Protein Alignment CCT7 and CCT1

DIOPT Version :10

• Sequence 1: NP_006420.1
• Gene: CCT7 / 10574
• HGNCID: 1622
• Length: 543
• Species: Homo sapiens
• Sequence 2: NP_524450.2
• Gene: CCT1 / 42649
• FlyBaseID: FBgn0003676
• Length: 557
• Species: Drosophila melanogaster
• Alignment Length: 550
• Identity: 197/550 - (35%)
• Similarity: 298/550 - (54%)
• Gaps: 35/550 - (6%)

Human    12 GTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAA 76
            ||..| |......|:.|...|:..|:::|||.|:||::||..|..|::|||||||:||:|.||||
  Fly    12 GTRQS-GASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLEVEHPAA 75

Human    77 KTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAV 141
            |.||::|:.||.|||||||||.:||||.||.....|::.:||..||..:|.|.:.|...|.|...
  Fly    76 KVLVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEACKYISEHLT 140

Human   142 TVKKADKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDA---VMMLDDLLQ----LKMIGIKK 199
            .  ..|::.:..|: ..|.|::|||:|.....||:.|||||   |.:.|...|    :|.|.:.|
  Fly   141 A--PVDELGRDSLI-NIAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRGQAAYSIKAINVLK 202

Human   200 VQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIRVHTVEDYQ 264
            ..|.:..:|.|:.|.|...|.:   .:..|||..|.|||.|:..|:....|...::.::..:..:
  Fly   203 AHGKSARESVLIPGYALNCTIA---SQQMPKKIVNAKIACLDFSLQKTKMKMGVQVLINDPDKLE 264

Human   265 AIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACGGS 329
            ||...|.:|..:::..|..:|..|||....:.|:..:||.:.......||.:.|||....|.|.:
  Fly   265 AIRARELDITKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKATGAA 329

Human   330 IQTSV------NALSADVLGRCQVFEETQIGGERYNFFTGCPKAKTCTFILRGGAEQFMEETERS 388
            ..||:      .:..|.::|......:.:|..:......|.......:.||||..:.:.:|.|||
  Fly   330 FITSLTNMDGEESFDASMVGEAAEVAQERICDDELILIKGTKARAAASIILRGPNDFYCDEMERS 394

Human   389 LHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNA 453
            :|||:.:|:|.:::..||||||.:|..||.||.:::.::..::||.|..:||:|.:||:.|..||
  Fly   395 VHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLVIPKTLSVNA 459

Human   454 GFDATNILNKLRARHAQGGT--------WYGVDINNEDIADNFEAFVWEPAMVRINALTAASEAA 510
            ..|||:::.|||:.|....|        |.|:|:....:.||.:|.|.||||.:|.:|..|:|||
  Fly   460 AKDATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKIKSLKFATEAA 524

Human   511 CLIVSVDETIK-NP-----RSTVDAPTAAG 534
            ..|:.:|:.|| ||     :|..|| .|||
  Fly   525 ITILRIDDMIKLNPEDKSGKSYADA-CAAG 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCT7	NP_006420.1	TCP1_eta	5..525	CDD:239456	191/539 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	524..543		5/10 (50%)
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	189/532 (36%)