DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment YME1L1 and CG5776

DIOPT Version :9

Sequence 1:	NP_647473.1	Gene:	YME1L1 / 10730	HGNCID:	12843	Length:	773	Species:	Homo sapiens
Sequence 2:	NP_001260420.1	Gene:	CG5776 / 34680	FlyBaseID:	FBgn0032450	Length:	799	Species:	Drosophila melanogaster

Alignment Length:	263	Identity:	95/263 - (36%)
Similarity:	150/263 - (57%)	Gaps:	6/263 - (2%)

- Green bases have known domain annotations that are detailed below.

Human   331 VQMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAG 394
            ::..||.:..:.|..|.:..:|:.:|: |.:..||..||.|.|:|||:.||||..||::|:|:|.
  Fly   527 IECPNVQWSDIGGQSELRLAMQQAIEWPLLHADKFQRLGIKPPRGILMFGPPGCSKTMIAKALAT 591

Human   395 EADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIE----SPMHPY 455
            |:.:.|....|.|...|:||.....:|.:||:|:..||.::|.||:|::||:|.|    |.....
  Fly   592 ESKLNFLSIKGPELFSMWVGESERAVREVFRKARQVAPAIVFFDEIDAIGGERSEGDGSSSGSSV 656

Human   456 SRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYL 520
            ..:.:.|||.|:||.:..:.|.|:.|||.|:.:|.||:||||.|..:.|..|..:.|.||||..|
  Fly   657 KERVLTQLLTELDGVEALQNVTIVAATNRPDMIDKALLRPGRIDRILYVGLPQCEARREILKIKL 721

Human   521 NKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRS 585
            ..:.....||.|.:.:.|.|:||||::.:.::|||:|.....|...:|..:| :..:...|.|.|
  Fly   722 RAMPISNDVDMEKLVQLTEGYSGAEIQAVCHEAALRALEQSFEAEDVKWTDF-EHALKAVPPRTS 785

Human   586 VEI 588
            .|:
  Fly   786 PEL 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L1	NP_647473.1	P-loop_NTPase	331..>395	CDD:304359	25/64 (39%)
		FtsH_fam	333..766	CDD:273520	95/261 (36%)
		AAA	375..506	CDD:278434	54/134 (40%)
		Peptidase_M41	586..764	CDD:279742	1/3 (33%)
CG5776	NP_001260420.1	SpoVK	288..785	CDD:223540	93/258 (36%)
		AAA	307..447	CDD:278434
		AAA	572..707	CDD:278434	54/134 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910