DRSC/TRiP Functional Genomics Resources

Multi Sequence Alignment :

Domains

Index TaxID Gene Name GeneID Protein ID Domain
start 		Domain
stop 		Domain
name 		Domain
description 		external_id
hs 9606 DGKB 1607 NP_001337634.1 673 694 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite propagated from UniProtKB/Swiss-Prot (Q9Y6T7.2)
hs 9606 DGKB 1607 NP_001337634.1 153 222 EFh EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051 CDD:238008
hs 9606 DGKB 1607 NP_001337634.1 771 804 Required for association with membranes and function in neurite spine formation. /evidence=ECO:0000305|PubMed:11719522 propagated from UniProtKB/Swiss-Prot (Q9Y6T7.2)
hs 9606 DGKB 1607 NP_001337634.1 440 561 DAGKc Diacylglycerol kinase catalytic domain (presumed); smart00046 CDD:214487
hs 9606 DGKB 1607 NP_001337634.1 582 762 DAGKa Diacylglycerol kinase accessory domain (presumed); smart00045 CDD:214486
hs 9606 DGKB 1607 NP_001337634.1 385 406 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite propagated from UniProtKB/Swiss-Prot (Q9Y6T7.2)
hs 9606 DGKB 1607 NP_001337634.1 308 366 C1_DGKbeta_rpt2 second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins; cd20891 CDD:410441
hs 9606 DGKB 1607 NP_001337634.1 238 303 C1_DGKbeta_rpt1 first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins; cd20845 CDD:410395
hs 9606 DGKB 1607 NP_001337634.1 6 149 DAG_kinase_N Diacylglycerol kinase N-terminus; pfam14513 CDD:464196
mm 10090 Dgkb 217480 XP_006515130.1 439 560 DAGKc Diacylglycerol kinase catalytic domain (presumed); smart00046 CDD:214487
mm 10090 Dgkb 217480 XP_006515130.1 307 365 C1_DGKbeta_rpt2 second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins; cd20891 CDD:410441
mm 10090 Dgkb 217480 XP_006515130.1 237 302 C1_DGKbeta_rpt1 first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins; cd20845 CDD:410395
mm 10090 Dgkb 217480 XP_006515130.1 6 148 DAG_kinase_N Diacylglycerol kinase N-terminus; pfam14513 CDD:464196
mm 10090 Dgkb 217480 XP_006515130.1 581 761 DAGKa Diacylglycerol kinase accessory domain (presumed); smart00045 CDD:214486
mm 10090 Dgkb 217480 XP_006515130.1 152 221 EFh EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051 CDD:238008
rn 10116 Dgkb 54248 XP_008762871.2 439 560 DAGKc Diacylglycerol kinase catalytic domain (presumed); smart00046 CDD:214487
rn 10116 Dgkb 54248 XP_008762871.2 307 365 C1_DGKbeta_rpt2 second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins; cd20891 CDD:410441
rn 10116 Dgkb 54248 XP_008762871.2 152 221 EFh EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051 CDD:238008
rn 10116 Dgkb 54248 XP_008762871.2 237 302 C1_DGKbeta_rpt1 first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins; cd20845 CDD:410395
rn 10116 Dgkb 54248 XP_008762871.2 6 148 DAG_kinase_N Diacylglycerol kinase N-terminus; pfam14513 CDD:464196
rn 10116 Dgkb 54248 XP_008762871.2 581 761 DAGKa Diacylglycerol kinase accessory domain (presumed); smart00045 CDD:214486
xt 8364 dgkb 100124765 XP_031759028.1 431 552 DAGKc Diacylglycerol kinase catalytic domain (presumed); smart00046 CDD:214487
xt 8364 dgkb 100124765 XP_031759028.1 573 753 DAGKa Diacylglycerol kinase accessory domain (presumed); smart00045 CDD:214486
xt 8364 dgkb 100124765 XP_031759028.1 311 369 C1_DGKbeta_rpt2 second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins; cd20891 CDD:410441
xt 8364 dgkb 100124765 XP_031759028.1 241 306 C1_DGKbeta_rpt1 first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins; cd20845 CDD:410395
xt 8364 dgkb 100124765 XP_031759028.1 156 225 EFh EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051 CDD:238008
xt 8364 dgkb 100124765 XP_031759028.1 9 152 DAG_kinase_N Diacylglycerol kinase N-terminus; pfam14513 CDD:464196
dr 7955 dgkb 557324 XP_073779977.1 - - - - -
dm 7227 Dgk 35738 NP_724619.2 1003 1194 DAGKa Diacylglycerol kinase accessory domain (presumed); smart00045 CDD:214486
dm 7227 Dgk 35738 NP_724619.2 573 694 DAGKc Diacylglycerol kinase catalytic domain (presumed); smart00046 CDD:214487
dm 7227 Dgk 35738 NP_724619.2 403 468 C1_DGKbeta_rpt1 first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins; cd20845 CDD:410395
dm 7227 Dgk 35738 NP_724619.2 477 528 C1_DGK_typeI_like_rpt2 second protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases; cd20851 CDD:410401
dm 7227 Dgk 35738 NP_724619.2 9 117 DAG_kinase_N Diacylglycerol kinase N-terminus; pfam14513 CDD:464196
dm 7227 Dgk 35738 NP_724619.2 317 386 EFh EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051 CDD:238008
ag 7165 Dgk 1270300 XP_061496901.1 - - - - -
ce 6239 dgk-3 186262 NP_499031.3 261 323 C1_DGK_typeI_rpt1 first protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases; cd20799 CDD:410349
ce 6239 dgk-3 186262 NP_499031.3 578 753 DAGKa Diacylglycerol kinase accessory domain (presumed); smart00045 CDD:214486
ce 6239 dgk-3 186262 NP_499031.3 429 551 DAGKc Diacylglycerol kinase catalytic domain (presumed); smart00046 CDD:214487
ce 6239 dgk-3 186262 NP_499031.3 330 378 C1_DGK_typeI_like_rpt2 second protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases; cd20851 CDD:410401
ce 6239 dgk-3 186262 NP_499031.3 2 170 DAG_kinase_N Diacylglycerol kinase N-terminus; pfam14513 CDD:464196
ce 6239 dgk-3 186262 NP_499031.3 174 243 EFh EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051 CDD:238008
is 6945 Dgk 8028078 XP_042144551.1 765 949 DAGKa Diacylglycerol kinase accessory domain (presumed); smart00045 CDD:214486
is 6945 Dgk 8028078 XP_042144551.1 622 743 DAGKc Diacylglycerol kinase catalytic domain (presumed); smart00046 CDD:214487
is 6945 Dgk 8028078 XP_042144551.1 507 558 C1_DGK_typeI_like_rpt2 second protein kinase C conserved region 1 (C1 domain) found in type I diacylglycerol kinases; cd20851 CDD:410401
is 6945 Dgk 8028078 XP_042144551.1 435 500 C1_DGKbeta_rpt1 first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins; cd20845 CDD:410395
is 6945 Dgk 8028078 XP_042144551.1 350 419 EFh EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051 CDD:238008
is 6945 Dgk 8028078 XP_042144551.1 42 >126 DAG_kinase_N Diacylglycerol kinase N-terminus; pfam14513 CDD:464196
sc 4932 PKC1 852169 NP_009445.2 828 1145 STKc_PKC Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C; cd05570 CDD:270722
sc 4932 PKC1 852169 NP_009445.2 413 464 C1_ScPKC1-like_rpt1 first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; cd20822 CDD:410372
sc 4932 PKC1 852169 NP_009445.2 478 536 C1_ScPKC1-like_rpt2 second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; cd20823 CDD:410373
sc 4932 PKC1 852169 NP_009445.2 110 181 HR1_PKC-like_2_fungi Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of fungal Protein Kinase C-like proteins; cd11620 CDD:212010
sc 4932 PKC1 852169 NP_009445.2 211 319 C2_fungal_Pkc1p C2 domain found in protein kinase C (Pkc1p) in Saccharomyces cerevisiae; cd08689 CDD:176071
sc 4932 PKC1 852169 NP_009445.2 1 72 HR1_PKC-like_1_fungi First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of fungal Protein Kinase C-like proteins; cd11621 CDD:212011
at 3702 DGK1 830686 NP_196409.1 363 489 DAGKc Diacylglycerol kinase catalytic domain (presumed); smart00046 CDD:214487
at 3702 DGK1 830686 NP_196409.1 507 664 DAGKa Diacylglycerol kinase accessory domain (presumed); smart00045 CDD:214486
at 3702 DGK1 830686 NP_196409.1 80 137 C1 Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); smart00109 CDD:197519
at 3702 DGK1 830686 NP_196409.1 150 215 C1_DGK_rpt2 second protein kinase C conserved region 1 (C1 domain) found in the diacylglycerol kinase family; cd20805 CDD:410355
ec 83333 yegS 946626 NP_416590.1 2 299 PRK13054 lipid kinase; Reviewed CDD:237281

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Alignment

Alignment done with MAFFT FFT-NS-2 (v7.305b) aligner. MAFFT References

Download raw alignment output file

Download fasta input file



Note:   &mbsp 2019, we've been having trouble with some alignments and are looking into the problem. If the alignment didn't work, please try again. If it still doesn't work, please download the fasta file and align off line. We're looking into it. Thanks.

hs  ---------------------------------MTNQE----KWAHLSPSEFSQLQKY--------------AEYSTKKLKDVL---------EEFHGNGVLA--KYNPEGKQDILNQTI [58]
mm  ---------------------------------MTNQE----KWAHLSPSEFSQLQKY--------------AEYSTKKLKDVL---------EEFHGNGVLA--KYNPEGKQDILNQTI [58]
rn  ---------------------------------MTNQE----KWAHLSPSEFSQLQKY--------------AEYSTKKLKDVL---------EEFHGNGVLA--KYNPEGKQDILNQTI [58]
xt  ------------------------------MTIMTNQE----KWVNLSPAEFSQLQKY--------------AEYSTKKLKDVL---------EEFHGNGVLA--KYNPEEKQDILKQAI [61]
dr  ---------------------------------MSNEE----KWVTLSPNEFSRLQDY--------------AQYTTKKLKDVL---------QEFHGGGILA--KYNPEEKPEILNQVI [58]
dm  ----------------------------------MNIGIAAPKWDKLSPREFLQLQEL--------------ASYSTRKLQDVL---------REFSSPSAASTPKCIPDG--DI----- [56]
ag  --------------------------------MASNI----HKWEKLSPSEFQQLQDL--------------ASYSTKKLQNVL---------QEFCSPATPSASRFHPDG--DI----- [54]
ce  --------------------------------------------MLLSPEQFSRLSEY--------------AAYSRRKLKDML---------SDFQQDGKFY-SYLSVDG-QTI----- [46]
is  MILLKRAWCSGARLEAASLPSRGTPDADDLRSPMRQDGMA-VKWEKLSPAEFQQLQDY--------------VQYSSKKLPDVL---------EEFKENGALS--KYNAEG--DI----- [87]
sc  -------------------------------------------------MSFSQLEQNIKKKIAVEENIIRGASALKKKTSNVMVIQKCNTNIREARQN-----LEYLEDSLKKLRLKTA [66]
at  ----------------------------------------------------------------------------------------------------------MDDDG--EL----- [7]
ec  -----------------------------------------------------------------------------------M---------AEFPA---------------SLL---- [9]
                                                                                                                      :     

hs  ----------DFEGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKS-----------------------KPALLS--------------------------------------- [106]
mm  ----------DFEGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPNVKS-----------------------KPALLS--------------------------------------- [106]
rn  ----------DFEGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPNVKS-----------------------KPALLS--------------------------------------- [106]
xt  ----------DFEGFQLFMKTFLEAELPDEFCKHLFMSFSNRFHNPSPSIQS-----------------------KSQLLS--------------------------------------- [109]
dr  YH-------CHFEGFKLFMETFLENELDEEFCEHLFLSFCNKDPKSSPSMTE-----------------------KQKIM---------------------------------------- [108]
dm  ----------DFDGFRRFLDAFLDCEAPLDLAKHLFVSFL------KPNVTQAQL--------------------HGRALN------------QMAAISSTAACAPVTSHT--KGSIPNI [126]
ag  ----------DYDGFRKFLDSFLDCETPDDLSQHLFISFL------QPALYQAQQQQ----------------HSHGKALS------------QMAAISSNAACAPVTSHN--RGSIPNL [128]
ce  ----------NIDGFRAFLIDYFGADLPSDLVDQLFLSFS------KPPIKE----------------------RRTSLFE--------D------AISTVRA----------------- [97]
is  ----------DLEGFQAFMDTYLEMDTPRDLVKHLFLSFVRKPAPSRPPIADGRLLKFRHLVAGKFQKDETLDERKTAVLHRTLTGGSLDKSAKMAAVTSTTACAPITSHTHHSGSLP-- [195]
sc  QQSQGENGSEDNERCNSKEYGFLSTKSPN---EHIFSRLD-LVKYDCPSLAQ-RIQYMLQQLEFKLQVEKQYQEANTKLTKLYQIDG--D------QRSSSAA---------EGGAMESK [164]
at  --------------------------------GMFFPSWT-----SKNPIDT--------------------VESRGLMFS--------------------------------------- [31]
ec  ------------------------------------------------------------------------------ILN--------------------------------------- [12]
                                                                                                                            

hs  -------------------------------------------------------------------GGLRMNKG--AITPPRTTSP-ANTCSPEVIH---------------------- [134]
mm  -------------------------------------------------------------------GGLRMNKG--AITPPR-SSP-ANTCSPEVIH---------------------- [133]
rn  -------------------------------------------------------------------GGLRMNKG--AITPPR-SSP-ANTCSPEVIH---------------------- [133]
xt  -------------------------------------------------------------------GGLRMNYR--SNSSSRSSSP-VSLRPPDVIQ---------------------- [137]
dr  --------------------------------------------------------------------GLKLIKG--SCPPLKVTS---QSRPLSTVQ---------------------- [133]
dm  NSIAEL-MPQCSGGGGGIGGTGGVAGAEGHAQARS---------SFVDKIHGITDKLH-----HSLGGHL-------SHDPSKTGS----VHPMLTVTPSPLASGPSMFQASNPARRSVD [220]
ag  NSIVDIPTPQPS-----------------QESQRN---------SFVERIHGLTDKL------QSL-GHLGLDGGGDSSNKGKCGT----VHPMLTVTPSPMGCTPPILQA--PFRRSAD [209]
ce  --------------------------------------------KFSESLSG---RM----------AGLNIAGGS-GQQTDRSQS----SEPQALVCI--------------------- [134]
is  ----ELANKQAQ-GAAVLSSTGAAPDASSGAARRDESAKPHLHLGFAERLHGLTEKL------HSIGGHLRSEGD--SSARTRTGS--ASIHPVVTVTQ--------------NYGDSTD [286]
sc  YRIQML----------------------NKALKKYQAINVDFD-QFKHQPNDIMDNQQPKFRRKQLTGVLTIGITA-ARDVDHIQSPMFARKPESYVTI------------------KID [242]
at  --------------------------------------------CFVAALVGILTIAY-----TAFQWRRNINLSW-TKAIARSKK---------------------------------- [67]
ec  ---------------------------------------------------------------------------------GKSTD---------------------------------- [17]
                                                                                      :                                     

hs  --------------------------------------------------------------------------------LKDIVCYLSLLERGRPEDKLEFMFR--------------- [159]
mm  --------------------------------------------------------------------------------LKDIVCYLSLLERGRPEDKLEFMFR--------------- [158]
rn  --------------------------------------------------------------------------------LKDIVCYLSLLERGRPEDKLEFMFR--------------- [158]
xt  --------------------------------------------------------------------------------LKDIVCYLSLLERGRPEDKLEFMFR--------------- [162]
dr  --------------------------------------------------------------------------------LKDMICYLSLLEGGRPEDKLEFMFR--------------- [158]
dm  SSPSHSAT-NHSQMSRNSSKKSSNSVNCKIDAVSRILPAIGRHCPGSLESGSAQAEKRADIKLLAR-KLSHFDPLTLKVPLKDVVCYLSLLEAGRPEDKLEFMFR--------------- [323]
ag  SSPSHSHSHSHSQISRNSSRKSNNSVNCRIE----------------------------DVRLIPR-KQSFLDPLLLKVPLKDVVCYLSLLEAGRPEDKLEFMFR--------------- [285]
ce  --PEDDV--MGPRVANNDSQEP-------------------------------------------------------RIPLKPLICTLSLLEADTPENKLDVVFH--------------- [180]
is  SSP------NQSQVSRNSSRKSNSSL---------LVHSV-------------------DLKPLRK-TSSHIDVHTVRVPLKDIICYLSLMEAGRPEDKLEFMFR--------------- [356]
sc  DTIKART-----KPSRNDRWSEDFQI--------------------PVEKGN-----EIEITVYDKVNDSLIPVAIMWLLLSDIAEEIRKKKAGQTNEQQGWVNASNINGGSSLASEEGS [332]
at  -NPKARH----------------------------------------------------------------------KVPVAP------------------------------------- [79]
ec  -----------------------------------------------------------------------------NLPLREAIM---------------------------------- [26]
                                                                                    :                                       

hs  -LYDTDGNGFLDSSELENIISQMMHVAEYL--EWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLEN-NVKDD-----GQHVWRLKHFNKPAYCNLCLNMLIGV-G [269]
mm  -LYDTDGNGFLDSSELENIIGQMMHVAEYL--EWDVTELNPILHEMMEEIDYDRDGTVSLEEWIQGGMTTIPLLVLLGLEN-NVKDD-----GQHVWRLKHFNKPAYCNLCLNMLIGV-G [268]
rn  -LYDTDGNGFLDSSELENIIGQMMHVAEYL--EWDVTELNPILHEMMEEIDYDRDGTVSLEEWIQGGMTTIPLLVLLGLEN-NVKDD-----GQHVWRLKHFNKPAYCNLCLNMLIGV-G [268]
xt  -LYDTDGNGYLDSTELESIITQMMHVAEYL--EWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLEN-NVKDD-----GQHVWRLKHFNKPAYCNLCLNMLIGL-G [272]
dr  -LYDTDGNGFLDSKELEHIISQMMHVAEYL--EWDITELKPILEEMMQEIDYDNDGMVSLEEWLQGGLTIIPLLVLLGLET-NVKDD-----GQHVWRLKHFSKPAYCNLCLNMLIGL-G [268]
dm  -LYDTDSNGVLDTAEMDAIVNQMMAVAEYL--GWDVSELRPILQEMMVEIDYDADGTVSLDEWQRGGMTTIPLLVLLGVDSTTLKED-----GIHVWRLKHFSKPAYCNLCLNMLVGL-G [434]
ag  -LYDTDGNGVLDTTETDAIVNQMMSVAEYL--GWDVSELRPILQDMMTEIDYDGDGCVSLEEWQRGGLTTIPLLVLLGVDN-TLKED-----GYHVWRLKHFSKPAYCNMCLNMLVGL-G [395]
ce  -VYDSDGNGFLDKSEIDGIIEQMMNVARYQ--QWDTIELEQVIRQMMVDIDYDNDGIVSFDEWRRGGLTNIPLLVLLGFDT-EMKED-----GSHVWRLRHFTKPTYCNACCSILVGWGG [291]
is  -LYDTDGNGYLDNNETECIVNQMMSVAEYL--GWDVSELKPILQEMMVEIDYDADGTVSLEEWKRGGMTTIPLLVLLGLDA-NVKDD-----GNHVWRLKHFNRPAYCNLCLNMLVGL-G [466]
sc  TLTSTYSNSAIQSTSAKNVQGENTSTSQISTNSWFVLEPS---GQILLTLGFHKSSQIERKQLM-GGLHRHGAII-------NRKEEIFEQHGHHFVQ-KSFYNIMCCAYCGDFL----R [436]
at  ----------------------------------------------------------------------------------------------HSWELDPIARAKNLNCCV-CLKSMSP [104]
ec  ----------------------------------------------------------------------------------LLREE-----G--------------------------- [32]
                                                                                                                            

hs  KQGLC--------CSFCKYTVHERCVARAPPSCIKTYVKSKRN-----TDVMHHYWV--------EGNCPTKCDKCHKTV-KCYQGLTGL-HCVWCQITLHNKCASHLKPE----CDCG- [361]
mm  KQGLC--------CSFCKYTVHERCVARAPPSCIKTYVKSKKN-----TDVMHHYWV--------EGNCPTKCDKCHKTV-KCYQGLTGL-HCVWCQTTLHNKCASHLKPE----CDCG- [360]
rn  KQGLC--------CSFCKYTVHERCVARAPPSCIKTYVKSKKN-----TDVMHHYWV--------EGNCPTKCDKCHKTV-KCYQGLTGL-HCVWCQTTLHNKCASHLKPE----CDCG- [360]
xt  KQGLC--------CSFCKYTVHERCVSRAPPSCIKTYVKSKKD-----TNVMHHFWV--------EGNCPTKCEKCHKAI-KCYQGLTGL-HCVWCQITLHNKCASHLKPE----CDCG- [364]
dr  KQGLC--------CSFCKYTVHERCVSRAPPSCIKTYVKSKKN-----TEIMHHFWV--------EGNCPSKCDKCHKTI-KCYQGLTGL-HCVWCQITLHNKCASHVKPE----CDCG- [360]
dm  KKGLC--------CVLCKYTVHERCVQHAPASCITTYVKSKKPK---CGGDLLHHWV--------EGNCYGRCSKCRKRI-KAYHGITGL-TCRWCHMMLHNRCASSVKKE----CTLG- [528]
ag  KKGLC--------CVLCKYTVHERCVQRAPASCIATYVKSKKSK---ATATFQHHWV--------EGNCYGRCSKCRKRI-KAYNGITGL-TCRWCRMMLHNKCATLVKAE----CTLG- [489]
ce  KQGLS--------CSLCKYTVHERCVRSAATNCIRTYSSRQQDK-------LYHHWQ--------DANATAKCVKCKATV-GVFQGKG----CRWCHNYVHHRCMSALAQE----CDLG- [378]
is  KKGLC--------CVFCKYTVHERCVQRAPASCINTYVKSKKS-----SQALVHHWT--------EGNCTGKCSKCKKTI-KSYNGITGL-HCRWCQMTLHNHCAPQVKPD----CALG- [558]
sc  YTGFQ--------CQDCKFLCHKKCYTNVVTKCIAKTSTDTDPDEAKLNHRIPHRFL------PTSNRGTKWCCHCGYIL---PWGRHKVRKCSECGIMCHAQCAHLVPDF----CGMSM [535]
at  SQAIVASESFFHRCTICGAAAHFNCSSSAPKDCKCVSMVGFEH--------VVHQWAVRWTEGADQTDDSSFCSYCDESCSSSFLGGSPIWCCLWCQRLVHVDCHSNMSNETGDICDLG- [215]
ec  ------------------MTIHVRVT-----------------------------WE--------KGDAARYVEEARK------------------------------------------ [55]
                         * .                               :         .         .                                            

hs  PLKDHILPPTTICPVVLQTL---PTSG-------------------VSVPEERQSTVKKEKS-GSQQPNKVIDKNK------------------------MQRANSVTVDGQGLQVT-PV [433]
mm  PLKDHILPPTTICPVVLQTM---PSAG-------------------ASVPEERQSTAKKEKS-SSQQPNKATDKNK------------------------MQRANSVTMDGQGLQIT-PV [432]
rn  PLKDHILPPTTICPVVLQTM---PTAG-------------------TSVPEERQSTAKKEKG-SSQQPNKVTDKNK------------------------MQRANSVTMDGQGLQIT-PI [432]
xt  PLKDHILPPTTICPVVL----------------------------------ERQSTLKREKN-CSQQGNKCGERIK------------------------MQRANSVTVDGQGLQIT-PI [424]
dr  SLRDHILPPNTICPVVL----------------------------------ERQSTLRKDS-------NQSGGRTK------------------------IQRTNSVSVDGQGLQIT-PL [414]
dm  EYSELIVPPTAICPAVL----------------------------------DRQRSVN-----------QAHKATH-------------------------------------FQITPPD [566]
ag  EFANLVLPPTAICPAVL----------------------------------DRQKSINFTT----NKGKSVPSTIH-------------------------------------FQIT-SD [533]
ce  ALVHHILPPTHIFPAFL----------------------------------ERKTSTS------------------------------------------LKNHNFSSHSASLLQAVSPS [422]
is  PHRDHILPPTSICPAVL----------------------------------ERQRSVTSGQ-------KKALSRTDSN---------------------MASESNQGSVSAMSFQVT-PV [615]
sc  EMANKIL---------------------------------KTIQDTKRNQEKKKRTVPSAQL-----GSSIGTANGSD----------------------LSPSKLAERANAPLPPQ-PR [594]
at  PLRRLIL-----CPLYVKELTRNPSGGFLSSITHGANELASTALASIRIQSKKYKQTNETSADTGNSGSNCDESTESTADTGPTVNGAHAVLENSISVMNGDSSNGDSDSNGKLEKK-PS [329]
ec  ------------------------------------------------------------------------------------------------------------------------ [55]
                                                                                                                            

hs  ---------------------------PGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSG-NGPMPGLNFFRDVPDFRVLAC------GGDGTVGWVLDCIEKANVGK-HPPV [518]
mm  ---------------------------PGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSG-NGPMPGLHFFRDVPDFRVLAC------GGDGTVGWILDCIEKANVVK-HPPV [517]
rn  ---------------------------PGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSG-NGPMPGLHFFRDVPDFRVLAC------GGDGTVGWILDCIEKANVVK-HPPV [517]
xt  ---------------------------SGTHPLLVFVNPKSGGKQGERIHRKFQYLLNPRQVYSLAG-IGPMPGLNFFRDVPDFKVLAC------GGDGTVGWILDCIDKANLIK-QPPV [509]
dr  ---------------------------EGTHPLLVFVNPKSGGKQGERIFRKFQYLLNPRQVYNLAK-SGPMPGYRSCRTVEYYKTLCCPLAFSLSFNEVLFYFLD---KANFEQ-NPPV [502]
dm  ---------------------------ELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSK-GGPKEGLTLFKDLPRFRVICC------GGDGTVGWVLEAMDSIELAS-QPAI [651]
ag  ---------------------------PSWCPLLVFINPKSGGRQGDRILRKFQYLLNPRQVYDLSK-GGPLEGLTMFKDVPNFKVICC------GGDGTVGWVLEAMDSIVLQT-QPSI [618]
ce  ---------------------------NDCRPLLVLVNPKSGGKQGVKILQKFEYLLNPRQVYDLSK-TGPEPGLQLFSTLKNCNILVC------GGDGTIGWVLESMDKMTFPHGRPPV [508]
is  ---------------------------TGTHPLLVLINPKSGGRQGMRILRKFQYLLNPRQVYNVSK-GGPIQGLQFFKDVVSYRVLCC------GGDGTVGWVLDTIDKLNYTQ-LPPV [700]
sc  --------------------------KHDKTPSPQKVGRDSPTKQHDPIIDKRISL----QTHGREK-------LNKFID---------------ENEAYLNFTEGAQQTAEFSS--PEK [660]
at  VKRTGSFGQKEYHALRSKLKYELADLPSDARPLLVFINKKSGAQRGDSLRQRLHLHLNPVQVFELSSVQGPEVGLFLFRKVPHFRVLVC------GGDGTAGWVLDAIEKQNFIS-PPAV [442]
ec  --------------------------------------------------------------FGVAT------------------VIAG------GGDGTINEVSTALIQCEGDD-IPAL [88]
                                                                  .                                  :                   *  

hs  AILPLGTGN-------DLA--RCLRWGGGYEG----ENLMKILKDIENSTEIMLDRWKFEVIP---------------------------------------NDK--------------- [571]
mm  AILPLGTGN-------DLA--RCLRWGGGYEG----ENLMKILKDIESSTEIMLDRWKFEVTP---------------------------------------NDK--------------- [570]
rn  AILPLGTGN-------DLA--RCLRWGGGYEG----ENLMKILKDIESSTEIMLDRWKFEVTP---------------------------------------NDK--------------- [570]
xt  AVLPLGTGN-------DLA--RCLRWGGGYEG----ENLMKFLKDIEIATVVLLDRWKIDVIP---------------------------------------NDK--------------- [562]
dr  CVLPLGTGN-------DLA--RCLHWGGGYDG----ESLLQILKDVQDSSEVMLDRWKINITP---------------------------------------VDR--------------- [555]
dm  GVIPLGTGN-------DLA--RCLRWGGGYEG----ENIPKLMDKFRRASTVMLDRWSIEVTNTPHSDDMRP--------KVTLHSN---MQKVIELSQSVVVDKSLMERFEEIQRQSKQ [747]
ag  GVIPLGTGN-------DLA--RCLRWGGGYEG----ESIPKILDKINRASVVMLDRWSIEVKNNPLAAEETPTATTMPGHKVTLSEN---VQKVIELSHRIIAEKSVIQAYDE-EENSTN [721]
ce  AVLPLGTGN-------DLA--RCLRWGGGYEN----ENLHKILEQIEKSSLIDMDRWQIKIEI--------------------------------------TENKSARRA---------- [567]
is  GILPLGTGN-------DLA--RCLRWGPGYES----ESLEKILQKVEKSTTVMMDRWKIDISN--------------------------------------MANS--------------- [754]
sc  TLDP--TSNRRSLGLTDLSIEHSQTW----------ESKDDLMRD-------ELELWKAQREE----------------MELEIKQDSGEIQEDLEVDHIDLETKQKLDW----ENKNDF [741]
at  AILPAGTGN-------DLS--RVLNWGGGLGSVERQGGLSTVLQNIEHAAVTVLDRWKVSILN--------------------------------------------------------- [496]
ec  GILPLGTAN-------DFA--TSV---------GIPEALDKALKLAIAGDAIAIDMAQVNKQT--------------------------------------------------------- [133]
     : *  *.*       *::                       :          ::  . .                                                            

hs  ------------------------------------------------------------------------------------------------------------------------ [571]
mm  ------------------------------------------------------------------------------------------------------------------------ [570]
rn  ------------------------------------------------------------------------------------------------------------------------ [570]
xt  ------------------------------------------------------------------------------------------------------------------------ [562]
dr  ------------------------------------------------------------------------------------------------------------------------ [555]
dm  VATSM---GTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLE [864]
ag  RATDVPLPPTANGTTQRAAVSDNN-------GFAIGPDAAGTARV---------------------AAMTATPPPTPT-TPFAGGADGPTVMEGFIAEHANRGAVDPPLTNG-------- [804]
ce  ------------------------------------------------------------------------------------------------------------------------ [567]
is  ------------------------------------------------------------------------------------------------------------------------ [754]
sc  READLTIDSTHTN------------PFRDMNSETFQIEQDHASKEV--------------LQE------TVSLAPTST------------------------------------------ [787]
at  ------------------------------------------------------------------------------------------------------------------------ [496]
ec  -------------------------CFINMATGGFG------TRIT-------------------------------------------------------------------------- [148]
                                                                                                                            

hs  -------------------------------------------------------------------DEKGDP----------------------------------------------- [577]
mm  -------------------------------------------------------------------DEKGDP----------------------------------------------- [576]
rn  -------------------------------------------------------------------DEKGDP----------------------------------------------- [576]
xt  -------------------------------------------------------------------DEKGDP----------------------------------------------- [568]
dr  -------------------------------------------------------------------DEGGDP----------------------------------------------- [561]
dm  TLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAA---------SSVLQQQ [975]
ag  -------------------GATTLVSSIAGV------------------------------------DEDDDD---VAANTGTNG-SAPPVDNGPCT-NDDDAAQRAEDDTVNSSYQQQQ [864]
ce  -------------------------------------------------------------------SEKGDT----------------------------------------------- [573]
is  -------------------------------------------------------------------DERGDP----------------------------------------------- [760]
sc  -----------------------------------------------------------------HASRTTDQ--------------------------------------------QSP [798]
at  -------------------------------------------------------------------QQGKQL----------------------------------------------- [502]
ec  -------------------------------------------------------------------TETPEK----------------------------------------------- [154]
                                                                        .  :                                                

hs  -----------------------------------VPYSIINNYFSIGVDASIAHRFH---------IMREKHPEKF------------------NSRMKNKFWYFEFGTSETFSATCKK [635]
mm  -----------------------------------VPYSIINNYFSIGVDASIAHRFH---------IMREKHPEKF------------------NSRMKNKFWYFEFGTSETFSATCKK [634]
rn  -----------------------------------VPYSIINNYFSIGVDASIAHRFH---------IMREKHPEKF------------------NSRMKNKFWYFEFGTSETFSATCKK [634]
xt  -----------------------------------VPYSIINNYFSIGVDASIAHRFH---------LMREKHPEKF------------------NSRMKNKFWYFEFGTSETFSATCKK [626]
dr  -----------------------------------VPYSIINNYFSIGVDASIAHRFH---------IMREKHPERF------------------NSRTKNKLWYFEFGTSETFSATCKK [619]
dm  QQQHLQFEQQQKP------------IKVQSDKDCTVPYNIINNYFSVGVDAAICVKFH---------LEREKNPHKF------------------NSRMKNKLWYFEYATSETFAASCKN [1056]
ag  QHHHSNGNATDKPRPEKKIIDLPKLIKPQVGSEFTVPYNIVNNYFSVGVDAAICVKFH---------LEREKNPHKF------------------NSRMKNKLWYFEYATSETFAASCKN [957]
ce  -----------------------------------PPYSIINNYFSIGVDASIAHRFH---------VMREKFPEKF------------------NSRMRNKLWYFELGTSETLSSSCKN [631]
is  -----------------------------------IPCNIFNNYFSIGVDASIAIKFH---------LEREKHPEKF------------------SSRMKNKMWYFEFATSETFFATCKN [818]
sc  QKSQTSTSAKHKKRA----------AKRR----------------KVSLDNFVLLKVLGKGNFGKVILSKSKNTDRLCAIKVLKKDNIIQNHDIESARAEKKVFLLATKTKHPF---LTN [889]
at  -----------------------------------QPPKYMNNYIGVGCDAKVALEIH---------NLREENPERF------------------YSQFMNKVLYAREGARSIMDRTFED [560]
ec  -------------------------LKA-----------------ALGSVSYIIHGLM---------RMDTLQPDRC------------------EIRGENFHW---------------- [189]
                                                  :.    :   .                ..:                     :  :                   

hs  LHESVEIECDGVQIDLIN-ISLEGIAILNIPSMHGGSNLW--GE---SKKRRS-------HRRIEKKGSDKRTTVTDAKELKFASQDLSDQ-------LLEVVGLEGAMEMGQIYTGLKS [735]
mm  LHESVEIECDGVQIDLIN-ISLEGIAILNIPSMHGGSNLW--GE---SKKKRS-------HRRIEKKGSDKRPTLTDAKELKFASQDLSDQ-------LLEVVGLEGAMEMGQIYTGLKS [734]
rn  LHESVEIECDGVQIDLIN-ISLEGIAILNIPSMHGGSNLW--GE---SKKKRS-------HRRIEKKGSDKRPTLTDAKELKFASQDLSDQ-------LLEVVGLEGAMEMGQIYTGLKS [734]
xt  LHEAIEIECDGIQMDLGN-ISLEGIAILNIPSMHGGSNLW--GE---TKKRRS-------NRRTDKKNSDKRTTVTDAKELKFAAQDLSDQ-------LLEVVGLEGAMEMGQIYTGLKS [726]
dr  LHDYLEVECDGITLNLSN-ISLEGIAILNIPSMHGGSNLW--GE---SKKRRG-------HRRTGKKSPEKKTTIVDPKQLLFAVQDPSDQ-------LLEVVGLEGAMEMGQIYTGLKS [719]
dm  LHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLW--GEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDR-------LIEVIGLENCLHMGQVRTGLRA [1167]
ag  LHEYLEIVCDGVSLELANGPQLQGIALLNIPYTHGGSNLW--GEHLSQKRMRK--GPF--RKKLKNSDKELSANSFNSVDLSIAIQDIGDS-------KIEVIGLENCLHMGQVRTGLRA [1064]
ce  LHEQIDILCDGESIDLGQDASLEGIALLNIPSIYGGSNLW--GRSRKSKGRMP--GLFP-MKNAEK------------MQLQTRVQDIGDG-------LIELVGLESAMQMGQIKAGVRG [727]
is  LHDDVDIMCDGVSLELSNGPSLQGIAVLNIPSIYGGSNLW--GDNAASRKRSR-------SKKRKKHDRDISTNSFNSVDLSSAVQDIGDR-------MIEVIGLESSMHMGQVKAGLRA [922]
sc  LYCSF---------------QTENRIYFAMEFIGGGDLMWHVQNQRLSVRRAK----------------------FYAAEVLLALKYFHDNGVIYRDLKLENILLTPEGHIKIADYGLCK [972]
at  FPWQVRVEVDGVDIEVPE--DAEGILVANIGSYMGGVDLW--QNE---------------DETYENFDP----------------QSMHDK-------IVEVVSISGTWHLGKLQVGLSR [638]
ec  -------QGDALVIGIGNGRQAG-----------GGQQLC--PNAL-----------------------------------------INDG-------LLQLRIFTGDEILPALVSTLKS [241]
                                      **  :                                                  *         ::   :     :      :  

hs  A----GRR--------------------------------------LAQCS----------CVVIRTSKSLPMQ--------IDG----------------------EPWMQT------- [766]
mm  A----GRR--------------------------------------LAQCS----------SVVIRTSKSLPMQ--------IDG----------------------EPWMQT------- [765]
rn  A----GRR--------------------------------------LAQCS----------SVVIRTSKSLPMQ--------IDG----------------------EPWMQT------- [765]
xt  A----GRR--------------------------------------LAQCS----------SVVLRTSKSLPMQ--------IDG----------------------EPWMQT------- [757]
dr  A----GRR--------------------------------------LAQCS----------SITIRTSKSLPMQ--------IDG----------------------EPWMQS------- [750]
dm  S----GRR--------------------------------------LAQCS----------EVIIKTKKTFPMQ--------IDG----------------------EPWMQM------- [1198]
ag  S----GRR--------------------------------------LAQCS----------EVIMTTKKTFPMQ--------IDG----------------------EPWMQG------- [1095]
ce  A-----RR--------------------------------------LSQCS----------TVVIQTHKSFPMQ--------IDG----------------------EPWMQP------- [757]
is  S----GRR--------------------------------------LAQCT----------SVVIRTRKRFPMQ--------IDG----------------------EPWVQP------- [953]
sc  DEMWYGNRTSTFCGTPEFMAPEILKEQEYTKAVDWWAFGVLLYQMLLCQSPFSGDDEDEVFNAILTDEPLYPIDMAGEIVQIFQGLLTKDPEKRLGAGPRDADEVMEEPFFRN---INFD [1089]
at  A-----RR--------------------------------------LAQGS----------AVKIQLCAPLPVQ--------IDG----------------------EPWNQQ------- [668]
ec  D----------------------------------------------EDNP----------NIIEGASSWFDIQAPHDITFNLDG----------------------EPLSGQNFHIEI- [282]
                                                    : .                     ::        ::*                      **           

hs  ---------PCTIKITHKNQAPMLMGPPPKTG-----LFCSLVKRTRNRSKE----------------- [804]
mm  ---------PCTIKITHKNQAPMLMGPPPKTG-----LFCSLIKRTRNRSKE----------------- [803]
rn  ---------PCTIKITHKNQAPMLMGPPPKTG-----LFCSLIKRTRNRSKE----------------- [803]
xt  ---------PCTIKITHKNQAPMLMGPPPKNG-----LFTSLIKGSRSKMKE----------------- [795]
dr  ---------PCTIKIVHENQARMLMGPPQSSS-----FF-SFFRRDRRESKD----------------- [787]
dm  ---------PCTIKVTHKNQVPMLMAPRSEKGRG---FF-NLLCS------------------------ [1230]
ag  ---------PCTIKLTHKNQVPMLMAPRSEKGSG---FF-SFLKR------------------------ [1127]
ce  ---------PCIIQITHKNQAKMLVAAAPRKRSSW-----MLLKRQSTNDDN----------------- [795]
is  ---------PCTIQITHKNQMPMLMAPAPMNKSRF-PFF-SLRKS------------------------ [987]
sc  DILNLRVKPPYIPEIKSPEDTSYFEQEFTSAPPTLTPLP-SVLTTSQQEEFRGFS---FMPDDLDL--- [1151]
at  ---------PCTLTISHHGQAFMLKRAAEEPLGHAAAIITDVLENAETNQVINASQKRTLLQEMALRLT [728]
ec  --------LPAALRCRLPPDCPLLR-------------------------------------------- [299]
             *         :   :                                             


Alignment Details

Alignment done with MAFFT FFT-NS-2 (v7.305b) aligner. MAFFT References
  • Strategy: Auto
  • Scoring Matrix: BLOSUM62
  • Gap Penalty: 1.53
  • Offset Value: 0.0