Protein Alignment YME1L1 and CG6512

DIOPT Version :9

• Sequence 1: NP_647473.1
• Gene: YME1L1 / 10730
• HGNCID: 12843
• Length: 773
• Species: Homo sapiens
• Sequence 2: NP_730248.2
• Gene: CG6512 / 39922
• FlyBaseID: FBgn0036702
• Length: 826
• Species: Drosophila melanogaster
• Alignment Length: 586
• Identity: 226/586 - (38%)
• Similarity: 338/586 - (57%)
• Gaps: 63/586 - (10%)

Human   235 FVKGFLLRDRGSDVESLDKLMKTKNIPEAHQDA--------FKTGFAEGF---LKAQALTQKTND 288
            ||..:|.:   ..||.|:.:.|........|::        |..|..:.|   |:| |.|::..:
  Fly   193 FVNSYLSK---GVVEKLEVVNKKWVRVRLQQNSNSGSGVLWFNIGSVDSFERNLEA-AQTEQGTE 253

Human   289 SLRRTRLI-------------LFVLLLFG--IYGLLKNPFL--SVRFRTTTGLDSAV-------- 328
            |:....:|             |..||:.|  :|.:.|:..:  ..|.|...||...|
  Fly   254 SINFVPVIYRNEVEAASLTGLLPTLLIIGFLVYMMRKSADMMGGGRGRKGGGLFGGVMQSTAKLT 318

Human   329 DPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVA 393
            :|.:: .|.|:.|.|.||||.|:.|.|.||||||::..||.|:|||.:|.|||||||||||:|.|
  Fly   319 NPNEI-GVGFKDVAGCEEAKIEIMEFVNFLKNPQQYIDLGAKIPKGAMLTGPPGTGKTLLAKATA 382

Human   394 GEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQ 458
            |||:|||...|||||.|||||||.||:|::|..|:.:|||::||||:|:||.||.......:|.|
  Fly   383 GEANVPFITVSGSEFLEMFVGVGPSRVRDMFAMARKHAPCILFIDEIDAVGRKRGGKTFGGHSEQ 447

Human   459 --TINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLN 521
              |:||||.|||||.....|:::.|||..:.||.||:||||||.|:.||.||:|||..|.|.:|.
  Fly   448 ENTLNQLLVEMDGFNTTTNVVVLAATNRVDILDKALMRPGRFDRQIYVPAPDIKGRASIFKVHLG 512

Human   522 KIKFDQSVDPEIIARG----TVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPE 582
            .:|  .|:|...::|.    |.||:||::.|:.|:|||.||.|.|:.:.:|..|.:.::::.|.|
  Fly   513 NLK--TSLDKNELSRKMAALTPGFTGADIANVCNEAALIAARDSKDSIVLKHFEQAIERVIAGME 575

Human   583 RRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQL 647
            :::..:..:.|...|:||:|||:..::.:.|.|:.|.:|:|||..||:...||: |.:..::.||
  Fly   576 KKTNVLAPEEKRTVAHHEAGHAVAGWFLEHADPLLKVSIIPRGKGLGYAQYLPK-DHYLLSKEQL 639

Human   648 LAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGK---- 708
            ..:|.:::||||||||.|  :.|||||..|....|.||...|.:|||:||:|.::: |.|:
  Fly   640 FDRMCMTLGGRVAEELFF--NRITTGAQDDLKKITDIAYSQVVRFGMNEKVGQVSF-DVGQAGDP 701

Human   709 -----LSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGK 768
                 .|.:|...|:.|:|.:::.::|....:|..|.:..:.:||.||..|.| :::..|.|.|.
  Fly   702 VFSKPYSEDTAQLIDNEVRSIIKCAHEATTSLLTKHKENVQKVAERLLQNEVL-SRDDMIELLGP 765

Human   769 K 769
            :
  Fly   766 R 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YME1L1	NP_647473.1	P-loop_NTPase	331..>395	CDD:304359	37/63 (59%)
		FtsH_fam	333..766	CDD:273520	195/447 (44%)
		AAA	375..506	CDD:278434	77/132 (58%)
		Peptidase_M41	586..764	CDD:279742	63/186 (34%)
CG6512	NP_730248.2	FtsH_ext	163..259	CDD:284011	16/69 (23%)
		FtsH_fam	271..764	CDD:273520	208/500 (42%)
		AAA	365..496	CDD:278434	76/130 (58%)
		Peptidase_M41	580..762	CDD:279742	64/186 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820