Protein Alignment HNRNPDL and lark

DIOPT Version :10

• Sequence 1: NP_112740.1
• Gene: HNRNPDL / 9987
• HGNCID: 5037
• Length: 420
• Species: Homo sapiens
• Sequence 2: NP_523957.1
• Gene: lark / 38811
• FlyBaseID: FBgn0011640
• Length: 352
• Species: Drosophila melanogaster
• Alignment Length: 376
• Identity: 76/376 - (20%)
• Similarity: 125/376 - (33%)
• Gaps: 135/376 - (35%)

Human   149 KMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFV-LFKDAASVDKVLELKEHK 212
            |:|||.|...|...:|.....::|.||:|.:        .:.:||| :..:....|.:..|..:.
  Fly     8 KLFIGNLDEKTQATELRALFEKYGTVVECDV--------VKNYGFVHMETEQQGRDAIQNLNGYT 64

Human   213 LDGKLIDPKRAKALKG-KEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNERRGF 276
            |:...|..:.||:.:. ..|..|:|||.|:..|...:::|.|..:|.:...::.        |.:
  Fly    65 LNEFAIKVEAAKSRRAPNTPTTKIFVGNLTDKTRAPEVRELFQKYGTVVECDIV--------RNY 121

Human   277 CFI-----------------TYTDEEPVKKLLESRYHQIGSGKCEIK--VAQPKEVYRQQQQQQK 322
            .|:                 ...|.:|:|.       |:.:.:...|  :..|::.||
  Fly   122 GFVHLDCVGDVQDAIKELNGRVVDGQPLKV-------QVSTSRVRPKPGMGDPEQCYR------- 172

Human   323 GGR------------GAAAGGR--------GGTRGRGRGQG-------------QNWNQGFN--N 352
            .||            |:|.|||        ||.|.|..|:.             .....||.  :
  Fly   173 CGRSGHWSKECPRLYGSAGGGREPPSPLSAGGYRDRMYGRDPYPPPPPPPPFLRDRIMDGFRDYD 237

Human   353 YYDQGYGNYNSAY------------------------------GGDQNYSGYGGYDYTGY----- 382
            |||:.:.:....|                              |..::.|...||| |.:
  Fly   238 YYDRRFEDSRDLYERRYQTSRMRDFPPPPISRREPMPLPPTLSGSLRSCSVSRGYD-TMFSRRSP 301

Human   383 -----NYGNYGYG----QGYADYS----GQQSTYGKASRGGGNHQNNYQPY 420
                 :.|...||    .||.|:|    .::....:..||.......|.||
  Fly   302 PPPRSSNGMSRYGSPTPHGYEDFSRDAFDERMISSRGMRGPSPPGRRYAPY 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPDL	NP_112740.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	96..120
		RRM1_hnRPDL	149..224	CDD:410152	18/75 (24%)
		RRM2_hnRPDL	234..308	CDD:409998	16/92 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..348		14/67 (21%)
		Necessary for interaction with TNPO1. /evidence=ECO:0000269|PubMed:9524220	342..420		22/140 (16%)
		Necessary for its nuclear import and export	396..420		4/27 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..420		3/21 (14%)
lark	NP_523957.1	RRM1_2_CoAA_like	8..73	CDD:409779	18/72 (25%)
		RRM1_2_CoAA_like	87..152	CDD:409779	14/79 (18%)
		hnRNP-R-Q	<88..>258	CDD:273732	36/191 (19%)