DRSC/TRiP Functional Genomics Resources

Multi Sequence Alignment :

Domains

Index TaxID Gene Name GeneID Protein ID Domain
start 		Domain
stop 		Domain
name 		Domain
description 		external_id
hs 9606 PIK3CG 5294 NP_002640.2 962 988 Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 propagated from UniProtKB/Swiss-Prot (P48736.3)
hs 9606 PIK3CG 5294 NP_002640.2 803 809 G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 propagated from UniProtKB/Swiss-Prot (P48736.3)
hs 9606 PIK3CG 5294 NP_002640.2 943 951 Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 propagated from UniProtKB/Swiss-Prot (P48736.3)
hs 9606 PIK3CG 5294 NP_002640.2 729 1095 PI3Kc_IB_gamma Catalytic domain of Class IB Phosphoinositide 3-kinase gamma; cd00894 CDD:270627
hs 9606 PIK3CG 5294 NP_002640.2 549 725 PI3Ka_I Phosphoinositide 3-kinase (PI3K) class I, accessory domain; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5)...; cd00872 CDD:238444
hs 9606 PIK3CG 5294 NP_002640.2 350 527 C2_PI3K_class_I_gamma C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks); cd08399 CDD:176044
hs 9606 PIK3CG 5294 NP_002640.2 203 312 PI3K_rbd PI3-kinase family, Ras-binding domain; smart00144 CDD:197540
hs 9606 PIK3CG 5294 NP_002640.2 1 192 PIK3CG_ABD PIK3 catalytic subunit gamma adaptor-binding domain; pfam19710 CDD:466155
mm 10090 Pik3cg 30955 NP_064668.2 962 988 Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 propagated from UniProtKB/Swiss-Prot (Q9JHG7.2)
mm 10090 Pik3cg 30955 NP_064668.2 803 809 G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 propagated from UniProtKB/Swiss-Prot (Q9JHG7.2)
mm 10090 Pik3cg 30955 NP_064668.2 943 951 Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 propagated from UniProtKB/Swiss-Prot (Q9JHG7.2)
mm 10090 Pik3cg 30955 NP_064668.2 549 725 PI3Ka_I Phosphoinositide 3-kinase (PI3K) class I, accessory domain; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5)...; cd00872 CDD:238444
mm 10090 Pik3cg 30955 NP_064668.2 729 1095 PI3Kc_IB_gamma Catalytic domain of Class IB Phosphoinositide 3-kinase gamma; cd00894 CDD:270627
mm 10090 Pik3cg 30955 NP_064668.2 203 312 PI3K_rbd PI3-kinase family, Ras-binding domain; smart00144 CDD:197540
mm 10090 Pik3cg 30955 NP_064668.2 350 527 C2_PI3K_class_I_gamma C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks); cd08399 CDD:176044
mm 10090 Pik3cg 30955 NP_064668.2 1 192 PIK3CG_ABD PIK3 catalytic subunit gamma adaptor-binding domain; pfam19710 CDD:466155
rn 10116 Pik3cg 298947 NP_001358229.1 350 527 C2_PI3K_class_I_gamma C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks); cd08399 CDD:176044
rn 10116 Pik3cg 298947 NP_001358229.1 729 1095 PI3Kc_IB_gamma Catalytic domain of Class IB Phosphoinositide 3-kinase gamma; cd00894 CDD:270627
rn 10116 Pik3cg 298947 NP_001358229.1 549 725 PI3Ka_I Phosphoinositide 3-kinase (PI3K) class I, accessory domain; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5)...; cd00872 CDD:238444
rn 10116 Pik3cg 298947 NP_001358229.1 1 192 PIK3CG_ABD PIK3 catalytic subunit gamma adaptor-binding domain; pfam19710 CDD:466155
rn 10116 Pik3cg 298947 NP_001358229.1 203 312 PI3K_rbd PI3-kinase family, Ras-binding domain; smart00144 CDD:197540
xt 8364 pik3cg 100158519 XP_012814080.1 568 744 PI3Ka_I Phosphoinositide 3-kinase (PI3K) class I, accessory domain; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5)...; cd00872 CDD:238444
xt 8364 pik3cg 100158519 XP_012814080.1 221 328 PI3K_rbd PI3-kinase family, ras-binding domain; cl02484 CDD:413336
xt 8364 pik3cg 100158519 XP_012814080.1 748 1118 PI3Kc_IB_gamma Catalytic domain of Class IB Phosphoinositide 3-kinase gamma; cd00894 CDD:270627
xt 8364 pik3cg 100158519 XP_012814080.1 366 546 C2_PI3K_class_I_gamma C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks); cd08399 CDD:176044
xt 8364 pik3cg 100158519 XP_012814080.1 15 208 PIK3CG_ABD PIK3 catalytic subunit gamma adaptor-binding domain; pfam19710 CDD:466155
dr 7955 pik3cg 406598 XP_021330656.1 16 208 PIK3CG_ABD PIK3 catalytic subunit gamma adaptor-binding domain; pfam19710 CDD:466155
dr 7955 pik3cg 406598 XP_021330656.1 739 1105 PI3Kc_IB_gamma Catalytic domain of Class IB Phosphoinositide 3-kinase gamma; cd00894 CDD:270627
dr 7955 pik3cg 406598 XP_021330656.1 559 735 PI3Ka_I Phosphoinositide 3-kinase (PI3K) class I, accessory domain; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5)...; cd00872 CDD:238444
dr 7955 pik3cg 406598 XP_021330656.1 366 537 C2_PI3K_class_I_gamma C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks); cd08399 CDD:176044
dr 7955 pik3cg 406598 XP_021330656.1 221 327 PI3K_rbd PI3-kinase family, ras-binding domain; pfam00794 CDD:395642
dm 7227 Pi3K92E 42446 NP_650902.1 727 1084 PI3Kc_I Catalytic domain of Class I Phosphoinositide 3-kinase; cd05165 CDD:270709
dm 7227 Pi3K92E 42446 NP_650902.1 552 723 PI3Ka_I Phosphoinositide 3-kinase (PI3K) class I, accessory domain; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5)...; cd00872 CDD:238444
dm 7227 Pi3K92E 42446 NP_650902.1 200 307 PI3K_rbd PI3-kinase family, Ras-binding domain; smart00144 CDD:197540
dm 7227 Pi3K92E 42446 NP_650902.1 339 517 C2_PI3K_class_I_beta_delta C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks); cd08693 CDD:176075
dm 7227 Pi3K92E 42446 NP_650902.1 56 132 PI3K_p85B PI3-kinase family, p85-binding domain; cl02483 CDD:470589
ag 7165 Pi3K92E 1272257 XP_061510893.1 - - - - -
ce 6239 age-1 174762 NP_496462.2 793 1181 Protein Kinases, catalytic domain The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453 CDD:473864
ce 6239 age-1 174762 NP_496462.2 606 798 PI3Ka Phosphoinositide 3-kinase family, accessory domain (PIK domain); smart00145 CDD:214537
ce 6239 age-1 174762 NP_496462.2 98 177 PI3K_p85B PI3-kinase family, p85-binding domain; smart00143 CDD:197539
ce 6239 age-1 174762 NP_496462.2 241 360 PI3K_rbd PI3-kinase family, Ras-binding domain; smart00144 CDD:197540
ce 6239 age-1 174762 NP_496462.2 420 574 C2_PI3K_like C2 domain present in phosphatidylinositol 3-kinases (PI3Ks); cd08380 CDD:176026
is 6945 LOC8042151 8042151 XP_029841474.1 505 676 PI3Ka Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in...; cl00271 CDD:412275
is 6945 LOC8042151 8042151 XP_029841474.1 320 471 C2 C2 domain; cl14603 CDD:472691
is 6945 LOC8042151 8042151 XP_029841474.1 171 289 PI3K_rbd PI3-kinase family, ras-binding domain; cl02484 CDD:413336
is 6945 LOC8042151 8042151 XP_029841474.1 32 105 PI3K_p85B PI3-kinase family, p85-binding domain; pfam02192 CDD:460483
is 6945 Pi3K92E 8036652 XP_029826199.2 697 1056 PI3Kc_I Catalytic domain of Class I Phosphoinositide 3-kinase; cd05165 CDD:270709
is 6945 Pi3K92E 8036652 XP_029826199.2 316 487 C2 C2 domain; cl14603 CDD:472691
is 6945 Pi3K92E 8036652 XP_029826199.2 178 281 PI3K_rbd PI3-kinase family, ras-binding domain; cl02484 CDD:413336
is 6945 Pi3K92E 8036652 XP_029826199.2 35 106 PI3K_p85B PI3-kinase family, p85-binding domain; pfam02192 CDD:460483
is 6945 LOC8042151 8042151 XP_029841474.1 679 1043 PI3Kc_I Catalytic domain of Class I Phosphoinositide 3-kinase; cd05165 CDD:270709
is 6945 Pi3K92E 8036652 XP_029826199.2 522 692 PI3Ka Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in...; cl00271 CDD:412275
sc 4932 VPS34 850941 NP_013341.1 528 871 PI3Kc_III Catalytic domain of Class III Phosphoinositide 3-kinase; cd00896 CDD:270628
sc 4932 VPS34 850941 NP_013341.1 <1 872 TEL1 Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]; COG5032 CDD:227365
sp 4896 pik3 2543444 NP_594699.1 450 797 PI3Kc_III Catalytic domain of Class III Phosphoinositide 3-kinase; cd00896 CDD:270628
sp 4896 pik3 2543444 NP_594699.1 <1 801 TEL1 Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]; COG5032 CDD:227365
at 3702 VPS34 842344 NP_176251.1 466 811 PI3Kc_III Catalytic domain of Class III Phosphoinositide 3-kinase; cd00896 CDD:270628
at 3702 VPS34 842344 NP_176251.1 274 432 PI3Ka_III Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III...; cd00870 CDD:238442
at 3702 VPS34 842344 NP_176251.1 25 178 C2_PI3K_class_III C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks); cd08397 CDD:176042

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Alignment

Alignment done with MAFFT FFT-NS-2 (v7.305b) aligner. MAFFT References

Download raw alignment output file

Download fasta input file



Note:   &mbsp 2019, we've been having trouble with some alignments and are looking into the problem. If the alignment didn't work, please try again. If it still doesn't work, please download the fasta file and align off line. We're looking into it. Thanks.

hs  --------------------------------------MELENYKQPVVLREDNCRRRRRMKPRSAAAS----LSSMEL-IPIEFVLPTSQRKCKSP--ETALLHVAGHGNVEQMKAQVW [75]
mm  --------------------------------------MELENYEQPVVLREDNLRRRRRMKPRSAAGS----LSSMEL-IPIEFVLPTSQRISKTP--ETALLHVAGHGNVEQMKAQVW [75]
rn  --------------------------------------MELENYEQPVVLREDNLRRRRRMKPRSAAGS----LSSMEL-IPIEFVLPTSQRISKTP--ETALLHVAGHGNVEQMKAQVW [75]
xt  ---MKKETLLCRG-NML------------------ASGMELDSYEQPVVLRDENQRRRRRMRPHSATSN----MFPMEQ-IPIEFILPTSNRCSKVQ--ETMLLEVAGNCSVEQMKAQIW [91]
dr  ---MTDKGGATAGFNTL------------------VMEQQASDDEPPVVRREENKRRRRRMKAFTSASA----V-SMEH-IAVEFVLPTTNKNSKTL--DTLQLDVTGNWTVEQVKVQLW [91]
dm  MNMMDNRALA-------------------------YVAHQPKYETPPEEA----------EPPCMRFSVNLW-KNEMLNWVDLICLLPNGF---------LLELRVNPANTIQVIKVEMV [75]
ag  MQRMRNATTTMKR-NTTTMPGGTD--SSWSVPHRIYLQQQQQQQQQQQQAHQQQQQQQQQQRP--RFDYGFW-KNPDES-TELIFLMPNGV---------MITMYIPIHITLDELKSDVW [104]
ce  MSMGRSPSTTFRS-RTGSH-GARDLIAGHGRNSRRISQMHVNILHPQLQTMVEQWQMRERPSLETENGKGSL-LLENEGVADIITMCPFGEVISVVFPWFLANVRTSLEIKLSDFKHQLF [117]
is  ------------------------------MPPS---------------------------------SGELWGFTLMPNTIVVDCLMPTGI---------IIPLDCARDATLESIKDNLW [48]
is6 -----------------------------MIPPSPFLL----------------------PDP--------W-ISDVELQVDVTVLLPNGL---------VLPLQVHRESTLEELKQCTW [51]
sc  ------------------------------------------------------------------------------------------------------------------------ [0]
sp  ------------------------------------------------------------------------------------------------------------------------ [0]
at  ------------------------------------------------------------------------------------------------------------------------ [0]
                                                                                                                            

hs  LRALETSVAADFYHRLGPHHFLLLYQ-KKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPS--EESQAFQRQLTALIGYDVTDV---SNVHDDELEFTRRGL------VTP [183]
mm  LRALETSVAAEFYHRLGPDQFLLLYQ-KKGQWYEIYDRYQVVQTLDCLHYWKLMHKSPGQIHVVQRHVPS--EETLAFQKQLTSLIGYDVTDI---SNVHDDELEFTRRRL------VTP [183]
rn  LRALETSVAAEFYHRLGPDQFLLLYQ-KKGQWYEIYDRYQVVQTLDCLRYWKMMHKSPGQIHVVQRHVPS--EETLAFQKQLTSLIGYDVTDI---SNVHDDELEFTRRRL------VTP [183]
xt  MHAIEKSHNSDFYQRLTPDQFLLQYQ-KKGQWYEIYDKHQVIQTLDCIMYWKVLQKTVGKIHIVQKEKIP--EEMIEYQKTLNYLIGYDVTDV---SNVHDDELEFTRRRL------VTP [199]
dr  HRAVTSKLCPEFYQKYSPDYCILLYQ-KKGNWYEIYDKQQVFQTLDCIRYWKALRKDVGKIHLVVRQQPA--EDSLQYQRFLNHLIGYDVTDV---SNVHDDELEFTRRKL------LTP [199]
dm  NQAKQMPLGYVIKEACEYQVYGI----STFNIEPYTDETK--RLSEVQPYFGILS-------LGERTDTTSFSSDYELTKMVNGMIGTTFDHN---RTHGSPEIDDFRLYMTQTCDNIEL [179]
ag  EEAERYPLYCHLGDKNKY-CFGTLAAGRTNSNTTYENEAET-RLMDVQPTLGILR-------FVEKSNVS------ENTKLMEN-ISSLLDSKLPVKTLVNPEVNDFRAKMSMLSEDIGS [208]
ce  ELIAPMKWGTYSVKPQDY-VFRQLN--NFGEIEVIFNDDQPLSKLELHGTFPMLF-------LYQPDGIN---RDKELMSDISHCLGYSLDKL---EESLDEELRQFRASLW-----ART [216]
is  DIAQKYPLFNRLGDPSSY-IFVSIT--RDAEKEEFYDESR--RLCDLHLFHPLLK-------IVEPKGNT---EEKKLNSEIRLAVGGCVHEF---DNMKDTEVIDFRRNILGVCKEAVD [150]
is6 REAERLPLYRCLRGRDTY-VFTCVSE-RTSEREEFADEGR--KLCDVRPFQALLR-------LVERPSDK---ADRQTNAQIGLLIGKGLNSF---DALKCPEVNEFRRTMRAFCTSIAD [154]
sc  ----------------------------------------------------------------------------MSLNNITFCVSQDLDVP------------------------LKV [20]
sp  --------------------------------------------------------------------------------MDRLVFSYCPSSK------------------------VTA [16]
at  ----------------------------------------------------------------------------MGANEFRFFLSCDINSP------------------------VTF [20]
                                                                                         ..                                 

hs  RMAEVAS--RDPKLYAMHPWV---TSKPLPEYLWKKIANNC--IFIVIHRSTTS----------QTIKVSPDDTPGAIL-QSFFTKMAKKKSLMDI---PESQSEQDFVLRVCGRDEYLV [282]
mm  RMAEVAG--RDAKLYAMHPWV---TSKPLPDYLSKKIANNC--IFIVIHRGTTS----------QTIKVSADDTPGTIL-QSFFTKMAKKKSLMNI---SESQSEQDFVLRVCGRDEYLV [282]
rn  RMAEVAG--RDAKLYAMHPWV---TSKPLPDYLSKKIVNNC--IFIVIHRGTTS----------QTIKVSADDTPDTIL-QSFFTKMAKKKSLMNI---PESQSEQDFVLRVCGRDEYLV [282]
xt  RMIELSR--RDARLYSMDPWV---TCKSLPEYLCQRIISNS--IFIIIHKGMTS----------HTIRVSIDDTPDVIL-HSFFTKMAKKKSLLDI---SEENSELDFVLRVCGRDEYII [298]
dr  RKIELSD--RDPNLYSMDPWM---TTTPMPEYLLSKISNNH--ILMVIHKETTS----------QTIKVSIDDTPVQVL-QSFFAKITNKRALLGI---SEDVSESDFVLRVCGREEYLY [298]
dm  ERSAYTW--QQRLLYEHPLRL--ANSTKMPELIRERHPTRT--FLIVVKNENDQS--------TFTLSVNEQDTPFSLT-ESTLQKMNRSQM-------KMNDRTSDYILKVSGRDEYLL [277]
ag  RRAVMTR--MERIAYQYPAKL--VSGAHVPEPISRRLTNGD--FCVVAISTDMQ----------LTVKVPCRATPDEVL-KRILKKQNPSKA-------RNENSSTEYILKVCGREEYIY [304]
ce  KKTCLTRGLEGTSHYAFPEEQYLCVGESCPKDLESKVKAAKLSYQMFWRKRKAEINGVCEKMMKIQIEFNPNETPKSLL-HTFLYEMRKLDV-----YDTDDPADEGWFLQLAGRTTFVT [330]
is  KRDSGSE--ECRASYVYPPEI--ESSHELPSNLERKLDKGLVMVCVWVLSDSGEK-------QKHTLEVDKDTRPENVIKEAILKKLKCSRMPKEEQLAKAQEYQKHYLLKVCGVNQYLL [259]
is6 KRAEWSP--LDQVKYRYPARVDRFCSQYPPPHMGDRISSADSTFGAEILFENGG---------MMTMNVAIGATPQALL-LLVMQSAASGEQ-------FLCHTVEGLVLKVCGREEYLL [255]
sc  K-----------------------------------------------------------------IKSLEGHKP--------LLKPSQKIL---------------------------- [39]
sp  RF----------------------------------------------------------LVKFCFIEYQDSQEPCICT--IQLFSGNESG----------------------------- [47]
at  R-----------------------------------------------------------------IEKLDGNLP--------VKKSSDSGVV--------------------------- [40]
    .                                                                 :       *        . .                                  

hs  G-ETPIKNFQWVRHCLKNGEEIHVVLDTPPDPA--LDEVRKEEWP---------------------------LVDDCTGV-----TGYHEQLTIHGKD-------HESVFTVSLWDCDRK [360]
mm  G-ETPLKNFQWVRQCLKNGDEIHLVLDTPPDPA--LDEVRKEEWP---------------------------LVDDCTGV-----TGYHEQLTIHGKD-------HESVFTVSLWDCDRK [360]
rn  G-ETPLKNFQWVRQCLKNGEEIHLVLDTPPDPA--LDEVRNEEWP---------------------------LVDDCTGV-----TGYHEQLTIHGKD-------HESVFTVSLWDCDRK [360]
xt  G-NAPIKDFHWIRQCIKNGQEIHLVLEKPPDPL--MDEVQKEQWP---------------------------LVDDCTGV-----TGYHEQLTIEGKD-------HEKIFTISLWDCNRK [376]
dr  G-NNAIKDFHWIRQCLKNGEEIHLVLEHPPNPE--QDVVQKEDWS---------------------------QVDDCTGV-----AGTHEQLTITEKD-------HEKVFTISLWDCNRK [376]
dm  G-DYPLIQFLYIQEMLSDSAVPNVVLQSVYRLESYINH-------------------------------------------------HNEQAMVTKRPLPKKRTVHLHKSISSLWDMGNY [347]
ag  G-AHPMISFQYVQDCLSRDETPTFVPRLVRTVEVFKNDIYDAREDFTQWSASAKPSSLY-----------GGSISSSSGYAGSAGSTYNTQSQ-------QSHTLRKVKYITS-WEIDAK [404]
ce  NPDVKLTSYDGVRSELESYRCPGFVVRR-------QSLVLKDY---CRPKPLYEPHYVRAHERKLALDVLSVSIDSTPKQ-----SKNSDMVMTDFRP-------TASLKQVSLWDLDAN [428]
is  K-TYPLCRYKYIRTCIAKGDIPQLMLML-------KDAVYKA----IPPSHYITPSYM-----------------------RRNPSTSSTQST---MPL---------------FRVDEV [326]
is6 E-ELPLLQYKYVQEKVSEGSTPQFTVVPISDIQTDHDMVY------AQIERCMEPSFC--------------------------------------RPSP-----HPDKLVSA-WMIGDP [324]
sc  --------------------NPELMLIG-------------------------------------------------------------------------------------------- [47]
sp  ----------------------SLMQ---------------------------------------------------------------------------------------------- [51]
at  --------------SIAEEKKPELYI---------------------------------------------------------------------------------------------- [52]
                           .                                                                                                

hs  FRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSP--KPFTEEVLWNVWLE-FSIKIKDLPKGALLNLQIYCGKAPALSSKAS----AESP---SSESKGKVQLLYYVNLLLID [470]
mm  FRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSP--KPFAEEVLWNVWLE-FGIKIKDLPKGALLNLQIYCCKTPSLSSKAS----AETP---GSESKGKAQLLYYVNLLLID [470]
rn  FRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSP--KLFTEEVLWNVWLE-FGIKIKDLPKGALLNLQIYCCKTPSLSSKAS----VETP---GSESKGKAQLLYYVNLLLID [470]
xt  FRVKIIGIDIPVLPKNTELIAFVEANIQHGQQVLSQRRTTC--KPFTEEVLWNSWLE-FDIKIKDLPKGALLNLQIFCGKAPTASNKSI----VQSPESTASDSKCKNQLLYYVNLLLID [489]
dr  FRVKILGIDIPVLPRNSELIVFVEASIFHGQQLLAQERTSS--KPFTEEVIWNTWLE-FNIKIKDLPKGARLSLQVSCGKAQTQTSK-------------ETECKNKSRLLYYVNLLLVD [480]
dm  FQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIF---EVTKMSRSK--KSSNNKDIALKDVPYNKNPLAWVNTTIFD [462]
ag  LQCTVHEIRGLNVESDKEL--GVQLGLFHGGKSLCKTERTRTVTVNSGAATWNETIL-FDINVSNVPRMARLCLVVY---ENMRTAKGTGIRTRRTKDGLI-------NPIAWVNTMVYD [511]
ce  LMIRPVNISGFDFPADVDMYVRIEFSVYVGTLTLASKSTT---KVNAQFAKWNKEMYTFDLYMKDMPPSAVLSIRVLYGKVKLKSEEFE---------------------VGWVNMSLTD [524]
is  FRVKILGASYVNVKDVDKI--YVRTGIYHGTESLCPFRDTQ--HVAHSNPKWDEQLE-FDMYIPDIPRSARLCVSIC---AVSQRKKRE-----------------ERCAIAWGNISLFD [421]
is6 FRVRVLSASSVNVESGAKL--VVEGGLYHGTELLCQTQRTQDCSVADGRGSWDQQLC-FDLAVRDLPQAVRLCLGLY---EVTRGTRHPRARRRLGPDLYA-------APLAWVNVTVYD [431]
sc  ----------SNVFPSSDLIVSLQVFDKERNRNLTLPIYTP-YIPFRNSRTWDYWLT-LPIRIKQLTFSSHLRIILW---EYNGSKQI--------------------PFFNLETSIFNL [132]
sp  -----------------KCFVS------------KIPNKSL-LPTELSKISTHEWLD-FGVTVSELSLNAKFVVSAW---KPSFNDEEV------------------YEFVGCTTYRLFD [119]
at  -----------------ECALYID------GAPFGLPMRTR-LKTTGPPYCWNELIT-LSSKYRDLTAHSQLAITVW---DVSCGKTE--------------------GLIGGATVLLFN [124]
                                           :            .  :  :     ::.    : :                                    .   .  .  

hs  HRFLLRRGEYVLHMWQISGK---------------------------------GEDQGSFNADKLTSATNPDKEN-------------SMSISILLDNYC---HPIAL------------ [529]
mm  HRFLLRHGDYVLHMWQISGK---------------------------------AEEQGSFNADKLTSATNPDKEN-------------SMSISILLDNYC---HPIAL------------ [529]
rn  HRFLLRHGGYVLHMWQISGK---------------------------------AEEQGSFNADKLTSATNPDKEN-------------SMSISILLDNYC---HPIAL------------ [529]
xt  HRFLLRQGEYVLHMWKIPGK---------------------------------GEEQGSINADKLTSATNPDKET-------------SMAISISLDKYC---HPVAL------------ [548]
dr  HRSLLRQGEFILHMWKMPEK---------------------------------SEDNSSVNADKLTSATNPDKNN-------------SMAVAILLDKYC---YPVAL------------ [539]
dm  HKDILRTGRHTLYTWTYADD----------------------------------IQSVEVFHPLGTIEPNPRKEEC----------ALVDLTFLSSGT-----GTVRY------------ [521]
ag  YKNQLKVDSVTLYTWDYAED----------------------------------AQSEDILHPLGTVEPNPNRDN------------MVVSVLLSFGTYGPEGRIIVY------------ [573]
ce  WRDELRQGQFLFHLW----------------------------------------------------APEPTANRSRIGENGAR-IGTNAAVTIEISSYG---GRVRM------------ [576]
is  YKSVLLSGRMNLHLWPVPKG------------------------------------MDELLNPLGITGSNPNRE--------------APCLVIEFDRFP---GQVTF------------ [476]
is6 FRGYLRFGCVDLSMWTYADEP--------------------------------HAEEMDLLHPMGTAVFNPEAHH-------------ATTLTIQFEPYHPS-HPVRY------------ [493]
sc  KDCTLKRGFESLKFRYDV-------------IDHCEVVTDNKDQENLNKYFQGEFTRLPWLDEITISKLRKQRENRTWPQGT---FV----LNLEFPMLE---LPVVFIEREIMNTQMNI [229]
sp  ENNLLRQGLQKIPLQTSKEIKKYSPTS----LELEQVKEINRLDGLLLKLQLGDVPSVNWLDDI---SFGKIKDFRS-KHMS---LVTIPILYLDFLQFS---FPVVFQRS-------YY [218]
at  SKMQMKSGKQKLRLWQGKEADGSFPTSTPGKVPRHERGELERLEKLMNKYERGQIQSIDWLDRLMLKSLDTIKEQESTKHGSSHLFVVI-----DFCSFE---HRVVFQESG-ANLFITA [235]
        :  .   :                                                             .                               :              

hs  ----------------------------------------------PKH-------------QPTPDPEGDRVRA--------EMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYES [582]
mm  ----------------------------------------------PKH-------------RPTPDPEGDRVRA--------EMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYES [582]
rn  ----------------------------------------------PKH-------------RPTPDPEGDRVRA--------EMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYES [582]
xt  ----------------------------------------------PKH-------------KLVCDPELERPRT--------EMPNQLRKQLEEIIATDPLHPLTPEDKELLWHFRSEI [601]
dr  ----------------------------------------------PKS-------------KDSPDIEGERGQR--------EMPNHLRKQFEQIIATDPLHPLTSEDKELLWHFRQEC [592]
dm  ----------------------------------------------PSEEV---VLQYAAD-REQVN-RLQRQLAGP-----EKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDI [585]
ag  ----------------------------------------------PGEEE---LLSHAAK-MSHRNEHLNRESA--------EDTRSIRAIMSAYMYNDRLNDIHEQDRNAIWAKRREC [635]
ce  ----------------------------------------------PSQGQYTYLVKHRSTWTETLNIMGDDYESCIRDPGYKKLQMLVKKHESGIV-------LEEDEQRHVWMWRRYI [643]
is  ----------------------------------------------PTMEQ---IEEYATF-IAQIKPSGDEDPS--------SWSENDKELVQEIIRRDPLSEISEQEKMLLWKMRYYC [538]
is6 ----------------------------------------------PMLDE---ILECAASCVKEKSTYLQ----GI-----GHASKSHREQLRQIAEQDPLAPLHEQDRQLLWFLRYDC [555]
sc  PTLKNNPGLSTDLREPNRNDPQIKISLGDKYHSTLKFYDPDQPNNDPIEEKYRRLE------RASKNANLDKQ---------VKPDIKKRDYLNKIINYPPGTKLTAHEKGSIWKYRYYL [334]
sp  PKSENRVYYSS--------------------------FDLELNLDSPAELKHRRLV------RSQRNGPLDKD---------LKPNSKIRKELESILSYPPSEELSLEEKDLIWKFRFYL [297]
at  PIGSTNEFVTV--------------------------WDTELGKTNPSENKQLKLA------RSLDRGIIDRD---------LKPSNIERKSIQRVLKYPPTRTLSGDERQLLWKFRFSL [314]
                                                  *                       :                  :              :  .::  :*  *   

hs  L-KHPKAYPKLFS-SVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLE-SLEDDDVLHYLLQLVQAVKFE----------------------------- [670]
mm  L-KHPKAYPKLFS-SVKWGQQEIVAKTYQLLARREIWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLE-SLEDDDVLHYLLQLVQAVKFE----------------------------- [670]
rn  L-KHPKAYPKLFS-SVKWGQQEIVAKTYQLLARREIWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLE-SLEDDDVLHYLLQLVQAVKFE----------------------------- [670]
xt  V-KHPEAYPKLLS-SVKWGQQEMVAKTYQLLSKREAWDDCSLDVGLTIQLLDCNFSDENVRAMAVQKLE-SLQDDDVLHYLLQLVQAVKFE----------------------------- [689]
dr  M-RDPKAYPKFLS-SVKWGKQEAVAITHYLLERSTIWDRSVLDVGLVLQLLDCHFSDENVRTIAVRKLE-TLGDDDVLRYLLQLVQAVKFE----------------------------- [680]
dm  LRELPEELSILLH-CVYWKERDDVADMWYLLKQ---WPLISIERSL--ELLDYAYPDPAVRRFAIRCLH-FLKDEDLLLYLLQLVQAIKHE----------------------------- [669]
ag  MKQMPQGLPCLLY-CVEWNNRDEVSEIVSLLQE---WPKLLVERAL--ELLDYAYADKYVRRYAVDCLR-TIEDDELLLYLLQLVQALKHE----------------------------- [719]
ce  QKQEPDLLIVLSELAFVWTDRENFSELYVMLEK---WKPPSVAAAL--TLLGKRCTDRVIRKFAVEKLNEQLSPVTFHLFILPLIQALKYE----------------------------- [729]
is  C-SVPDSLPKLLD-AHKWNSRDHVAQLYKLLKS---WQQVSPETAL--ELLDCKYADMFVRKYAVAWLDVSLSDELLSQYLLQLVQVLKYE----------------------------- [622]
is6 L-ELPHVLPKLLL-SLRWGDHCDVALMQALLQI---WKLLKPEQAL--ELLDYSYPDNYVRSFAVRCLR-QMSDEELSLYLLQLVQALKHE----------------------------- [638]
sc  M-NNKKALTKLLQ-STNLREESERVEVLELMDS---WAEIDIDDAL--ELLGSTFKNLSVRSYAVNRLK-KASDKELELYLLQLVEAVCFENLSTFSDKSNSEFTIVDAVSSQKLSGDSM [446]
sp  T-RNKKAMTKFLK-SVVWTDSSEVNQALSLLDS---WTEIDIDDAL--ELLSPSFVHPKVRAYAVSRLE-TASNEELLLYLLQLVQALRYDNPISSDERFQP------------------ [391]
at  M-SEKRALTKFLR-CVEWSDVQEAKQAIQLMYK---WEMIDVCDAL--ELLSPLFESEEVRAYAVSVLE-RADDEELQCYLLQLVQALRF-------ERSDR------------------ [401]
              :   .    .         ::     *       .*   **.       :*  *:  *        .  ::* *::.: .                              

hs  ---------------------------PYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIA-------QSRHYQQRFAVILEAYLRGCGT-----------AMLHDFTQQVQVIEMLQKV [745]
mm  ---------------------------PYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIA-------QSRHYQQRFAVILEAYLRGCGT-----------AMLQDFTQQVHVIEMLQKV [745]
rn  ---------------------------PYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIA-------QSRHYQQRFAVILEAYLRGCGK-----------AMLQDFTQQVHVIEMLQKV [745]
xt  ---------------------------PYHDSALSRFLLKRALQSKRIGHFLFWFLRSEIA-------QSMHYQQRFAVILEAYLRGCGK-----------AMLDDFTRQVQVTEILHKV [764]
dr  ---------------------------PYHDSALARFLLKRALRSKRIGHFLFWFLRSEIA-------QSMHYQQRYAVILEAYLRGCGE-----------EMLQDFRKQVEITEALQKV [755]
dm  ---------------------------SYLESDLVVFLLERALRNQRIGHYFFWHLRSEM--------QTPSMQTRFGLLLEVYLKGCKH-----------H-VAPLRKQLHVLEKLKQG [742]
ag  ---------------------------SYLNCDLVYFLLQRALHNQHIGHYLFWHLRSEI--------SVPSVQVRFGLILEAYLLGSPE-----------H-VAVLLKQMQCLRYLQTC [792]
ce  ---------------------------PRAQSEVGMMLLTRALCDYRIGHRLFWLLRAEIARLRDCDLKSEEYR-RISLLMEAYLRGNEE-----------H-IKIITRQVDMVDELTRI [809]
is  ---------------------------PYLDNDLGKFLIKRSLLNYNIGHFFFWHLKSEM--------HDPSVAVRFGLLLEGFCRGIGT-----------H-LKSVVRQVGALEKLTQL [695]
is6 ---------------------------SFLDCDLVKFLLERALKNRHIGHQMFWLLRCEM--------QVAALSVKFGLILEAYCHGAPD-----------H-REALLKQAEAFFKLRAL [711]
sc  LLSTSHANQKLLKSISSESETSGTESLPIVISPLAEFLIRRALVNPRLGSFFYWYLKSES--------EDKPYLDQILSS---FWSRLDK-----------KSRNILNDQVRLINVLREC [544]
sp  -------------------------------SPLALFLVNRAISSPSIGNDLYWYLVVEI--------EDEPVSKLFSSVMFLFQKELSK------SVEGRLIRETLSAQAKFVEKLLRI [466]
at  -------------------------------SCLSQFLVQRALQNIELASFLRWYVAVEL--------HDHVYAKRFYSTYELLEENIIKLPPGVNGEDGYQLWQSLVRQTELTAQLCSI [482]
                                     :  :*: *.: .  :.  : * :  *                                               .  *      *   

hs  TLDIKSLSAEKYDVSSQVISQLKQKLENLQNS----QLPE-SFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKC-ADPTALSNETI----GIIFKHGDDLRQDMLILQILRIMESIW [855]
mm  TIDIKSLSAEKYDVSSQVISQLKQKLESLQNS----NLPE-SFRVPYDPGLKAGTLVIEKCKVMASKKKPLWLEFKC-ADPTVLSNETI----GIIFKHGDDLRQDMLILQILRIMESIW [855]
rn  TIDIKSLSAEKYDVSSQVISQLKQKLESLQNS----SLPE-SFRVPYDPGLKAGTLVIEKCKVMASKKKPLWLEFKR-ADPTVLSNETI----GIIFKHGDDLRQDMLILQILRIMESIW [855]
xt  TMEIKSVSAEKYDVTSQVITQLRQKLEKLQNSKLPDKLPD-SFRVPYDPGLRAGSLVVEKCKVMASKKKPLWLEFKC-SDTTALSNETI----GIIFKHGDDLRQDMLILQILRIMGSIW [878]
dr  AREIKQISAEKYDISAQVVFQLRQKLEGLQVL----GLPD-SFKVPYDPGLRAGALVIEQCKVMASKKKPLWLQFKR-ADPTTLSSDTI----GIIFKDGDDLRQDMLILQILLIMESIW [865]
dm  SLIA------KKGSKEKVKTMLQDFLRDQRNS----AVFQ-NIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFEN-ADVNA---SDV----HIIFKNGDDLRQDMLTLQMLRVMDQLW [843]
ag  SDNV------KKGSKEKGRTLLIEQL--AKEG----HVTS-DLISPLNPSYRCKAVRTDRCKVMDSKMRPLWIVYEN-SDANG---DDI----HMIFKNGDDLRQDMLTLQMLRIMDRIW [891]
ce  STLV------KGMPKDVATMKLRDELRSIS------HKME-NMDSPLDPVYKLGEMIIDKAIVLGSAKRPLMLHWKN-KNPKS---DLHLPFCAMIFKNGDDLRQDMLVLQVLEVMDNIW [912]
is  TDSMKER---KDDTQKERLKFLMEQFSKPDFL----EALQ-NFPSPLNNSCILGDLIVADCKILDSAKKPLWLLWKN-PDHLA---EQILDHHEIIFKNGDDLRQDMLTLQVIRIMDSIW [803]
is6 GNQIHESS-KKKDSREKMVATMREHMSKEAFR----ATFR-NLCSPLDPCHVFSQIKPELCRFMDSKMKPLWLVFEN-SDAVA---EDI----AIIFKHGDDLRQDMLTLQMIRIMDKLW [817]
sc  CETIKR----LKDTTAKKMELLVHLLETKVRPLV--KVR--PIALPLDPDVLICDVCPETSKVFKSSLSPLKITFKT-TLNQP---------YHLMFKVGDDLRQDQLVVQIISLMNELL [646]
sp  SKSVQS----FRGTRLKKIEYLKVLLEDHKYHLL--DFHALPL--PLDPSVNIVGIIPDACTVFKSTMQPLRLLFKC-QDGSK---------YPIIFKNGDDLRQDQLVIQILTLMDKLL [568]
at  TREVRN----VRGNTQKKIEKLRQLLGGLLSELT--YFEE-PIRSPLTPNVLIKGIVAGESSLFKSALHPLRLTFRTPEEGGS---------CKLIFKKGDDLRQDQLVVQMVWLMDRLL [586]
                         :   :                :  *         :    . .: *   ** : :.                  ::** ******* * :*:: :*  : 

hs  ETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQ---STV-GNTGAFKDEVLNHWLKEKSPTEE-------------------------KFQAAVERFVYSCAGYCVATFVLGIGD [946]
mm  ETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAQIQQ---STV-GNTGAFKDEVLNHWLKEKCPIEE-------------------------KFQAAVERFVYSCAGYCVATFVLGIGD [946]
rn  EAESLDLCLLPYGCISTGDKIGMIEIVKDATTIAQIQQ---STV-GNTGAFKDEVLNHWLKEKCPIEE-------------------------KFQAAVERFVYSCAGYCVATFVLGIGD [946]
xt  EAESLDLCLLPYGCISTGNKIGMIEIVKDATTIAQIQQ---STV-GNTGAFKDEVLSQWLKEKCPIEE-------------------------KFSAAVERFVYSCAGYCVATFVLGIGD [969]
dr  ELESLDLSLLPYGCISTGNKIGMIEIVKDATTIANIQQ---STV-GNTGAFKDEILSQWLREKCVNED-------------------------KHQQAVDRFVFSCGGYCVATYVLGIGD [956]
dm  KRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKE-KGMF-SATSPFKKGSLLSWLKEHNKPAD-------------------------KLNKAINEFTLSCAGYCVATYVLGVAD [936]
ag  KSHGYDFRMNPYSCISTDHKLGLIEVVLNAETIANIQKE-RGMF-SATSPFKKGSLLAWLREHNGTED-------------------------LLAKAIQEFTLSCAGYCVATYVLGVAD [984]
ce  KAANIDCCLNPYAVLPMGEMIGIIEVVPNCKTIFEIQVG-TGFMNTAVRSIDPSFMNKWIRKQCGIEDEKKKSKKDSTKNPIEKKIDNTQAMKKYFESVDRFLYSCVGYSVATYIMGIKD [1031]
is  QKEGLDLRMMPYACLSTGKQVGMIEVVRNAKTVMNIQKK-GGR--MAAFQVDSTQLHKWIREKNK-RE-------------------------RYKQAIETFTLSCAGYCVATFILGIGD [894]
is6 KDEGYDFRMIPYQCLSTDQNVGLIEVVRNASTIANIQKL-HNS--SATSAFKKGSLFAWIKEHNKTQE-------------------------SLRRAVENFTLSCAGYCVATYVLGVAD [909]
sc  KNENVDLKLTPYKILATGPQEGAIEFIPN-DTLASILSKYHG-I------------LGYLKLHYPDE---------------------NATLGVQGWVLDNFVKSCAGYCVITYILGVGD [731]
sp  KKEKLDLHLKPYRILATGPTHGAVQFVPS-KTLATILAEYHGSV------------LAYLRENNPDDG------------------LNSANYGIDPVAMDNYVRSCAGYCVITYLLGVGD [657]
at  KLENLDLCLTPYKVLATGHDEGMLEFIPS-RSLAQILSE-HRSI------------TSYLQKFHPDE---------------------HAPFGITATCLDTFIKSCAGYSVITYILGIGD [671]
    :    *  :  *  :.     * ::.:    ::  *                      :::                                     :: :  ** **.* *:::*: *

hs  RHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPF----VLTPDFLFVMGTSGK--KTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKED--IEYIRDALTV- [1057]
mm  RHNDNIMISETGNLFHIDFGHILGNYKSFLGINKERVPF----VLTPDFLFVMGSSGK--KTSPHFQKFQDVCVRAYLALRHHTNLLIILFSMMLMTGMPQLTSKED--IEYIRDALTV- [1057]
rn  RHNDNIMISETGNLFHIDFGHILGNYKSFLGINKERVPF----VLTPDFLFVMGTSGK--KTSPHFQKFQDVCVRAYLALRHHTNLLIILFSMMLMTGMPQLTSKED--IEYIRDALMV- [1057]
xt  RHNDNIMVTESGNLFHIDFGHILGNYKSFLGINKERVPF----VLTPDFLYVMGTSGK--KTSQYFNKFQDVCVKAYLALRHHTNLMIILFSMMLMTGMPQLTSKED--IEYIRDSLTV- [1080]
dr  RHNDNIMITETGNLFHIDFGHILGNYKSFLGISKERVPF----VLTPDFLYLMGTTGK--KSSPNFLQFQNVCLKAYLALRHHTNLLIILFSMMLMTGMPQLTSKED--IEYIREALTV- [1067]
dm  RHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPF----VLTHDFVYVINKGFND-RESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKD--LDYLRETLVL- [1048]
ag  RHSDNIMVKKTGQLFHIDFGHILGHFKEKFGFRRERVPF----VLTHDFVYVINNGRTD-REAQEFCRFQTLCEEAFLILRQHGCLILSLFSMMISTGLPELSSEKD--LNYLRETLVL- [1096]
ce  RHSDNLMLTEDGKYFHIDFGHILGHGKTKLGIQRDRQPF----ILTEHFMTVIRSGKSVDGNSHELQKFKTLCVEAYEVMWNNRDLFVSLFTLMLGMELPELSTKAD--LDHLKKTLFCN [1145]
is  RNPDNIMVNEEGQIFHIDFGHFLGHFKKKFGINRERVPF----VLTEDFLHVIAKGQENPRKSKEFQSFQELCGKAYLLLHRHAHLLITLFTMMLSTGIPELQSIDD--IGYLRKTLQV- [1007]
is6 RHSDNIMIKANGELFHIDYGHILGKFKEKFGIKRERVPF----VLTHDFVHVITHGHR--RKATAFNRFQEYCERAFLILRRQGSLMISLFAMMLTTGMPELTSEKD--LDYLRDALVL- [1020]
sc  RHLDNLLVTPDGHFFHADFGYILG---------QDPKPFPPLMKLPPQIIEAFGG-----AESSNYDKFRSYCFVAYSILRRNAGLILNLFELMKTSNIPDIRIDPNGAILRVRERFNL- [836]
sp  RHLDNLLITKDGHFFHADFGYILG---------RDPKLFSPAMKLSKEMVEGMGG-----YNSPFYQQFKSYCYTTFTALRKSSNLILNLFSLMVDANIPDIKFDKEKVVYKVKERFCL- [762]
at  RHLDNLLLTDDGRLFHVDFAFILG---------RDPKPFPPPMKLCKEMVEAMGG-----AESQYYTRFKSYCCEAYNILRKSSNLILNLFHLMAGSTIPDIASDPEKGILKLQEKFRL- [776]
    *: **:::.  *. ** *:..:**         ::   *     *  .::  :         :     *:  *  ::  : .   *:: ** :*    :*::    :  :  ::. :   

hs  GKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQG-EKHSA- [1102]
mm  GKSEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQG-EKHSA- [1102]
rn  GRSEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQG-EKHSA- [1102]
xt  GKNEESAKKHFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGVEKHSA- [1126]
dr  GRSEDEAKQHFLDQIEICRDKGWTVQFNWFLHLVLGIKQGVEKRSA- [1113]
dm  DYTEEKAREHFRAKFSEALANSWKTSLNWASHNF-------SKNNKQ [1088]
ag  DKTEEEARTHFKLKFSEALANSWKTSLNWASHNF-------SKNNRQ [1136]
ce  GESKEEARKFFAGIYEEAFNGSWSTKTNWLFHAV-------KHY--- [1182]
is  EKSEEQALEYFQNQFFEAYGGAWTTKVDWFFHSV-------KHF--- [1044]
is6 DYSEADALAHFRAKFEEALNNSWTTSINWFAHNI-------SKDNK- [1059]
sc  NMSEEDATVHFQNLINDSVNALLPIVID-HLHNL-------AQYWRT [875]
sp  QMSESDAIKYFEQLINDSVSALFPQIID-RMHNL-------AQYMRS [801]
at  DMDDEACIHFFQDLINESVSALFPQMVE-TIHRW-------AQYWR- [814]
       .  .  .*      .         :   *          :    


Alignment Details

Alignment done with MAFFT FFT-NS-2 (v7.305b) aligner. MAFFT References
  • Strategy: Auto
  • Scoring Matrix: BLOSUM62
  • Gap Penalty: 1.53
  • Offset Value: 0.0