Protein Alignment: HYOU1 and Hsc70Cb

• Sequence 1: XP_005271449.1
• Gene: HYOU1
• HGNCID: 16931
• Length: 1000
• Species: Homo sapiens
• Sequence 2: NP_001189103.1
• Gene: Hsc70Cb
• FlyBaseID: FBgn0026418
• Length: 836
• Species: Drosophila melanogaster
• Alignment Length: 965
• Identity: 255/966 (26%)
• Similarity: 440/966 (46%)
• Gaps: 164/966 (17%)

Human    33 LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATL 97
            ::|:.:|.|:||..||..:.| .:|.:.|..|.|.||..|.....:|..|.:|.:..:.|.|.|:
  Fly     1 MSVIGIDFGNESCYVAAARSG-GIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTV 64

Human    98 RYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQ----------TVHFQISSQLQFSPEEVLGM 152
            ..|:.|||::.::|||        :||||..|.|.          .|:: :.....|.||::..|
  Fly    65 GGFKRLLGRKFNDPHV--------QHELTSIPARVEARGDGSIGIKVNY-LGEDQHFGPEQLTAM 120

Human   153 VLNYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFR 217
            :....:..:....:..:.|.||..||||..|||:|:|.||::|||.||:|:|:.|||||:||.::
  Fly   121 LFTKLKETSAAAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYK 185

Human   218 RKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRER 282
            ........:|::|.|.|..|...:...:...|         |::....:|: :||.:::|.|.:.
  Fly   186 NDLFEDKPRNVIFVDFGHSSLQASACAFTKGK---------LKMLASTWDQ-IGGRDIDLALGDY 240

Human   283 LAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHM-AQIEGLMDDVDFKAKVTRV 346
            .|..|.|:.|    .:.:.|.||..:||.|..:||..:|||:..: ..||..:||:|..:.:.|.
  Fly   241 FAKEFQERYK----INAKTNARANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRS 301

Human   347 EFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINA 411
            :.|||||.:.:||....::.|..:::.||:|..|.:|||::|:|.|:: |::.|..:.....:|.
  Fly   302 QMEELCAPVLQRVEQTFKRLLAESKLQLDDIHSVEIVGGSSRIPSVKQ-LIEQVFNKPASTTLNQ 365

Human   412 DEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKHNKRVLFSRMGPY 476
            |||.:.||..|.|.:|.|.:|:.|.|.|...|.:.|.:..|....||       :..:|.:....
  Fly   366 DEAVSRGAALQCAIMSPAVRVREFGVTDIQNYAVKVLWDSEGSAAPG-------EIEIFPQYHAS 423

Human   477 PQRKVITFNRYSHDFNFHINYGDLGFLGPEDLRV-FGSQNLTTVKLKGVGDSFKKYPDYESKGIK 540
            |..:::|.|| ...||..|.||.         :| :..|.:...|:|.|    |.....|.:.:|
  Fly   424 PFSRLLTINR-KGPFNVSIVYGQ---------QVPYPDQTIGVWKVKDV----KPTERGEGQDVK 474

Human   541 AHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEE 605
            ....::.:|::.:...     ||||....||:.
  Fly   475 LKVRINNNGIVLISSA-----TLVEKKEAEEAA-------------------------------- 502

Human   606 ESPAE--GSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSE 668
             :.||  .|:::||:|.....|.    .||.|        :|..|.|     ::.:.|.|..|
  Fly   503 -AAAEQAASEEKPGDQTNNTGEP----ADGQQ--------EAYCENE-----DDNNTSTASSP-- 547

Human   669 KAEAGPEGVAPAPEG------EKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLT 727
                |.:|.|...:|      :||:|.::    ..|:.:|.......  |.| |:...|:...:.
  Fly   548 ----GGQGWAQRVKGWFGSGADKKKKASK----ATELPLECTTHGFS--PVD-LSNYTQQESKMI 601

Human   728 LRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTV 792
            ..|.::.||..|.|:||.|:::.::||....::....|.:||:|..:|:....||.::|......
  Fly   602 GNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVEAEREKIVSQLNDLENWLYEDGEDCERD 666

Human   793 MLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSM-------FLKGARLIPEMDQIFT 850
            :...:|..|.:....:..|..:.::.|   :|.|.|.|..::       |.||   :|:.|.: |
  Fly   667 IYTSRLQALHQKTDPIKLRASDYEQGP---AAFDELKNSIAIARLAVAEFRKG---VPKYDHL-T 724

Human   851 EVEMTTLEKVINETWAWKNATLAEQAKLPAT-EKPVLLSKDIEAKMMALDREVQYLLNKAKFTKP 914
            |.|...:.:..::..:|.:|.|.:..:.|.| :.||.:|. :..::..|:..|..::|:|   ||
  Fly   725 ETEFINISETADKAQSWLDANLPKFTQSPRTADSPVQISA-VRQEVQTLNSCVSSVINRA---KP 785

Human   915 RPRPKDKNGTRAEPPLNASASDQ--GEKVIPPAGQTEDAEPISEPEKVETAGSEP 967
            :|.|    ...|.||.:.:.::|  ||    ||..:.|...:....: ..||::|
  Fly   786 KPTP----AKTATPPKDEANAEQNGGE----PAANSGDKMDVDNNGQ-SAAGNDP 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HYOU1	XP_005271449.1	HSP70	35..672	CDD:278441	180/651 (28%)
		NBD_sugar-kinase_HSP70_actin	36..424	CDD:302596	126/399 (32%)
		PHA00666	601..>739	CDD:222808	32/146 (22%)
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	128/404 (32%)
		HSP70	3..682	CDD:278441	213/793 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900