DRSC/TRiP Functional Genomics Resources

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Protein Alignment DOP1B and CG15099

DIOPT Version :10

Sequence 1:NP_005119.2 Gene:DOP1B / 9980 HGNCID:1291 Length:2298 Species:Homo sapiens
Sequence 2:NP_001261081.1 Gene:CG15099 / 37176 FlyBaseID:FBgn0034400 Length:2683 Species:Drosophila melanogaster


Alignment Length:2813 Identity:804/2813 - (28%)
Similarity:1259/2813 - (44%) Gaps:753/2813 - (26%)


- Green bases have known domain annotations that are detailed below.


Human     4 EEQELLNDYRYRSYSSVIEKALRNFESSSEWADLISSLGKLNKALQSNLRYSLLPRRLLISKRLA 68
            |||:|:.:.:||:|.:.|:|||||||.|||||||||:||||:||:.||.:|.::||||.|:||||
  Fly     9 EEQKLMAEAKYRTYMTNIDKALRNFEYSSEWADLISALGKLSKAISSNTQYQVIPRRLKIAKRLA 73

Human    69 QCLHPALPSGVHLKALETYEIIFKIVGTKWLAKDLFLYSCGLFPLLAHAAVSVRPVLLTLYEKYF 133
            ||:||||||||||||||||.:||...|.:.||.: |:||.||||||.:||::|||.||.:||.||
  Fly    74 QCMHPALPSGVHLKALETYSVIFSKTGPERLATE-FIYSAGLFPLLGYAAMNVRPALLAIYETYF 137

Human   134 LPLQKLLLPSLQAFIVGLLPGLEEGSEISDRTDALLLRLSLVVGKEVFYTALWGSVLASPSIRLP 198
            :||...|.|:|..|:.|:|||.:.|.:..:|..|||.::...|....|||.||.||..:.:||||
  Fly   138 VPLGDKLRPALSGFLNGVLPGYDCGLDHFERISALLKQVCNAVNPMHFYTVLWESVANNAAIRLP 202

Human   199 ASVFVVGHINRDAPGREQKYMLGTNHQLTVKSLRASLLDSNVLVQRNNLEIVLFFFPFYTCLDSN 263
            |..:::.|.|:....:||.|::|.|.::.:.:|...|.||.:|||||.||.:|..||.:|.|   
  Fly   203 AITYLLEHFNKRLDMQEQIYIMGHNREIMMSALCVCLNDSLILVQRNTLEFLLLGFPMHTVL--- 264

Human   264 ERAIPLLRSDIVRILSAATQTLLRRDMSLNRRLYAWLLGSDIKGNTVVPES---EISNS-YEDQS 324
                 |...|:|::::....|:|||||||||||::|||||::..|:...::   :.||: .|::.
  Fly   265 -----LSEDDLVKLVTNGLNTILRRDMSLNRRLFSWLLGSEVAKNSPTYDTLSLDTSNAPLEEEP 324

Human   325 SYFFEKYSKDLLVEGLAEILHQKFIDADVEERHHAYLKPFRVLISLLDKPEIGPQVVGNLFLEVI 389
            ..:|.|:|:.:|::.|...|......|.::      |||:|:::|||||.|||..|:..:..::|
  Fly   325 EPYFVKHSRHILIKALITTLRLSLECAPMD------LKPYRIMLSLLDKAEIGSAVLDYVLHDII 383

Human   390 RAFYSYCRDALGSDLKLSYTQSGNSLISAIKENRNASEIVKTVNLLITSLSTDFLWDYMTRCFEE 454
            ||.               |..|||            :|.:|:.|||..:....::|.|||..|| 
  Fly   384 RAM---------------YISSGN------------AEALKSANLLFATFDPAYIWSYMTNMFE- 420

Human   455 CFRPVKQRYSVRNSV--------------SPPPTVSELCALLVFLLDVIPLELYSEVQTQYLPQV 505
              :..:|..|::...              |..|.|.|:|.|..|||:.:.||:|:|....|||:|
  Fly   421 --KACQQANSMQEKSQAGETSGKYACDVGSGDPCVLEICVLTEFLLETVSLEMYTETTRVYLPKV 483

Human   506 LGCLVQPLAEDMEALSLPELTHALKTCFKVLSKVQ---MPPSYLD--TESTSGTSSPVK------ 559
            ...:.|.|:..|:.:|..|:|.:||.|.|::|:||   ..|..|:  .|.:.|:||..|      
  Fly   484 FLAITQLLSLHMDHISSNEITASLKLCMKIVSRVQPMITSPIKLNKLIEQSGGSSSDEKITMNSA 548

Human   560 --------GENGKIILETK--------------AVIPGDEDASFPPLKSEDSGIGLSASSPELSE 602
                    |..|..:.::|              :..|.||:.    :....|...:...||...:
  Fly   549 SDAGKTEAGAQGNSLEKSKSDSRLNQFAENTLHSADPNDEEL----IHRSASNQSVGRQSPNKKK 609

Human   603 HLRVPRVS-LERD----DVWKKGGSMQRTFLCIQELIANF-----------ASKNIFGVQLTASG 651
            ...:.|:| |::|    |..::..|...|...|::|.|..           ..|::..:|...|.
  Fly   610 AKSISRLSELDKDISASDTGQQSSSDLDTPRSIKKLKAKAKVPFIRSPKKQRPKDMVLIQSNTSA 674

Human   652 EES---KSEEPAGKRDRDGTQSLAANDSSRKNSW------------------------------E 683
            |.|   .:|||. ....|.|.....::.||....                              |
  Fly   675 EVSDGPSAEEPK-SAPPDQTPQFQLDEESRATQQRGFSILEKCIRQYEIFFEVYLSRKLLHIESE 738

Human   684 PKPITVP-QFKQMLSDLFTA-------------------------------------------RG 704
            ||..:|. |.::..|.:.|:                                           |.
  Fly   739 PKECSVKVQLQRTTSTIHTSNLFMAEQVLDHECPVRESQIERLFNLLRVDIVPRSKQLQRLLNRS 803

Human   705 SPFKTKSSESPSSSPSSPARKNGGEWDVEKVVIDLGGSREER-----------REAFAAACHLLL 758
            .|....:||..|.|.:...::       :.::||....|..:           |.|...|..||:
  Fly   804 LPLPASASELSSDSEAQEEKQ-------QSLLIDGQTQRSVQQLAELQLSPSLRGAVKLAATLLV 861

Human   759 DCATFP-----VYLSEEETEQLCATLFQLPGAGDSSFPSWLKSLMTICC-CVTDCYLQNVAISTL 817
            :.:|||     |.|.:.|.|                .|:|||.|..:.| ..:|..||..:|:||
  Fly   862 EMSTFPNCNKHVVLDKNEPE----------------LPNWLKVLCLVACFAQSDKELQVASITTL 910

Human   818 LEVINHSQSLALVIEDKMKRYKSSGHNPFFGKLQMVTVPPIAPGILKVIAEKTDFYQRVARVLWN 882
            .::|:..:|   .||          |....|...:|.:|.:..|.:..:.:.|..:|.|:.:||:
  Fly   911 FDLISLLRS---QIE----------HTTSPGVTFVVMLPLLKFGHVSYMEQHTRVFQLVSSILWD 962

Human   883 QLNKETREHHVTCVELFYRLH-CLAPTANICEDIICH---------------------------- 918
            .|.....: ......|.::|| ||  .:.:.|.:|.:                            
  Fly   963 YLGTAGID-PAQIAALLHQLHSCL--ESGLVETVIGNRMQSQHLLQMQSQSRSDLGKAAIRNFQM 1024

Human   919 ------ALLDPDKGT------RLEALFRFSVIWHLTREIQGSRVTSHNRSFDRSLFVVLDSLACT 971
                  .||.|.:.|      :..:..:|.::|||.|:.|.:      |.|:::|..|||:||..
  Fly  1025 ERLAEAQLLCPTESTERLRESQARSFKKFELLWHLGRDKQTA------RGFEKTLLKVLDTLALP 1083

Human   972 D-GAIGAAAQGWLVRALSLGDVARILEPVLLLLLQPKTQRTSIHCLKQENSADDLHRWFNRKKT- 1034
            . .:.......||..:|..||:||:.:|:..:||...::|..|..::|      |:|....:.| 
  Fly  1084 HYMSERTFVTNWLQASLLRGDLARLTKPLYKILLSASSKRVGIVHMQQ------LYRESETEVTP 1142

Human  1035 SF-REACAVPEPQ----------ESGSEEHLPLSQF----------------------------- 1059
            :| |:..|:...|          .||:::..|:..|                             
  Fly  1143 AFERDVYAISSEQGNVKYHHMETSSGNKKKSPIRNFPKKIFGVTLSGGKANKVSNFVSDKSTVAT 1207

Human  1060 ---------------------------TTVDREAIWAEVEKEPEKYPLRGELSEEELPYY---VE 1094
                                       |.::...|....::.|.:..|...:.|.|.|..   ..
  Fly  1208 CSEATQDMNTIGLIINPLENANDFDDETDLEEPRIEIPHKETPLEQKLASAMDESEQPSQEQPAN 1272

Human  1095 LPDRTAHGAPDSSEHTESAD---------TSSCHTDSENTSSFSSPSHDLQELSNEENCCAPIPM 1150
            .||.:.....|.::|::|:|         ||....||...||.:..|.|::....:   |     
  Fly  1273 QPDNSLQYDQDITDHSDSSDFESDSELRETSIEKEDSITVSSSAGVSDDVKRFVGD---C----- 1329

Human  1151 GGRAYPKRSALLAAFQSESFKAGAKLSLVRVDSDKTQASESFSSDEEAD----LELQA------- 1204
                   .|...|..|.|..|:.....|.|   :||....|.:|.|:.|    .||||       
  Fly  1330 -------ESVTDALTQHEKIKSRKTYRLTR---EKTPGENSLNSLEQKDHDSISELQADALPADE 1384

Human  1205 ----------------------------------------------------------------- 1204
                                                                             
  Fly  1385 YFREDKKLGKRKKVLTSGEKKRLSCISKTSTDSNISGSHVEQPEQEEETEPGTESTINVEDKRRN 1449

Human  1205 --LTTSRL-----------------LKQQR-----------ERQEAVEALFK------------- 1226
              |.||:|                 |:|..           |.|.:|.:..|             
  Fly  1450 LSLETSKLQPDMQKTLEKGKQNVEILRQNNAAAAAAAAAAAEEQISVRSSMKSTVSLTDAAHLYH 1514

Human  1227 -HILLYLQPYDSRRVLYAFSVLEAVLKTNPKEFIEAVSRTSMDTSSTAHLNLISNLLARHQEALI 1290
             |:|:||..||:|:.|||...|..::..:.:.|:.....||..::|      :..||.||::::.
  Fly  1515 NHLLIYLAIYDTRQTLYALQTLRNIICCDKRTFLCLSITTSFSSAS------LKQLLVRHRKSIS 1573

Human  1291 GQSFYGKL----QTQVPNVCPHSLLLELLTYLCLSFLRSYYPCYLKVSHR------DILGNRDVQ 1345
            |:.|.|.:    ..|....|   :.||||..|||.:.|.|:......:.|      ||:.||.:|
  Fly  1574 GKGFDGSVGNSEYAQGYRGC---MQLELLVTLCLFYARGYFQKESLDAQRQSPTLQDIVNNRRIQ 1635

Human  1346 VKSVEVLIRIMMQLVSVAKSSEGKNVEFIHSLLQRCKVQEFVLLSLSASMYTSQKRYGLATAHHG 1410
            ::|:|:|..|..:|:.:.|........:|..||.|.|:|:.:|..|::|:.:    |||....:.
  Fly  1636 LESIELLTLICSELIEIVKGMGRGLANYIADLLARAKLQKVMLHCLNSSVCS----YGLKGNTNS 1696

Human  1411 RALPEDSLFEESLINLGQDQIWSEHPLQIELLKLLQVLIVLEHHLGRAHEEAENQPDLSREWQRA 1475
            .:..|..|   |..:...||:.:: ..|::||:||..:|.|||.:   |:..::.|..:.| ..|
  Fly  1697 GSYAEQVL---SFNDPQDDQLHAD-CFQLQLLRLLLAVIRLEHEV---HQLRQDTPPAAGE-DSA 1753

Human  1476 LN------FQQAISALQYVQPHPLTSQGLLVSAVVRGLQPAYGYGMHPAWVSLVTHSLPYFG-KS 1533
            .|      .:.|.:.::|:....::.|.:.::||:..||......:|..|..|||.||..|. .|
  Fly  1754 GNASPTRLAEGATANVKYLPNCLISQQPMFLAAVLGALQQERLRHLHRNWTDLVTSSLNCFSFGS 1818

Human  1534 LGWTVTPFVVQICKNLDDLVKQYESESVKLSVSTTSKRENISPDYPLTLLEGLTTISHFCLLEQA 1598
            |...|...|.|:|.|||           ::|.....::.:..|||.::.||.||.:.|:|||:..
  Fly  1819 LTNIVISVVHQLCSNLD-----------RISKMGLPQQRHFPPDYVVSQLEALTILCHYCLLDNT 1872

Human  1599 NQ-------------------------------------NKKTMAAGDPAN--LRNARNAILEEL 1624
            .|                                     ::.:.:|..|.|  |:.||||:|..|
  Fly  1873 QQTALSHLFNQAYPQTSSSAQSSSTGQLLNSIVHSFLSASESSTSAPAPRNPQLQAARNAVLSHL 1937

Human  1625 PRTVNTMALLWNVLRKEETQKRPVDLLGATKGSSSVYFKTTKTIRQKILDFLNPLTAHLGVQLTA 1689
            ||.::::|.:|:   .|..|.|||                    ||::|:||:|::.|.|....|
  Fly  1938 PRIMSSVAAIWD---SELGQLRPV--------------------RQQLLEFLSPVSLHHGSNFLA 1979

Human  1690 AVAAVWSRK-------------KAQRHSKMKIIPTASASQLTLVDLVCALSTLQTDTLLHLVKEV 1741
            |||..|.::             :.||:|.::..|    :||:||.||.::..:..|:.:..:..|
  Fly  1980 AVAVTWQQRGIATNMNGLSIAEQFQRNSVLQACP----AQLSLVSLVSSIRVMPMDSFVMTLHHV 2040

Human  1742 VKRPPQVKGGDEKSPL---VDIPVLQFCYAFLQRLPVPALQENFSSLLGVLKESVQLNLAPPGYF 1803
            |:.||.:    .:.|.   :::..|:..|.:::..|.|.|.:.:||||.::::.  |||.||..|
  Fly  2041 VRSPPPI----HRPPAQLSIEVSALELFYFYMKSAPAPQLADAWSSLLALIRDG--LNLTPPAQF 2099

Human  1804 LLLSMLNDFVTRTPNL--ENKKDQKDLQEITQKILEAVGNIAGSSLEQTSWLSRNLEVKAQPQAS 1866
            .||.:||:||.|.|.:  ::||:.::|.::|.::::::.::|||.||||:||.|||.||      
  Fly  2100 ALLMLLNEFVQRCPQMPFQDKKEVRELHDVTSRLVDSLSSVAGSCLEQTTWLRRNLAVK------ 2158

Human  1867 LEESDAEEDLYDAAAASAMVSSSAPSVYSVQALSLLAEVLASLLDMVYRSDEKEKAVPLISRLLY 1931
                   ||. |..|....|.......||:||.|:||.:|::|||:.|.|.||:|.|.:::.|||
  Fly  2159 -------EDT-DGLAKDNSVGGGGLQQYSLQAQSVLAAILSNLLDVAYGSQEKDKVVNIVTPLLY 2215

Human  1932 YVFPYLRNHSAYNAPSFRAGAQLLSSLSGYAYTKRAWRKEVLELFLDPAFFQMDTSCV-HWKSII 1995
            .:.|||:||:|.|.|.|.|.:.||:|||||.||::||||::|:|.||.|||||..||: .|:.|:
  Fly  2216 NITPYLKNHTARNVPFFYACSALLASLSGYQYTRKAWRKDMLDLLLDNAFFQMHLSCLPFWRMIM 2280

Human  1996 DHLLTHEKTMFKDLMN----MQSSSLKLFSS----FEQKAMLLKRQAFAVFSGELDQYHLYLPLI 2052
            |.|:|::.|.|::||.    .|:.||.:|:|    :||:||||||.||.::..|.||::.|:|.|
  Fly  2281 DSLMTYDNTTFRELMTRVSLSQAGSLNIFTSRDQEYEQRAMLLKRLAFVIYCSEFDQHNKYMPDI 2345

Human  2053 QERLTDNLR-VGQTSIVAAQMFLFFRVLLLRISPQHLTSLWPIMVSELIQTFTQLEEDLKDEDE- 2115
            ||:|.::|| |.....|.|.:||.|||||||:||.|:||||||:::|::|.|.|:|::||.|.| 
  Fly  2346 QEQLANSLRLVPMGPSVQAAVFLCFRVLLLRMSPDHVTSLWPIIIAEMVQVFLQMEQELKSESEE 2410

Human  2116 ---SLRSTNKVNRTKVSVPDANGPSVGEIPQSEL----ILYLSACKFLDTALSFPPDKMPLFQIY 2173
               .||..:.::   ||...|:|.|.|...|:.:    .:.|.|||.|:.....|..|:|.||:|
  Fly  2411 RNQQLRLPSGID---VSWSAASGASNGYNSQTPMQHWRSVQLEACKLLELGCVLPATKLPHFQMY 2472

Human  2174 RWAFIPEVDTEGPAFLSDVEENHQEC-----------------KPHTVRILELLKLKFGEISSSD 2221
            ||||:      |..|  ||.| .:.|                 .||..|:..|:.:|:       
  Fly  2473 RWAFV------GTEF--DVHE-EEVCLPNGSLENLATLPSALYVPHVRRVARLMDMKY------- 2521

Human  2222 EITMKSEFPLLRQHS----------VSSIRQLMPFFMTLNGAFKTQRQLPADSPGTPFLDFPVTD 2276
                .|:.|:|::.|          :.|:::|..||.||..:....|.. ||:.         .|
  Fly  2522 ----TSQSPILQRPSNRHLMLHFQQLQSLQELYAFFTTLGISCPQPRNF-ADTE---------ND 2572

Human  2277 SPRILKQLEECIEYDFLE 2294
            ....||::||.:..||||
  Fly  2573 VANCLKEIEEVLANDFLE 2590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DOP1BNP_005119.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 577..598 2/20 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 650..686 12/68 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 706..727 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1097..1139 13/50 (26%)
Dopey_N <1951..2107 CDD:471021 84/165 (51%)
Dopey_N 11..304 CDD:461183 151/292 (52%)
CG15099NP_001261081.1 Dopey_N 17..301 CDD:461183 152/292 (52%)
Dopey_N <2200..2477 CDD:471021 130/279 (47%)

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