Protein Alignment: HYOU1 and Hsc70-1

• Sequence 1: XP_005271449.1
• Gene: HYOU1
• HGNCID: 16931
• Length: 1000
• Species: Homo sapiens
• Sequence 2: NP_524063.1
• Gene: Hsc70-1
• FlyBaseID: FBgn0001216
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 798
• Identity: 198/799 (25%)
• Similarity: 323/799 (40%)
• Gaps: 209/799 (26%)

Human    33 LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATL 97
            |..:.:|||:....|.:.:.| .:||:.|.:..|.||..|...|:||..||:|.:....||..|:
  Fly     4 LPAVGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTI 67

Human    98 RYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQLQ-FSPEEVLGMVLNYSRSLA 161
            ...:.|:|::.|:..|......:| .|:..:..:..:..:...:.: |.||||..|||...|..|
  Fly    68 FDAKRLIGRRFDDATVQSDMKHWP-FEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETA 131

Human   162 EDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQ 226
            |.:....:.|||:|||.:||.::|:|...|..:|||.||::||:.||.|::||:.::   .|:.:
  Fly   132 EAYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQ---GTSER 193

Human   227 NIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQR 291
            |::.:|:|.|:...:::|.      |.|:   .:::....|..|||.:.:.||.......|..:.
  Fly   194 NVLIFDLGGGTFDVSVLTI------EDGI---FEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKH 249

Human   292 KGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLF 356
            |    ||:.:|.||:.:|.....|.|..||::.....:|:.|.:.|||...|||..||||..|||
  Fly   250 K----KDLGQNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLF 310

Human   357 ERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAVY 421
            .....||.:||:.|:|...:|..::||||:||:|:||.:|......:||.|:||.|||.|.||..
  Fly   311 RGTMEPVAKALRDAKMDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAV 375

Human   422 QAAAL--SKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHS--LKHNKRVLFSRMGPYPQRKVI 482
            |||.|  .|:..|:..::.|  |.|:    :..:|...|:.:  :|.|..:      |..|.::.
  Fly   376 QAAILHGDKSEAVQDLLLLD--VTPL----SLGIETAGGVMTTLIKRNTTI------PTKQTQIF 428

Human   483 TFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIKAHFNLDE 547
            |            .|.|                                              ::
  Fly   429 T------------TYAD----------------------------------------------NQ 435

Human   548 SGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGS 612
            .|||.     .||        |.|..:|:..|::.
  Fly   436 PGVLI-----QVF--------EGERAMTRDNNSLG------------------------------ 457

Human   613 KDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGE-------------KATEKENGDKSEAQ 664
                      |.|..|        .||.|:|  .|:.|             .|.||..|.::...
  Fly   458 ----------KFELSA--------IPPAPRG--VPQVEVTFDIDANGILNVTALEKSTGKENRIT 502

Human   665 KPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLR 729
            ..::|.....|.:               .|||.:                  |::.::      .
  Fly   503 ITNDKGRLSKEDI---------------ERMVND------------------AEAYRQ------A 528

Human   730 DLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVML 794
            |.::::|..|.|.||::.|:.:..|.........:...||.|..:.|....|| |....|.....
  Fly   529 DEQQRDRINAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWL-DANQLAERQEF 592

Human   795 KEKLAELRKLCQGLFFRV 812
            :.|..||.::|..:..|:
  Fly   593 EHKQQELERICSPIITRL 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HYOU1	XP_005271449.1	HSP70	35..672	CDD:278441	171/655 (26%)
		NBD_sugar-kinase_HSP70_actin	36..424	CDD:302596	132/389 (34%)
		PHA00666	601..>739	CDD:222808	21/151 (14%)
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	198/799 (25%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	134/393 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900