DRSC/TRiP Functional Genomics Resources

Multi Sequence Alignment :

Domains

Index TaxID Gene Name GeneID Protein ID Domain
start 		Domain
stop 		Domain
name 		Domain
description 		external_id
hs 9606 PIK3CD 5293 NP_005017.3 890 898 Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 propagated from UniProtKB/Swiss-Prot (O00329.2)
hs 9606 PIK3CD 5293 NP_005017.3 175 281 PI3K_rbd PI3-kinase family, ras-binding domain; pfam00794 CDD:395642
hs 9606 PIK3CD 5293 NP_005017.3 909 935 Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 propagated from UniProtKB/Swiss-Prot (O00329.2)
hs 9606 PIK3CD 5293 NP_005017.3 676 1042 PI3Kc_IA_delta Catalytic domain of Class IA Phosphoinositide 3-kinase delta; cd05174 CDD:270718
hs 9606 PIK3CD 5293 NP_005017.3 751 757 G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 propagated from UniProtKB/Swiss-Prot (O00329.2)
hs 9606 PIK3CD 5293 NP_005017.3 503 684 PI3Ka Phosphoinositide 3-kinase family, accessory domain (PIK domain); smart00145 CDD:214537
hs 9606 PIK3CD 5293 NP_005017.3 314 481 C2_PI3K_class_I_beta_delta C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks); cd08693 CDD:176075
hs 9606 PIK3CD 5293 NP_005017.3 287 312 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite propagated from UniProtKB/Swiss-Prot (O00329.2)
hs 9606 PIK3CD 5293 NP_005017.3 34 107 PI3K_p85B PI3-kinase family, p85-binding domain; pfam02192 CDD:460483
mm 10090 Pik3cd 18707 XP_006538704.1 504 713 PI3Ka Phosphoinositide 3-kinase family, accessory domain (PIK domain); smart00145 CDD:214537
mm 10090 Pik3cd 18707 XP_006538704.1 314 481 C2_PI3K_class_I_beta_delta C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks); cd08693 CDD:176075
mm 10090 Pik3cd 18707 XP_006538704.1 34 107 PI3K_p85B PI3-kinase family, p85-binding domain; pfam02192 CDD:460483
mm 10090 Pik3cd 18707 XP_006538704.1 705 1072 PI3Kc_IA_delta Catalytic domain of Class IA Phosphoinositide 3-kinase delta; cd05174 CDD:270718
mm 10090 Pik3cd 18707 XP_006538704.1 182 281 PI3K_rbd PI3-kinase family, ras-binding domain; pfam00794 CDD:395642
rn 10116 Pik3cd 366508 XP_038966422.1 679 1046 PI3Kc_IA_delta Catalytic domain of Class IA Phosphoinositide 3-kinase delta; cd05174 CDD:270718
rn 10116 Pik3cd 366508 XP_038966422.1 504 687 PI3Ka Phosphoinositide 3-kinase family, accessory domain (PIK domain); smart00145 CDD:214537
rn 10116 Pik3cd 366508 XP_038966422.1 314 481 C2_PI3K_class_I_beta_delta C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks); cd08693 CDD:176075
rn 10116 Pik3cd 366508 XP_038966422.1 182 281 PI3K_rbd PI3-kinase family, ras-binding domain; pfam00794 CDD:395642
rn 10116 Pik3cd 366508 XP_038966422.1 34 107 PI3K_p85B PI3-kinase family, p85-binding domain; pfam02192 CDD:460483
xt 8364 pik3ca 100144924 NP_001119972.1 34 107 PI3K_p85B PI3-kinase family, p85-binding domain; pfam02192 CDD:460483
xt 8364 pik3ca 100144924 NP_001119972.1 173 292 PI3K_rbd PI3-kinase family, ras-binding domain; cl02484 CDD:413336
xt 8364 pik3cb 780390 NP_001072928.1 533 697 PI3Ka_I Phosphoinositide 3-kinase (PI3K) class I, accessory domain; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5)...; cd00872 CDD:238444
xt 8364 pik3cb 780390 NP_001072928.1 328 495 C2_PI3K_class_I_beta_delta C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks); cd08693 CDD:176075
xt 8364 pik3ca 100144924 NP_001119972.1 695 1064 Protein Kinases, catalytic domain The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453 CDD:473864
xt 8364 pik3cb 780390 NP_001072928.1 35 108 PI3K_p85B PI3-kinase family, p85-binding domain; pfam02192 CDD:460483
xt 8364 pik3ca 100144924 NP_001119972.1 525 696 PI3Ka_I Phosphoinositide 3-kinase (PI3K) class I, accessory domain; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5)...; cd00872 CDD:238444
xt 8364 pik3ca 100144924 NP_001119972.1 325 484 C2_PI3K_class_I_alpha C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks); cd08398 CDD:176043
xt 8364 pik3cb 780390 NP_001072928.1 172 279 PI3K_rbd PI3-kinase family, Ras-binding domain; smart00144 CDD:197540
xt 8364 pik3cb 780390 NP_001072928.1 701 1062 PI3Kc_IA_beta Catalytic domain of Class IA Phosphoinositide 3-kinase beta; cd05173 CDD:270717
dr 7955 pik3cd 394174 NP_957493.1 505 676 PI3Ka_I Phosphoinositide 3-kinase (PI3K) class I, accessory domain; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5)...; cd00872 CDD:238444
dr 7955 pik3cd 394174 NP_957493.1 188 280 PI3K_rbd PI3-kinase family, ras-binding domain; cl02484 CDD:413336
dr 7955 pik3cd 394174 NP_957493.1 676 1038 PI3Kc_IA_delta Catalytic domain of Class IA Phosphoinositide 3-kinase delta; cd05174 CDD:270718
dr 7955 pik3cd 394174 NP_957493.1 34 107 PI3K_p85B PI3-kinase family, p85-binding domain; pfam02192 CDD:460483
dr 7955 pik3cd 394174 NP_957493.1 315 481 C2_PI3K_class_I_beta_delta C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks); cd08693 CDD:176075
dm 7227 Pi3K92E 42446 NP_650902.1 56 132 PI3K_p85B PI3-kinase family, p85-binding domain; cl02483 CDD:470589
dm 7227 Pi3K92E 42446 NP_650902.1 339 517 C2_PI3K_class_I_beta_delta C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks); cd08693 CDD:176075
dm 7227 Pi3K92E 42446 NP_650902.1 200 307 PI3K_rbd PI3-kinase family, Ras-binding domain; smart00144 CDD:197540
dm 7227 Pi3K92E 42446 NP_650902.1 552 723 PI3Ka_I Phosphoinositide 3-kinase (PI3K) class I, accessory domain; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5)...; cd00872 CDD:238444
dm 7227 Pi3K92E 42446 NP_650902.1 727 1084 PI3Kc_I Catalytic domain of Class I Phosphoinositide 3-kinase; cd05165 CDD:270709
ag 7165 Pi3K92E 1272257 XP_061510893.1 - - - - -
ce 6239 age-1 174762 NP_496462.2 241 360 PI3K_rbd PI3-kinase family, Ras-binding domain; smart00144 CDD:197540
ce 6239 age-1 174762 NP_496462.2 420 574 C2_PI3K_like C2 domain present in phosphatidylinositol 3-kinases (PI3Ks); cd08380 CDD:176026
ce 6239 age-1 174762 NP_496462.2 606 798 PI3Ka Phosphoinositide 3-kinase family, accessory domain (PIK domain); smart00145 CDD:214537
ce 6239 age-1 174762 NP_496462.2 793 1181 Protein Kinases, catalytic domain The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453 CDD:473864
ce 6239 age-1 174762 NP_496462.2 98 177 PI3K_p85B PI3-kinase family, p85-binding domain; smart00143 CDD:197539
is 6945 Pi3K92E 8036652 XP_029826199.2 522 692 PI3Ka Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in...; cl00271 CDD:412275
is 6945 Pi3K92E 8036652 XP_029826199.2 35 106 PI3K_p85B PI3-kinase family, p85-binding domain; pfam02192 CDD:460483
is 6945 Pi3K92E 8036652 XP_029826199.2 178 281 PI3K_rbd PI3-kinase family, ras-binding domain; cl02484 CDD:413336
is 6945 Pi3K92E 8036652 XP_029826199.2 316 487 C2 C2 domain; cl14603 CDD:472691
is 6945 Pi3K92E 8036652 XP_029826199.2 697 1056 PI3Kc_I Catalytic domain of Class I Phosphoinositide 3-kinase; cd05165 CDD:270709
sc 4932 VPS34 850941 NP_013341.1 528 871 PI3Kc_III Catalytic domain of Class III Phosphoinositide 3-kinase; cd00896 CDD:270628
sc 4932 VPS34 850941 NP_013341.1 <1 872 TEL1 Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]; COG5032 CDD:227365
sp 4896 pik3 2543444 NP_594699.1 450 797 PI3Kc_III Catalytic domain of Class III Phosphoinositide 3-kinase; cd00896 CDD:270628
sp 4896 pik3 2543444 NP_594699.1 <1 801 TEL1 Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]; COG5032 CDD:227365
at 3702 VPS34 842344 NP_176251.1 466 811 PI3Kc_III Catalytic domain of Class III Phosphoinositide 3-kinase; cd00896 CDD:270628
at 3702 VPS34 842344 NP_176251.1 274 432 PI3Ka_III Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III...; cd00870 CDD:238442
at 3702 VPS34 842344 NP_176251.1 25 178 C2_PI3K_class_III C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks); cd08397 CDD:176042

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Alignment

Alignment done with MAFFT FFT-NS-2 (v7.305b) aligner. MAFFT References

Download raw alignment output file

Download fasta input file



Note:   &mbsp 2019, we've been having trouble with some alignments and are looking into the problem. If the alignment didn't work, please try again. If it still doesn't work, please download the fasta file and align off line. We're looking into it. Thanks.

hs  ---------------------------------------------------------MPPGVDCPMEFWTKEE-----------------NQSVVVDFLLPTG---------VYLNFPVS [37]
mm  ---------------------------------------------------------MPPGVDCPMEFWTKEE-----------------SQSVVVDFLLPTG---------VYLNFPVS [37]
rn  ---------------------------------------------------------MPPGVDCPMEFWTKEE-----------------SQSVAVDFLLPTG---------VYLNFPVS [37]
xt  ---------------------------------------------------------MPP-RPSSGELWGIHL----------------MPPRILVECLLPNG---------MVVVLECL [37]
xt6 ---------------------------------------------------------MPPIMD-HMDIWTADTP---------------LPPDICVDVLLPTG---------IYVQMDVP [38]
dr  ---------------------------------------------------------MPPGVYGMQEVWEMEG-----------------RQHVNIEFLLPTG---------IYLNFTVA [37]
dm  MNMMDNRALA----------------------YVAHQPKYETPPEEA----------EPPCMRFSVNLWKNEM-----------------LNWVDLICLLPNG---------FLLELRVN [62]
ag  MQRMRNATTTMKRNTTTMPGGTDSSWSVPHRIYLQQQQQQQQQQQQAHQQQQQQQQQQRP--RFDYGFWKNPD-----------------ES-TELIFLMPNG---------VMITMYIP [91]
ce  MSMGRSPSTTF-RSRTGSHGARD---------LIAGHGRNSRRISQMHVNI------LHPQLQTMVEQWQMRERPSLETENGKGSLLLENEGVADIITMCPFGEVISVVFPWFLANVRTS [104]
is  --------------------------MIPPSPFLL----------------------PDP--------WISDV-----------------ELQVDVTVLLPNG---------LVLPLQVH [38]
sc  ------------------------------------------------------------------------------------------------------------------------ [0]
sp  ------------------------------------------------------------------------------------------------------------------------ [0]
at  ------------------------------------------------------------------------------------------------------------------------ [0]
                                                                                                                            

hs  RNANLSTIKQLLWHRAQYEPLFHMLSGPEAY-VFTCIN--QTAEQQELEDEQR-RLC--DVQPFLPVLRLVAREGDR---VKKLINSQISLLIGKGLHEF---DSLCDPEVNDFRAKMCQ [145]
mm  RNANLSTIKQVLWHRAQYEPLFHMLSDPEAY-VFTCVN--QTAEQQELEDEQR-RLC--DIQPFLPVLRLVAREGDR---VKKLINSQISLLIGKGLHEF---DSLRDPEVNDFRTKMRQ [145]
rn  RNANLSTIKQVLWHRAQYEPFFHMLSDPEAY-VFTCVN--QTAEQQELEDEQR-RLC--DIQPFLPVLRLVAREGDR---VKKLINSQISLLIGKGLHEF---DSLRDPEVNDFRTKMRQ [145]
xt  REATLVNIKHELFKEARKYPLYHLLQDESSY-IFVSVT--QEAEREEFFDETR-RLC--DLRLFQPFLKVVEPVGNR---EEKILNREIGFAIGMPVCEF---DMVKDSEVQDFRKNILN [145]
xt6 RDASISHIKQLLWKHAQSYPLFHLLLEIDSY-MFQCVN--HNAVHEELEDETQ-RLC--DVRPFLPVLKLVSRSCNP---AEKL-DSKIGVLIGKGLQEF---DALKDNEVMEFRSKMRS [145]
dr  CSDTISTIKKMLWKNAKNEPLFSALSDPDAY-VFTCIN--MTAEREELEDEQR-RLC--DVRPFLPILRLVAREGDR---VEKLITTQINQLIGKGHHEF---DSQKNHELNEFRTKMRA [145]
dm  PANTIQVIKVEMVNQAKQMPLGYVIKEACEYQVYGI----STFNIEPYTDETK-RLS--EVQPYFGILSLGERTDTTSFSSDYELTKMVNGMIGTTFDHN---RTHGSPEIDDFRLYMTQ [172]
ag  IHITLDELKSDVWEEAERYPLYCHLGDKNKY-CFGTLAAGRTNSNTTYENEAETRLM--DVQPTLGILRFVEKSNVS------ENTKLMEN-ISSLLDSKLPVKTLVNPEVNDFRAKMSM [201]
ce  LEIKLSDFKHQLFELIAPMKWGTYSVKPQDY-VFRQLN--NFGEIEVIFNDDQ-PLSKLELHGTFPMLFLYQPDGIN---RDKELMSDISHCLGYSLDKL---EESLDEELRQFRASLWA [214]
is  RESTLEELKQCTWREAERLPLYRCLRGRDTY-VFTCVSE-RTSEREEFADEGR-KLC--DVRPFQALLRLVERPSDK---ADRQTNAQIGLLIGKGLNSF---DALKCPEVNEFRRTMRA [147]
sc  -------------------------MSLNNI-----------------------TFC-----------------------VSQDLDVPLKVK---------------------------- [21]
sp  -----------------------------MD-----------------------RLV-----------------------FSYCPSSKVTARF--------------------------- [18]
at  -------------------------MGANEF-----------------------RFF-----------------------LSCDINSPVTFR---------------------------- [21]
                                                           :                                :                               

hs  FCEEAAARRQQLGWEAWLQYSFPLQL--EPSAQTWGPGTLRLPNRA----LLVNVKFEGSEE----------SFT-FQVSTKDVPLALMACALRKKATVF-------RQPLVEQPEDYTL [241]
mm  FCEEAAAHRQQLGWVEWLQYSFPLQL--EPSARGWRAGLLRVSNRA----LLVNVKFEGSEE----------SFT-FQVSTKDMPLALMACALRKKATVF-------RQPLVEQPEEYAL [241]
rn  FCEEAAAHRQQLGWVEWLQYSFPLQL--EPSARGWRAGLLHVSNRP----LLVNVKFEGSEE----------SFT-FQVSTKDMPLALMACALRKKATVF-------RQPLVERPEEYAL [241]
xt  VCKDSVELRDANGPISRALYVYPPNV--ESSSELPKHIESKLDKGQIIVVIWVIVSPNNEKQ----------KYS-LKINHDCVPEHVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYIL [252]
xt6 ISEAKIQSLLGLTWVEWLKRTFPPEL--EPSIQDNIQGKLY--GGN----IVVAIHFENCQD----------VFS-FQVSPNMVPVKVNELAIRKRLTIH------GREAEEVDPEDFVL [240]
dr  FCEEHAYLRQTLPWDKWMEYNFPCDL--EPCSSVTQSGKSR-SIKK----IFVNVKFEGSEE----------TFV-LQQDPQDLPVVLKRNALRKKSTVF-------RSVKQEKPEDYSL [240]
dm  TCDNIELERSAYTWQQRLLYEHPLRL--ANSTKMPELIRERHPTRT----FLIVVKNENDQS----------TFT-LSVNEQDTPFSLTESTLQKMNRS--------QMKMNDRTSDYIL [267]
ag  LSEDIGSRRAVMTRMERIAYQYPAKL--VSGAHVPEPISRRLTNGD----FCVVAISTDMQ------------LT-VKVPCRATPDEVLKRILKKQNPS--------KARNENSSTEYIL [294]
ce  RTKKTCLTRGLEGTSH---YAFPEEQYLCVGESCPKDLESKVKAAK----LSYQMFWRKRKAEINGVCEKMMKIQ-IEFNPNETPKSLLHTFLYEMRKLDV------YDTDDPADEGWFL [320]
is  FCTSIADKRAEWSPLDQVKYRYPARVDRFCSQYPPPHMGDRISSADS--TFGAEILFENGG-----------MMT-MNVAIGATPQALLLLVMQSAASG--------EQFLCHTVEGLVL [245]
sc  ----------------------------------------------------------------------------IKSLEGHKP-------LLKPSQKIL------------------- [39]
sp  ----------------------------------------------------------------------LVKFCFIEYQDSQEPC-ICTIQLFSGNESG-------------------- [47]
at  ----------------------------------------------------------------------------IEKLDGNLP-------VKKSSDSGVVS----------------- [41]
                                                                                ..      *       : .                         

hs  QVNGRHEYLYG-SYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRA-----KP-------------------------------------PPIPAKKPSSVS--- [315]
mm  QVNGRHEYLYG-NYPLCHFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRA-----KP-------------------------------------PPIPAKKPSSVS--- [315]
rn  QVNGRHEYLYG-SYPLCHFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRV-----KP-------------------------------------PPIPAKKPSSVS--- [315]
xt  KVCGCDEYLLE-KYPLSQYKYIRSCIMLGRMPNLMLMAKDSLYS---------------------QIPVDVFT--------------------------------MPSYSRRISTAAPYM [318]
xt6 QVNGRLEFVFG-DHPLIQFQYIRNCVMNKALPHLTLVECCNIKKLFDQEMSEIEHAVRRKSSMHPALP-------------------------------------MPLPPKKRGASMKTL [322]
dr  QVNERWEFIYG-KYPLCQFKYIFTCLHGGLTPHLTMVHYSSIVKYQEEQSGLSNQVSRSRAQ---SKP-------------------------------------PPLPLKRQNTCS--- [316]
dm  KVSGRDEYLLG-DYPLIQFLYIQEMLSDSAVPNVVLQSVYRLESYINH-----------------------------------------HNEQAMV-------TKRPLPKKRTVHLHKSI [338]
ag  KVCGREEYIYG-AHPMISFQYVQDCLSRDETPTFVPRLVRTVEVFKNDIYDAREDFTQWSAS---AKPSSLYGGSISSSSGYAGSAGSTYNTQSQ--------------QSHTLRKVKYI [396]
ce  QLAGRTTFVTNPDVKLTSYDGVRSELESYRCPGFVVRRQSLVLK----------DYCRPKPL---YEPHYVRA----------------HERKLALDVLSVSIDSTPKQSKNSDMVMTDF [411]
is  KVCGREEYLLE-ELPLLQYKYVQEKVSEGSTPQFTVVPISDIQTDHDMVY------AQIERC---MEPSFC----------------------------------RPSP-----HPDKLV [316]
sc  ------------------------------NPELMLI----------------------------------------------------------------------------------- [46]
sp  --------------------------------SLMQ------------------------------------------------------------------------------------ [51]
at  -------------------------IAEEKKPELYI------------------------------------------------------------------------------------ [52]
                                     .                                                                                      

hs  ----------LWSLEQPFRIELIQGS--KVNADERMKL--VVQAGLFHG--NEMLCKTVSSSEVSVCSEP-VWKQRLE-FDINICDLPRMARLCF-ALYAVIEKAKKA--RSTK----KK [410]
mm  ----------LWSLEQPFSIELIEGR--KVNADERMKL--VVQAGLFHG--NEMLCKTVSSSEVNVCSEP-VWKQRLE-FDISVCDLPRMARLCF-ALYAVVEKAKKA--RSTK----KK [410]
rn  ----------LWSLEQPFCIELIEGR--KVNADERMKL--VVQAGLFHG--NEMLCKTVSSSEVNVCSEP-VWKQRLE-FDISICDLPRMARLCF-ALYAVVEKAKKA--RSTK----KK [410]
xt  NGEASAK--SLWAINSTLRIKILCATYVNVNIRDIDKI--YVRTGIYHG--VEPLCDNVNTQRVPCSNPR--WNEWLL-YDMFIPDLPRAARLCL-SICSV---------KGRKG---AK [416]
xt6 NMR---D--IVWNIVQPYKIILSKGS--RLNTED--SV--LVRAGLFHG--TELLCKPTMTPEVQGKNDH-VWNETLE-FEINVCDLPRMARLCF-AIYAVLDKPRNK--NKTKYQTIKK [424]
dr  ----------LWSIQEPFYIYLLQGS--RVNADEGMKL--VVQAGLFHG--SELLCKVVTSNEVSVCFDP-VWDQKLV-FDINVSDLPRMSRLCF-ALYGVIEKTKK---RPTK----KK [410]
dm  SS--------LWDMGNYFQLTLHSIS--NVNFDKTRALKVGVHVCLYHG--DKKLCAQRSTDSPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCI-VIFEVTKMSRSK--KSSN----NK [439]
ag  TS---------WEIDAKLQCTVHEIR--GLNVESDKEL--GVQLGLFHG--GKSLCKTERTRTVTVNSGAATWNETIL-FDINVSNVPRMARLCL-VVYENMRTAKGTGIRTRR----TK [495]
ce  RPTASLKQVSLWDLDANLMIRPVNIS--GFDFPADVDMYVRIEFSVYVG--TLTL-ASKSTTKVNAQFAK--WNKEMYTFDLYMKDMPPSAVLSIRVLYGKVK---------------LK [509]
is  SA---------WMIGDPFRVRVLSAS--SVNVESGAKL--VVEGGLYHG--TELLCQTQRTQDCSVADGRGSWDQQLC-FDLAVRDLPQAVRLCL-GLYEVTRGTRHPRARRRL----GP [415]
sc  ----------------------------GSNVFPSSDL--IVSLQVFDKERNRNLTLPIYTPYIPFRNSR-TWDYWLT-LPIRIKQLTFSSHLRI-ILWEY---------------NGSK [118]
sp  ------------------------------------KC--FVS------------KIPNKSLLPTELSKI-STHEWLD-FGVTVSELSLNAKFVV-SAWKP---------------SFND [103]
at  ------------------------------------EC--ALYID------GAPFGLPMRTRLKTTGPPY-CWNELIT-LSSKYRDLTAHSQLAI-TVWDV---------------SCGK [110]
                                             :                  :            .  :        ::.    : .                         

hs  SKKA------DCPIAWANLMLFDYKDQLKTGERCLYMWPSVPD---------------------EKGELLN-------------------PTGTVRSNPNTDS------AAA--LLICLP [476]
mm  SKKA------DCPIAWANLMLFDYKDQLKTGERCLYMWPSVPD---------------------EKGELLN-------------------PAGTVRGNPNTES------AAA--LVIYLP [476]
rn  SKKA------DCPIAWANLMLFDYKDQLKTGERCLYMWPSVPD---------------------EKGELMN-------------------PAGTVRGNPNTES------AAA--LVIYLP [476]
xt  E--------EHCPLAWGNINLFDYTDTLVSGKMALNLWP-VPH---------------------GLEDLLN-------------------PIGVSGSNPNKE-------TPC--LELEFD [478]
xt6 SGKM------HFPVAWVNTMVFDYKGQLRSGDHVLHCWSSFPD---------------------ELEEMLN-------------------PMGTVRTNPYTEN------TTT--LHIKFH [490]
dr  NKRA------DCPLAWVNTMVFDYKDQLKTGEFSLSTWPSVPD---------------------DKGDLLN-------------------PMGTVEKNPNIDS------TAG--LLIRFP [476]
dm  DIALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTYADD--------------------IQSVEVFH-------------------PLGTIEPNPRKEECA---LVDL--TFLSSG [515]
ag  DGLI-------NPIAWVNTMVYDYKNQLKVDSVTLYTWDYAED--------------------AQSEDILH-------------------PLGTVEPNPNRDN-----MVVS--VLLSFG [562]
ce  S--------EEFEVGWVNMSLTDWRDELRQGQFLFHLWAPEPTA-----------------NRSRIGENGA-------------------RIGT---------------NAA--VTIEIS [568]
is  DLYA-------APLAWVNVTVYDFRGYLRFGCVDLSMWTYADEP------------------HAEEMDLLH-------------------PMGTAVFNPEAHH------ATT--LTIQFE [483]
sc  QI---------PFFNLETSIFNLKDCTLKRGFESLKFRYDV-------------IDHCEVVTDNKDQENLNKYFQGEFTRLPWLDEITISKLRKQRENRTWPQGT---FV----LNLEFP [209]
sp  EEV-------YEFVGCTTYRLFDENNLLRQGLQKIPLQTSKEIKKYSPTS----LELEQVKEINRLDGLLLKLQLGDVPSVNWLDDI---SFGKIKDFRS-KHMS---LVTIPILYLDFL [205]
at  TE---------GLIGGATVLLFNSKMQMKSGKQKLRLWQGKEADGSFPTSTPGKVPRHERGELERLEKLMNKYERGQIQSIDWLDRLMLKSLDTIKEQESTKHGSSHLFVVI-----DFC [216]
                 .   .  .      :  .   :                                                                                     

hs  EVAP--HPV------------YYPALEKIL----E-----------------------------------LGRH----------SECVHVT-------------EEEQLQLREILERRGS [520]
mm  EVAP--HPV------------YFPALEKIL----E-----------------------------------LGRH----------GERGRIT-------------EEEQLQLREILERRGS [520]
rn  EVAP--HPV------------YFPALEKIL----E-----------------------------------LGRH----------GERGRIT-------------EEEQLQLREILERRGS [520]
xt  CFS---SPV------------KFPDMTAIEDHANK----------------------------------VLEREMGYNYSHSGLSNRIVREN---------EVRESDKEQLKAISNRDPL [540]
xt6 DYSK--EPI------------SYPPFDKILEKAAE-----------------------------------IARN----------SDSLSTSG---------RGGKKLNIELKEIMERDPL [542]
dr  NIRP--HPL------------YYPPIEKLN----E-----------------------------------LGPN----------GEKVIAT-------------KEEHQKLKEIVDNKNS [520]
dm  T-----GTV------------RYPSEEVVLQYAAD-----------------------------------REQV----------N-RLQRQLAGP-----EKPIKELKELMANYTGLDKI [567]
ag  TYGPEGRII------------VYPGEEELLSHAAK-----------------------------------MSHR----------NEHLNRESA--------EDTRSIRAIMSAYMYNDRL [617]
ce  SYG---GRV------------RMPSQGQYTYL--------------------------------------VKHR-------STWTETLNIMGDDYESCIRDPGYKKLQMLVKK---HESG [625]
is  PYHPS-HPV------------RYPMLDEILECAAS----------------------------------CVKEK----------STYLQ----GI-----GHASKSHREQLRQIAEQDPL [537]
sc  MLE---LPVVFIEREIMNTQMNIPTLKNNPGLSTDLREPNRNDPQIKISLGDKYHSTLKFYDPDQPNNDPIEEK----------YRRLERASKNANLDKQVKPDIKKRDYLNKIINYPPG [316]
sp  QFS---FPVVFQRS-------YYPKSENRVYYSS--------------------------FDLELNLDSPAELK----------HRRLVRSQRNGPLDKDLKPNSKIRKELESILSYPPS [279]
at  SFE---HRVVFQESG-ANLFITAPIGSTNEFVTV--------------------------WDTELGKTNPSENK----------QLKLARSLDRGIIDRDLKPSNIERKSIQRVLKYPPT [296]
            :              *                                                                                   .  :         

hs  GELYEHEKDLVWKLRHEVQEHFPEALARL-LLVTKWNKHEDVAQ-----------------------------MLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSL-RKLTDDELF [609]
mm  GELYEHEKDLVWKMRHEVQEHFPEALARL-LLVTKWNKHEDVAQVSREGGSGRQPRGRWTVPAHPYLTTKLSQMLYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSL-RKLTDDELF [638]
rn  GELYEHEKDLVWKMRHEVQEHFPEALARL-LLVTKWNKHEDVAQ--------------------------LSQMLYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSL-RKLTDDELF [612]
xt  SEITEQEKEFLWSHRLYCR-NIPEILPKL-LLSVKWNCRDDVSQ-----------------------------MYCLLKEWPAIRPEQAMELLDFNYPDRIVRSFAVSCLEKYLTDDKLS [629]
xt6 CQLSENEKDLIWTLRYDCRENFPGSLPKL-LLSVKWNKLEDVAQ-----------------------------LQALLQIWSKLPPRDALELLDFNYPDQYVREYAVNCL-KPMSDEELS [631]
dr  TEFFEDEKEPLWKLREELRLKYPESLPKL-LLITKWNKHEDVAQ-----------------------------MVGLLQKWPELPALHALELLDYSFPDPHVRFFTIRCL-RKLPDDKLF [609]
dm  YEMVDQDRNAIWERRNDILRELPEELSIL-LHCVYWKERDDVAD-----------------------------MWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCL-HFLKDEDLL [656]
ag  NDIHEQDRNAIWAKRRECMKQMPQGLPCL-LYCVEWNNRDEVSE-----------------------------IVSLLQEWPKLLVERALELLDYAYADKYVRRYAVDCL-RTIEDDELL [706]
ce  IVLEEDEQRHVWMWRRYIQKQEPDLLIVLSELAFVWTDRENFSE-----------------------------LYVMLEKWKPPSVAAALTLLGKRCTDRVIRKFAVEKLNEQLSPVTFH [716]
is  APLHEQDRQLLWFLRYDCL-ELPHVLPKL-LLSLRWGDHCDVAL-----------------------------MQALLQIWKLLKPEQALELLDYSYPDNYVRSFAVRCL-RQMSDEELS [625]
sc  TKLTAHEKGSIWKYRYYLM-NNKKALTKL-LQSTNLREESERVE-----------------------------VLELMDSWAEIDIDDALELLGSTFKNLSVRSYAVNRL-KKASDKELE [404]
sp  EELSLEEKDLIWKFRFYLT-RNKKAMTKF-LKSVVWTDSSEVNQ-----------------------------ALSLLDSWTEIDIDDALELLSPSFVHPKVRAYAVSRL-ETASNEELL [367]
at  RTLSGDERQLLWKFRFSLM-SEKRALTKF-LRCVEWSDVQEAKQ-----------------------------AIQLMYKWEMIDVCDALELLSPLFESEEVRAYAVSVL-ERADDEELQ [384]
      :  .::  :*  *          :  :           :                                   ::  *       :: **.       :  :::  * .      : 

hs  QYLLQLVQVLKYESYLD--------------------------------------------------------CELTKFLLDRALANRKIGHFLFWHLRSEMH-------VPSVALRFGL [666]
mm  QYLLQLVQVLKYESYLD--------------------------------------------------------CELTKFLLGRALANRKIGHFLFWHLRSEMH-------VPSVALRFGL [695]
rn  QYLLQLVQVLKYESYLD--------------------------------------------------------CELTKFLLGRALANRKIGHFLFWHLRSEMH-------VPSVALRFGL [669]
xt  QYLIQLVQVMKYEQYLD--------------------------------------------------------NHLVRFLLKKALVNQRIGHFFFWLLKSEMH-------NKTVSQRFGL [686]
xt6 QYLLQLVQVLKYEPFLD--------------------------------------------------------CALSRFLLQRALDNRRIGQFLFWHLRSEVH-------NPAVSVQFGL [688]
dr  QYLLQLVQVLKYESYLD--------------------------------------------------------CDLTSFLLERALANKKIGHFLFWHLRSEMH-------VPSVSLRFGL [666]
dm  LYLLQLVQAIKHESYLE--------------------------------------------------------SDLVVFLLERALRNQRIGHYFFWHLRSEMQ-------TPSMQTRFGL [713]
ag  LYLLQLVQALKHESYLN--------------------------------------------------------CDLVYFLLQRALHNQHIGHYLFWHLRSEIS-------VPSVQVRFGL [763]
ce  LFILPLIQALKYEPRAQ--------------------------------------------------------SEVGMMLLTRALCDYRIGHRLFWLLRAEIARLRDCDLKSEEYRRISL [780]
is  LYLLQLVQALKHESFLD--------------------------------------------------------CDLVKFLLERALKNRHIGHQMFWLLRCEMQ-------VAALSVKFGL [682]
sc  LYLLQLVEAVCFENLSTFSDKSNSEFTIVDAVSSQKLSGDSMLLSTSHANQKLLKSISSESETSGTESLPIVISPLAEFLIRRALVNPRLGSFFYWYLKSESE---DKPYLDQILSS--- [518]
sp  LYLLQLVQALRYDNPISSDERFQP-------------------------------------------------SPLALFLVNRAISSPSIGNDLYWYLVVEIE---DEPVSKLFSSVMFL [435]
at  CYLLQLVQALRF-------ERSDR-------------------------------------------------SCLSQFLVQRALQNIELASFLRWYVAVELH---DHVYAKRFYSTYEL [445]
     ::: *::.: .                                                               :  :*: :*: .  :.  : * :  *                   

hs  ILEAYCRGST--------HHMKVLMKQGEALSKLKALNDFVKLSS-QKTPKPQTKELMHLCMRQEAYLEALSHLQS-----PLDPSTLLAEVC-VEQCTFMDSKMKPLWIMYSN-EEAGS [770]
mm  IMEAYCRGST--------HHMKVLMKQGEALSKLKALNDFVKVSS-QKTTKPQTKEMMHMCMRQETYMEALSHLQS-----PLDPSTLLEEVCSVEQCTFMDSKMKPLWIMYSS-EEAGS [800]
rn  IMEAYCRGST--------HHMKVLMKQGEALSKLKALNDFVKASS-QKTTKPQTKEMMHMCMRQETYMEALSHLQS-----PLDPSTLLEEVCSVEQCTFMDSKMKPLWIMYSS-EKAGG [774]
xt  LLESYCRACG--------MYLKHLSKQVEAMEKLINLTDILKQEK-KDETQKVQMKFLVEQMKRPDFMDALQGFTS-----PLNPAHQLGNLR-LEECRIMSSAKRPLWLNWEN-PDIMS [790]
xt6 LLEAYCRGSV--------AHMKVLSRQVEALNKLRTLNGLIKLNA-VKLSKVKNKDNMHTCLRENAYKEALMHIQS-----PLNPSITLSELV-VEKCKYMDSKMKPLWIVYNN-RGFGS [792]
dr  ILEAYCRGSI--------FHIKSLMKQNEALNKMKALNDFVKSAS-QKATRIQTTEDMKVCIKQETYMEALSDVVS-----PLSPSIILCELC-ADKCKFMDSKMKPLWLMYKS-KY--- [767]
dm  LLEVYLKGCK--------HHVAPLRKQLHVLEKLKQGSLIA-----KKGSKEKVKTMLQDFLRDQRNSAVFQNIQN-----PLNPSFRCSGVT-PDRCKVMDSKMRPLWVVFEN-ADVNA [813]
ag  ILEAYLLGSP--------EHVAVLLKQMQCLRYLQTCSDNV-----KKGSKEKGRTLLIEQL--AKEGHVTSDLIS-----PLNPSYRCKAVR-TDRCKVMDSKMRPLWIVYEN-SDANG [861]
ce  LMEAYLRGNE--------EHIKIITRQVDMVDELTRISTLV-----KGMPKDVATMKLRDELR--SISHKMENMDS-----PLDPVYKLGEMI-IDKAIVLGSAKRPLMLHWKN-KNPKS [878]
is  ILEAYCHGAP--------DHREALLKQAEAFFKLRALGNQIHESSKKKDSREKMVATMREHMSKEAFRATFRNLCS-----PLDPCHVFSQIK-PELCRFMDSKMKPLWLVFEN-SDAVA [787]
sc  FWSRLDK-----------KSRNILNDQVRLINVLRECCETIKR---LKDTTAKKMELLVHLL--ETKVRPLVKVR--PIALPLDPDVLICDVC-PETSKVFKSSLSPLKITFKT-TLNQP [618]
sp  FQKELSK------SVEGRLIRETLSAQAKFVEKLLRISKSVQS---FRGTRLKKIEYLKVLL--EDHKYHLLDFHALPL--PLDPSVNIVGII-PDACTVFKSTMQPLRLLFKC-QDGSK [540]
at  LEENIIKLPPGVNGEDGYQLWQSLVRQTELTAQLCSITREVRN---VRGNTQKKIEKLRQLL--GGLLSELTYFEE-PIRSPLTPNVLIKGIV-AGESSLFKSALHPLRLTFRTPEEGGS [558]
    : .                    :  *      :                       :   :           .       ** *      :     .  : *   ** : :        

hs  GGSV-----GIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNM-AATAAFNKDALLNWLKSKN-PGEALDR------------- [870]
mm  AGNV-----GIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNM-AATAAFNKDALLNWLKSKN-PGEALDR------------- [900]
rn  AGSV-----GIIFKNGDDLRQDMLTLQMIQLMDFLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNM-AATAAFNKDALLNWLKSKN-PGEALDR------------- [874]
xt  -EMLFLN-NEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRCSHTIMQIQC-KGGL-KGALQFNSHTLHQWLKDKN-KGETYDA------------- [892]
xt6 -DSL-----GIIFKNGDDLRQDMLALQLLRLMDMLWKEAGLDLRIVPYGCLATGDRCGFIEVVSAAETIADIQLDSSNL-AAAAAFNKDALLNWIKECH-SGDDLER------------- [891]
dr  -DSV-----GIIFKNGDDLRQDMLTLQMIQIMDILWKTEGLDLRMQPYGCLSTGNKTGLIEVVKNSDTIANIQRNNSNS-AATAAFNKDALLNWLKSKN-PGDKLDQ------------- [866]
dm  -SDV-----HIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMF-SATSPFKKGSLLSWLKEHNKPADKLNK------------- [913]
ag  -DDI-----HMIFKNGDDLRQDMLTLQMLRIMDRIWKSHGYDFRMNPYSCISTDHKLGLIEVVLNAETIANIQKERGMF-SATSPFKKGSLLAWLREHNGTEDLLAK------------- [961]
ce  --DLHLPFCAMIFKNGDDLRQDMLVLQVLEVMDNIWKAANIDCCLNPYAVLPMGEMIGIIEVVPNCKTIFEIQVGTGFMNTAVRSIDPSFMNKWIRKQCGIEDEKKKSKKDSTKNPIEKK [996]
is  -EDI-----AIIFKHGDDLRQDMLTLQMIRIMDKLWKDEGYDFRMIPYQCLSTDQNVGLIEVVRNASTIANIQKLHNS--SATSAFKKGSLFAWIKEHNKTQESLRR------------- [886]
sc  --------YHLMFKVGDDLRQDQLVVQIISLMNELLKNENVDLKLTPYKILATGPQEGAIEFIPN-DTLASILSKY-----------HG-ILGYLKLHY-PDE---N---------ATLG [704]
sp  --------YPIIFKNGDDLRQDQLVIQILTLMDKLLKKEKLDLHLKPYRILATGPTHGAVQFVPS-KTLATILAEY-----------HGSVLAYLRENN-PDDGLNS---------ANYG [630]
at  --------CKLIFKKGDDLRQDQLVVQMVWLMDRLLKLENLDLCLTPYKVLATGHDEGMLEFIPS-RSLAQILSE------------HRSITSYLQKFH-PDE---H---------APFG [644]
              ::** ******* *.:*:: :*: : :    *  :  *  :.     * ::.:    ::  *                  :  :::      :                 

hs  ------------AIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKT--NNSEKFERFRGYCERAYTILRRHGLLFLH [976]
mm  ------------AIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKT--NNSEKFERFRGYCERAYTILRRHGLLFLH [1006]
rn  ------------AIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKT--NNSEKFERFRGYCERAYTILRRHGLLFLH [980]
xt  ------------AIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDNGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGIQECTKTRDFERFQEMCYKAYLAIRQHANLFIN [1000]
xt6 ------------AIEEFTLSCAGYCVATYVLGIGDRHNDNIMVRKTGQLFHIDFGHILGNFKSKFKIKRERGPFILTYDFIHVIQQGKP--GNTEKFGRFRQCCEDAYLILRRNGNLIIT [997]
dr  ------------AIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKSKFGINRERVPFILTYDFVHVIQEGRT--NNSEKFERFRVCCEQAYKILCRNGTLFVN [972]
dm  ------------AINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFND-RESKEFCHFQELCERAFLVLRKHGCLILS [1020]
ag  ------------AIQEFTLSCAGYCVATYVLGVADRHSDNIMVKKTGQLFHIDFGHILGHFKEKFGFRRERVPFVLTHDFVYVINNGRTD-REAQEFCRFQTLCEEAFLILRQHGCLILS [1068]
ce  IDNTQAMKKYFESVDRFLYSCVGYSVATYIMGIKDRHSDNLMLTEDGKYFHIDFGHILGHGKTKLGIQRDRQPFILTEHFMTVIRSGKSVDGNSHELQKFKTLCVEAYEVMWNNRDLFVS [1116]
is  ------------AVENFTLSCAGYCVATYVLGVADRHSDNIMIKANGELFHIDYGHILGKFKEKFGIKRERVPFVLTHDFVHVITHGHR--RKATAFNRFQEYCERAFLILRRQGSLMIS [992]
sc  VQGW--------VLDNFVKSCAGYCVITYILGVGDRHLDNLLVTPDGHFFHADFGYILG---------QDPKPFPPLMKLPPQIIEAFGG-AESSNYDKFRSYCFVAYSILRRNAGLILN [806]
sp  IDPV--------AMDNYVRSCAGYCVITYLLGVGDRHLDNLLITKDGHFFHADFGYILG---------RDPKLFSPAMKLSKEMVEGMGG-YNSPFYQQFKSYCYTTFTALRKSSNLILN [732]
at  ITAT--------CLDTFIKSCAGYSVITYILGIGDRHLDNLLLTDDGRLFHVDFAFILG---------RDPKPFPPPMKLCKEMVEAMGG-AESQYYTRFKSYCCEAYNILRKSSNLILN [746]
                 :: :  **.**.* *:::*: *** .*:::   *. ** *:..:*.         ::   *    .:   :  .     ::    :*:  *  ::  : .   *:: 

hs  LFALMRAAGLPELSCSKD--IQYLKDSLAL-GKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ [1044]
mm  LFALMRAAGLPELSCSKD--IQYLKDSLAL-GKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ [1074]
rn  LFALMRAAGLPELSCSKD--IQYLKDSLAL-GKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ [1048]
xt  LFSMMLGSGMPELQSFDD--IAYIRKTLAL-DKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKHL--- [1065]
xt6 LFALMLTAGLPELSSVKD--IQYVKDSLAL-GKKEEDALKQFRQKFDEALKESWTTKVNWMAHTMRKDYKA [1065]
dr  LFALMKAAGLPELNSSKD--IQYLKDSLAL-GKSEEEALKNFKVKFNEALRESWKTKVNWMMHTFAKDNR- [1039]
dm  LFSMMISTGLPELSSEKD--LDYLRETLVL-DYTEEKAREHFRAKFSEALANSWKTSLNWASHNFSKNNKQ [1088]
ag  LFSMMISTGLPELSSEKD--LNYLRETLVL-DKTEEEARTHFKLKFSEALANSWKTSLNWASHNFSKNNRQ [1136]
ce  LFTLMLGMELPELSTKAD--LDHLKKTLFCNGESKEEARKFFAGIYEEAFNGSWSTKTNWLFHAVKHY--- [1182]
is  LFAMMLTTGMPELTSEKD--LDYLRDALVL-DYSEADALAHFRAKFEEALNNSWTTSINWFAHNISKDNK- [1059]
sc  LFELMKTSNIPDIRIDPNGAILRVRERFNL-NMSEEDATVHFQNLINDSVNALLPIVIDHL-HNLAQYWRT [875]
sp  LFSLMVDANIPDIKFDKEKVVYKVKERFCL-QMSESDAIKYFEQLINDSVSALFPQIIDRM-HNLAQYMRS [801]
at  LFHLMAGSTIPDIASDPEKGILKLQEKFRL-DMDDEACIHFFQDLINESVSALFPQMVETI-HRWAQYWR- [814]
    ** :*    :*::    :  :  ::. :      .  .   *    .::         :   *   :    


Alignment Details

Alignment done with MAFFT FFT-NS-2 (v7.305b) aligner. MAFFT References
  • Strategy: Auto
  • Scoring Matrix: BLOSUM62
  • Gap Penalty: 1.53
  • Offset Value: 0.0