Protein Alignment MED12 and SRB8

DIOPT Version :10

• Sequence 1: NP_005111.2
• Gene: MED12 / 9968
• HGNCID: 11957
• Length: 2177
• Species: Homo sapiens
• Sequence 2: NP_010004.1
• Gene: SRB8 / 850442
• SGDID: S000000677
• Length: 1427
• Species: Saccharomyces cerevisiae
• Alignment Length: 336
• Identity: 70/336 - (20%)
• Similarity: 126/336 - (37%)
• Gaps: 63/336 - (18%)

Human    22 PDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAK----ISSNFSSIIAEKLR 82
            ||..|.:....||::.|..|.:||.:.|.|:.:...:..:|..:...    :|..|..||  |:|
Yeast    31 PDFKPWEHTAAEDQILANFVAKGFYHTPMVNFESISARSSVHESLVTQSNILSQQFDKII--KIR 93

Human    83 ---CNTLPD---TGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGT-KPLTQLAKKVPIFSKKE 140
               .|.:|.   |....|.....:...|...|.:    ||..:|:.: ..|.::.|.:|...|:.
Yeast    94 EDHINKIPSNSTTTLHGPGFQLPNRITLTDHRKE----TWLHELSSSHTSLVKIGKFIPHGLKRR 154

Human   141 EVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKR------------HVDPFMEWTQIITKY 193
            :|........:|:.||.||||  |.|:........|||            |:  ..:||......
Yeast   155 QVIEQCYLKFIPLKRAIWLIK--CCYFIEWKSNHKKKRSNAAGADDAISMHL--LKDWTDTFVYI 215

Human   194 LWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWV 258
            |.:.:..|..:|...               ..:....||..|..||....:...::::..|..|:
Yeast   216 LEKLIFDMTNHYNDS---------------QQLRTWKRQISYFLKLLGNCYSLRLINKEIFHHWL 265

Human   259 LECFEKIRPGEDELLKLLLPLLLRYSGEFVQ---------SAYLSRRLAYFCTRRLALQLDGVSS 314
            :|...|:.  ..|.|.|.|.:|:.:..:..|         :...|::..:|    |..::..:..
Yeast   266 VEFINKME--NFEFLPLSLHILMIFWNDICQIDTNAPVAATITSSQKEPFF----LVTKITDMLL 324

Human   315 HSSHVISAQST 325
            |..:::|:..:
Yeast   325 HKYYIVSSSKS 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED12	NP_005111.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	12..35		4/12 (33%)
		Med12	106..161	CDD:462818	14/55 (25%)
		Med12-LCEWAV	286..757	CDD:463472	6/49 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..344		0/3 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	627..669
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	690..717
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1241..1266
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1394..1415
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1450..1474
		Interaction with CTNNB1 and GLI3. /evidence=ECO:0000269|PubMed:17000779	1616..2051
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1738..1829
		Med12-PQL	1819..2022	CDD:463471
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1919..1938
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1967..1989
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2115..2149
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2158..2177
SRB8	NP_010004.1	Med12	113..175	CDD:462818	15/65 (23%)