Protein Alignment STAMBP and CG2224

DIOPT Version :10

• Sequence 1: NP_006454.1
• Gene: STAMBP / 10617
• HGNCID: 16950
• Length: 424
• Species: Homo sapiens
• Sequence 2: NP_651796.1
• Gene: CG2224 / 43617
• FlyBaseID: FBgn0039773
• Length: 420
• Species: Drosophila melanogaster
• Alignment Length: 439
• Identity: 190/439 - (43%)
• Similarity: 273/439 - (62%)
• Gaps: 49/439 - (11%)

Human     5 GDVSLPPEDRVRALSQLGSAVEVNEDIPPRRYFRSGVEIIRMASIYSEEGNIEHAFILYNKYITL 69
            |||.  |::|::.||..|:.:||::::|..||:|||.|::|||::|..|||.|:|||||.:|:||
  Fly    11 GDVE--PQERMKHLSHCGNLIEVDKNMPVTRYYRSGTEMLRMANVYLREGNHENAFILYLRYMTL 73

Human    70 FIEKLPKHRDYKSAVIPEKKDTVKKLKEIAFPKAEELKAELLKRYTKEYTEYNEEKKKEAEELAR 134
            ||||:.:|.||.| |..|.:|..:|:|:...|..|:|:|:||..|.:||.::  ...||||.:
  Fly    74 FIEKIRQHPDYGS-VKAEVRDINRKIKDEIMPTTEKLRAKLLTHYQREYEQF--LASKEAERV-- 133

Human   135 NMAIQQELEKEKQRVAQ-QKQQQLEQEQFHAFEEMIRNQELEKERLKIVQEFGKVDPGLGGPLVP 198
                 :|||:|::|..: |:|::.|:....|...:|      ...|.::     :|.| ..|..|
  Fly   134 -----KELERERERERERQRQKEREKAGSSAIPSLI------PANLHVL-----IDEG-NQPSAP 181

Human   199 DLEKPSLDVFPT----------------LTVSSIQPSDCHTTVRPAKPPVVDRSLKPGALSNSES 247
            ||......|:|.                |..:|...:|..|..:|:    .||:.|| :.:.::|
  Fly   182 DLGLLDQVVYPNDFPTGANRSLPGSGLLLPAASEAAADKTTNSKPS----FDRNQKP-SYNRTDS 241

Human   248 IPTIDGLRHVVVPGRLCPQFLQLASANTARGVETCGILCGKLMRNEFTITHVLIPKQSAGSDYCN 312
            : ....||.|.|||.....||:||.|||::.:||||:|.|.|.:|:..|||::.|:|....|.||
  Fly   242 L-LAGSLRLVYVPGDTMEVFLKLALANTSKNIETCGVLAGHLSQNQLYITHIITPQQQGTPDSCN 305

Human   313 TENEEELFLIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESVAIVCSPKFQETGFF 377
            |.:||::|.:|||..|||||||||||||||||||||||||||||:|:||::||||:||:..||||
  Fly   306 TMHEEQIFDVQDQMQLITLGWIHTHPTQTAFLSSVDLHTHCSYQIMMPEALAIVCAPKYNTTGFF 370

Human   378 KLTDH-GLEEISSCRQKGFHPHSKDPPLFCSCSHVTVVDRA-VTITDLR 424
            .||.| ||:.|:.|||.|||||..|||||....|:.:.::| :.:.|||
  Fly   371 ILTPHYGLDYIAQCRQSGFHPHPNDPPLFMEAQHIRMDNQAKIKVIDLR 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STAMBP	NP_006454.1	Interaction with CHMP3. /evidence=ECO:0000269|PubMed:17146056	1..127		55/121 (45%)
		USP8_dimer	13..117	CDD:462647	49/103 (48%)
		Interaction with STAM. /evidence=ECO:0000269|PubMed:10383417	227..231		1/3 (33%)
		MPN_AMSH_like	254..424	CDD:163697	100/171 (58%)
		JAMM motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01182	335..348		12/12 (100%)
CG2224	NP_651796.1	USP8_dimer	11..120	CDD:462647	53/111 (48%)
		MPN_AMSH_like	247..419	CDD:163697	100/171 (58%)