Protein Alignment HNRNPDL and Rb97D

DIOPT Version :10

• Sequence 1: NP_112740.1
• Gene: HNRNPDL / 9987
• HGNCID: 5037
• Length: 420
• Species: Homo sapiens
• Sequence 2: NP_524520.1
• Gene: Rb97D / 43231
• FlyBaseID: FBgn0004903
• Length: 471
• Species: Drosophila melanogaster
• Alignment Length: 212
• Identity: 73/212 - (34%)
• Similarity: 113/212 - (53%)
• Gaps: 30/212 - (14%)

Human   144 QQDD-------GKMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAAS 201
            ::||       .|:|||||:..|::::|..:..::|:|||..:..|..|.|||||||:.:..:..
  Fly    21 EEDDICELEHLRKLFIGGLAPYTTEENLKLFYGQWGKVVDVVVMRDAATKRSRGFGFITYTKSLM 85

Human   202 VDKVLELKEHKLDGKLIDPKRAKALKGKE------PPKKVFVGGLSPDTSEEQIKEYFGAFGEIE 260
            ||:..|.:.|.:|||.::.|||.....:|      ..||:|||||..:..||.::|||..||.:.
  Fly    86 VDRAQENRPHIIDGKTVEAKRALPRPERESRETNISVKKLFVGGLKDNHDEECLREYFLQFGNVV 150

Human   261 NIELPMDTKTNERRGFCFITYTDEEPVKKLLESRYHQIGSGKCEIKVA----------QP----- 310
            :::|..|..|.:||||.|:.:.|.:.|.|.:..:.|.|.....::|.:          ||
  Fly   151 SVKLLTDKTTGKRRGFAFVEFDDYDAVDKAILKKQHAIKYVHVDVKKSIYNLDKKEKQQPGGLAN 215

Human   311 --KEVYRQQQQQQKGGR 325
              |....||||||.||:
  Fly   216 AIKPSLNQQQQQQGGGQ 232

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPDL	NP_112740.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	96..120
		RRM1_hnRPDL	149..224	CDD:410152	30/74 (41%)
		RRM2_hnRPDL	234..308	CDD:409998	27/73 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..348		8/13 (62%)
		Necessary for interaction with TNPO1. /evidence=ECO:0000269|PubMed:9524220	342..420
		Necessary for its nuclear import and export	396..420
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..420
Rb97D	NP_524520.1	RRM2_hnRNPA_like	124..196	CDD:409766	26/71 (37%)
		RRM_SF	33..110	CDD:473069	31/76 (41%)