DRSC/TRiP Functional Genomics Resources

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Protein Alignment HNRNPDL and sqd-1

DIOPT Version :10

Sequence 1:NP_112740.1 Gene:HNRNPDL / 9987 HGNCID:5037 Length:420 Species:Homo sapiens
Sequence 2:NP_001380080.1 Gene:sqd-1 / 177392 WormBaseID:WBGene00022235 Length:308 Species:Caenorhabditis elegans


Alignment Length:303 Identity:98/303 - (32%)
Similarity:148/303 - (48%) Gaps:29/303 - (9%)


- Green bases have known domain annotations that are detailed below.


Human   133 AEGSKINASKNQ-----------QDDGKMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTG 186
            |..:|||.:.::           .:|.|:|:||:|.:.:.:||:.:.:::|||....:|.|...|
 Worm     3 ATDNKINGNASETIKENGHSTKGNEDKKIFVGGISPEVNNEDLSSHFTQYGEVAQAQVKYDRTNG 67

Human   187 RSRGFGFVLFKDAASVDKVLELKEHKLDGKLIDPKRAKALKGKEPPKKVFVGGLSPDTSEEQIKE 251
            |||||.||.|.........|..:|..:.||.::.|.||:.:.    ||||||||..|.||:.::.
 Worm    68 RSRGFAFVEFTTGEGCKLALAAREQTIKGKSVEVKPAKSREN----KKVFVGGLPSDYSEQDLRS 128

Human   252 YFGAFGEIENIELPMDTKTNERRGFCFITYTDEEPVKKLLESRYHQIGSGKCEIKVAQPKEVYRQ 316
            :|..||::::||.|.|.:|..||.|.||.:.:||...|.........|:.:|::|.|.|      
 Worm   129 HFEQFGKVDDIEWPFDKQTKARRNFAFIVFEEEESADKASSQTKQTFGTRECDVKKAVP------ 187

Human   317 QQQQQKGGRGAAAGGRGGTRGRGRGQGQNWNQGFNNYYDQGYGNYNSAYGGDQNYSGYGGYDYTG 381
            |.::..|.:|...||||...|||......|..|:.......||...:|:|   ::.|.|.|...|
 Worm   188 QGKRFPGAQGRMPGGRGMYGGRGGNNNSGWYAGWGQIGAMPYGATGAAWG---DWYGNGYYGQQG 249

Human   382 YNYGN-----YGYGQGYADYSGQQSTYGKASRGGGNHQNNYQP 419
            ..:.|     .|||.||..::|..|.:......|....||.||
 Worm   250 AAHHNNSGSSQGYGSGYQSFAGNNSGFDYQQAQGARQGNNGQP 292

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HNRNPDLNP_112740.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..83
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 96..120
RRM1_hnRPDL 149..224 CDD:410152 26/74 (35%)
RRM2_hnRPDL 234..308 CDD:409998 29/73 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 313..348 11/34 (32%)
Necessary for interaction with TNPO1. /evidence=ECO:0000269|PubMed:9524220 342..420 23/83 (28%)
Necessary for its nuclear import and export 396..420 7/24 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..420 7/22 (32%)
sqd-1NP_001380080.1 RRM2_NsCP33_like 30..104 CDD:410187 26/73 (36%)
RRM_SF 111..185 CDD:473069 29/73 (40%)
Blue background indicates that the domain is not in the aligned region.

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