DRSC/TRiP Functional Genomics Resources

Multi Sequence Alignment :

Domains

Index TaxID Gene Name GeneID Protein ID Domain
start 		Domain
stop 		Domain
name 		Domain
description 		external_id
hs 9606 SIRT1 23411 NP_036370.2 538 540 Phosphorylated at one of three serine residues propagated from UniProtKB/Swiss-Prot (Q96EB6.2)
hs 9606 SIRT1 23411 NP_036370.2 425 431 Nuclear export signal. /evidence=ECO:0000250 propagated from UniProtKB/Swiss-Prot (Q96EB6.2)
hs 9606 SIRT1 23411 NP_036370.2 523 549 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite propagated from UniProtKB/Swiss-Prot (Q96EB6.2)
hs 9606 SIRT1 23411 NP_036370.2 254 489 SIRT1 Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins...; cd01408 CDD:238699
hs 9606 SIRT1 23411 NP_036370.2 256 259 Required for interaction with the sumoylated form of CCAR2. /evidence=ECO:0000269|PubMed:25406032 propagated from UniProtKB/Swiss-Prot (Q96EB6.2)
hs 9606 SIRT1 23411 NP_036370.2 143 541 Interaction with CCAR2 propagated from UniProtKB/Swiss-Prot (Q96EB6.2)
hs 9606 SIRT1 23411 NP_036370.2 223 230 Nuclear localization signal. /evidence=ECO:0000250 propagated from UniProtKB/Swiss-Prot (Q96EB6.2)
hs 9606 SIRT1 23411 NP_036370.2 138 145 Nuclear export signal. /evidence=ECO:0000250 propagated from UniProtKB/Swiss-Prot (Q96EB6.2)
hs 9606 SIRT1 23411 NP_036370.2 32 39 Nuclear localization signal. /evidence=ECO:0000250 propagated from UniProtKB/Swiss-Prot (Q96EB6.2)
hs 9606 SIRT1 23411 NP_036370.2 2 139 Interaction with CLOCK. /evidence=ECO:0000250|UniProtKB:Q923E4 propagated from UniProtKB/Swiss-Prot (Q96EB6.2)
hs 9606 SIRT1 23411 NP_036370.2 562 587 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite propagated from UniProtKB/Swiss-Prot (Q96EB6.2)
hs 9606 SIRT1 23411 NP_036370.2 663 726 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite propagated from UniProtKB/Swiss-Prot (Q96EB6.2)
hs 9606 SIRT1 23411 NP_036370.2 1 135 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite propagated from UniProtKB/Swiss-Prot (Q96EB6.2)
hs 9606 SIRT1 23411 NP_036370.2 2 268 Interaction with H1-4. /evidence=ECO:0000269|PubMed:15469825 propagated from UniProtKB/Swiss-Prot (Q96EB6.2)
mm 10090 Sirt1 93759 NP_062786.1 514 539 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite propagated from UniProtKB/Swiss-Prot (Q923E4.2)
mm 10090 Sirt1 93759 NP_062786.1 425 431 Nuclear export signal propagated from UniProtKB/Swiss-Prot (Q923E4.2)
mm 10090 Sirt1 93759 NP_062786.1 248 251 Required for interaction with the sumoylated form of CCAR2. /evidence=ECO:0000250|UniProtKB:Q96EB6 propagated from UniProtKB/Swiss-Prot (Q923E4.2)
mm 10090 Sirt1 93759 NP_062786.1 246 481 SIRT1 Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins...; cd01408 CDD:238699
mm 10090 Sirt1 93759 NP_062786.1 138 145 Nuclear export signal propagated from UniProtKB/Swiss-Prot (Q923E4.2)
mm 10090 Sirt1 93759 NP_062786.1 152 171 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite propagated from UniProtKB/Swiss-Prot (Q923E4.2)
mm 10090 Sirt1 93759 NP_062786.1 75 125 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite propagated from UniProtKB/Swiss-Prot (Q923E4.2)
mm 10090 Sirt1 93759 NP_062786.1 135 533 Interaction with CCAR2. /evidence=ECO:0000250|UniProtKB:Q96EB6 propagated from UniProtKB/Swiss-Prot (Q923E4.2)
mm 10090 Sirt1 93759 NP_062786.1 32 39 Nuclear localization signal propagated from UniProtKB/Swiss-Prot (Q923E4.2)
mm 10090 Sirt1 93759 NP_062786.1 2 131 Interaction with CLOCK. /evidence=ECO:0000269|PubMed:18662547 propagated from UniProtKB/Swiss-Prot (Q923E4.2)
mm 10090 Sirt1 93759 NP_062786.1 2 268 Interaction with H1-4. /evidence=ECO:0000250|UniProtKB:Q96EB6 propagated from UniProtKB/Swiss-Prot (Q923E4.2)
mm 10090 Sirt1 93759 NP_062786.1 1 56 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite propagated from UniProtKB/Swiss-Prot (Q923E4.2)
mm 10090 Sirt1 93759 NP_062786.1 653 713 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite propagated from UniProtKB/Swiss-Prot (Q923E4.2)
mm 10090 Sirt1 93759 NP_062786.1 223 230 Nuclear localization signal propagated from UniProtKB/Swiss-Prot (Q923E4.2)
rn 10116 Sirt1 309757 NP_001401888.1 248 483 SIRT1 Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins...; cd01408 CDD:238699
xt 8364 sirt1 100145679 XP_012821550.2 294 529 SIRT1 Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins...; cd01408 CDD:238699
dr 7955 sirt1 797132 XP_001334440.5 - - - - -
dm 7227 Sirt1 34708 NP_477351.1 222 476 SIRT1 Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins...; cd01408 CDD:238699
ag 7165 LOC1273019 1273019 XP_311957.5 174 422 SIRT1 Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins...; cd01408 CDD:238699
ce 6239 sir-2.1 177924 NP_001255484.1 146 376 SIRT1 Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins...; cd01408 CDD:238699
is 6945 LOC8052934 8052934 XP_029844606.2 222 458 SIRT1 Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins...; cd01408 CDD:238699
is 6945 LOC8052934 8052934 XP_029844606.2 <149 228 DUF592 Protein of unknown function (DUF592); pfam04574 CDD:368003
sc 4932 HST1 854086 NP_014573.1 53 207 DUF592 Protein of unknown function (DUF592); pfam04574 CDD:368003
sc 4932 SIR2 851520 NP_010242.1 255 517 SIRT1 Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins...; cd01408 CDD:238699
sc 4932 SIR2 851520 NP_010242.1 104 261 DUF592 Protein of unknown function (DUF592); pfam04574 CDD:368003
sc 4932 HST1 854086 NP_014573.1 201 461 SIRT1 Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins...; cd01408 CDD:238699
sp 4896 sir2 3361342 NP_001018840.1 70 162 DUF592 Protein of unknown function (DUF592); pfam04574 CDD:368003
sp 4896 sir2 3361342 NP_001018840.1 157 420 SIRT1 Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins...; cd01408 CDD:238699
at 3702 SRT1 835670 NP_200387.1 45 252 SIRT7 Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; cd01410 CDD:238701
at 3702 SRT2 830782 NP_001078550.1 88 362 SIRT4 Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; cd01409 CDD:238700
ec 83333 cobB 945687 NP_415638.3 31 271 PRK00481 NAD-dependent deacetylase; Provisional CDD:234777

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Alignment

Alignment done with MAFFT FFT-NS-2 (v7.305b) aligner. MAFFT References

Download raw alignment output file

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Note:   &mbsp 2019, we've been having trouble with some alignments and are looking into the problem. If the alignment didn't work, please try again. If it still doesn't work, please download the fasta file and align off line. We're looking into it. Thanks.

hs  ----------------------------------------------------------------MADEAALALQPGGSPSA----AGADREAASSPAGEPLRKRPRRDGPGLERSP---G [49]
mm  ----------------------------------------------------------------MADEVALALQAAGSPSA----AAA-MEAASQPADEPLRKRPRRDGPGLGRSP---G [48]
rn  ----------------------------------------------------------------MADEAALALQAGGSPSA----AAA-MEAASQPADEPLRKRPRRDGPGLGRSP---G [48]
xt  MTLYCRFRFPTPSPFVVAVPAHPQVPCEWLVCYCTRHTAGEPIGNGVSRGSLRSIVQ------LMGDSFSGSGKMADSDRVGFPIAGA-VLAVSKENGEPLSKRQRLEDTGGGGSQLVGA [113]
dr  ----------------------------------------------------------------MAD-------------------GENKRAESAEPDEPLPKKPRL------------L [25]
dm  ----------------------------------------------------------------MMEN---------------------------------YEEIRL---GHIRSKDLGN [20]
ag  ----------------------------------------------------------------MSQE--------EHPAI--------AAAPSLPHLAPMLQCIGAG----------GG [30]
ce  ----------------------------------------------------------------MSRD-----------------SGN-------------------------------- [7]
is  ----------------------------------------------------------------MADR---------------------RESLCA---SPAYKRPRLEN----DSNLLGL [28]
sc  MNI---------------------LLMQRIVSFI----------LVVSQGRYFHVGELTM---TMLKR----------PQE-------------EESDNNATKKLKT------RLTY--- [54]
sc6 MTI---------------------PHMKYAVS-------------KTSENKVSNTVSPTQDKDAIRKQ----------PDD------------IINNDEPSHKKIKVAQPDSLRETNT-T [63]
sp  ----------------------------------------------------------------MASN----------PLD------------NNMPTTPVEEKIPVA------------ [22]
at  ----------------------------------------------------------------MSLG-----------------YAE-------------------------------- [7]
at6 -----------------------------MLS--------------------------------MNMR---------------RVFG--GVSTDLFPSRSMYRPLQS------------- [29]
ec  ----------------------------------------------------------------MLSR-----------------RGH-RLSRFRKNKRRLRERLR-------------- [24]
                                                                    :                                                       

hs  EPGGAAPEREVPAAARGCPGAAA---AALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPS----REPPLADNLYDE----------DDDD---EGEEEEE----AAAAAIGYRDN [145]
mm  EPS--A---AVAPAAAGCEAASAAAPAALWREA-AG-AAASAEREAPATAVAGDGDNGSGLR-------REPRAADDF--------------DDD---EGEEEDEAAAAAAAAAIGYRDN [137]
rn  EPSAAA---AAAAAAAGCEAASAAAPAALWREA-AGAAAASAEREAPATAAAGDGDNGPGLR-------REPRAADDF--------------DDD---EGEEEDE-AAAAAAAAIGYRDN [139]
xt  ESEGKA---ALPPIA-----------ASLQEEGEASSAMESKSR----------AHNGSGFQGL--------PLGTYLVQ------------GQE---EGGAEEMPNGDLSDQAVDYGAG [186]
dr  ELSGDS-EHSATAGA-----------DTLDEKP----ARMDESQQALS------INNNNNTRPTE----PGQP-------------------ADP---EPEISEL--------------- [82]
dm  QVPDTT--QFYPPTKFDFGAEIL---ASTSTEAEAEAEATATTTEPATSELAGKANGEIKTKTLAAR--EEQEIGANLEHKTKNPTKSMGEDEDD---EEEEEEDDE------------- [117]
ag  ESDGDP--TATLAAA-------------------AAAASTASAIAGVSVAL------------------TEPA-------------------SDPTI-TPLGPSPPAS------------ [79]
ce  ---------------------------------DSEVAVTHGEVQEITE--------------------ENPEIGSMHITQ-----------------ETDISDAPE------------- [44]
is  SIPNDV---VMPP-------------EEFKRQKFASDAANVSEVTSSSDANSEMCNGDSGFHELTSTSGADLPNGDGLFPE-----------NDNVVTEGVAQESPA---------FLGA [112]
sc  ---------------------------------------------------------------------------------------------------------PCI------------ [57]
sc6 DPLGHT-KAALGEVA---------SMELKPTNDMDPLAVSAASVVSMS--------------------------------------------NDVL--KPETPKGPII------------ [115]
sp  --------------------------------SYSPSSSGSSSGASLL--------------------------------------------VDIMCGSKETE----------------- [49]
at  ------------------------------------------------------------------------------------------------------------------------ [7]
at6 --------------------------------------------------------------------------GGNLVML--------------------------------------- [36]
ec  ------------------------------------------------------------------------------------------------------------------------ [24]
                                                                                                                            

hs  LLFGDEIITNGFHSCE--SDEEDRASHASSS---DWTPRPR-IGPYTFVQQHLMIGTDPRTILKDLLPE--------------------------------------------------- [208]
mm  LLLTDGLLTNGFHSCE--SDDDDRTSHASSS---DWTPRPR-IGPYTFVQQHLMIGTDPRTILKDLLPE--------------------------------------------------- [200]
rn  LLLADEIITNGFHSCE--SDDDDRASHASSS---DWTPRPR-IGPYTFVQQHLMIGTDPRTILKDLLPE--------------------------------------------------- [202]
xt  IHLDDD-LAGGFHSCD--SEDDDGASHASSS---DWAPRPC-IGPYTFVQRHLMMGTDPRTILKDLLPD--------------------------------------------------- [248]
dr  --TDEGVHSNGFTSPDLLRDDDDCSSRASSS---DWTPQPQ-IGSYRFIQQHIMRGTDPRAILKDLLPE--------------------------------------------------- [145]
dm  --EEEEDDEEGITGTS--NEDEDSSSNCSSSVEPDWKLR--------WLQREFYTGRVPRQVIASIMPHF-------------------------------------------------- [175]
ag  -------IVNGAVGPE-------VAAAAAVGALPDFQHYDE---SEDDAEDPYHSESISIERIRQYLSDK------------LGFHTGDGF----------------ENENGS------- [147]
ce  ------------TNTDSSRQRTESTTSVSSE---SWQNNDEMMSNLRRAQRLLDDGATPLQIIQQIFPDF-------------------------------------------------- [99]
is  LGCEED---DGASTLSELSGLSDLSEPSSGS---EWKPSSE--GPMGWVQRQMSLGADPRALLERLLPE--------------------------------------------------- [173]
sc  --LGKDKVTGKFIFPA-ITKDDVMNAR------------------------LFLKDNDLKTFLEYFLPVEVNSIYIYFMIKLLGFDVKDKELFMALNSNITSNKERSSAELSSIHAKAED [150]
sc6 --ISKNPSNGIFYGPS-FTKRESLNAR------------------------MFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVHINSQERVQDLGS----AIS [204]
sp  ---DEEVDSDEWDKPE-TENISDLDERSE--------------------MVRYLRASGYAKFLEKYLIEE--ELPVRSILKKLGI----------------------------------- [108]
at  -------------------------------------------------KLSFIEDVGQVGMAEFFDPSH-------------------------------------------------- [28]
at6 -----------FKGCRRFVRTTCRVSIPGGS-----------LGNESKAPPRFLRD-------RKIVPDA-------------------------------------------------- [77]
ec  -------------------------------------------------QRIFFR--------DKVVPEAMEK----------------------------------------------- [40]
                                                                                                                            

hs  -TIPPPELDDMTLWQIVINILS----EPPKRKKRKDINTIEDAVKLLQEC--KKIIVLTGAGVSVSCGIPDFRSRD-GIYARLAVDFPDLPDPQAMFDIEYFRKDP-------------- [306]
mm  -TIPPPELDDMTLWQIVINILS----EPPKRKKRKDINTIEDAVKLLQEC--KKIIVLTGAGVSVSCGIPDFRSRD-GIYARLAVDFPDLPDPQAMFDIEYFRKDP-------------- [298]
rn  -TIPPPELDDMTLWQIVINILS----EPPKRKKRKDINTIEDAVKLLQEC--KKIIVLTGAGVSVSCGIPDFRSRD-GIYARLAVDFPDLPDPQAMFDIEYFRKDP-------------- [300]
xt  -TVAPSELDDMTLWQIVINILS----DPPKRKKRKDINTIDDAVKLLQES--KKIIVLTGAGVSVSCGIPDFRSRD-GIYARLAVDFPDLPNPQAMFDIEYFRKDP-------------- [346]
dr  -TVLPPDLDDMTLWQIIINI-S----EPPKRKKRKDINTLEDVVRLLNER--KKILVLTGAGVSVSCGIPDFRSRD-GIYARLAVDFPDLPDPQAMFDIDYFRRDP-------------- [242]
dm  ATGLAGDTDDSVLWDYLAHLLN----EPKRRNKLASVNTFDDVISLVKKS--QKIIVLTGAGVSVSCGIPDFRSTN-GIYARLAHDFPDLPDPQAMFDINYFKRDP-------------- [274]
ag  --------------------------GGAARRRVLETVDIDGVLKHWKSGGFKKIVTMVGAGISTSAGIPDFRSPNTGLYNNLMKY--NLPYPQAIFELEYLHQNP-------------- [225]
ce  NASRIATMSENAHFAILSDLLE----RAPVRQKLTNYNSLADAVELFKTK--KHILVLTGAGVSVSCGIPDFRSKD-GIYARLRSEFPDLPDPTAMFDIRYFRENP-------------- [198]
is  GALVPPSLDRLTLWRILVSVLSE--DEPPRRAKLPHVNTLDDVVHLLRSC--RRILVLTGAGVSVSCGIPDFRSRD-GIYARLSKDFPALPDPQAMFDIHYFRKDP-------------- [274]
sc  EDELTDPLEKKHAVKLIKDLQKAINKVLSTRLRLPNFNTIDHFTATLRNA--KKILVLTGAGVSTSLGIPDFRSSE-GFYSKIRHL--GLEDPQDVFNLDIFLQDP-------------- [251]
sc6 VTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSNFFTIDHFIQKLHTA--RKILVLTGAGVSTSLGIPDFRSSE-GFYSKIKHL--GLDDPQDVFNYNIFMHDP-------------- [305]
sp  --NLPSALEEFEDIDLLPLLKEVLKREVARRIKLPHFNTFEDVVNLLKKA--KNVVVLVGAGISTSLGILDFRSDN-GFYARLARH--GLSEPSEMFDIHTFRENP-------------- [207]
at  -------------------LLQC---------------KIEELAKLIQKS--KHLVVFTGAGISTSCGIPDFRGPK-GIWT-LQREGKDLPKAS-------------------------- [84]
at6 --------------------------DPP------NMEDIHKLYRLFEQS--SRLTILTGAGVSTECGIPDYRSPN-GAYSSGFKP----------ITHQEFTRSSRARRRYWARSYAGW [152]
ec  ----------------------------------------------------PRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVE--DVATPEG------FDRDPEL-----------V [88]
                                                         .:  :.***:*.. **  :*. . * :                                        

hs  RPFFKF-AKEIYPGQFQPSLCHKFIALSDKE-GKLLRNYTQNIDTLEQVAGIQ--RIIQCHGSFATASCLICKYKVD------------------------CEAVRGDIFNQV------- [391]
mm  RPFFKF-AKEIYPGQFQPSLCHKFIALSDKE-GKLLRNYTQNIDTLEQVAGIQ--RILQCHGSFATASCLICKYKVD------------------------CEAVRGDIFNQV------- [383]
rn  RPFFKF-AKEIYPGQFQPSLCHKFIALSDKE-GKLLRNYTQNIDTLEQVAGIQ--RIIQCHGSFATASCLICKYKVD------------------------CEAVRGDIFNQV------- [385]
xt  RPFFKF-AKEIFPGQFQPSLCHRFIAMLDKE-EKLLRNYTQNIDTLEQVAGIE--KIIQCHGSFAEASCLVCKYKVD------------------------CEAVREDIFNQI------- [431]
dr  RPFFKF-AKEIYPGQFQPSPCHRFISMLDKK-GRLLRNYTQNIDTLEQVAGIQ--KIIQCHGSFATASCLICKHKVD------------------------CEAIREDIFNQV------- [327]
dm  RPFYKF-AREIYPGEFQPSPCHRFIKMLETK-GKLLRNYTQNIDTLERVAGIQ--RVIECHGSFSTASCTKCRFKCN------------------------ADALRADIFAQR------- [359]
ag  KPFFTL-AKELYPGTFKPTPSHYFVRLLEQK-GLLVRHYTQNIDTLERIAGIPEDKIVEAHGTFYTNHCLECKIAYS------------------------LEFVKEKIFADE------- [312]
ce  APFYNF-AREIFPGQFVPSVSHRFIKELETS-GRLLRNYTQNIDTLEHQTGIK--RVVECHGSFSKCTCTRCGQKYD------------------------GNEIREEVLAMR------- [283]
is  RPFFKF-AKEIYPGQFLPSPSHCFIKRLEES-GKLLRNYTQNIDTLEQMCGIR--NVITCHGSFATASCTRCRHKVD------------------------CHTIKDDIFNQR------- [359]
sc  SVFYNI-AHMVLPPENMYSPLHSFIKMLQDK-GKLLRNYTQNIDNLESYAGIDPDKLVQCHGSFATASCVTCHWQIP------------------------GEKIFENIRNLE------- [338]
sc6 SVFYNI-ANMVLPPEKIYSPLHSFIKMLQMK-GKLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLP------------------------GERIFNKIRNLE------- [392]
sp  EIFYTF-ARDLLPETNHYSPSHAFIRLLEKK-NKLSTLFTQNIDNLEKKTGLSDNKIIQCHGSFATATCIKCKHKVD------------------------GSELYEDIRNQR------- [294]
at  LPFHRA----------MPSMTHMALVELERA-GILKFVISQNVDGLHLRSGIPREKLSELHGDSFMEMCPSCGAEYL------------------------RDFEVETIGLKET------ [163]
at6 RRFTAA----------QPGPAHTALASLEKA-GRINFMITQNVDRLHHRAGSDP---LELHGTVYTVMCLECGFSFPRDLFQDQLKAINPKWAEAIESIDHGDPGSEKSFGMKQRPDGDI [258]
ec  QAFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHGELLKVRCSQSGQVLDW----------------------TGDVTPED------------ [172]
      *                  *  :   :          :**:* *.   *         **      *  .                                                

hs  ------------VPRCP--RC---PA--------------------DEPLA--------------------IMKPEIVFFGENLP---EQFHRAMKY-DKDEVDLLIVIGSSL------- [443]
mm  ------------VPRCP--RC---PA--------------------DEPLA--------------------IMKPEIVFFGENLP---EQFHRAMKY-DKDEVDLLIVIGSSL------- [435]
rn  ------------VPRCP--RC---PA--------------------DEPLA--------------------IMKPEIVFFGENLP---EQFHRAMKY-DKDEVDLLIVIGSSL------- [437]
xt  ------------VPRCP--RC---SS--------------------DEPLA--------------------IMKPDIVFFGENLP---EQFHRAMKY-DKNEVDLLIVIGSSL------- [483]
dr  ------------VPHCP--RC---PS--------------------DVPYA--------------------IMKPDIVFFGENLP---EFFHRAMKQ-DKDEVDLLIVIGSSL------- [379]
dm  ------------IPVCP--QC--QPNKE---------------QSVDASVAV--TEEELR-----QLVENGIMKPDIVFFGEGLP---DEYHTVMAT-DKDVCDLLIVIGSSL------- [430]
ag  ------------VPTCP---CG------------------------------------------------GVIKPDIVFFGEGLP---ERFHMLPHQ-DFAECDLLIIMGTSL------- [358]
ce  ------------VAHCK--RC------------------------------------------------EGVIKPNIVFFGEDLG---REFHQHVTE-DKHKVDLIVVIGSSL------- [330]
is  ------------IPLCP--EC--PPG--------------------EDAMA--------------------VMKPDIVFFGEGLS---PEFHQAMAR-DKAECDLLIVMGSSL------- [412]
sc  ------------LPLCP--YC------------YQKRKQYFPMSNGNNTV-----QTNINFNSP-ILKSYGVLKPDMTFFGEALP---SRFHKTIRK-DILECDLLICIGTSL------- [415]
sc6 ------------LPLCP--YC------------YKKRREYFP-EGYNNKVGVAASQGSMSERPPYILNSYGVLKPDITFFGEALP---NKFHKSIRE-DILECDLLICIGTSL------- [474]
sp  ------------VSYCN--ECGKPPLKLRRVGQNKKEKHYF--SDGDSES----SEDDLA--QP------GIMKPDITFFGEALP---DSFFNKVGSGELEETDLLICIGTSL------- [376]
at  ------------SRKCSVEKCG------------------------------------------------AKLKDTVLDWEDALP--PKEIDPAEKH--CKKADLVLCLGTSL------- [212]
at6 EIDEKFWEEGFHIPVCE--KCK------------------------------------------------GVLKPDVIFFGDNIP--KERATQAMEV--AKQSDAFLVLGSSLMTMSAFR [324]
ec  --------------KCH--CCQ-FPA---------------------------------------------PLRPHVVWFGE-MPLGMDEIYMALSM-----ADIFIAIGTSG------- [217]
                   *    *                                                   ::  :  : : :                   * .: :*:*        

hs  ------------------KVRPVALIPSSIPHEVPQILI-NREPLPHLHF---------------------DVELLG-DCDVIINELCHRLGGE---YAKLCCNPVKLSEITEKPPRTQK [519]
mm  ------------------KVRPVALIPSSIPHEVPQILI-NREPLPHLHF---------------------DVELLG-DCDVIINELCHRLGGE---YAKLCCNPVKLSEITEKPPRPQK [511]
rn  ------------------KVRPVALIPSSIPHEVPQILI-NREPLPHLHF---------------------DVELLG-DCDVIINELCHRLGGE---YAKLCCNPVKLSEITEKPPRTQK [513]
xt  ------------------KVRPVALIPSSIPHEVPQILI-NREPLPHLHF---------------------DIELLG-DCDVIINELCQRLDGK---YSQLCTNSLKLSQITEKPPRIHK [559]
dr  ------------------KVRPVALIPSSIPHDVPQVLI-NREPLPHLNF---------------------DVELLG-DCDVIVNELCHRLNGD---FQQLCYNSSRLSEITEKPA---- [451]
dm  ------------------KVRPVAHIPSSIPATVPQILI-NREQLHHLKF---------------------DVELLG-DSDVIINQICHRLSDNDDCWRQLCCDESVLTESKEL------ [503]
ag  ------------------TVQPFASLVEYVNDDCVRLLI-NRDKVGCNSFGFLRSMVFGEGLCFDLPGNRRDVAWTG-NCDDGCFFLADQLGWGDE-LRKLVE-----TEHAKIKP---- [448]
ce  ------------------KVRPVALIPHCVDKNVPQILI-NRESLPHYNA---------------------DIELLG-NCDDIIRDICFSLGGS---FTELITSYDSIMEQQGK-TKSQK [405]
is  ------------------KVRPVALIPSSIPADVPQILI-NREPLKHVTF---------------------DVELLG-DCDVIIHELCHRLG----------------WEVT---PDGQP [472]
sc  ------------------KVAPVSEIVNMVPSHVPQILI-NRDMVTHAEF---------------------DLNLLG-FCDDVASLVAKKCHWDIP-HKKWQD----------------- [476]
sc6 ------------------KVAPVSEIVNMVPSHVPQVLI-NRDPVKHAEF---------------------DLSLLG-YCDDIAAMVAQKCGWTIP-HKKWND----------------- [535]
sp  ------------------KVAPVSELISVIPPTTPQIYI-SRTPVRHTQF---------------------DVNFLSPYCDWVIVEICKRAGWLNE-LQALCD----------------- [438]
at  ------------------QITPACNLPLKCLKGGGKIVIVNLQKTPKDKKA--------------------NVVIHG-LVDKVVAGVMESLNMKIPPYVRIDLFQIILTQSISGDQRFIN [293]
at6 LCRAAHEAGAMTAIVNIGETRADDIVPLKINARVGEIL--------HRVL---------------------DVGSLS------------------------------------------- [372]
ec  ------------------HVYPAAGFVH-------------------------------------------EAKLHG------------------------------------------- [233]
                         .   .                                             :    .                                           

hs  ELAYLSE----------LPPTPLHVSED----------------------------------------SSSPERTSPPDSSVIVTLLDQA----------AKSN-DDLDVSE-----SKG [573]
mm  ELVHLSE----------LPPTPLHISED----------------------------------------SSSPERTVPQDSSVIATLVDQA----------TNNNVNDLEVSE------SS [565]
rn  ELVHLSE----------LPPTPLHISED----------------------------------------SSSPERTVPQDSSVIATLVDQT----------IKNKVDDLEVSE-----PKS [568]
xt  GFLTSPE---------TVPSTDLNTGQ-------------------------------------------SPAL----QSDLRGTDLQLS----------ASNTMRSLEKPEEASKLSHN [613]
dr  -----------------APEHTENTSADHSHADAEHIENTSADRDDADAEHIENTSADHSHADAEHIENTSADRDDADAEHIENTSADHSHADAEHI-ENTSADRDDAEHTENTPT-DHA [552]
dm  -----------------MPPEHSNHHLHHHLLHHRH-------------------------------CSSESERQSQLDTDTQSIKSNSS---ADYILGSAGTCSDSGFESS-----TFS [567]
ag  -----------------IRPIATN------------------------------------------------------------------------------------------------ [455]
ce  --------------------------------------------------------------------PSQNKRQLISQEDFLNICMKEKR-------NDDSSDEPTLKKPR-------- [442]
is  ALTQLDS----------LPSLRDSLGAG---------------------------------GDAVAPCSSSPDA--------------------------AVPDSTSGEVVE-------- [515]
sc  -----------------LK----------------------------------------------------------------------------------------------------- [478]
sc6 -----------------LK----------------------------------------------------------------------------------------------------- [537]
sp  -----------------LPECH----------------------------------------------SGSKTR---------------------------------------------- [449]
at  WTLRVASVHGLTSQLPFIKSIEVSFSDNHNY-------------------------------------------------------------------KDAVLDKQPFLMKR-------- [338]
at6 -----------------VPAL--------------------------------------------------------------------------------------------------- [376]
ec  ------------------------------------------------------------------------------------------------------------------------ [233]
                                                                                                                            

hs  CMEEKPQEVQTSRNVESIA--------------------EQMENP-------DLKNVGSSTGEKNERTSVAGT--------------------VRKCWPNRVA--------KEQISRRLD [638]
mm  CVEEKPQEVQTSRNVENI----------------------NVENP-------DFKAVGSSTADKNERTSVAET--------------------VRKCWPNRLA--------KEQISKRLE [628]
rn  CVEEKSQEVQTYRNVESI----------------------NVENP-------DFKAVGSSTGDKNERTSVAET--------------------VRKCWPNRLA--------KEQISKRLD [631]
xt  CSEEN-LEVSKEANT-------------------------QLSN------------------EKDQETAEKDTD-----------------IDSAKDLESKYT--------KEQISKRLD [664]
dr  NAEHTEHTSAGHVNAEHIEHMSTDHANAKDDQSSLSVNEEELASPAAETHALDSTEISAHT-ERSKEADAVNTDDAACVKDEENTDRLRVEM-RRRCWRSRIC--------QSPISKRLG [662]
dm  CGKRS-----TAAEAAAIERIKTDILVELNETTALSCDRLGLEGP--QTTVESYRHLSI---DSSKDSGIEQCDNEATPSYVRPSNLVQ----ETKTVAPSLTPIPQQRGKRQTAAERLQ [673]
ag  ----------------------------------------AIAVP-DGTVV-----------DMEPTTDIHHTDDHCL-------------VDDAECLLPEDE-------HFNDVADGLS [503]
ce  ----------------------------------MSVADDSMDSE-----KNNFQEIQKH--KSEDDDDTRNSDD----------------I-LKKIKHPRLL----------SITEMLH [494]
is  ----------------------------------CSV---GPDRP------------------------------------------------SQGPWKPR-----------ESVAARLP [539]
sc  ----------------------------------------------------------------KIDYNCTEIDK--------------------------------------------- [489]
sc6 ----------------------------------------------------------------NKNFKCQEKDK--------------------------------------------- [548]
sp  --------------------------------------------------------------AFETDLDIKFEEP--------------------------------------------- [462]
at  ---------RTARNE------TFDIFFKVNYSDGCDCVSTQLSLPFEF--------------KISTEEHVEIIDKEAVLQSLREK-----AVEESSCGQSGVV-------ERRVVSEPRS [417]
at6 ------------------------------------------------------------------------------------------------------------------------ [376]
ec  ---------------------------------------------------------------------------------------------------------------AHTVELNLE [242]
                                                                                                                            

hs  GNQYLFLPPN-RYIFHGAEV-------------YSDSEDDVLSSSSCGSNSDSGT-----------------------------CQSPSLEE--------------PMEDESEIEE-FYN [700]
mm  GNQYLFVPPN-RYIFHGAEV-------------YSDSEDDVLSSSSCGSNSDSGT-----------------------------CQSPSLEE--------------PLEDESEIEE-FYN [690]
rn  GNQYLFVPPN-RYIFHGAEV-------------YSDSEDDALSSSSCGSNSDSGT-----------------------------CQSPSLEE--------------PLEDESEIEE-FYN [693]
xt  STQFLFLAPN-RYIFHGAEV-------------FSDSDED-LTSSSCGTNSDSES-----------------------------LLSPSLHE--------------PIEEDSDTEECFHA [726]
dr  ASQYLFQAPN-RYVFHGAEV-------------YSSSEDE--SSSSCSSESDG-----------------------------------SFQ-----------------HEDSEVEENGAA [714]
dm  PGTFYSHTNNYSYVFPGAQVFWD--------NDYSDDDDE-EEERSHNRHSDLFGNVGHNYKDDDEDACDLNAVP------LSPLLPPSLEAHIVT--DIVNGSNEPLPNSSPGQKRTAC [776]
ag  G-----QGGG-VVVCAGAGV--D-DSEGSVQAMATDPHHDHDEPTVLEPHHPNHPHHHHHH---------------------HTTEPNSHHHH----HAQLHHHHAHHQHHPEQQQQQHE [589]
ce  DNKCVAISAH-QTVFPGAECSFDLETLKLVRDVHHETHCESSCGSSCSSNADSEAN--------------------------QLSRAQSLDDFVLSDEDRKNTIHLDLQRADSCDGDFQY [587]
is  GGHFLFTPPS-TYVFSGAEV-------------FVESEDS-DSPSPAEEESDS-----------------------------------SFSS----------------DEEEEAAGTGSA [593]
sc  -------------------------------GTYKIKKQPRKKQQ--------------------------------------------------------------------------- [503]
sc6 -------------------------------GVYVVTSDEHPKTL--------------------------------------------------------------------------- [562]
sp  -------------------------------STYHITSTTNGSC---------------------------------------------------------------------------- [475]
at  E----------AVVYATVTSL----------RTYH-------SQQSLLANGD-----------------------------LKWKLEGSGTS----------------RKRSRTGKRKSK [465]
at6 ------------------------------------------------------------------------------------------------------------------------ [376]
ec  PSQVGNEFAE-KYYGPASQV-----------------------------------------------------VPEFVEKLLKGLKAGSIA----------------------------- [279]
                                                                                                                            

hs  GLED------EPDVPERAGGAGFGTDGDDQEAINEAISVKQ---------EVTDMNYPSNKS--- [747]
mm  GLED------DTERPECAGGSGFGADGGDQEVVNEAIATRQ---------ELTDVNYPSDKS--- [737]
rn  GLED------DADRPECAGGS--GADGGDQEAVNEAIAMKQ---------ELTDVNCTPDKSEHY [741]
xt  KYEN------ETDTDNRA----------DLEREPERVVLYQSDDL--LGIDGTTMNL-------- [765]
dr  MTDK------ETDTETVQ----------DSEHRRLQTHCTQHTQ--------------------- [742]
dm  IIEQQPTPAIETEIPPLKKRR-------PSEENKQQTQIERSEESPPPG-QLAAV---------- [823]
ag  KMEE------HHDDEEV-----------VVEQHPKTTTMEDKT---------------------- [615]
ce  ELSE------TIDPETFSH---------LCEEMRI------------------------------ [607]
is  MECE------AADRPPVGQQGSPGRQG-EAETARGS----------------------------- [622]
sc  ----------------------------------------------------------------- [503]
sc6 ----------------------------------------------------------------- [562]
sp  ----------------------------------------------------------------- [475]
at  ALAE------ETKA--------------------------------------------------- [473]
at6 ----------------------------------------------------------------- [376]
ec  ----------------------------------------------------------------- [279]
                                                                     


Alignment Details

Alignment done with MAFFT FFT-NS-2 (v7.305b) aligner. MAFFT References
  • Strategy: Auto
  • Scoring Matrix: BLOSUM62
  • Gap Penalty: 1.53
  • Offset Value: 0.0