DRSC/TRiP Functional Genomics Resources

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Protein Alignment: HYOU1 and Hsp70Aa

Sequence 1:XP_005271449.1 Gene:HYOU1 HGNCID:16931 Length:1000 Species:Homo sapiens
Sequence 2:NP_731651.1 Gene:Hsp70Aa FlyBaseID:FBgn0013275 Length:642 Species:Drosophila melanogaster

Alignment Length:794 Identity:203/795 (26%)
Similarity:340/795 (43%) Gaps:195/795 (25%)


Human    33 LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATL 97
            :..:.:|||:....|.:.:.| .:||:.|.:..|.||..|...::||..||.|.:....||:.|:
  Fly     1 MPAIGIDLGTTYSCVGVYQHG-KVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTV 64

Human    98 RYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQ-LQFSPEEVLGMVLNYSRSLA 161
            ...:.|:|::.|:|.:|.....:| .::..|..:..:..:...: .:|:|||:..|||...:..|
  Fly    65 FDAKRLIGRKYDDPKIAEDMKHWP-FKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETA 128

Human   162 EDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQ 226
            |.:..:.|.|||||||.:||.::|:|...|..:|||.||::||:.||.||:||:    |.|...:
  Fly   129 EAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGL----DKNLKGE 189

Human   227 -NIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQ 290
             |::.:|:|.|:...:|:|..     |..:   .::|....|..|||.:.:.||...||..|..:
  Fly   190 RNVLIFDLGGGTFDVSILTID-----EGSL---FEVRSTAGDTHLGGEDFDNRLVTHLADEFKRK 246

Human   291 RKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADL 355
            .|    ||:|.||||:.:|...|.|.|..||::.:...:|:.|.:..||..||:|..||||||||
  Fly   247 YK----KDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADL 307

Human   356 FERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAV 420
            |.....||::||..|:|...:|..::||||:||:|:||.:|......:.|..:||.|||.|.||.
  Fly   308 FRNTLQPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAA 372

Human   421 YQAAALS--KAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHS--LKHNKRVLFSRMGPYPQRKV 481
            .|||.||  ::.|::..::.|  |.|:    :..:|...|:.:  ::.|.|:        |.::.
  Fly   373 VQAAILSGDQSGKIQDVLLVD--VAPL----SLGIETAGGVMTKLIERNCRI--------PCKQT 423

Human   482 ITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQN--LTTVKLKGVGDSFKKYPDYESKGIKAHFN 544
            .||:.|:.      |...:.....|..|.....|  |.|..|.|:..:.:..|.     |:..|:
  Fly   424 KTFSTYAD------NQPGVSIQVYEGERAMTKDNNALGTFDLSGIPPAPRGVPQ-----IEVTFD 477

Human   545 LDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPA 609
            ||.:|:|::             ||:|.||......||                            
  Fly   478 LDANGILNV-------------SAKEMSTGKAKNITI---------------------------- 501

Human   610 EGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGP 674
                                                        :.:.|..|:|           
  Fly   502 --------------------------------------------KNDKGRLSQA----------- 511

Human   675 EGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKA 739
                                   ||              |::....:|..|   .|.:.::|..:
  Fly   512 -----------------------EI--------------DRMVNEAEKYAD---EDEKHRQRITS 536

Human   740 ANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKE---KLAEL 801
            .|:||:::|..:..:.|....::. |..:..:..|.:....||:..    ||...:|   ||.||
  Fly   537 RNALESYVFNVKQAVEQAPAGKLD-EADKNSVLDKCNDTIRWLDSN----TTAEKEEFDHKLEEL 596

Human   802 RKLCQGLFFRVEER 815
            .:.|..:..::.::
  Fly   597 TRHCSPIMTKMHQQ 610

Known Domains:


GeneSequenceDomainRegion External IDIdentity
HYOU1XP_005271449.1 HSP70 35..672 CDD:278441 179/645 (28%)
NBD_sugar-kinase_HSP70_actin 36..424 CDD:302596 139/390 (36%)
PHA00666 601..>739 CDD:222808 10/138 (7%)
Hsp70AaNP_731651.1 PTZ00009 2..642 CDD:240227 203/794 (26%)
HSPA1-2_6-8-like_NBD 3..379 CDD:212675 141/394 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
eggNOG 1 0.900 E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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