Protein Alignment HYOU1 and Hsc70-3

DIOPT Version :9

• Sequence 1: XP_005271449.1
• Gene: HYOU1 / 10525
• HGNCID: 16931
• Length: 1000
• Species: Homo sapiens
• Sequence 2: NP_001285139.1
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Alignment Length: 694
• Identity: 191/694 - (27%)
• Similarity: 326/694 - (46%)
• Gaps: 123/694 - (17%)

Human    35 VMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTL-KENERFFGDSAASMAIKNPKATLR 98
            |:.:|||:....|.:.|.| .:||:.|.:..|.||..|.. .:.||..||:|.:....||:.|:.
  Fly    31 VIGIDLGTTYSCVGVYKNG-RVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVF 94

Human    99 YFQHLLGKQADNPHVALYQARFPEHELTFDP-----QRQTVHFQISSQ---LQFSPEEVLGMVLN 155
            ..:.|:|::..:.:|        :|::.|.|     :....|..:.:.   ..|:|||:..|||.
  Fly    95 DAKRLIGREWSDTNV--------QHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLG 151

Human   156 YSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKD 220
            ..:..||.:..:.:..||:|||.:||.|:|:|...|..:|||:|:::||:.||.|::||:.:::.
  Fly   152 KMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKKEG 216

Human   221 INTTAQNIMFYDMGSGSTVCTIVT-----YQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLR 280
                .:|::.:|:|.|:...:::|     :::|.|..              |..|||.:.:.|:.
  Fly   217 ----EKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNG--------------DTHLGGEDFDQRVM 263

Human   281 ERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTR 345
            :....|:    |.::.||:|::.||:.||.||..:.|..||.:.....:||...:..||...:||
  Fly   264 DHFIKLY----KKKKGKDIRKDNRAVQKLRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTR 324

Human   346 VEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNIN 410
            .:||||..|||.....|||:.|:.|:|:..::.:::||||:||:|:||:::....|.:|..:.||
  Fly   325 AKFEELNLDLFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGIN 389

Human   411 ADEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKHNKRVLFSRMGP 475
            .|||.|.||..||..||........|:.|  |.|:    |..:|...|:.:      .|..|...
  Fly   390 PDEAVAYGAAVQAGVLSGEQDTDAIVLLD--VNPL----TMGIETVGGVMT------KLIPRNTV 442

Human   476 YPQRKVITFNRYS---HDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYESK 537
            .|.:|...|:..|   |.....:..|:...  .:|..:.|..:||     |:..:.:..|.
  Fly   443 IPTKKSQVFSTASDNQHTVTIQVYEGERPM--TKDNHLLGKFDLT-----GIPPAPRGIPQ---- 496

Human   538 GIKAHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTK----LGNTISSLFGGGTTP------- 591
             |:..|.:|.:|:|.:             |||::.|..|    :.|..:.|     ||
  Fly   497 -IEVSFEIDANGILQV-------------SAEDKGTGNKEKIVITNDQNRL-----TPEDIDRMI 542

Human   592 -DAKENGTD--TVQEEEESPAE------------GSKDEPGEQV--ELKEEAEAPVEDGSQPPPP 639
             ||::...:  .::|..||..|            |.||:.|.::  :.|.:.|:.:::..:....
  Fly   543 RDAEKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQ 607

Human   640 EPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPEGVAPAPEG 683
            .|  ||.||..|..:|:.  ::..|....|...|..| ||.|||
  Fly   608 NP--DADPEEYKKQKKDL--EAIVQPVIAKLYQGAGG-APPPEG 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HYOU1	XP_005271449.1	HSP70	35..672	CDD:278441	184/681 (27%)
		NBD_sugar-kinase_HSP70_actin	36..424	CDD:302596	124/401 (31%)
		PHA00666	601..>739	CDD:222808	26/97 (27%)
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	125/402 (31%)
		PTZ00009	32..643	CDD:240227	186/688 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810