DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HNRNPDL and gar2

DIOPT Version :9

Sequence 1:	NP_112740.1	Gene:	HNRNPDL / 9987	HGNCID:	5037	Length:	420	Species:	Homo sapiens
Sequence 2:	NP_593531.1	Gene:	gar2 / 2542869	PomBaseID:	SPAC140.02	Length:	500	Species:	Schizosaccharomyces pombe

Alignment Length:	341	Identity:	84/341 - (24%)
Similarity:	147/341 - (43%)	Gaps:	67/341 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    91 KSSSIQRSAAAAAATRTARQHPPADSSVTMEDMNEYSNIEE-------FAEGSKINASKNQQDDG 148
            |..|.:.|:.:.:::.::.:...:|||...|  :|.|:.:|       .:|......:|..||..
pombe   198 KEGSSESSSDSESSSDSSSESGDSDSSSDSE--SESSSEDEKKRKAEPASEERPAKITKPSQDSN 260

Human   149 K---MFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLELKE 210
            :   :|:|.|||:...:.|.:....:|.:|...:..|..:|||:|:|:|.|:...:....:....
pombe   261 ETCTVFVGRLSWNVDDQWLGQEFEEYGTIVGARVIMDGQSGRSKGYGYVDFETPEAAKAAVAANG 325

Human   211 HK-LDGKLI-----DPKRAKAL------------KGKEPPKKVFVGGLSPDTSEEQIKEYFGAFG 257
            .| :||:::     :|:.|...            :..||...||||.||.:.:|:.:...||..|
pombe   326 TKEIDGRMVNLDLSNPRPANPQPYAQQRAGNFGDQLSEPSDTVFVGNLSFNATEDDLSTAFGGCG 390

Human   258 EIENIELPMDTKTNERRGFCFITYTDEEPVKKLLESRYHQIGSGKCEIKVAQPKEVYRQQQQQQK 322
            :|::|.||.|.::...:||.::|::|.:..||.:|...|.|....|.:..:.|:.
pombe   391 DIQSIRLPTDPQSGRLKGFGYVTFSDIDSAKKCVEMNGHFIAGRPCRLDFSTPRT---------- 445

Human   323 GGRGAAAGGRGGTRGRGRGQGQNWNQGFNNYYDQGYGNYNSAYGGDQNYSGYGGYDYTGYNYGNY 387
              .|.:.|||||..|||                        .:||...:.|..|....|...||.
pombe   446 --GGGSRGGRGGFGGRG------------------------GFGGRGGFGGGRGRGRGGARSGNP 484

Human   388 GYGQGYADYSGQQSTY 403
            ..| ..|.:||.:.|:
pombe   485 NRG-SVAPFSGNKVTF 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPDL	NP_112740.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..83
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..120		4/23 (17%)
		RRM1_hnRPDL	149..224	CDD:410152	20/83 (24%)
		RRM2_hnRPDL	234..308	CDD:409998	25/73 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..348		9/34 (26%)
		Necessary for interaction with TNPO1. /evidence=ECO:0000269\|PubMed:9524220	342..420		12/62 (19%)
		Necessary for its nuclear import and export	396..420		3/8 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..420		2/6 (33%)
gar2	NP_593531.1	RRM1_gar2	264..339	CDD:240893	19/74 (26%)
gar2	NP_593531.1	RRM2_gar2	368..439	CDD:240894	25/70 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870