DRSC/TRiP Functional Genomics Resources

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Protein Alignment HNRNPDL and rnp24

DIOPT Version :10

Sequence 1:NP_112740.1 Gene:HNRNPDL / 9987 HGNCID:5037 Length:420 Species:Homo sapiens
Sequence 2:NP_594970.1 Gene:rnp24 / 2542965 PomBaseID:SPAC3G6.04 Length:369 Species:Schizosaccharomyces pombe


Alignment Length:261 Identity:59/261 - (22%)
Similarity:111/261 - (42%) Gaps:56/261 - (21%)


- Green bases have known domain annotations that are detailed below.


Human   115 DSSVTMEDMNEYSNIEEFAEGSKINASKNQQDDGK-----------MFIGGLSWDTSKKDLTEYL 168
            |.:.|.|.:.|....|| ....:::|...::::|:           :::|.||:.|:|:.||::.
pombe    62 DGNWTPEALEEAKKKEE-KRLKRLDAKYGRKEEGESQEESKRSPWGIWVGNLSFHTTKEILTDFF 125

Human   169 SR-----FGEVVDCTIK---TDPVTG-----------RSRGFGFVLFKDAASVDKVLELKEHKLD 214
            .|     ..||.:..||   |:.:|.           :::||.:|.|....::...|:..|..|:
pombe   126 VRETSEMIKEVSEENIKPITTEQITRIHMPMSKEKRFQNKGFAYVDFATEDALKLALQCSEKALN 190

Human   215 GKLIDPKRAKALKG-------------------KEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIE 260
            |:.|..|......|                   |||...:|||.|..:|::..:||:||..|:|.
pombe   191 GRNILIKSNTDFSGRPSKPANTLSKTASIQSSKKEPSSILFVGNLDFETTDADLKEHFGQVGQIR 255

Human   261 NIELPMDTKTNERRGFCFITYTDEEPVKKLLESRYHQIGSGKCEIKVAQPK-EVYRQQQQQQKGG 324
            .:.|.....|.:.:||.|:.:.|.:...|.:|     :|.....::..:.: :..|.:....:.|
pombe   256 RVRLMTFEDTGKCKGFGFVDFPDIDTCMKAME-----LGHNSWRLEYGEDRSKRMRNKSPMARSG 315

Human   325 R 325
            |
pombe   316 R 316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HNRNPDLNP_112740.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..83
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 96..120 1/4 (25%)
RRM1_hnRPDL 149..224 CDD:410152 24/104 (23%)
RRM2_hnRPDL 234..308 CDD:409998 20/73 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 313..348 3/13 (23%)
Necessary for interaction with TNPO1. /evidence=ECO:0000269|PubMed:9524220 342..420
Necessary for its nuclear import and export 396..420
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..420
rnp24NP_594970.1 RRM1_Nop13p_fungi 107..199 CDD:409830 24/91 (26%)
RRM2_Nop13p_fungi 230..299 CDD:409831 20/73 (27%)
Blue background indicates that the domain is not in the aligned region.

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