Protein Alignment HYOU1 and Hsp70Bbb

DIOPT Version :9

• Sequence 1: XP_005271449.1
• Gene: HYOU1 / 10525
• HGNCID: 16931
• Length: 1000
• Species: Homo sapiens
• Sequence 2: NP_788663.1
• Gene: Hsp70Bbb / 50022
• FlyBaseID: FBgn0051354
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 794
• Identity: 203/794 - (25%)
• Similarity: 343/794 - (43%)
• Gaps: 195/794 - (24%)

Human    33 LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATL 97
            :..:.:|||:....|.:.:.| .:||:.|.:..|.||..|...::||..||.|.:....||:.|:
  Fly     1 MPAIGIDLGTTYSCVGVYQHG-KVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTV 64

Human    98 RYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQ-LQFSPEEVLGMVLNYSRSLA 161
            ...:.|:|::.|:|.:|.....:| .::..|..:..:..:...: .:|:|||:..|||...:..|
  Fly    65 FDAKRLIGRKYDDPKIAEDMKHWP-FKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETA 128

Human   162 EDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRR-KDINTTA 225
            |.:..:.|.|||||||.:||.::|:|...|..:|||.||::||:.||.||:||:.:. ||    .
  Fly   129 EAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKD----E 189

Human   226 QNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQ 290
            :|::.:|:|.|:...:|:|..     |..:   .::|....|..|||.:.:.||...||    |:
  Fly   190 RNVLIFDLGGGTFDVSILTID-----EGSL---FEVRSTAGDTHLGGEDFDNRLVTHLA----EE 242

Human   291 RKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADL 355
            .|.:..||:|.||||:.:|...|.|.|..||::.:...:|:.|.:..||..||:|..||||||||
  Fly   243 FKRKYKKDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADL 307

Human   356 FERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAV 420
            |.....||::||..|:|...:|..::||||:||:|:||.:|.:....:.|..:||.|||.|.||.
  Fly   308 FRNTLQPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAA 372

Human   421 YQAAALS--KAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHS--LKHNKRVLFSRMGPYPQRKV 481
            .|||.||  ::.|::..::.|  |.|:    :..:|...|:.:  ::.|.|:        |.::.
  Fly   373 VQAAILSGDQSGKIQDVLLVD--VAPL----SLGIETAGGVMTKLIERNCRI--------PCKQT 423

Human   482 ITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQN--LTTVKLKGVGDSFKKYPDYESKGIKAHFN 544
            .||:.||.      |...:.....|..|.....|  |.|..|.|:..:.:..|.     |:..|:
  Fly   424 KTFSTYSD------NQPGVSIQVYEGERAMTKDNNALGTFDLSGIPPAPRGVPQ-----IEVTFD 477

Human   545 LDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPA 609
            ||.:|:|::             ||:|.||......||
  Fly   478 LDANGILNV-------------SAKEMSTGKAKNITI---------------------------- 501

Human   610 EGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGP 674
                                                        :.:.|..|:|
  Fly   502 --------------------------------------------KNDKGRLSQA----------- 511

Human   675 EGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKA 739
                                   ||              |::....:|..|   .|.:.::|..:
  Fly   512 -----------------------EI--------------DRMVNEAEKYAD---EDEKHRQRITS 536

Human   740 ANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKE---KLAEL 801
            .|:||:::|..:..:.|....::. |..:..:..|.:....||:..    ||...:|   |:.||
  Fly   537 RNALESYVFNVKQSVEQAPAGKLD-EADKNSVLDKCNETIRWLDSN----TTAEKEEFDHKMEEL 596

Human   802 RKLCQGLFFRVEER 815
            .:.|..:..::.::
  Fly   597 TRHCSPIMTKMHQQ 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HYOU1	XP_005271449.1	HSP70	35..672	CDD:278441	180/644 (28%)
		NBD_sugar-kinase_HSP70_actin	36..424	CDD:302596	138/389 (35%)
		PHA00666	601..>739	CDD:222808	10/137 (7%)
Hsp70Bbb	NP_788663.1	PTZ00009	2..641	CDD:240227	203/793 (26%)
		HSPA1-2_6-8-like_NBD	3..379	CDD:212675	140/393 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810