DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SCO2 and Scox

DIOPT Version :9

Sequence 1:	NP_001162580.1	Gene:	SCO2 / 9997	HGNCID:	10604	Length:	266	Species:	Homo sapiens
Sequence 2:	NP_608884.1	Gene:	Scox / 33711	FlyBaseID:	FBgn0262467	Length:	251	Species:	Drosophila melanogaster

Alignment Length:	240	Identity:	112/240 - (46%)
Similarity:	158/240 - (65%)	Gaps:	17/240 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    34 RSWLLSRQGPA---------ETGGQGQPQGPGLRTRLLITGLFGAGLGGAWLALRAEKERLQQQK 89
            |.|   .|.||         .|.|    :||.....|.:.|..|||..|..|.:::||:..:.::
  Fly    13 RRW---AQQPAIRHYAAPADSTKG----KGPISWRSLAVIGALGAGGVGFMLYVKSEKDEARMKE 70

Human    90 RTEALRQAAVGQGDFHLLDHRGRARCKADFRGQWVLMYFGFTHCPDICPDELEKLVQVVRQLEAE 154
            |...|.:||:| |.:.|:|.:|..|...||.|:|:|:|||||||||||||||||:..||.::|..
  Fly    71 RQRQLGKAAIG-GSWELVDSQGAVRKSEDFLGKWLLIYFGFTHCPDICPDELEKMAAVVDEVEKS 134

Human   155 PGLPPVQPVFITVDPERDDVEAMARYVQDFHPRLLGLTGSTKQVAQASHSYRVYYNAGPKDEDQD 219
            |..|.|||:|||||||||..|.:|:||::|.|:||||||:.:|:.:...::|||::|||:|||.|
  Fly   135 PQTPAVQPIFITVDPERDSKEVVAKYVKEFSPKLLGLTGTVEQIRKVCKAFRVYFSAGPRDEDND 199

Human   220 YIVDHSIAIYLLNPDGLFTDYYGRSRSAEQISDSVRRHMAAFRSV 264
            |||||:|.:||:||||.|.||||::|..:|...|:..::|.:.|:
  Fly   200 YIVDHTIIMYLVNPDGEFVDYYGQNRDKDQCVASILVNIAKWNSM 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCO2	NP_001162580.1	SCO	101..242	CDD:239266	82/140 (59%)
Scox	NP_608884.1	SCO1-SenC	81..217	CDD:396962	80/136 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147991
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1999
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51910
OrthoDB	1	1.010	-	-		D1462537at2759
OrthoFinder	1	1.000	-	-		FOG0002408
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100983
Panther	1	1.100	-	-	O	PTHR12151
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1293
SonicParanoid	1	1.000	-	-		X1597
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.750