DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment THOC1 and Hpr1

DIOPT Version :9

Sequence 1:	XP_011524074.1	Gene:	THOC1 / 9984	HGNCID:	19070	Length:	664	Species:	Homo sapiens
Sequence 2:	NP_649594.1	Gene:	Hpr1 / 40723	FlyBaseID:	FBgn0037382	Length:	701	Species:	Drosophila melanogaster

Alignment Length:	705	Identity:	260/705 - (36%)
Similarity:	380/705 - (53%)	Gaps:	96/705 - (13%)

- Green bases have known domain annotations that are detailed below.

Human     8 FSLPEARTRFTKSTREALNNKNIKPLLSTFSQVP-GSENEKKCTLDQAFRGILEEEIINHSSCEN 71
            |:|..|   |.|:...|:.:..::.|:..:::.| .:|::|:..:|.|||.:|.:.:  ......
  Fly    19 FALQSA---FEKALELAITDGKVELLVKEYNRFPANTEHDKRLPMDHAFRVLLMKRL--DEDVSR 78

Human    72 VLAIISLAIGGVTEGICTASTPFVLLGDVLDCLPLDQCDTIFTFVEKNVATWKSNTFYSAGKNYL 136
            :..::.|::......|.:.:.|.|||.|..|.:.||:|..||.|||..|..||...|:|:.||.:
  Fly    79 IGELVRLSVEATRAEIVSNTIPVVLLIDTFDVVTLDKCQKIFQFVEDMVEVWKEEIFFSSCKNNI 143

Human   137 LRMCNDLLRRLSKSQNTVFCGRIQLFLARLFPLSEKSGLNLQSQFNLENVTVFNTNEQESTLGQK 201
            ||||||||||||::|||||||||||||::.||.||:||||:.|:|||:|.|.:..:
  Fly   144 LRMCNDLLRRLSRTQNTVFCGRIQLFLSKFFPFSERSGLNIVSEFNLDNFTEYGLD--------- 199

Human   202 HTEDREEGMDVEEGEMGDEEAPTTCSIPIDYNLYRKFWSLQDYFRNPVQCYEKISWKTFLKYSEE 266
             ::|.:|. |.:|.|...|:.|    :.|||:||.|||||||:||||.|||.|..||.|..:::.
  Fly   200 -SKDHDES-DNKELEDTAEDIP----LKIDYDLYCKFWSLQDFFRNPNQCYNKPQWKMFQMHADN 258

Human   267 VLAVFKSYKLDDTQASRKKMEELKTGGEHV---------------------YFAKFLTSEKLMDL 310
            :|..|.|:||:|.   |:...|..:|.:..                     :||||||:.||:.|
  Fly   259 ILQSFSSFKLEDV---RQSSNENASGTDQAMDVDEEAVDTTAVSSVIKANHFFAKFLTNPKLLAL 320

Human   311 QLSDSNFRRHILLQYLILFQYLKGQVKFKSSNYVLTDEQSLWIEDTTKSVYQLLSENPPDGERFS 375
            ||||:||||.:|:|:|||||||:..|||||....||.:|:.:|::|...||:||.|.||.|:|||
  Fly   321 QLSDANFRRAVLVQFLILFQYLQVSVKFKSDTQTLTADQADFIKETESRVYKLLEETPPYGKRFS 385

Human   376 KMVEHILNTEENWNSWKNEGCPSFVKESVCFVHDRTSDTKPTRIIRKRTAPEDFL-GKGPTKKIL 439
            :.|.|:|..||.||:||||||..|.|.....:.:  .|:|||...|.|....|.| ....:.|..
  Fly   386 RTVYHMLAREEMWNNWKNEGCKEFKKPEEPTLSE--EDSKPTPNKRPRRPLGDALRDASRSGKFY 448

Human   440 MGNEELTRLWNLCPDNMEACKSETREHMPTLEEFFEEAIEQADPENMVENEYKAVNNSNYGWRAL 504
            :||:.||||||..|||::|||||.|..:|.||.:.|...|:.||.              :.||||
  Fly   449 LGNDNLTRLWNYSPDNLQACKSEQRNFLPLLETYLETPHEKVDPA--------------FEWRAL 499

Human   505 RLLARRSPHFFQPTNQQFKSLPEYLENMVIKLAKELPP---------PSEE-------------- 546
            |||||::||||...:|....:.:|||.:..:|.::..|         .||.
  Fly   500 RLLARQTPHFFTSLSQPSSKISDYLEQVRKRLIRDKEPKPAALLSNNSSENNFGLSVNNVHTEGE 564

Human   547 ------IKTGEDEDE---EDNDALLKE-NESPDVRRDKPVTGEQIEVFANKLGEQWKILAPYLEM 601
                  ::.||.|.:   |||:.:::| :|.|...:...||.|.||..|..:||.|..:...:..
  Fly   565 QDATVALQDGEPEQDLEVEDNEPVVEEVDEVPAHEKPLMVTKEHIEEVAPLIGEPWMKVGKKIGF 629

Human   602 KDSEIRQIECDSEDMKMRAKQLLVAWQDQEGVHATPENLINALNKSGLSDLAESL 656
            .:.|:...:.:.....:...::|..|...:. .||.||....|....::..||::
  Fly   630 TNDELLFFQMEHPTANVACVKMLTNWISDDD-DATLENWAYMLEGLEMNKAAEAV 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
THOC1	XP_011524074.1	efThoc1	74..546	CDD:288785	216/502 (43%)
THOC1	XP_011524074.1	Death_NMPP84	572..657	CDD:260030	19/85 (22%)
Hpr1	NP_649594.1	efThoc1	79..538	CDD:288785	214/492 (43%)
Hpr1	NP_649594.1	Death	606..687	CDD:278932	17/79 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141594
Domainoid	1	1.000	386	1.000	Domainoid score	I812
eggNOG	1	0.900	-	-		E1_KOG2491
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38012
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1849
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58811
OrthoDB	1	1.010	-	-		D148325at33208
OrthoFinder	1	1.000	-	-		FOG0005707
OrthoInspector	1	1.000	-	-		oto90156
orthoMCL	1	0.900	-	-		OOG6_103415
Panther	1	1.100	-	-	LDO	PTHR13265
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1913
SonicParanoid	1	1.000	-	-		X4105
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800