DRSC/TRiP Functional Genomics Resources

Multi Sequence Alignment :

Domains

Index TaxID Gene Name GeneID Protein ID Domain
start 		Domain
stop 		Domain
name 		Domain
description 		external_id
hs 9606 PIK3CB 5291 NP_006210.1 706 1067 PI3Kc_IA_beta Catalytic domain of Class IA Phosphoinositide 3-kinase beta; cd05173 CDD:270717
hs 9606 PIK3CB 5291 NP_006210.1 778 784 G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 propagated from UniProtKB/Swiss-Prot (P42338.1)
hs 9606 PIK3CB 5291 NP_006210.1 532 702 PI3Ka_I Phosphoinositide 3-kinase (PI3K) class I, accessory domain; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5)...; cd00872 CDD:238444
hs 9606 PIK3CB 5291 NP_006210.1 410 418 Nuclear localization signal propagated from UniProtKB/Swiss-Prot (P42338.1)
hs 9606 PIK3CB 5291 NP_006210.1 324 501 C2_PI3K_class_I_beta_delta C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks); cd08693 CDD:176075
hs 9606 PIK3CB 5291 NP_006210.1 916 924 Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 propagated from UniProtKB/Swiss-Prot (P42338.1)
hs 9606 PIK3CB 5291 NP_006210.1 935 961 Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 propagated from UniProtKB/Swiss-Prot (P42338.1)
hs 9606 PIK3CB 5291 NP_006210.1 41 118 PI3K_p85B PI3-kinase family, p85-binding domain; smart00143 CDD:197539
hs 9606 PIK3CB 5291 NP_006210.1 180 288 PI3K_rbd PI3-kinase family, Ras-binding domain; smart00144 CDD:197540
mm 10090 Pik3cb 74769 NP_083370.2 910 918 Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 propagated from UniProtKB/Swiss-Prot (Q8BTI9.2)
mm 10090 Pik3cb 74769 NP_083370.2 772 778 G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 propagated from UniProtKB/Swiss-Prot (Q8BTI9.2)
mm 10090 Pik3cb 74769 NP_083370.2 700 1061 PI3Kc_IA_beta Catalytic domain of Class IA Phosphoinositide 3-kinase beta; cd05173 CDD:270717
mm 10090 Pik3cb 74769 NP_083370.2 404 412 Nuclear localization signal (NLS). /evidence=ECO:0000250 propagated from UniProtKB/Swiss-Prot (Q8BTI9.2)
mm 10090 Pik3cb 74769 NP_083370.2 318 495 C2_PI3K_class_I_beta_delta C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks); cd08693 CDD:176075
mm 10090 Pik3cb 74769 NP_083370.2 174 282 PI3K_rbd PI3-kinase family, Ras-binding domain; smart00144 CDD:197540
mm 10090 Pik3cb 74769 NP_083370.2 35 112 PI3K_p85B PI3-kinase family, p85-binding domain; smart00143 CDD:197539
mm 10090 Pik3cb 74769 NP_083370.2 929 955 Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 propagated from UniProtKB/Swiss-Prot (Q8BTI9.2)
mm 10090 Pik3cb 74769 NP_083370.2 526 696 PI3Ka_I Phosphoinositide 3-kinase (PI3K) class I, accessory domain; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5)...; cd00872 CDD:238444
rn 10116 Pik3cb 85243 NP_445933.1 916 924 Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 propagated from UniProtKB/Swiss-Prot (Q9Z1L0.1)
rn 10116 Pik3cb 85243 NP_445933.1 706 1067 PI3Kc_IA_beta Catalytic domain of Class IA Phosphoinositide 3-kinase beta; cd05173 CDD:270717
rn 10116 Pik3cb 85243 NP_445933.1 778 784 G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 propagated from UniProtKB/Swiss-Prot (Q9Z1L0.1)
rn 10116 Pik3cb 85243 NP_445933.1 532 702 PI3Ka_I Phosphoinositide 3-kinase (PI3K) class I, accessory domain; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5)...; cd00872 CDD:238444
rn 10116 Pik3cb 85243 NP_445933.1 410 418 Nuclear localization signal (NLS). /evidence=ECO:0000250 propagated from UniProtKB/Swiss-Prot (Q9Z1L0.1)
rn 10116 Pik3cb 85243 NP_445933.1 324 501 C2_PI3K_class_I_beta_delta C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks); cd08693 CDD:176075
rn 10116 Pik3cb 85243 NP_445933.1 180 288 PI3K_rbd PI3-kinase family, Ras-binding domain; smart00144 CDD:197540
rn 10116 Pik3cb 85243 NP_445933.1 935 961 Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 propagated from UniProtKB/Swiss-Prot (Q9Z1L0.1)
rn 10116 Pik3cb 85243 NP_445933.1 41 118 PI3K_p85B PI3-kinase family, p85-binding domain; smart00143 CDD:197539
xt 8364 pik3cb 780390 NP_001072928.1 328 495 C2_PI3K_class_I_beta_delta C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks); cd08693 CDD:176075
xt 8364 pik3cb 780390 NP_001072928.1 533 697 PI3Ka_I Phosphoinositide 3-kinase (PI3K) class I, accessory domain; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5)...; cd00872 CDD:238444
xt 8364 pik3cb 780390 NP_001072928.1 35 108 PI3K_p85B PI3-kinase family, p85-binding domain; pfam02192 CDD:460483
xt 8364 pik3cb 780390 NP_001072928.1 172 279 PI3K_rbd PI3-kinase family, Ras-binding domain; smart00144 CDD:197540
xt 8364 pik3cb 780390 NP_001072928.1 701 1062 PI3Kc_IA_beta Catalytic domain of Class IA Phosphoinositide 3-kinase beta; cd05173 CDD:270717
dr 7955 pik3cb 100002263 XP_005157523.1 716 1077 Protein Kinases, catalytic domain The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453 CDD:473864
dr 7955 pik3cb 100002263 XP_005157523.1 334 511 C2_PI3K_class_I_beta_delta C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks); cd08693 CDD:176075
dr 7955 pik3cb 100002263 XP_005157523.1 190 281 PI3K_rbd PI3-kinase family, ras-binding domain; cl02484 CDD:413336
dr 7955 pik3cb 100002263 XP_005157523.1 37 109 PI3K_p85B PI3-kinase family, p85-binding domain; pfam02192 CDD:460483
dr 7955 pik3cb 100002263 XP_005157523.1 548 713 PI3Ka Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in...; cl00271 CDD:412275
dm 7227 Pi3K92E 42446 NP_650902.1 200 307 PI3K_rbd PI3-kinase family, Ras-binding domain; smart00144 CDD:197540
dm 7227 Pi3K92E 42446 NP_650902.1 727 1084 PI3Kc_I Catalytic domain of Class I Phosphoinositide 3-kinase; cd05165 CDD:270709
dm 7227 Pi3K92E 42446 NP_650902.1 552 723 PI3Ka_I Phosphoinositide 3-kinase (PI3K) class I, accessory domain; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5)...; cd00872 CDD:238444
dm 7227 Pi3K92E 42446 NP_650902.1 339 517 C2_PI3K_class_I_beta_delta C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks); cd08693 CDD:176075
dm 7227 Pi3K92E 42446 NP_650902.1 56 132 PI3K_p85B PI3-kinase family, p85-binding domain; cl02483 CDD:470589
ag 7165 Pi3K92E 1272257 XP_061510893.1 - - - - -
ce 6239 age-1 174762 NP_496462.2 793 1181 Protein Kinases, catalytic domain The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453 CDD:473864
ce 6239 age-1 174762 NP_496462.2 606 798 PI3Ka Phosphoinositide 3-kinase family, accessory domain (PIK domain); smart00145 CDD:214537
ce 6239 age-1 174762 NP_496462.2 420 574 C2_PI3K_like C2 domain present in phosphatidylinositol 3-kinases (PI3Ks); cd08380 CDD:176026
ce 6239 age-1 174762 NP_496462.2 241 360 PI3K_rbd PI3-kinase family, Ras-binding domain; smart00144 CDD:197540
ce 6239 age-1 174762 NP_496462.2 98 177 PI3K_p85B PI3-kinase family, p85-binding domain; smart00143 CDD:197539
is 6945 Pi3K92E 8036652 XP_029826199.2 522 692 PI3Ka Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in...; cl00271 CDD:412275
is 6945 Pi3K92E 8036652 XP_029826199.2 316 487 C2 C2 domain; cl14603 CDD:472691
is 6945 Pi3K92E 8036652 XP_029826199.2 178 281 PI3K_rbd PI3-kinase family, ras-binding domain; cl02484 CDD:413336
is 6945 Pi3K92E 8036652 XP_029826199.2 697 1056 PI3Kc_I Catalytic domain of Class I Phosphoinositide 3-kinase; cd05165 CDD:270709
is 6945 Pi3K92E 8036652 XP_029826199.2 35 106 PI3K_p85B PI3-kinase family, p85-binding domain; pfam02192 CDD:460483
sc 4932 VPS34 850941 NP_013341.1 528 871 PI3Kc_III Catalytic domain of Class III Phosphoinositide 3-kinase; cd00896 CDD:270628
sc 4932 VPS34 850941 NP_013341.1 <1 872 TEL1 Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]; COG5032 CDD:227365
sp 4896 pik3 2543444 NP_594699.1 450 797 PI3Kc_III Catalytic domain of Class III Phosphoinositide 3-kinase; cd00896 CDD:270628
sp 4896 pik3 2543444 NP_594699.1 <1 801 TEL1 Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]; COG5032 CDD:227365
at 3702 VPS34 842344 NP_176251.1 466 811 PI3Kc_III Catalytic domain of Class III Phosphoinositide 3-kinase; cd00896 CDD:270628
at 3702 VPS34 842344 NP_176251.1 274 432 PI3Ka_III Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III...; cd00870 CDD:238442
at 3702 VPS34 842344 NP_176251.1 25 178 C2_PI3K_class_III C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks); cd08397 CDD:176042

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Alignment

Alignment done with MAFFT FFT-NS-2 (v7.305b) aligner. MAFFT References

Download raw alignment output file

Download fasta input file



Note:   &mbsp 2019, we've been having trouble with some alignments and are looking into the problem. If the alignment didn't work, please try again. If it still doesn't work, please download the fasta file and align off line. We're looking into it. Thanks.

hs  ---------------------------------------------------MCFSFIMPPAMADILDIWAV-----------------DSQIASDGSIPVDFLLPTGIYIQLEVP----- [47]
mm  ---------------------------------------------------------MPPAMADNLDIWAV-----------------DSQIASDGAISVDFLLPTGIYIQLEVP----- [41]
rn  ---------------------------------------------------MCFRSIMPPAMADTLDIWAV-----------------DSQIASDGSISVDFLLPTGIYIQLEVP----- [47]
xt  ---------------------------------------------------------MPPIM-DHMDIWTA-----------------DTPLPPD--ICVDVLLPTGIYVQMDVP----- [38]
dr  ---------------------------------------------------------MPPAKTDQLDLWA------------------ESGLDGDDQVMVDFLLPTGIYIQMEVP----- [40]
dm  MNMMDNRALA----------------------YVAHQPKYETPPEEA----------EPPCMRFSVNLWKN-----------------EMLNWVD----LICLLPNGFLLELRVN----- [62]
ag  MQRMRNATTTMKRNTTTMPGGTDSSWSVPHRIYLQQQQQQQQQQQQAHQQQQQQQQQQRP--RFDYGFWKN-----------------PDES-TE----LIFLMPNGVMITMYIP----- [91]
ce  MSMGRSPSTTF-RSRTGSHGARD---------LIAGHGRNSRRISQMHVN------ILHPQLQTMVEQWQMRERPSLETENGKGSLLLENEGVAD----IITMCPFGEVISVVFPWFLAN [100]
is  --------------------------------------------------------MIPPSPFLLPDPWIS-----------------DVELQVD----VTVLLPNGLVLPLQVH----- [38]
sc  -------------------------------------------------------------------------------------------MSLNN---ITFCVSQDLDVPLKVK----- [21]
sp  -----------------------------------------------------------------------------------------------M---DRLVFSYCPSSKVTAR-FLVK [21]
at  -------------------------------------------------------------------------------------------MGANE---FRFFLSCDINSPVTFR----- [21]
                                                                                                            .      :        

hs  ----REATISYIKQMLWKQVHNYPMFNLLMDIDSY-MFACVNQ--TAVYEELEDETR-RLCDVRPFLPVLKLVTRS------CD-PGEK-LDSKIGVLIGKGLHEFDSLKDPEVNEFRRK [151]
mm  ----REATISYIKQMLWKQVHNYPMFNLLMDIDSY-MFACVNQ--TAVYEELEDETR-RLCDVRPFLPVLKLVTRS------CD-PAEK-LDSKIGVLIGKGLHEFDALKDPEVNEFRRK [145]
rn  ----REATISYIKQMLWKQVHNYPMFNLLMDIDSY-MFACVNQ--TAVYEELEDETR-RLCDVRPFLPVLKLVTRS------CD-PAEK-LDSKIGVLIGKGLHEFDALKDPEVNEFRRK [151]
xt  ----RDASISHIKQLLWKHAQSYPLFHLLLEIDSY-MFQCVNH--NAVHEELEDETQ-RLCDVRPFLPVLKLVSRS------CN-PAEK-LDSKIGVLIGKGLQEFDALKDNEVMEFRSK [142]
dr  ----RESTIQHIKLLLWKEAQTYPLFSLLGEMEGH-MFECVNQ--AAVHEELEDETR-RLCDVRPFLPVLKLITRN------CG-RAERLLDSKIGVLIGKGLHELDALQDQEVKDFRSK [145]
dm  ----PANTIQVIKVEMVNQAKQMPLGYVIKEACEYQVYGI----STFNIEPYTDETK-RLSEVQPYFGILSLGERTDTTSFSSDYELTKMVNGMIGTTFDHN----RTHGSPEIDDFRLY [169]
ag  ----IHITLDELKSDVWEEAERYPLYCHLGDKNKY-CFGTLAAGRTNSNTTYENEAETRLMDVQPTLGILRFVEKSNVS------ENTKLMEN-ISSLLDSKL-PVKTLVNPEVNDFRAK [198]
ce  VRTSLEIKLSDFKHQLFELIAPMKWGTYSVKPQDY-VFRQLNN-FGEIEVIFNDDQPLSKLELHGTFPMLFLYQPDGI-------NRDKELMSDISHCLGYSLDKLEESLDEELRQFRAS [211]
is  ----RESTLEELKQCTWREAERLPLYRCLRGRDTY-VFTCVSE-RTSEREEFADEGR-KLCDVRPFQALLRLVERP------SD-KADRQTNAQIGLLIGKGLNSFDALKCPEVNEFRRT [144]
sc  ----------------------------IKSLEGH----------------------------KP------LLKPSQKIL------------------------------NPELMLIGSN [49]
sp  -------------------------FCFIEYQDSQ----------------------------EPCICTIQLFSGNESG---------------------------------SLMQ---- [51]
at  ----------------------------IEKLDGN----------------------------LP------VKKSSDSGVV-----------------------SIAEEKKPELYI---- [52]
                                                                           .                                        .:      

hs  MRKFSEEKILSLVGLSWMDWLKQTYPPEHE--------PSIPENLEDKLYGGKLIVAVHFENCQD----------VFSFQVSPNMNPIKVNELAIQKRLTIHGKE-DEVSPYDYVLQVSG [252]
mm  MRKFSEAKIQSLVGLSWIDWLKHTYPPEHE--------PSVLENLEDKLYGGKLVVAVHFENSQD----------VFSFQVSPNLNPIKINELAIQKRLTIRGKE-DEASPCDYVLQVSG [246]
rn  MRKFSEDKIQSLVGLSWIDWLKHTYPPEHE--------PSVLENLEDKLYGGKLVVAVHFENSQD----------VFSFQVSPNLNPIKINELAIQKRLTIRGKE-EEASPCDYVLQVSG [252]
xt  MRSISEAKIQSLLGLTWVEWLKRTFPPELE--------PSIQDNIQGKLYGGNIVVAIHFENCQD----------VFSFQVSPNMVPVKVNELAIRKRLTIHGREAEEVDPEDFVLQVNG [244]
dr  MKRISEEKMQQMQMMSWGQWLRSSYSPQLD--------TSSLDNLIER-HEGIIKITMHYDQSQD----------TASLKVSLNCTVSEVMDHALKKWQTTHGPEEDIGARSNYVLRVSD [246]
dm  MTQTCDNIELERSAYTWQQRLLYEHPLRLA------NSTKMPELIRERHPTRTFLIVVKNENDQS----------TFTLSVNEQDTPFSLTESTLQK--MNRSQMKMNDRTSDYILKVSG [271]
ag  MSMLSEDIGSRRAVMTRMERIAYQYPAKLV------SGAHVPEPISRRLTNGDFCVVAISTDMQ------------LTVKVPCRATPDEVLKRILKK--QNPSKARNENSSTEYILKVCG [298]
ce  LWARTKKTCLTRGLEGTSH---YAFPEEQY-LC---VGESCPKDLESKVKAAKLSYQMFWRKRKAEINGVCEKMMKIQIEFNPNETPKSLLHTFLYEMRKLDVYDTDDPADEGWFLQLAG [324]
is  MRAFCTSIADKRAEWSPLDQVKYRYPARVDRFCSQYPPPHMGDRISSA--DSTFGAEILFENG-G----------MMTMNVAIGATPQALLLLVMQS--AASGEQFLCHTVEGLVLKVCG [249]
sc  V-----------------------FPSS---DL------------------------------------------IVSLQVFDKE----------------------------------- [66]
sp  -------------------------------KC------------------------------------------FVS------------------------------------------ [56]
at  -------------------------------EC------------------------------------------ALYID---------------------------------------- [59]
                                                                                                                            

hs  RVEYVFG-DHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSS---NLPL------------------------------------------PLPPKK------- [319]
mm  RVEYVFG-DHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAIEAAINRNSS---NLPL------------------------------------------PLPPKK------- [313]
rn  RVEYVFG-DHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAIEAAINRNSS---SLPL------------------------------------------PLPPKK------- [319]
xt  RLEFVFG-DHPLIQFQYIRNCVMNKALPHLTLVECCNIKKLFDQEMSEIEHAVRRKSSMHPALPM------------------------------------------PLPPKKRGASMKT [321]
dr  RLEFLFE-DYPLIQYKYIRACLSTGENPHLTVVHFDIVKSMFEKEIATVGSVLARKTS---NPPL------------------------------------------PLPPKKRQTTVRT [320]
dm  RDEYLLG-DYPLIQFLYIQEMLSDSAVPNVVLQSVYRLESYINH-----------------------------------------HNEQAMVTK------------RPLPKKR---TVHL [334]
ag  REEYIYG-AHPMISFQYVQDCLSRDETPTFVPRLVRTVEVFKNDIYDAREDFTQWSAS---AKPSSLYGGSISSSSGYAGSAGSTYNTQSQ-------------------QSH---TLRK [392]
ce  RTTFVTNPDVKLTSYDGVRSELESYRCPGFVVRRQSLVLKDY-------------------CRPKPLY---------------EPHYVRAHERKLALDVLSVSIDSTPKQSKN-SDMVMT [409]
is  REEYLLE-ELPLLQYKYVQEKVSEGSTPQFTVVPISDIQTDHDMVYAQIERCM--EPSF--CRPS------------------------------------------PHPDKL------- [315]
sc  ------------------------------------------------------RNRNL--TLPI-------------------------------------------------YTPYIP [81]
sp  -------------------------------------------------------------KIPN-------------------------------------------------KSLLPT [66]
at  -------------------------------------------------------GAPF--GLPM-------------------------------------------------RTRLKT [73]
                                                                                                                            

hs  ------------TRIISHVWENNNPFQIVLVKGNKLNTEETVKV--HVRAGLFHGTELLCKTIVSSEVS---GKNDHIWNEPLE-FDINICDLPRMARLCFAVYAVLDKVKTK--KSTKT [419]
mm  ------------TRVISHIWDNNNPFQITLVKGNKLNTEETVKV--HVRAGLFHGTELLCKTVVSSEIS---GKNDHIWNEQLE-FDINICDLPRMARLCFAVYAVLDKVKTK--KSTKT [413]
rn  ------------TRVISHVWGNNNPFQIVLVKGNKLNTEETVKV--HVRAGLFHGTELLCKTVVSSEIS---GKNDHIWNEQLE-FDINICDLPRMARLCFAVYAVLDKVKTK--KSTKT [419]
xt  ----------LNMRDI--VWNIVQPYKIILSKGSRLNTEDS--V--LVRAGLFHGTELLCKPTMTPEVQ---GKNDHVWNETLE-FEINVCDLPRMARLCFAIYAVLDKPRNK------- [414]
dr  S---SMSASQLPQQLHTCVWKVHSLFRINLVKANKVNAEDAAKI--QVRAGLFHGTELLCKTAVSNESS---SRSEHVWNKTLE-FDIPVCDLPRMARLCFAIYAVMDKVKKQ--RSTKN [429]
dm  ------------HKSISSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNG--NFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSK--KSSNN [438]
ag  ------------VKYITS-WEIDAKLQCTVHEIRGLNVESDKEL--GVQLGLFHGGKSLCKTERTRTVTV--NSGAATWNETIL-FDINVSNVPRMARLCLVVYENMRTAKGTGIRTRRT [494]
ce  DFRPTAS-----LKQVS-LWDLDANLMIRPVNISGFDFPADVDMYVRIEFSVYVGTLTLASKSTTKV-----NAQFAKWNKEMYTFDLYMKDMPPSAVLSIRVLYGKVKLKSE------- [511]
is  -----VS-----------AWMIGDPFRVRVLSASSVNVESGAKL--VVEGGLYHGTELLCQTQRTQDCSVADGRGS--WDQQLC-FDLAVRDLPQAVRLCLGLYEVTRGTRHP--RARRR [412]
sc  ------------------------------------------------------------------------FRNSRTWDYWLT-LPIRIKQLTFSSHLRIILWEYNGSKQI-------- [120]
sp  ------------------------------------------------------------------------ELSKISTHEWLD-FGVTVSELSLNAKFVVSAWKPSFNDEEV------- [106]
at  ------------------------------------------------------------------------TGPPYCWNELIT-LSSKYRDLTAHSQLAITVWDVSCGKTE-------- [112]
                                                                                   .  :  :     ::.    : .                   

hs  INPSKYQTIRKAGKV------HYPVAWVNTMVFDFKGQLRTGDIILHS---------------------------------------------WSSFPDE--LEEM--LNPMGTVQTNPY [484]
mm  INPSKYQTIRKAGKV------HYPVAWVNTMVFDFKGQLRSGDVILHS---------------------------------------------WSSFPDE--LEEM--LNPMGTVQTNPY [478]
rn  INPSKYQTIRKAGKV------HYPVAWVNTMVFDFKGQLRSGDVILHS---------------------------------------------WSSFPDE--LEEM--LNPMGTVQTNPY [484]
xt  -NKTKYQTIKKSGKM------HFPVAWVNTMVFDYKGQLRSGDHVLHC---------------------------------------------WSSFPDE--LEEM--LNPMGTVRTNPY [478]
dr  THLNKYQTIRKAGKV------HYPIAWVNTMVFDYRGQLKTGDIILHC---------------------------------------------WSSFPDE--LEEM--LNPIGTIQTNPY [494]
dm  ----------KDIALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYT---------------------------------------------W-TYADD--IQSVEVFHPLGTIEPNPR [500]
ag  ----------KDGLI-------NPIAWVNTMVYDYKNQLKVDSVTLYT---------------------------------------------W-DYAED--AQSEDILHPLGTVEPNPN [549]
ce  ---------------------EFEVGWVNMSLTDWRDELRQGQFLFHL---------------------------------------------W---APEPTANRSRIGENGARIGTN-- [560]
is  LGPDLYAA---------------PLAWVNVTVYDFRGYLRFGCVDLSM---------------------------------------------W-TYADEPHAEEMDLLHPMGTAVFNPE [471]
sc  ----------------------PFFNLETSIFNLKDCTLKRGFESLKFRYDV-------------IDHCEVVTDNKDQENLNKYFQGEFTRLPW--------LDEI-TISKLRKQRENRT [196]
sp  ---------------------YEFVGCTTYRLFDENNLLRQGLQKIPLQTSKEIKKYSPTS----LELEQVKEINRLDGLLLKLQLGDVPSVNW--------LDDI----SFGKIKDFRS [189]
at  ----------------------GLIGGATVLLFNSKMQMKSGKQKLRLWQGKEADGSFPTSTPGKVPRHERGELERLEKLMNKYERGQIQSIDW--------LDRL-MLKSLDTIKEQES [201]
                            .   .  .      :: .   :                                               *         :                

hs  TENAT--------ALHVKF-PENKK-----QPYYY----------------------------------------------------------PPFDKIIEKAAE-IA-SSDSANVSSRG [530]
mm  AENAT--------ALHITF-PENKK-----QPCYY----------------------------------------------------------PPFDKIIEKAAE-LA-SGDSANVSSRG [524]
rn  AENAT--------ALHIKF-PENKK-----QPYYY----------------------------------------------------------PPFDKIIEKAAE-IA-SGDSANVSSRG [530]
xt  TENTT--------TLHIKF-HDYSK-----EPISY----------------------------------------------------------PPFDKILEKAAE-IARNSDSLSTSGRG [525]
dr  TENAT--------ELHISF-PEYST-----QPVVF----------------------------------------------------------PAFDKILEKAAE-IAGASDSMSM-GRG [540]
dm  KEECA--------LVDLTF-LSSGT-----GTVRY----------------------------------------------------------PSEEVVLQYAAD-REQVN-RLQRQLAG [546]
ag  RDN----------MVVSVL-LSFGTYGPEGRIIVY----------------------------------------------------------PGEEELLSHAAK-MSHRNEHLNRESA- [598]
ce  ----A--------AVTIEI-SSYG------GRVRM----------------------------------------------------------PSQGQYTYLVKH-RSTWTETLNIMGDD [602]
is  AHHAT--------TLTIQFEPYHPS-----HPVRY----------------------------------------------------------PMLDEILECAASCVKEKSTYLQGIGHA [520]
sc  WPQGT---FV----LNLEF-PMLE------LPVVFIEREIMNTQMNIPTLKNNPGLSTDLREPNRNDPQIKISLGDKYHSTLKFYDPDQPNNDPIEEKYRRLE---RASKNANLDKQVKP [299]
sp  -KHMS---LVTIPILYLDF-LQFS------FPVVFQRS-------YYPKSENRVYYSS--------------------------FDLELNLDSPAELKHRRLV---RSQRNGPLDKDLKP [262]
at  TKHGSSHLFVVI-----DF-CSFE------HRVVFQESG-ANLFITAPIGSTNEFVTV--------------------------WDTELGKTNPSENKQLKLA---RSLDRGIIDRDLKP [279]
                      :                                                                          *                    .     

hs  GKK-----FLPVLKEILDR----DPLSQLCENEMDLIWTLRQDCREIFPQSLPKL-LLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCL-RQMSDEELSQYL [639]
mm  GKK-----FLAVLKEILDR----DPLSQLCENEMDLIWTLRQDCRENFPQSLPKL-LLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCL-RQMSDEELSQYL [633]
rn  GKK-----FLAVLKEILDR----DPLSQLCENEMDLIWTLRQDCRENFPQSLPKL-LLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCL-RQMSDEELSQYL [639]
xt  GKK-----LNIELKEIMER----DPLCQLSENEKDLIWTLRYDCRENFPGSLPKL-LLSVKWNKLEDVAQLQALLQIWSKLPPRDALELLDFNYPDQYVREYAVNCL-KPMSDEELSQYL [634]
dr  GKK-----FYIELKEIMER----DPLSQLCENEKDLIWTLRYDCRENFPQSLPKL-LLSVKWSKHEDMAQLQALLQIWPKLSPRDALELLDFNYPDQYVREFAVSCL-KDMSDDELLQYL [649]
dm  PEK-----PIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELSIL-LHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCL-HFLKDEDLLLYL [659]
ag  --E-----DTRSIRAIMSAYMYNDRLNDIHEQDRNAIWAKRRECMKQMPQGLPCL-LYCVEWNNRDEVSEIVSLLQEWPKLLVERALELLDYAYADKYVRRYAVDCL-RTIEDDELLLYL [709]
ce  YESCIRDPGYKKLQMLVKKH---ESGIVLEEDEQRHVWMWRRYIQKQEPDLLIVLSELAFVWTDRENFSELYVMLEKWKPPSVAAALTLLGKRCTDRVIRKFAVEKLNEQLSPVTFHLFI [719]
is  SKS-----HREQLRQIAEQ----DPLAPLHEQDRQLLWFLRYDCLE-LPHVLPKL-LLSLRWGDHCDVALMQALLQIWKLLKPEQALELLDYSYPDNYVRSFAVRCL-RQMSDEELSLYL [628]
sc  DIK-----KRDYLNKIINY----PPGTKLTAHEKGSIWKYRYYLMNN-KKALTKL-LQSTNLREESERVEVLELMDSWAEIDIDDALELLGSTFKNLSVRSYAVNRL-KKASDKELELYL [407]
sp  NSK-----IRKELESILSY----PPSEELSLEEKDLIWKFRFYLTRN-KKAMTKF-LKSVVWTDSSEVNQALSLLDSWTEIDIDDALELLSPSFVHPKVRAYAVSRL-ETASNEELLLYL [370]
at  SNI-----ERKSIQRVLKY----PPTRTLSGDERQLLWKFRFSLMSE-KRALTKF-LRCVEWSDVQEAKQAIQLMYKWEMIDVCDALELLSPLFESEEVRAYAVSVL-ERADDEELQCYL [387]
                :. :            :  .:   :*  *          :  :   .    .  :      ::  *       :* **.       :* :*:  * .  .   :  ::

hs  LQLVQVLKYEPFLD--------------------------------------------------------CALSRFLLERALGNRRIGQFLFWHLRSEVH-------IPAVSVQFGVILE [696]
mm  LQLVQVLKYEPFLD--------------------------------------------------------CALSRFLLERALDNRRIGQFLFWHLRSEVH-------TPAVSVQFGVILE [690]
rn  LQLVQVLKYEPFLD--------------------------------------------------------CALSRFLLERALDNRRIGQFLFWHLRSEVH-------TPAVSIQFGVILE [696]
xt  LQLVQVLKYEPFLD--------------------------------------------------------CALSRFLLQRALDNRRIGQFLFWHLRSEVH-------NPAVSVQFGLLLE [691]
dr  LQLVQVLRYEPYYD--------------------------------------------------------CSLSRFLLERAQTSRKIGHFLFWHLRSEMY-------MPAVSVHFALILE [706]
dm  LQLVQAIKHESYLE--------------------------------------------------------SDLVVFLLERALRNQRIGHYFFWHLRSEMQ-------TPSMQTRFGLLLE [716]
ag  LQLVQALKHESYLN--------------------------------------------------------CDLVYFLLQRALHNQHIGHYLFWHLRSEIS-------VPSVQVRFGLILE [766]
ce  LPLIQALKYEPRAQ--------------------------------------------------------SEVGMMLLTRALCDYRIGHRLFWLLRAEIARLRDCDLKSEEYRRISLLME [783]
is  LQLVQALKHESFLD--------------------------------------------------------CDLVKFLLERALKNRHIGHQMFWLLRCEMQ-------VAALSVKFGLILE [685]
sc  LQLVEAVCFENLSTFSDKSNSEFTIVDAVSSQKLSGDSMLLSTSHANQKLLKSISSESETSGTESLPIVISPLAEFLIRRALVNPRLGSFFYWYLKSESE---DKPYLDQILSS---FWS [521]
sp  LQLVQALRYDNPISSDERFQP-------------------------------------------------SPLALFLVNRAISSPSIGNDLYWYLVVEIE---DEPVSKLFSSVMFLFQK [438]
at  LQLVQALRF-------ERSDR-------------------------------------------------SCLSQFLVQRALQNIELASFLRWYVAVELH---DHVYAKRFYSTYELLEE [448]
    * *::.: .                                                             . :  :*: **  .  :.  : * :  *                   : .

hs  AYCRGSV--------GHMKVLSKQVEALNKLKTLNSLIKLNAV--KLNRAKGKEAMHTCLKQSAYREALSDLQS-----PLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDS-- [799]
mm  AYCRGSV--------GHMKVLSKQVEALNKLKTLNSLIKLNAV--KLSRAKGKEAMHTCLKQSAYREALSDLQS-----PLNPCVILSELYVEKCKYMDSKMKPLWLVYSSRAFGEDS-- [793]
rn  AYCRGSV--------GHMKVLSKQVEALNKLKTLNSLIKLNAM--KLNRAKGKEAMHTCLKQSAYREALSDLQS-----PLNPCVILSELYVEKCRYMDSKMKPLWLVYSNRAFGEDA-- [799]
xt  AYCRGSV--------AHMKVLSRQVEALNKLRTLNGLIKLNAV--KLSKVKNKDNMHTCLRENAYKEALMHIQS-----PLNPSITLSELVVEKCKYMDSKMKPLWIVYNNRGFGSDS-- [794]
dr  AYCRGCI--------PHIEVLKKQVEALNKLKAVNELIKLGTIKTKTKQAHLKEAMMSCLRQTGFIETLSDLHS-----PLNPNILLAGVSVEKCKYMDSKMKPLWIVYNNKLLGGET-- [811]
dm  VYLKGCK--------HHVAPLRKQLHVLEKLKQGSLIAK------KGSKEKVKTMLQDFLRDQRNSAVFQNIQN-----PLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASD-- [815]
ag  AYLLGSP--------EHVAVLLKQMQCLRYLQTCSDNVK------KGSKEKGRTLLIEQL--AKEGHVTSDLIS-----PLNPSYRCKAVRTDRCKVMDSKMRPLWIVYENSDANGDD-- [863]
ce  AYLRGNE--------EHIKIITRQVDMVDELTRISTLVK------GMPKDVATMKLRDELR--SISHKMENMDS-----PLDPVYKLGEMIIDKAIVLGSAKRPLMLHWKNKNPKSDLHL [882]
is  AYCHGAP--------DHREALLKQAEAFFKLRALGNQIHESSKK-KDSREKMVATMREHMSKEAFRATFRNLCS-----PLDPCHVFSQIKPELCRFMDSKMKPLWLVFENSDAVAED-- [789]
sc  RLDK-----------KSRNILNDQVRLINVLRECCETIK----RLKDTTAKKMELLVHLL--ETKVRPLVKVR--PIALPLDPDVLICDVCPETSKVFKSSLSPLKITFKT-TLNQP--- [618]
sp  ELSK------SVEGRLIRETLSAQAKFVEKLLRISKSVQ----SFRGTRLKKIEYLKVLL--EDHKYHLLDFHALPL--PLDPSVNIVGIIPDACTVFKSTMQPLRLLFKC-QDGSK--- [540]
at  NIIKLPPGVNGEDGYQLWQSLVRQTELTAQLCSITREVR----NVRGNTQKKIEKLRQLL--GGLLSELTYFEE-PIRSPLTPNVLIKGIVAGESSLFKSALHPLRLTFRTPEEGGS--- [558]
                        :  *      *       :                :   :           .       ** *      :    .  : *   ** : :           

hs  --VGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNV-AAAAAFNKDALLNWLKEYN-SGDDLDR------------------- [896]
mm  --VGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNV-AATAAFNKDALLNWLKEYN-SGDDLDR------------------- [890]
rn  --VGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNV-AATAAFNKDALLNWLKEYN-SGDDLDR------------------- [896]
xt  --LGIIFKNGDDLRQDMLALQLLRLMDMLWKEAGLDLRIVPYGCLATGDRCGFIEVVSAAETIADIQLDSSNL-AAAAAFNKDALLNWIKECH-SGDDLER------------------- [891]
dr  --VGIIFKNGDDLRQDMLTLQILKLMDLLWKEANLDLRIVPYGCLATGDHSGLIEVVSSADTIANIQKTSSNM-AAAAAFNKDALLNWLKDKN-SGDALDK------------------- [908]
dm  --VHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMF-SATSPFKKGSLLSWLKEHNKPADKLNK------------------- [913]
ag  --IHMIFKNGDDLRQDMLTLQMLRIMDRIWKSHGYDFRMNPYSCISTDHKLGLIEVVLNAETIANIQKERGMF-SATSPFKKGSLLAWLREHNGTEDLLAK------------------- [961]
ce  PFCAMIFKNGDDLRQDMLVLQVLEVMDNIWKAANIDCCLNPYAVLPMGEMIGIIEVVPNCKTIFEIQVGTGFMNTAVRSIDPSFMNKWIRKQCGIEDEKKKSKKDSTKNPIEKKIDNTQA [1002]
is  --IAIIFKHGDDLRQDMLTLQMIRIMDKLWKDEGYDFRMIPYQCLSTDQNVGLIEVVRNASTIANIQKL-HNS-SATSAFKKGSLFAWIKEHNKTQESLRR------------------- [886]
sc  --YHLMFKVGDDLRQDQLVVQIISLMNELLKNENVDLKLTPYKILATGPQEGAIEFIPN-DTLASILSK-----------YHG-ILGYLKLHY-PDE---N---------ATLGVQGW-- [708]
sp  --YPIIFKNGDDLRQDQLVIQILTLMDKLLKKEKLDLHLKPYRILATGPTHGAVQFVPS-KTLATILAE-----------YHGSVLAYLRENN-PDDGLNS---------ANYGIDPV-- [634]
at  --CKLIFKKGDDLRQDQLVVQMVWLMDRLLKLENLDLCLTPYKVLATGHDEGMLEFIPS-RSLAQILSE------------HRSITSYLQKFH-PDE---H---------APFGITAT-- [648]
        ::** ******* *.:*:: :*: : *    *  :  *  :.     * ::.:    ::  *                  :  :::      :                       

hs  ------AIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKT--GNTEKFGRFRQCCEDAYLILRRHGNLFITLFALML [1008]
mm  ------AIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKT--GNTEKFGRFRQCCEDAYLILRRHGNLFITLFALML [1002]
rn  ------AIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKT--GNTEKFGRFRQCCEDAYLILRRHGNLFITLFALML [1008]
xt  ------AIEEFTLSCAGYCVATYVLGIGDRHNDNIMVRKTGQLFHIDFGHILGNFKSKFKIKRERGPFILTYDFIHVIQQGKP--GNTEKFGRFRQCCEDAYLILRRNGNLIITLFALML [1003]
dr  ------AIEEFTLSCAGYCVATYVLGIGDRHSDNIMVRSTGQLFHIDFGHILGNFKSKFGIKRERVPFILTHDFIHVIQEGKT--GNTEKFGNFRQYCEEAYMILRKNGNLFITLFALML [1020]
dm  ------AINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFN-DRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMI [1026]
ag  ------AIQEFTLSCAGYCVATYVLGVADRHSDNIMVKKTGQLFHIDFGHILGHFKEKFGFRRERVPFVLTHDFVYVINNGRT-DREAQEFCRFQTLCEEAFLILRQHGCLILSLFSMMI [1074]
ce  MKKYFESVDRFLYSCVGYSVATYIMGIKDRHSDNLMLTEDGKYFHIDFGHILGHGKTKLGIQRDRQPFILTEHFMTVIRSGKSVDGNSHELQKFKTLCVEAYEVMWNNRDLFVSLFTLML [1122]
is  ------AVENFTLSCAGYCVATYVLGVADRHSDNIMIKANGELFHIDYGHILGKFKEKFGIKRERVPFVLTHDFVHVITHGHR--RKATAFNRFQEYCERAFLILRRQGSLMISLFAMML [998]
sc  ------VLDNFVKSCAGYCVITYILGVGDRHLDNLLVTPDGHFFHADFGYILG---------QDPKPFPPLMKLPPQIIEAFG-GAESSNYDKFRSYCFVAYSILRRNAGLILNLFELMK [812]
sp  ------AMDNYVRSCAGYCVITYLLGVGDRHLDNLLITKDGHFFHADFGYILG---------RDPKLFSPAMKLSKEMVEGMG-GYNSPFYQQFKSYCYTTFTALRKSSNLILNLFSLMV [738]
at  ------CLDTFIKSCAGYSVITYILGIGDRHLDNLLLTDDGRLFHVDFAFILG---------RDPKPFPPPMKLCKEMVEAMG-GAESQYYTRFKSYCCEAYNILRKSSNLILNLFHLMA [752]
           :: :  **.**.* :*::*: *** **:::   *. ** *:..***         ::   *    .:   :  .     ::    .*:  *  ::  : .   *::.** :* 

hs  TAGLPELTSVKD--IQYLKDSLAL-GKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS [1070]
mm  TAGLPELTSVKD--IQYLKDSLAL-GKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS [1064]
rn  TAGLPELTSVKD--IQYLKDSLAL-GKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS [1070]
xt  TAGLPELSSVKD--IQYVKDSLAL-GKKEEDALKQFRQKFDEALKESWTTKVNWMAHTMRKDYKA [1065]
dr  TAGLPELTSVKD--IQYLKDSLAL-GKTDEEALKQFRQKFDEALRESWTTKVNWMAHIVAHPS-- [1080]
dm  STGLPELSSEKD--LDYLRETLVL-DYTEEKAREHFRAKFSEALANSWKTSLNWASHNFSKNNKQ [1088]
ag  STGLPELSSEKD--LNYLRETLVL-DKTEEEARTHFKLKFSEALANSWKTSLNWASHNFSKNNRQ [1136]
ce  GMELPELSTKAD--LDHLKKTLFCNGESKEEARKFFAGIYEEAFNGSWSTKTNWLFHAVKHY--- [1182]
is  TTGMPELTSEKD--LDYLRDALVL-DYSEADALAHFRAKFEEALNNSWTTSINWFAHNISKDNK- [1059]
sc  TSNIPDIRIDPNGAILRVRERFNL-NMSEEDATVHFQNLINDSVNALLPIVIDHL-HNLAQYWRT [875]
sp  DANIPDIKFDKEKVVYKVKERFCL-QMSESDAIKYFEQLINDSVSALFPQIIDRM-HNLAQYMRS [801]
at  GSTIPDIASDPEKGILKLQEKFRL-DMDDEACIHFFQDLINESVSALFPQMVETI-HRWAQYWR- [814]
       :*::    :  :  ::. :      .  .   *    .::.        :   *   :    


Alignment Details

Alignment done with MAFFT FFT-NS-2 (v7.305b) aligner. MAFFT References
  • Strategy: Auto
  • Scoring Matrix: BLOSUM62
  • Gap Penalty: 1.53
  • Offset Value: 0.0