DRSC/TRiP Functional Genomics Resources

Multi Sequence Alignment :

Domains

Index TaxID Gene Name GeneID Protein ID Domain
start 		Domain
stop 		Domain
name 		Domain
description 		external_id
hs 9606 DGKG 1608 NP_001337.2 578 752 DAGKa Diacylglycerol kinase accessory domain (presumed); smart00045 CDD:214486
hs 9606 DGKG 1608 NP_001337.2 337 395 C1_DGKgamma_rpt2 second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase gamma (DAG kinase gamma) and similar proteins; cd20892 CDD:410442
hs 9606 DGKG 1608 NP_001337.2 436 557 DAGKc Diacylglycerol kinase catalytic domain (presumed); smart00046 CDD:214487
hs 9606 DGKG 1608 NP_001337.2 255 328 C1 protein kinase C conserved region 1 (C1 domain) superfamily; cl00040 CDD:412127
hs 9606 DGKG 1608 NP_001337.2 179 248 EFh EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051 CDD:238008
hs 9606 DGKG 1608 NP_001337.2 117 154 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite propagated from UniProtKB/Swiss-Prot (P49619.3)
hs 9606 DGKG 1608 NP_001337.2 768 791 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite propagated from UniProtKB/Swiss-Prot (P49619.3)
hs 9606 DGKG 1608 NP_001337.2 82 103 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite propagated from UniProtKB/Swiss-Prot (P49619.3)
hs 9606 DGKG 1608 NP_001337.2 5 175 DAG_kinase_N Diacylglycerol kinase N-terminus; pfam14513 CDD:464196
mm 10090 Dgkg 110197 XP_017172339.1 621 795 DAGKa Diacylglycerol kinase accessory domain (presumed); smart00045 CDD:214486
mm 10090 Dgkg 110197 XP_017172339.1 298 371 C1 protein kinase C conserved region 1 (C1 domain) superfamily; cl00040 CDD:412127
mm 10090 Dgkg 110197 XP_017172339.1 479 600 DAGKc Diacylglycerol kinase catalytic domain (presumed); smart00046 CDD:214487
mm 10090 Dgkg 110197 XP_017172339.1 380 438 C1_DGKgamma_rpt2 second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase gamma (DAG kinase gamma) and similar proteins; cd20892 CDD:410442
mm 10090 Dgkg 110197 XP_017172339.1 176 291 EFh EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051 CDD:238008
mm 10090 Dgkg 110197 XP_017172339.1 5 172 DAG_kinase_N Diacylglycerol kinase N-terminus; pfam14513 CDD:464196
rn 10116 Dgkg 25666 NP_037258.1 433 554 DAGKc Diacylglycerol kinase catalytic domain (presumed); smart00046 CDD:214487
rn 10116 Dgkg 25666 NP_037258.1 334 392 C1_DGKgamma_rpt2 second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase gamma (DAG kinase gamma) and similar proteins; cd20892 CDD:410442
rn 10116 Dgkg 25666 NP_037258.1 252 325 C1 protein kinase C conserved region 1 (C1 domain) superfamily; cl00040 CDD:412127
rn 10116 Dgkg 25666 NP_037258.1 176 245 EFh EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051 CDD:238008
rn 10116 Dgkg 25666 NP_037258.1 83 150 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite propagated from UniProtKB/Swiss-Prot (P49620.1)
rn 10116 Dgkg 25666 NP_037258.1 5 172 DAG_kinase_N Diacylglycerol kinase N-terminus; pfam14513 CDD:464196
rn 10116 Dgkg 25666 NP_037258.1 768 788 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite propagated from UniProtKB/Swiss-Prot (P49620.1)
rn 10116 Dgkg 25666 NP_037258.1 575 749 DAGKa Diacylglycerol kinase accessory domain (presumed); smart00045 CDD:214486
xt 8364 dgkb 100124765 XP_031759028.1 573 753 DAGKa Diacylglycerol kinase accessory domain (presumed); smart00045 CDD:214486
xt 8364 dgkb 100124765 XP_031759028.1 431 552 DAGKc Diacylglycerol kinase catalytic domain (presumed); smart00046 CDD:214487
xt 8364 dgkb 100124765 XP_031759028.1 9 152 DAG_kinase_N Diacylglycerol kinase N-terminus; pfam14513 CDD:464196
xt 8364 dgkb 100124765 XP_031759028.1 311 369 C1_DGKbeta_rpt2 second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins; cd20891 CDD:410441
xt 8364 dgkb 100124765 XP_031759028.1 241 306 C1_DGKbeta_rpt1 first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins; cd20845 CDD:410395
xt 8364 dgkb 100124765 XP_031759028.1 156 225 EFh EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051 CDD:238008
dr 7955 dgkg 567728 XP_073768719.1 - - - - -
dm 7227 Dgk 35738 NP_724619.2 1003 1194 DAGKa Diacylglycerol kinase accessory domain (presumed); smart00045 CDD:214486
dm 7227 Dgk 35738 NP_724619.2 573 694 DAGKc Diacylglycerol kinase catalytic domain (presumed); smart00046 CDD:214487
dm 7227 Dgk 35738 NP_724619.2 403 468 C1_DGKbeta_rpt1 first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins; cd20845 CDD:410395
dm 7227 Dgk 35738 NP_724619.2 317 386 EFh EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051 CDD:238008
dm 7227 Dgk 35738 NP_724619.2 9 117 DAG_kinase_N Diacylglycerol kinase N-terminus; pfam14513 CDD:464196
dm 7227 Dgk 35738 NP_724619.2 477 528 C1_DGK_typeI_like_rpt2 second protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases; cd20851 CDD:410401
ag 7165 Dgk 1270300 XP_061496901.1 - - - - -
ce 6239 dgk-3 186262 NP_499031.3 2 170 DAG_kinase_N Diacylglycerol kinase N-terminus; pfam14513 CDD:464196
ce 6239 dgk-3 186262 NP_499031.3 261 323 C1_DGK_typeI_rpt1 first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases; cd20799 CDD:410349
ce 6239 dgk-3 186262 NP_499031.3 330 378 C1_DGK_typeI_like_rpt2 second protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases; cd20851 CDD:410401
ce 6239 dgk-3 186262 NP_499031.3 578 753 DAGKa Diacylglycerol kinase accessory domain (presumed); smart00045 CDD:214486
ce 6239 dgk-3 186262 NP_499031.3 174 243 EFh EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051 CDD:238008
ce 6239 dgk-3 186262 NP_499031.3 429 551 DAGKc Diacylglycerol kinase catalytic domain (presumed); smart00046 CDD:214487
is 6945 Dgk 8028078 XP_042144551.1 42 >126 DAG_kinase_N Diacylglycerol kinase N-terminus; pfam14513 CDD:464196
is 6945 Dgk 8028078 XP_042144551.1 350 419 EFh EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051 CDD:238008
is 6945 Dgk 8028078 XP_042144551.1 765 949 DAGKa Diacylglycerol kinase accessory domain (presumed); smart00045 CDD:214486
is 6945 Dgk 8028078 XP_042144551.1 622 743 DAGKc Diacylglycerol kinase catalytic domain (presumed); smart00046 CDD:214487
is 6945 Dgk 8028078 XP_042144551.1 507 558 C1_DGK_typeI_like_rpt2 second protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases; cd20851 CDD:410401
is 6945 Dgk 8028078 XP_042144551.1 435 500 C1_DGKbeta_rpt1 first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins; cd20845 CDD:410395
at 3702 DGK1 830686 NP_196409.1 80 137 C1 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); smart00109 CDD:197519
at 3702 DGK1 830686 NP_196409.1 150 215 C1_DGK_rpt2 second protein kinase C conserved region 1 (C1 domain) found in the diacylglycerol kinase family; cd20805 CDD:410355
at 3702 DGK1 830686 NP_196409.1 363 489 DAGKc Diacylglycerol kinase catalytic domain (presumed); smart00046 CDD:214487
at 3702 DGK1 830686 NP_196409.1 507 664 DAGKa Diacylglycerol kinase accessory domain (presumed); smart00045 CDD:214486
ec 83333 yegS 946626 NP_416590.1 2 299 PRK13054 lipid kinase; Reviewed CDD:237281

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Alignment

Alignment done with MAFFT FFT-NS-2 (v7.305b) aligner. MAFFT References

Download raw alignment output file

Download fasta input file



Note:   &mbsp 2019, we've been having trouble with some alignments and are looking into the problem. If the alignment didn't work, please try again. If it still doesn't work, please download the fasta file and align off line. We're looking into it. Thanks.

hs  ---------------------------------MGEE----RWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLK--QYDPHE-------PISYDVFKLFMRAYLEVDLPQPLSTH [74]
mm  ---------------------------------MSEE----QWVSLSSEEFDQLQKYSEYSSKKIKDVLAEFNEGGSLR--QYDPHK-------PISYDVFKLFMRAYLEVDLPQPLSTH [74]
rn  ---------------------------------MSDG----QWVCLSSEEFDQLQKYSEYSSKKIKDVLAEFNEGGSLK--QYDPHK-------PISYDVFKLFMRAYLEVDLPQPLSTN [74]
xt  -----------------------------MTIMTNQE----KWVNLSPAEFSQLQKYAEYSTKKLKDVLEEFHGNGVLA--KYNPEEKQDILKQAIDFEGFQLFMKTFLEAELPDEFCKH [85]
dr  -----------------------------------MG----DWVCLSPAEFSQLQQYSEYSSKKLKDVLEEFHGNGVLS--KYNPEQKQDVLNQPIDYEGFQLFMTTYLENDIPEELCKH [79]
dm  ---------------------------------MNIGIAAPKWDKLSPREFLQLQELASYSTRKLQDVLREFSSPSAASTPKCIPDG-------DIDFDGFRRFLDAFLDCEAPLDLAKH [80]
ag  -------------------------------MASNI----HKWEKLSPSEFQQLQDLASYSTKKLQNVLQEFCSPATPSASRFHPDG-------DIDYDGFRKFLDSFLDCETPDDLSQH [78]
ce  -------------------------------------------MLLSPEQFSRLSEYAAYSRRKLKDMLSDFQQDGKFY-SYLSVDG------QTINIDGFRAFLIDYFGADLPSDLVDQ [70]
is  MILLKRAWCSGARLEAASLPSRGTPDADDLRSPMRQDGMAVKWEKLSPAEFQQLQDYVQYSSKKLPDVLEEFKENGALS--KYNAEG-------DIDLEGFQAFMDTYLEMDTPRDLVKH [111]
at  -----------------------------------------------------------------------MDDDGELG-----------------------MFFPSWTSKN-PIDTVES [25]
ec  --------------------------------------------------------------------MAEF-----------------------------------------PASL--- [8]
                                                                           :                                         *      

hs  LFLAFSQKPRHE-TSDHPT-----------------------------------EGASNSEANSADTNI------------------------------QNADNAT-------KADEAC- [120]
mm  LFLAFSQKPRQE-TPDHPK-----------------------------------EGASSSEPNVSDY---------------------------------NSDNAA-------KADEAC- [117]
rn  LFLAFSQKPRQE-TPDHPK-----------------------------------EGASSSEPNVSDS---------------------------------NAESTA-------KADAAC- [117]
xt  LFMSFSNRF--------------------------------------------------------------------------------------------------------------- [94]
dr  LFTSFKSKNGGEGSPDTSR-----------------------------------AGAGILEPKSIDAGISIQTEVACAPITGMNGKS-----ILSAMSRHTAESSAGITPGSGATTSPCS [159]
dm  LFVSFLKPNVTQAQL---------------------------------------HGRALNQMAAISS------TAACAPVTSHTKGSIPNINSIAEL-MPQCSGGGGGIGGTGGVAGAE- [153]
ag  LFISFLQPALYQAQQQQHS-----------------------------------HGKALSQMAAISS------NAACAPVTSHNRGSIPNLNSIVDIPTPQPS----------------- [140]
ce  LFLSFSKPPIKE------------------------------------------------------------------------------------------------------------ [82]
is  LFLSFVRKP----APSRPPIADGRLLKFRHLVAGKFQKDETLDERKTAVLHRTLTGGSLDKSAKMAA---VTSTTACAPITSHTHHS----GSLPELANKQAQGAA-VLSSTGAAPDASS [219]
at  RGLMFS----------------------------------------------------------------------C------------------------------------------- [32]
ec  ------------------------------------------------------------------------------------------------------------------------ [8]
                                                                                                                            

hs  ------------------------------------------APDTESN-MAEKQAPAEDQVAATPLEPP-------------------------------VPRSSS--SESP------- [157]
mm  ------------------------------------------APDTESK-TTKTQAPSKELEAAAPWEDP-------------------------------GALASS--SDAP------- [154]
rn  ------------------------------------------APDTESK-PIKTQVPSEELEAAAPWGEP-------------------------------NAPASS--SDAP------- [154]
xt  ----------------------------------HNP-----SPSIQSK----SQLLSGGLRMNYRSNSS--------------------------------SRSSSPVSLRP------- [132]
dr  SRSSSQRS----------------------GTGGHTPRGPHRSPGTQPKPPTGSSSSSNALALSKTSNSPRLSP-----------ERNQSE------NRTSLRRSPSPQKGSPS------ [234]
dm  GHAQARSS--------FVDKIHGITDKLHHSLGGHL-----------SHDPSKTGSVHPMLTVTPSPLAS--GPSMFQASNPARRSVDSSPSHSAT-NHSQMSRNSSKKSSNSVNCKIDA [251]
ag  -QESQRNS--------FVERIHGLTDKL-QSL-GHLGL----DGGGDSSNKGKCGTVHPMLTVTPSPMGC--TPPILQA--PFRRSADSSPSHSHSHSHSQISRNSSRKSNNSVNCRIE- [240]
ce  ----RRTSL-------FEDAISTVRAKFSESLSGRMAG--LNIAGGSGQQTDRSQSSEPQALVCIPEDDV-MGP-----------------------------RVANNDSQEP------- [152]
is  GAARRDESAKPHLHLGFAERLHGLTEKL-HSIGGHLRS----EGDSSARTRTGSASIHPVVTVTQNYGDS----------------TDSSP------NQSQVSRNSSRKSNSSLLVHSV- [311]
at  ----------------FVAALVGI------------------------------------LTIAYTAFQW-------------RRNINLSW-----------TKAIARSKKNP------- [69]
ec  ------------------------------------------------------------------------------------------------------------------------ [8]
                                                                                                                            

hs  --------------------------------------------VVYLKDVVCYLSLLETGRPQDKLEFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRP---------- [223]
mm  --------------------------------------------VVYLKDVVCYLSLMETGRPQDKLEFMFRLYDSDENGLLDQAEMDQIVSQMLHVAQYLEWDPTELRPERCLRQQDEV [230]
rn  --------------------------------------------IVYLKDVVCYLSLMETGRPQDKLEFMFRLYDSDENELLDQAELDQIVSQMLHVAQYLEWDPTELRP---------- [220]
xt  ------------------------------------------PDVIQLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGYLDSTELESIITQMMHVAEYLEWDVTELNP---------- [200]
dr  ------------------------------------------PQVVFLKDIVCYLSLLERGTPEDKLEFMFRLYDTDGNGLLDSSELDRIINQMVHVAEYLEWDSTELRP---------- [302]
dm  VSRILPAIGRHCPGSLESGSAQAEKRADIKLLARKLSHFDPLTLKVPLKDVVCYLSLLEAGRPEDKLEFMFRLYDTDSNGVLDTAEMDAIVNQMMAVAEYLGWDVSELRP---------- [361]
ag  ---------------------------DVRLIPRKQSFLDPLLLKVPLKDVVCYLSLLEAGRPEDKLEFMFRLYDTDGNGVLDTTETDAIVNQMMSVAEYLGWDVSELRP---------- [323]
ce  --------------------------------------------RIPLKPLICTLSLLEADTPENKLDVVFHVYDSDGNGFLDKSEIDGIIEQMMNVARYQQWDTIELEQ---------- [218]
is  ---------------------------DLKPLRKTSSHIDVHTVRVPLKDIICYLSLMEAGRPEDKLEFMFRLYDTDGNGYLDNNETECIVNQMMSVAEYLGWDVSELKP---------- [394]
at  -------KARH---------------------------------KVPVA------------------------------------------------------------P---------- [79]
ec  --------------------------------------------------------LILNGKSTDNL------------------------------------------P---------- [20]
                                                                                                                            

hs  ------------------------------------ILKEMLQGMDYDRDGFVSLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGV-RKQGLC----- [301]
mm  YTWQKLQFPSLPSRGNSMIETQRTEKLEPSVEELSMILKEMLQGMDYDKDGFVSLQEWINGGMTTIPLLVLLGMDDSGSKGDGRHAWTLKHFKKPTYCNFCRAMLMGV-GKQGLC----- [344]
rn  ------------------------------------ILKEMLQGMDYNKDGFVSLEEWVSGGMTTIPLLVLLGMDDSASKGDGRHAWTLKHFKKPTYCNFCHIMLMGV-RKQGLC----- [298]
xt  ------------------------------------ILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENN-VKDDGQHVWRLKHFNKPAYCNLCLNMLIGL-GKQGLC----- [277]
dr  ------------------------------------ILKEMMEEIDYDRDGTVTLEEWIRGGMTTIPLLVLLGMETN-VQEDGQHIWKLKHFNKPAYCNYCHTMLLGV-RKQGLC----- [379]
dm  ------------------------------------ILQEMMVEIDYDADGTVSLDEWQRGGMTTIPLLVLLGVDSTTLKEDGIHVWRLKHFSKPAYCNLCLNMLVGL-GKKGLC----- [439]
ag  ------------------------------------ILQDMMTEIDYDGDGCVSLEEWQRGGLTTIPLLVLLGVDN-TLKEDGYHVWRLKHFSKPAYCNMCLNMLVGL-GKKGLC----- [400]
ce  ------------------------------------VIRQMMVDIDYDNDGIVSFDEWRRGGLTNIPLLVLLGFDTE-MKEDGSHVWRLRHFTKPTYCNACCSILVGWGGKQGLS----- [296]
is  ------------------------------------ILQEMMVEIDYDADGTVSLEEWKRGGMTTIPLLVLLGLDAN-VKDDGNHVWRLKHFNRPAYCNLCLNMLVGL-GKKGLC----- [471]
at  ------------------------------------------------------------------------------------HSWELDPIARAKNLN-CCVCLKSMSPSQAIVASESF [114]
ec  ------------------------------------LREAIML-----------------------------------LREEG------------------------------------- [32]
                                                                                                                            

hs  ---CTYCKYTVHERCVSRNIPGCVKTYSKAKRS--GEVMQHAWV--------EGNSSVKCDRCHKSIKCYQSVTARH----CVWCRMTFHRKC--ELSTL----CDGGELRDHILLPTSI [398]
mm  ---CIYCKYTVHQRCVSKTIHGCVKTNSKAKRS--GEVMQHAWV--------EGNSSVKCDRCHKSIKCYQSVTARH----CVWCRMTFHRKC--ELSTV----CDGGELKDHILLPTSI [441]
rn  ---CIYCKYAVHQRCVSNSIPGCVKTYSKAKRS--GEVMQHAWV--------EGNSSVKCDRCHKSIKCYQSVTARH----CVWCRMTFHRKC--ELSTA----CDGGELKDHILLPTSI [395]
xt  ---CSFCKYTVHERCVSRAPPSCIKTYVKSKKD--TNVMHHFWV--------EGNCPTKCEKCHKAIKCYQGLTGLH----CVWCQITLHNKCASHLKPE----CDCGPLKDHILPPTTI [376]
dr  ---CALCKYTVHERCVSKDIAPCISTYAKSRRH--TNAMQHVWM--------EGNSSAKCDKCHRSIKCYQGLTGLH----CVWCQITLHNKCASNMKPE----CDGGPLRDHTLLPSYI [478]
dm  ---CVLCKYTVHERCVQHAPASCITTYVKSKKPKCGGDLLHHWV--------EGNCYGRCSKCRKRIKAYHGITGLT----CRWCHMMLHNRCASSVKKE----CTLGEYSELIVPPTAI [540]
ag  ---CVLCKYTVHERCVQRAPASCIATYVKSKKSKATATFQHHWV--------EGNCYGRCSKCRKRIKAYNGITGLT----CRWCRMMLHNKCATLVKAE----CTLGEFANLVLPPTAI [501]
ce  ---CSLCKYTVHERCVRSAATNCIRTYSSRQQDK----LYHHWQ--------DANATAKCVKCKATVGVFQ---GKG----CRWCHNYVHHRCMSALAQE----CDLGALVHHILPPTHI [390]
is  ---CVFCKYTVHERCVQRAPASCINTYVKSKKS--SQALVHHWT--------EGNCTGKCSKCKKTIKSYNGITGLH----CRWCQMTLHNHCAPQVKPD----CALGPHRDHILPPTSI [570]
at  FHRCTICGAAAHFNCSSSAPKDCKCVSMVGFEH-----VVHQWAVRWTEGADQTDDSSFCSYCDES--CSSSFLGGSPIWCCLWCQRLVHVDCHSNMSNETGDICDLGPLRRLILCPLYV [227]
ec  --------MTIHVRVT--------------------------WE--------KGDAARYVEEARK------------------------------------------------------- [55]
             : * .                            *         . :       .                                                         

hs  ----------------------------------------------------------------------CPITRDRPGEKSDG-----------------------CVSAKGELVM--- [422]
mm  ----------------------------------------------------------------------CPVSGDRQGGKSDG-----------------------SVAAKGELVT--- [465]
rn  ----------------------------------------------------------------------YPVTRDRQAGKSDS-----------------------GAAAKGELVM--- [419]
xt  ----------------------------------------------------------------------CPVVLERQSTLKR---EKNCSQQGNKCGERIKMQRANSVTVDGQGL---- [419]
dr  ----------------------------------------------------------------------CPVVLDRHSAVKRGEGESSPSTSPEDTGQCFKF------TGDGQAL---- [518]
dm  ----------------------------------------------------------------------CPAVLDRQRSVN--------------------------------QAHK-A [557]
ag  ----------------------------------------------------------------------CPAVLDRQKSINFT-------------------------TNKGKSVPS-T [525]
ce  ----------------------------------------------------------------------FPAFLERKTSTSLKN---------------------HNFSSHSASLL--- [416]
is  ----------------------------------------------------------------------CPAVLERQRSVTSGQ-KKALSRTDSNMA---------SESNQGSVSA--- [607]
at  KELTRNPSGGFLSSITHGANELASTALASIRIQSKKYKQTNETSADTGNSGSNCDESTESTADTGPTVNGAHAVLENSISVMNGDSSNGDSDSNGKLEKKPSVKRTGSFGQKEYHALRSK [347]
ec  ------------------------------------------------------------------------------------------------------------------------ [55]
                                                                                                                            

hs  -QYKII-PTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDN-GGPTPGLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAK-HPPVAVLPLGTGNDLARCLRWGGGYEG- [537]
mm  -QYKII-PSPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPEQVFNLDN-GGPTPGLNFFHDTPDFRVLACGGDGTVGWILDCIDKANFTK-HPPVAVLPLGTGNDLARCLRWGGGYEG- [580]
rn  -QYKII-PSPGTHPLLVLVNPKSGGRQGERILQKFHYLLNPKQVFNLDK-GGPTPGLNFFQDTPDFRVLACGGDGTVGWILDCIDKANFTK-HPPVAVLPLGTGNDLARCLRWGGGYEG- [534]
xt  ---QIT-PISGTHPLLVFVNPKSGGKQGERIHRKFQYLLNPRQVYSLAG-IGPMPGLNFFRDVPDFKVLACGGDGTVGWILDCIDKANLIK-QPPVAVLPLGTGNDLARCLRWGGGYEG- [532]
dr  ---QIT-PLPGTHPLLVLVNPKSGGRQGERVLRKFQYLLNPRQVYSLER-GGPMAGLNFFRDVPDFRVLACGGDGSVGWILDCIDKASFAR-HPPVAILPLGTGNDLARCLRWGGGYEG- [631]
dm  THFQITPPDELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSK-GGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAMDSIELAS-QPAIGVIPLGTGNDLARCLRWGGGYEG- [674]
ag  IHFQIT-SDPSWCPLLVFINPKSGGRQGDRILRKFQYLLNPRQVYDLSK-GGPLEGLTMFKDVPNFKVICCGGDGTVGWVLEAMDSIVLQT-QPSIGVIPLGTGNDLARCLRWGGGYEG- [641]
ce  ---QAVSPSNDCRPLLVLVNPKSGGKQGVKILQKFEYLLNPRQVYDLSK-TGPEPGLQLFSTLKNCNILVCGGDGTIGWVLESMDKMTFPHGRPPVAVLPLGTGNDLARCLRWGGGYEN- [531]
is  MSFQVT-PVTGTHPLLVLINPKSGGRQGMRILRKFQYLLNPRQVYNVSK-GGPIQGLQFFKDVVSYRVLCCGGDGTVGWVLDTIDKLNYTQ-LPPVGILPLGTGNDLARCLRWGPGYES- [723]
at  LKYELADLPSDARPLLVFINKKSGAQRGDSLRQRLHLHLNPVQVFELSSVQGPEVGLFLFRKVPHFRVLVCGGDGTAGWVLDAIEKQNFIS-PPAVAILPAGTGNDLSRVLNWGGGLGSV [466]
ec  --------------------------------------------FGVAT------------------VIAGGGDGTINEVSTALIQCEGDD-IPALGILPLGTANDFATSV-------GI [105]
                                                : :                    ::  ****: . :   : .       *.:.::* **.**::  :       . 

hs  ---GSLTKILKDIEQSPLVMLDRWHLEVIP------------------------------------------------------------------------------------------ [564]
mm  ---GSLTKILKEIEQSPLVMLDRWYLEVMP------------------------------------------------------------------------------------------ [607]
rn  ---GSLTKILKEIEQSPLVMLDRWYLEVMP------------------------------------------------------------------------------------------ [561]
xt  ---ENLMKFLKDIEIATVVLLDRWKIDVIP------------------------------------------------------------------------------------------ [559]
dr  ---GSLVKFLRDIEHSTEVLLDRWNIDIVP------------------------------------------------------------------------------------------ [658]
dm  ---ENIPKLMDKFRRASTVMLDRWSIEVTNTPHSDDMRP--------KVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSM---GTAASSTSIMMASKTETEMETMATMEFG [780]
ag  ---ESIPKILDKINRASVVMLDRWSIEVKNNPLAAEETPTATTMPGHKVTLSENVQKVIELSHRIIAEKSVIQAYDE-EENSTNRATDVPLPPTANGTTQRAAVSDNN-------GFAIG [750]
ce  ---ENLHKILEQIEKSSLIDMDRWQIKIEIT-----------------------------------------------ENKSA------------------------------------- [564]
is  ---ESLEKILQKVEKSTTVMMDRWKIDISNM----------------------------------------------------------------------------------------- [751]
at  ERQGGLSTVLQNIEHAAVTVLDRWKVSILN------------------------------------------------------------------------------------------ [496]
ec  P--EALDKALKLAIAGDAIAIDMAQVNKQTC-------------------------------------------------------------------------------FINMATGGFG [144]
         : . :     .    :*   :.                                                                                             

hs  ------------------------------------------------------------------------------------------------------------------------ [564]
mm  ------------------------------------------------------------------------------------------------------------------------ [607]
rn  ------------------------------------------------------------------------------------------------------------------------ [561]
xt  ------------------------------------------------------------------------------------------------------------------------ [559]
dr  ------------------------------------------------------------------------------------------------------------------------ [658]
dm  SSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVG [900]
ag  PDAAGTARV---------------------AAMTATPPPTPT-TPFAGGADGPTVMEGFIAEHANRGAVDPPLTNG---------------------------GATTLVSSIAGV----- [816]
ce  ------------------------------------------------------------------------------------------------------------------------ [564]
is  ------------------------------------------------------------------------------------------------------------------------ [751]
at  ------------------------------------------------------------------------------------------------------------------------ [496]
ec  ------TRIT-------------------------------------------------------------------------------------------------------------- [148]
                                                                                                                            

hs  ----------------------------REEVENGDQ----------------------------------------------------------------------------------V [574]
mm  ----------------------------REEVENGDQ----------------------------------------------------------------------------------V [617]
rn  ----------------------------REEVENGDQ----------------------------------------------------------------------------------V [571]
xt  ----------------------------NDKDEKGDP----------------------------------------------------------------------------------V [569]
dr  ----------------------------DDKEEKGDP----------------------------------------------------------------------------------V [668]
dm  SNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAA---------SSVLQQQQQQHLQFEQQQKP------------IKVQSDKDCTV [999]
ag  -------------------------------DEDDDD---VAANTGTNG-SAPPVDNGPCT-NDDDAAQRAEDDTVNSSYQQQQQHHHSNGNATDKPRPEKKIIDLPKLIKPQVGSEFTV [900]
ce  ----------------------------RRASEKGDT----------------------------------------------------------------------------------P [574]
is  ----------------------------ANSDERGDP----------------------------------------------------------------------------------I [761]
at  --------------------------------QQGKQ--------------------------------------------------------------------L-------------Q [503]
ec  ----------------------------TETPEKLKA----------------------------------------------------------------------------------- [157]
                                    :  .                                                                                    

hs  PYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSN-IFLEGIAILNIPSMYGGTNLWGENKKNRAVIR-------ESRK- [685]
mm  PYNIMNNYFSIGVDASIAHRFHMMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVEVDLSN-IFLEGIAILNIPSMYGGTNLWGETKKNRAVIR-------ESRK- [728]
rn  PYNIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVEVDLSN-IFLEGIAILNIPSMYGGTNLWGETKKNRAVIR-------ESRK- [682]
xt  PYSIINNYFSIGVDASIAHRFHLMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHEAIEIECDGIQMDLGN-ISLEGIAILNIPSMHGGSNLWGETKKRRSNRR-------TDKKN [681]
dr  PYSIVNNYFSIGVDASIAHRFHLMREKHPEKFNSRMKNKLWYFEFGTTETISATCKKLNETIEVECDGIILDLSS-TSLEGIAVLNIPSMHGGSNLWGETKKRRNYNR-------MSKKV [780]
dm  PYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKSAGPFGKSKKLR [1119]
ag  PYNIVNNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHEYLEIVCDGVSLELANGPQLQGIALLNIPYTHGGSNLWGEHLSQKRMRK--GPF--RKKLK [1016]
ce  PYSIINNYFSIGVDASIAHRFHVMREKFPEKFNSRMRNKLWYFELGTSETLSSSCKNLHEQIDILCDGESIDLGQDASLEGIALLNIPSIYGGSNLWGRSRKSKGRMPGLFPMKNAEKM- [693]
is  PCNIFNNYFSIGVDASIAIKFHLEREKHPEKFSSRMKNKMWYFEFATSETFFATCKNLHDDVDIMCDGVSLELSNGPSLQGIAVLNIPSIYGGSNLWGDNAASRKRSR-------SKKRK [874]
at  PPKYMNNYIGVGCDAKVALEIHNLREENPERFYSQFMNKVLYAREGARSIMDRTFEDFPWQVRVEVDGVDIEVPE--DAEGILVANIGSYMGGVDLWQ---------------------- [599]
ec  ---------ALGSVSYIIHGLMRMDTLQPDRCEIRGENFHW-----------------------QGDALVIGIGN-GRQAG----------GGQQLCPNAL------------------- [215]
             .:*  : :   :       *.:   :  *                            *.  : : .     *          ** :*                        

hs  --------GVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQ--------VDGEPWMQP-------CCTIKITHKNQAPMMMGPPQKS---- [778]
mm  --------SVTDPKELKCCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVTIRTNKLLPMQ--------VDGEPWMQP-------QCTIKITHKNQAPMMMGPPQKS---- [821]
rn  --------SVTDPKELKCCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVTIRTKKLLPMQ--------VDGEPWMQP-------PCMIKITHKNQAPMMMGPPQKS---- [775]
xt  S-DKRT--TVTDAKELKFAAQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVLRTSKSLPMQ--------IDGEPWMQT-------PCTIKITHKNQAPMLMGPPPKN---- [779]
dr  P-ERMTGSTVTDAKELKFCVQDLSDQLLEVVGLEGAIEMGQIYTGLKSAGRRLAQCSNVTIRTSRLLPMQ--------IDGEPWMQP-------PCTIRITHKNQVPMLLGPPQKT---- [880]
dm  AGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQ--------IDGEPWMQM-------PCTIKVTHKNQVPMLMAPRSEKGR-- [1222]
ag  NSDKELSANSFNSVDLSIAIQDIGDSKIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIMTTKKTFPMQ--------IDGEPWMQG-------PCTIKLTHKNQVPMLMAPRSEKGS-- [1119]
ce  --------------QLQTRVQDIGDGLIELVGLESAMQMGQIKAGVRGA-RRLSQCSTVVIQTHKSFPMQ--------IDGEPWMQP-------PCIIQITHKNQAKMLVAAAPRKRS-- [781]
is  KHDRDISTNSFNSVDLSSAVQDIGDRMIEVIGLESSMHMGQVKAGLRASGRRLAQCTSVVIRTRKRFPMQ--------IDGEPWVQP-------PCTIQITHKNQMPMLMAPAPMNKSR- [978]
at  --NEDETYENFDP-------QSMHDKIVEVVSISGTWHLGKLQVGLSRA-RRLAQGSAVKIQLCAPLPVQ--------IDGEPWNQQ-------PCTLTISHHGQAFMLKRAAEEPLGHA [694]
ec  ----------------------INDGLLQLRIFTGDEILPALVSTLKSD----EDNPNIIEGASSWFDIQAPHDITFNLDGEPLSGQNFHIEILPAALRCRLPPDCPLLR---------- [299]
                          : *  :::  : .   :  :   :        : . :       : :*        :****            . :      :  ::           

hs  -SFFS-LRRKSRSKD------------------- [791]
mm  -SFFS-LRRKSRSKD------------------- [834]
rn  -SFFS-LRRKSRSKD------------------- [788]
xt  -GLFTSLIKGSRSKMKE----------------- [795]
dr  -PFFF-FKKRNRSRD------------------- [893]
dm  -GFFNLLCS------------------------- [1230]
ag  -GFFSFLKR------------------------- [1127]
ce  -SWML-LKRQSTNDDN------------------ [795]
is  FPFFS-LRKS------------------------ [987]
at  AAIITDVLENAETNQVINASQKRTLLQEMALRLT [728]
ec  ---------------------------------- [299]
                                      


Alignment Details

Alignment done with MAFFT FFT-NS-2 (v7.305b) aligner. MAFFT References
  • Strategy: Auto
  • Scoring Matrix: BLOSUM62
  • Gap Penalty: 1.53
  • Offset Value: 0.0