGAELE-------NLVNQAALK-AAVDGKEMVTMKELEFS 573
            :..:.:.|.      ..:||....::..:::       |:..:..|| .|:|..|.:   |...|
  Fly   765 LMTENAPDDMKEYAYSALARVLQAYNSGDIDDNVKETLNIDRKMRLKNEALDPNEFL---EYFLS 826

Human   574 KDK-ILMGPERRSVEIDNK 591
            |:: .:..|:.:.::..||
  Fly   827 KNEPPIFPPDEKIMDKFNK 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YME1L1	NP_647473.1	P-loop_NTPase	331..>395	CDD:304359	20/68 (29%)
		FtsH_fam	333..766	CDD:273520	64/290 (22%)
		AAA	375..506	CDD:278434	33/141 (23%)
		Peptidase_M41	586..764	CDD:279742	2/6 (33%)
CG14183	NP_649172.3	AAA	622..751	CDD:278434	33/140 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910