DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HNRNPDL and HRP1

DIOPT Version :9

Sequence 1:	NP_112740.1	Gene:	HNRNPDL / 9987	HGNCID:	5037	Length:	420	Species:	Homo sapiens
Sequence 2:	NP_014518.1	Gene:	HRP1 / 853997	SGDID:	S000005483	Length:	534	Species:	Saccharomyces cerevisiae

Alignment Length:	456	Identity:	128/456 - (28%)
Similarity:	184/456 - (40%)	Gaps:	141/456 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    91 KSSSIQRSAAAAAATRTARQHPPA-----DSSVTMEDMNEYSN--------IEEFAEGSKINASK 142
            |:...|.||.:|.|...|....|:     ....||....:.|:        .:...|.||.:.||
Yeast    92 KNEKKQESATSANANANASSAGPSGLPWEQLQQTMSQFQQPSSQSPPQQQVTQTKEERSKADLSK 156

Human   143 NQQDDGKMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLE 207
               :..|||||||:|||::.:|.||..::|.|.|..|..||.|||||||||:.|:..:|||:|::
Yeast   157 ---ESCKMFIGGLNWDTTEDNLREYFGKYGTVTDLKIMKDPATGRSRGFGFLSFEKPSSVDEVVK 218

Human   208 LKEHKLDGKLIDPKRAKALKGKEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNE 272
             .:|.||||:||||||.....::...|:||||:.||...::.:|:|..:|.|.:.:|.:|..|.:
Yeast   219 -TQHILDGKVIDPKRAIPRDEQDKTGKIFVGGIGPDVRPKEFEEFFSQWGTIIDAQLMLDKDTGQ 282

Human   273 RRGFCFITYTDEEPVKKLLESRYHQIGSGKCEIKVAQPKEVYRQQQQQQKGGRGAAAGGRGGTRG 337
            .|||.|:||...:.|.::.::::......|.|||.|:|:  :.||:....||..  .|.....||
Yeast   283 SRGFGFVTYDSADAVDRVCQNKFIDFKDRKIEIKRAEPR--HMQQKSSNNGGNN--GGNNMNRRG 343

Human   338 RGRGQGQNWNQGFNN------------------------YYDQ---------------------- 356
            ...|...::||.:.|                        ||.|
Yeast   344 GNFGNQGDFNQMYQNPMMGGYNPMMNPQAMTDYYQKMQEYYQQMQKQTGMDYTQMYQQQMQQMAM 408

Human   357 ---GY---------------------------------------GNYN----------------- 362
               |:                                       ||.:
Yeast   409 MMPGFAMPPNAMTLNQPQQDSNATQGSPAPSDSDNNKSNDVQTIGNTSNTDSGSPPLNLPNGPKG 473

Human   363 -SAYGGDQNYSGYGGYDYTGYN--YGNYGYGQGYADYS----GQQSTYGKASRGGGNHQNN-YQP 419
             |.|..|.| |||      |||  .|:........||:    |.....|:..|||.|.:|| |.|
Yeast   474 PSQYNDDHN-SGY------GYNRDRGDRDRNDRDRDYNHRSGGNHRRNGRGGRGGYNRRNNGYHP 531

Human   420 Y 420
            |
Yeast   532 Y 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPDL	NP_112740.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..83
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..120		7/28 (25%)
		RRM1_hnRPDL	149..224	CDD:410152	43/74 (58%)
		RRM2_hnRPDL	234..308	CDD:409998	25/73 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..348		8/34 (24%)
		Necessary for interaction with TNPO1. /evidence=ECO:0000269\|PubMed:9524220	342..420		31/190 (16%)
		Necessary for its nuclear import and export	396..420		10/28 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..420		9/22 (41%)
HRP1	NP_014518.1	PABP-1234	<144..463	CDD:130689	93/326 (29%)
		RRM1_Hrp1p	161..236	CDD:409991	43/75 (57%)
		RRM2_Hrp1p	244..321	CDD:409767	26/76 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I2313
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1143
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.960