Protein Alignment HYOU1 and Hsc70-4

DIOPT Version :10

• Sequence 1: NP_001397970.1
• Gene: HYOU1 / 10525
• HGNCID: 16931
• Length: 1000
• Species: Homo sapiens
• Sequence 2: NP_524356.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Alignment Length: 698
• Identity: 190/698 - (27%)
• Similarity: 320/698 - (45%)
• Gaps: 127/698 - (18%)

Human    36 MSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATLRYF 100
            :.:|||:....|.:.:.| .:||:.|.:..|.||..|...:.||..||:|.:....||..|:...
  Fly     7 VGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFDA 70

Human   101 QHLLGKQADN----------PHVALYQARFPEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLN 155
            :.|:|::.|:          |...:.....|:.|:|:..:::|          |.|||:..|||.
  Fly    71 KRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKT----------FFPEEISSMVLT 125

Human   156 YSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKD 220
            ..:..||.:..:.:.:||||||.:||.::|:|...|..:|||.||::||:.||.|::||:.::.
  Fly   126 KMKETAEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKA- 189

Human   221 INTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAG 285
              ...:|::.:|:|.|:...:|::.      :.|:   .:::....|..|||.:.:    .||..
  Fly   190 --VGERNVLIFDLGGGTFDVSILSI------DDGI---FEVKSTAGDTHLGGEDFD----NRLVT 239

Human   286 LFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEE 350
            .|.::.|.:..||:..|.||:.:|.....|.|..||::.....:|:.|.:..||...:||..|||
  Fly   240 HFVQEFKRKHKKDLTTNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEE 304

Human   351 LCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAA 415
            |.||||.....||::||:.|::....|..::||||:||:|:||.:|......:||.|:||.|||.
  Fly   305 LNADLFRSTMDPVEKALRDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAV 369

Human   416 AMGAVYQAAAL--SKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKHNKRVLFSRMGPYPQ 478
            |.||..|||.|  .|:.:|:..::.|  |.|:    :..:|...|:.|      ||..|....|.
  Fly   370 AYGAAVQAAILHGDKSQEVQDLLLLD--VTPL----SLGIETAGGVMS------VLIKRNTTIPT 422

Human   479 RKVITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTT--------VKLKGVGDSFKKYPDYE 535
            ::..||..||.:        ..|.|    ::|:..:...|        .:|.|:..:.:..|.
  Fly   423 KQTQTFTTYSDN--------QPGVL----IQVYEGERAMTKDNNLLGKFELSGIPPAPRGVPQ-- 473

Human   536 SKGIKAHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDT 600
               |:..|::|.:|:|::        |.:|.|..:|:.:| :.|....|        :||:....
  Fly   474 ---IEVTFDIDANGILNV--------TALERSTNKENKIT-ITNDKGRL--------SKEDIERM 518

Human   601 VQEEEESPAEGSKDEPGEQVELKEEAEAPV--------EDGSQPPPPEPKGDATPEGEKATE--- 654
            |.|.|:...|..|.:  |.:..|...|:..        ||..:....:  .|.|...:|..|
  Fly   519 VNEAEKYRNEDEKQK--ETIAAKNGLESYCFNMKATLDEDNLKTKISD--SDRTTILDKCNETIK 579

Human   655 ----KENGDKSEAQKPSEKAE-------------AG--PEGVAPAPEG 683
                .:..||.|.:...::.|             ||  |.|:...|.|
  Fly   580 WLDANQLADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGGPGG 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HYOU1	NP_001397970.1	ASKHA_NBD_HSP70_HYOU1	34..424	CDD:466828	126/397 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	578..694		28/136 (21%)
		LGT	<593..694	CDD:469786	26/121 (21%)
		Prevents secretion from ER. /evidence=ECO:0000255	997..1000
Hsc70-4	NP_524356.1	PTZ00009	1..612	CDD:240227	184/681 (27%)