Protein Alignment HNRNPDL and Rox8

DIOPT Version :10

• Sequence 1: NP_112740.1
• Gene: HNRNPDL / 9987
• HGNCID: 5037
• Length: 420
• Species: Homo sapiens
• Sequence 2: NP_732944.2
• Gene: Rox8 / 42848
• FlyBaseID: FBgn0005649
• Length: 470
• Species: Drosophila melanogaster
• Alignment Length: 234
• Identity: 58/234 - (24%)
• Similarity: 95/234 - (40%)
• Gaps: 32/234 - (13%)

Human   150 MFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLELKEHKLD 214
            :::|.|....|:..|....|..|.|..|.|..:|   .:..:.|:.:.:..:....|.    .::
  Fly     9 LYVGNLDSSVSEDLLIALFSTMGPVKSCKIIREP---GNDPYAFIEYSNYQAATTALT----AMN 66

Human   215 GKLIDPKRAKALKGKEP---PK-------KVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTK 269
            .:|...|..|......|   ||       .:|||.|||:...|.::|.|..||||.|..:..|..
  Fly    67 KRLFLEKEIKVNWATSPGNQPKTDISSHHHIFVGDLSPEIETETLREAFAPFGEISNCRIVRDPH 131

Human   270 TNERRGFCFITYTDEEPVKKLLESRYHQ-IGSGKCEI-----KVAQPKEVYRQQQQQQKGGRGAA 328
            |.:.:|:.|:::..:...:..:::...| |||.....     |:..|:|      ..:.||:|
  Fly   132 TMKSKGYAFVSFVKKAEAENAIQAMNGQWIGSRSIRTNWSTRKLPPPRE------PSKGGGQG-- 188

Human   329 AGGRGGTRGRGRGQGQNWNQGFNNYYDQGYGNYNSAYGG 367
             ||.||..|.|.|...:....|...|:|......:.|.|
  Fly   189 -GGMGGGPGNGSGVKGSQRHTFEEVYNQSSPTNTTVYCG 226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPDL	NP_112740.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	96..120
		RRM1_hnRPDL	149..224	CDD:410152	14/73 (19%)
		RRM2_hnRPDL	234..308	CDD:409998	23/79 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..348		10/34 (29%)
		Necessary for interaction with TNPO1. /evidence=ECO:0000269|PubMed:9524220	342..420		5/26 (19%)
		Necessary for its nuclear import and export	396..420
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..420
Rox8	NP_732944.2	RRM1_TIA1_like	9..80	CDD:409788	15/77 (19%)
		RRM2_TIA1_like	96..170	CDD:409789	22/73 (30%)
		RRM_SF	221..292	CDD:473069	2/6 (33%)