Protein Alignment ATP8A1 and CG33298

DIOPT Version :10

• Sequence 1: XP_011511917.1
• Gene: ATP8A1 / 10396
• HGNCID: 13531
• Length: 1171
• Species: Homo sapiens
• Sequence 2: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Alignment Length: 1335
• Identity: 409/1335 - (30%)
• Similarity: 642/1335 - (48%)
• Gaps: 271/1335 - (20%)

Human     3 TMRRTVSE---IRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQ---PQLTK-------FCNNHV 54
            |:|||.:.   .|.....|...|...|::       .||:..|.   |:..|       |..|.:
  Fly   198 TLRRTEAPPWWKRLTLCNYNTGDKFEERS-------YRTVVPNHTVPPKTPKRDHPNGQFVGNKI 255

Human    55 STAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIE 119
            .|.||.:::|:|:.|..||.|.||.:|:||.||..:|::|..|:...::|:||:|.|.|:|::.|
  Fly   256 RTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFE 320

Human   120 DIKRHKADNAVNKKQTQVL--RNGAWEIVHWEKVNVGDIVIIKGKEYIPADTVLLSSSEPQAMCY 182
            |.:|..:|..:|....:|.  ....::.|.|:::.|||||.:...|.:|||.:||.:|:||.:||
  Fly   321 DRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCY 385

Human   183 IETSNLDGETNLKIRQGLPATSDIKDVDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGA 247
            |:|.:||||||||.|:.:....:::.:....:...|:|.::|...||.|.|.:.......||:..
  Fly   386 IDTCDLDGETNLKRREVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPIST 450

Human   248 DQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVC 312
            :.:|||.::|:||.::.|||||.||:||.|.|::.|..|.|.||:..|:.::....||:.:.:|.
  Fly   451 ECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVG 515

Human   313 SVGSAIWNRRHSGKDWYLNLNYGGASNFGLN------FLTFIILFNNLIPISLLVTLEVVKFTQA 371
            ::|..:|....:    :..:.|...:....|      |.|:|::...:||:||.||:|:.|..|.
  Fly   516 AIGCRMWLSSFT----HFPVPYLPPNKLTANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQV 576

Human   372 YFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHVP- 435
            :.|:.::|:....|:.....|..|:.|||||:::||:|||||||.|.|.|::|.:.|..|.|.|
  Fly   577 FHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPS 641

Human   436 EPEDYGCSPDEWQNSQFGDEKTFSDSSLLENLQNNHPTAPIICEFLTMMAVCHT----AVPERE- 495
            |.|.....|.........::...||.:.|.......|.|..|.|||.::|:|:|    |.|.|:
  Fly   642 ELEKIYSKPGAPAPPLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDM 706

Human   496 ----------------------------------------------------------------- 495
                                                                             
  Fly   707 MNASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAES 771

Human   496 ----------------------------------------------------------------- 495
                                                                             
  Fly   772 RSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVI 836

Human   496 GDKI----------------------------------IYQAASPDEGALVRAAKQLNFVFTGRT 526
            ..||                                  :|:|.||||.|||.||...:.....|:
  Fly   837 NSKITSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRS 901

Human   527 PDSVIID--SLGQEERYELLNVLEFTSARKRMSVIVR-TPSGKLRLYCKGADTVIYDRLAETSK- 587
            |:.:::.  ..|....||:|.||.|.|:||.||::|| ..|.::.||.||||:.|...|...|.
  Fly   902 PNQILVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHN 966

Human   588 -----YKEITLKHLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELI 647
                 .:|.|.:.|:::|.||||.|..|...::.:|:.:|.|.:|....|::||..:|.:|:..:
  Fly   967 SPEGILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKL 1031

Human   648 EKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVIN 712
            |.||.|||||.|||:|||.|||||.:|:.|.|.:|:|||||.||||||.:|.||..:.|.:|.:.
  Fly  1032 ESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLT 1096

Human   713 EGSLDVEDRAVEGTRETLSRHCTT----LGDALRKENDFALIIDGKTLKYALTFGVRQY--FLDL 771
            ..|.|..:.|:......:....||    .|.:|||:.. ||::|||||.:.|....:..  ||.|
  Fly  1097 ARSRDAAETAINFYLTDMENDKTTSTLGYGQSLRKKQR-ALVVDGKTLTFILDPKSKLILPFLRL 1160

Human   772 ALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAANS 836
            :..|.:|:|||.:||||:.:|::||:::.:.|||||||||||||||.|.|||||||.||:||..:
  Fly  1161 SKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMA 1225

Human   837 SDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIG 901
            :|:::.:|:||:.||:.||.|.|:|:|:.|||.||||.....:..|:....|||||::.::..:.
  Fly  1226 ADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLM 1290

Human   902 LYNVMFTAMPPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFP 966
            |||::||::|||.:|::::...::.:||.|.|||..:..:.:....||:..|:.|:.|:::|:..
  Fly  1291 LYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVA 1355

Human   967 LKALQYGTAFGNGKTSDYLLLGNFVYTFVVITVCLKAGL-----ETSYWTWFSHIAIWGSIALWV 1026
            |.|.         ..||   :|.:.:...:...||.|.|     |...||....::|..|:..:.
  Fly  1356 LCAY---------AESD---VGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFY 1408

Human  1027 VF-----------FGIYSSLWPAIPMAPDMSGEAAMLFSSGVFWMGLLFIPVASLLLDVVYKVIK 1080
            :|           ||:.||.|...           :.|:|.|.|:        .::|..|..|:.
  Fly  1409 LFAIVYDSVCMNCFGVRSSYWVIF-----------VCFASAVHWL--------VIMLSTVVAVLP 1454

Human  1081 RTAFKTLVDEVQELEAKSQDPGAVVLGKSLTERAQ 1115
            |....|:     .:.....|...|:| :|..||::
  Fly  1455 RLLLTTV-----RISLCPDDSTKVIL-QSKRERSR 1483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A1	XP_011511917.1	ATPase-Plipid	49..1093	CDD:273734	390/1252 (31%)
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	360/1107 (33%)