Protein Alignment YME1L1 and Rpt4R

DIOPT Version :10

• Sequence 1: NP_647473.1
• Gene: YME1L1 / 10730
• HGNCID: 12843
• Length: 773
• Species: Homo sapiens
• Sequence 2: NP_648525.1
• Gene: Rpt4R / 39351
• FlyBaseID: FBgn0036224
• Length: 398
• Species: Drosophila melanogaster
• Alignment Length: 413
• Identity: 126/413 - (30%)
• Similarity: 191/413 - (46%)
• Gaps: 74/413 - (17%)

Human   214 RTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLMKTKNIP-EAHQDAFKTGFAEGFL 277
            |.|.|.:...:|.|.:.|.             |.:::|....|..|.. |..:|..|...:.|.:
  Fly    14 RVRALTNYRTKLLEHREIE-------------SKLKALRDKYKVVNAEYEKSEDDLKALQSVGQM 65

Human   278 KAQALTQKTNDSL--------------RR----------TRLILFVLLLFGIYGLLKNPFLSVRF 318
            ..:.|.|.|.|:.              ||          ||:.|.|..|           ..:|:
  Fly    66 VGEILKQLTPDNFIVKASNGPRYVVGCRRQINKEKLKPGTRVALDVTTL-----------TIMRY 119

Human   319 RTTTGLDSAVDPVQMK-------NVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGI 375
                 |...|||:...       ||.:..:.|:.:..:||:||:|. |.||..|..:|...|||.
  Fly   120 -----LPREVDPLVYNMTHEDPGNVNYAEIGGLGQQIRELREVIELPLLNPDIFLRVGISPPKGC 179

Human   376 LLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDEL 440
            ||.|||||||||||||:|.:.|..|.....|...:.::|..|..||.:|..|:.:.||:||:||:
  Fly   180 LLYGPPGTGKTLLARAIASQMDANFLKVVSSAIVDKYIGESARLIREMFAYARDHQPCIIFMDEI 244

Human   441 DSVGGKRIE--SPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVT 503
            |::||:|..  :......::|:.:||.:||||.....|.:|.|||.|:.||.||:||||.|.::.
  Fly   245 DAIGGRRFSEGTSADREIQRTLMELLNQMDGFDALGQVKMIMATNRPDTLDPALLRPGRLDRKLE 309

Human   504 VPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMK 568
            :|.|:...|.:|||.:...:.....:|.|.:.:.:..|:||:|.|:..:|.|.|....:|.|..:
  Fly   310 IPLPNEVARMDILKIHAEPLNKRGEIDYEAVVKLSDLFNGADLRNICTEAGLFALRCDREFVIQE 374

Human   569 ELEFSKDKILMGPERRSVEIDNK 591
            :...:..||          .|||
  Fly   375 DFMKAVRKI----------ADNK 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YME1L1	NP_647473.1	HflB	<332..767	CDD:440233	96/270 (36%)
Rpt4R	NP_648525.1	PRK03992	13..388	CDD:179699	126/413 (31%)