DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HYOU1 and Hsc70-4

DIOPT Version :9

Sequence 1:	XP_005271449.1	Gene:	HYOU1 / 10525	HGNCID:	16931	Length:	1000	Species:	Homo sapiens
Sequence 2:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster

Alignment Length:	698	Identity:	190/698 - (27%)
Similarity:	320/698 - (45%)	Gaps:	127/698 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    36 MSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATLRYF 100
            :.:|||:....|.:.:.| .:||:.|.:..|.||..|...:.||..||:|.:....||..|:...
  Fly     7 VGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFDA 70

Human   101 QHLLGKQADN----------PHVALYQARFPEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLN 155
            :.|:|::.|:          |...:.....|:.|:|:..:::|          |.|||:..|||.
  Fly    71 KRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKT----------FFPEEISSMVLT 125

Human   156 YSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKD 220
            ..:..||.:..:.:.:||||||.:||.::|:|...|..:|||.||::||:.||.|::||:.::.
  Fly   126 KMKETAEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKA- 189

Human   221 INTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAG 285
              ...:|::.:|:|.|:...:|::.      :.|:   .:::....|..|||.:.:    .||..
  Fly   190 --VGERNVLIFDLGGGTFDVSILSI------DDGI---FEVKSTAGDTHLGGEDFD----NRLVT 239

Human   286 LFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEE 350
            .|.::.|.:..||:..|.||:.:|.....|.|..||::.....:|:.|.:..||...:||..|||
  Fly   240 HFVQEFKRKHKKDLTTNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEE 304

Human   351 LCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAA 415
            |.||||.....||::||:.|::....|..::||||:||:|:||.:|......:||.|:||.|||.
  Fly   305 LNADLFRSTMDPVEKALRDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAV 369

Human   416 AMGAVYQAAAL--SKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKHNKRVLFSRMGPYPQ 478
            |.||..|||.|  .|:.:|:..::.|  |.|:    :..:|...|:.|      ||..|....|.
  Fly   370 AYGAAVQAAILHGDKSQEVQDLLLLD--VTPL----SLGIETAGGVMS------VLIKRNTTIPT 422

Human   479 RKVITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTT--------VKLKGVGDSFKKYPDYE 535
            ::..||..||.:        ..|.|    ::|:..:...|        .:|.|:..:.:..|.
  Fly   423 KQTQTFTTYSDN--------QPGVL----IQVYEGERAMTKDNNLLGKFELSGIPPAPRGVPQ-- 473

Human   536 SKGIKAHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDT 600
               |:..|::|.:|:|::        |.:|.|..:|:.:| :.|....|        :||:....
  Fly   474 ---IEVTFDIDANGILNV--------TALERSTNKENKIT-ITNDKGRL--------SKEDIERM 518

Human   601 VQEEEESPAEGSKDEPGEQVELKEEAEAPV--------EDGSQPPPPEPKGDATPEGEKATE--- 654
            |.|.|:...|..|.:  |.:..|...|:..        ||..:....:  .|.|...:|..|
  Fly   519 VNEAEKYRNEDEKQK--ETIAAKNGLESYCFNMKATLDEDNLKTKISD--SDRTTILDKCNETIK 579

Human   655 ----KENGDKSEAQKPSEKAE-------------AG--PEGVAPAPEG 683
                .:..||.|.:...::.|             ||  |.|:...|.|
  Fly   580 WLDANQLADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGGPGG 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HYOU1	XP_005271449.1	HSP70	35..672	CDD:278441	184/683 (27%)
		NBD_sugar-kinase_HSP70_actin	36..424	CDD:302596	126/397 (32%)
		PHA00666	601..>739	CDD:222808	24/113 (21%)
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	184/681 (27%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	128/400 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810