Protein Alignment HYOU1 and Hsp70Bc

DIOPT Version :10

• Sequence 1: NP_001397970.1
• Gene: HYOU1 / 10525
• HGNCID: 16931
• Length: 1000
• Species: Homo sapiens
• Sequence 2: NP_650209.1
• Gene: Hsp70Bc / 48583
• FlyBaseID: FBgn0013279
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 794
• Identity: 203/794 - (25%)
• Similarity: 342/794 - (43%)
• Gaps: 195/794 - (24%)

Human    33 LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATL 97
            :..:.:|||:....|.:.:.| .:||:.|.:..|.||..|...::||..||.|.:....||:.|:
  Fly     1 MPAIGIDLGTTYSCVGVYQHG-KVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTV 64

Human    98 RYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQ-LQFSPEEVLGMVLNYSRSLA 161
            ...:.|:|::.|:|.:|.....:| .::..|..:..:..:...: .:|:|||:..|||...:..|
  Fly    65 FDAKRLIGRKYDDPKIAEDMKHWP-FKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETA 128

Human   162 EDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQ 226
            |.:..:.|.|||||||.:||.::|:|...|..:|||.||::||:.||.||:||:    |.|...:
  Fly   129 EAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGL----DKNLKGE 189

Human   227 -NIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQ 290
             |::.:|:|.|:...:|:|..     |..:   .::|....|..|||.:.:.||...||    |:
  Fly   190 RNVLIFDLGGGTFDVSILTID-----EGSL---FEVRSTAGDTHLGGEDFDNRLVTHLA----EE 242

Human   291 RKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADL 355
            .|.:..||:|.||||:.:|...|.|.|..||::.:...:|:.|.:..||..||:|..||||||||
  Fly   243 FKRKYKKDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADL 307

Human   356 FERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAV 420
            |.....||::||..|:|...:|..::||||:||:|:||.:|.:....:.|..:||.|||.|.||.
  Fly   308 FRNTLQPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAA 372

Human   421 YQAAALS--KAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHS--LKHNKRVLFSRMGPYPQRKV 481
            .|||.||  ::.|::..::.|  |.|:    :..:|...|:.:  ::.|.|:        |.::.
  Fly   373 VQAAILSGDQSGKIQDVLLVD--VAPL----SLGIETAGGVMTKLIERNCRI--------PCKQT 423

Human   482 ITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQN--LTTVKLKGVGDSFKKYPDYESKGIKAHFN 544
            .||:.||.      |...:.....|..|.....|  |.|..|.|:..:.:..|.     |:..|:
  Fly   424 KTFSTYSD------NQPGVSIQVYEGERAMTKDNNALGTFDLSGIPPAPRGVPQ-----IEVTFD 477

Human   545 LDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPA 609
            ||.:|:|::             ||:|.||......||
  Fly   478 LDANGILNV-------------SAKEMSTGKAKNITI---------------------------- 501

Human   610 EGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGP 674
                                                        :.:.|..|:|
  Fly   502 --------------------------------------------KNDKGRLSQA----------- 511

Human   675 EGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKA 739
                                   ||              |::....:|..|   .|.:.::|..:
  Fly   512 -----------------------EI--------------DRMVNEAEKYAD---EDEKHRQRITS 536

Human   740 ANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKE---KLAEL 801
            .|:||:::|..:..:.|....::. |..:..:..|.:....||:..    ||...:|   |:.||
  Fly   537 RNALESYVFNVKQSVEQAPAGKLD-EADKNSVLDKCNETIRWLDSN----TTAEKEEFDHKMEEL 596

Human   802 RKLCQGLFFRVEER 815
            .:.|..:..::.::
  Fly   597 TRHCSPIMTKMHQQ 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HYOU1	NP_001397970.1	ASKHA_NBD_HSP70_HYOU1	34..424	CDD:466828	138/391 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	578..694		5/115 (4%)
		LGT	<593..694	CDD:469786	3/100 (3%)
		Prevents secretion from ER. /evidence=ECO:0000255	997..1000
Hsp70Bc	NP_650209.1	PTZ00009	2..641	CDD:240227	203/793 (26%)