DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CDC34 and Ubc4

DIOPT Version :9

Sequence 1:	XP_005259747.1	Gene:	CDC34 / 997	HGNCID:	1734	Length:	269	Species:	Homo sapiens
Sequence 2:	NP_001287013.1	Gene:	Ubc4 / 39133	FlyBaseID:	FBgn0015321	Length:	199	Species:	Drosophila melanogaster

Alignment Length:	171	Identity:	57/171 - (33%)
Similarity:	82/171 - (47%)	Gaps:	43/171 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    22 EEPVE-GFRVTLVDEGDLYNW-----EVAIFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTK 80
            ||.|: ..::.||::    :|     |:|  |||:|.||||.|...:|.|..||::||..||:|:
  Fly    20 EEIVQCSIKIELVND----SWTELRGEIA--GPPDTPYEGGKFVLEIKVPETYPFNPPKVRFITR 78

Human    81 MWHPNIYE-TGDVCISILHPPVDDPQSGELPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDA 144
            :|||||.. ||.:|:.||             .:.|.....:||:|||:.:||.......|.  ||
  Fly    79 IWHPNISSVTGAICLDIL-------------KDNWAAAMTLRTVLLSLQALLAAAEPDDPQ--DA 128

Human   145 SVMYRKWKESKGKDREYTDIIRTQEH--------PGHLPSC 177
            .|.|      :.||: |...:.|.:|        |...|.|
  Fly   129 VVAY------QFKDK-YDLFLLTAKHWTNAYAGGPHTFPDC 162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDC34	XP_005259747.1	COG5078	6..162	CDD:227410	51/146 (35%)
CDC34	XP_005259747.1	UBCc	11..162	CDD:238117	51/146 (35%)
Ubc4	NP_001287013.1	COG5078	1..153	CDD:227410	54/160 (34%)
		UQ_con	8..149	CDD:278603	54/156 (35%)
		UBA_II_E2_UBCD4	163..198	CDD:270574	57/171 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000