DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment YME1L1 and CG4908

DIOPT Version :9

Sequence 1:	NP_647473.1	Gene:	YME1L1 / 10730	HGNCID:	12843	Length:	773	Species:	Homo sapiens
Sequence 2:	NP_609358.1	Gene:	CG4908 / 34360	FlyBaseID:	FBgn0032195	Length:	431	Species:	Drosophila melanogaster

Alignment Length:	357	Identity:	84/357 - (23%)
Similarity:	137/357 - (38%)	Gaps:	83/357 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   181 LYRHHSR-ALQSICSDLQY-----WPVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVK-- 237
            |:|.|.. .|:..|.|..|     |.....:|..:.|...|..:|:.:..:..:.:..||..|
  Fly    42 LFRRHCMITLEVPCRDKSYQWLLKWITIRGARKTQHLSVETNFVQNDNGTIKTSYDFIPSIGKHL 106

Human   238 -----GFLLRDRGSDVESLDKLM-------------KTKNI-----PEAHQDAFKTGFAEGFLKA 279
                 .::..:|..:.::||..|             ..|.|     .||.|           |..
  Fly   107 FQYKGNWIQVERTREQQTLDLHMGVPWETVTLTAFGNNKGIYFDILEEARQ-----------LAL 160

Human   280 QALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGV 344
            :|...||              :|:...|....||...|.|..||      .|.:...|.:.:
  Fly   161 EATEGKT--------------VLYTAMGAEWRPFGHPRRRRPTG------SVVLDRGTSQRI--- 202

Human   345 EEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFD 409
                  :.:..:|:|:...:|..|....:|.||.||||.||:....|:|||.:......:.||
  Fly   203 ------IADCQDFIKSSLWYTQRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSVCLLNLSE-- 259

Human   410 EMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHP-----YSRQTINQLLAEMDG 469
               .|:...|:.:|...|...:  :|.::::|:....|..:|...     .:|.|.:.||..:||
  Fly   260 ---RGLTDDRLNHLLNVAPEQS--IILLEDIDAAFVSREATPQQKSAFDGLNRITFSGLLNCLDG 319

Human   470 FKPNEGVIIIGATNFPEALDNALIRPGRFDMQ 501
            ....|..|:...||:.:.||.||:||||.|::
  Fly   320 VGSTEARIVFMTTNYIDRLDPALVRPGRIDLK 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L1	NP_647473.1	P-loop_NTPase	331..>395	CDD:304359	17/63 (27%)
		FtsH_fam	333..766	CDD:273520	47/174 (27%)
		AAA	375..506	CDD:278434	41/132 (31%)
		Peptidase_M41	586..764	CDD:279742
CG4908	NP_609358.1	BCS1_N	23..192	CDD:214980	36/180 (20%)
CG4908	NP_609358.1	RecA-like_BCS1	202..354	CDD:410918	46/166 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810