DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MED12 and kto

DIOPT Version :9

Sequence 1:NP_005111.2 Gene:MED12 / 9968 HGNCID:11957 Length:2177 Species:Homo sapiens
Sequence 2:NP_524786.1 Gene:kto / 44830 FlyBaseID:FBgn0001324 Length:2531 Species:Drosophila melanogaster


Alignment Length:2692 Identity:908/2692 - (33%)
Similarity:1246/2692 - (46%) Gaps:702/2692 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    10 EHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFS 74
            |.|||||.||||||:||||.||:|||||..|||.||...|.:| ||.|:|.|.:.|.:|:|:.||
  Fly     7 EKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLS-DEFGTAHNSNVNASKVSAFFS 70

Human    75 SIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKK 139
            .::|:|....|||||||:|.|:|.|||||.|:.|.:..::.||.||||.|||..|||:.|.|:||
  Fly    71 GVLAKKEELMTLPDTGRKKQQINCKDNFWPVSPRRKCTVDAWFKDLAGNKPLLSLAKRAPSFNKK 135

Human   140 EEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHV-DPFMEWTQIITKYLWEQLQKMAE 203
            ||:|..|.:..|.:.||.|.||::.||..:.:|:|.|||.: ||..|||..:.|::.|.|.|:.|
  Fly   136 EEIFITLCENQVNMQRATWFIKLSAAYTLSFTESKNKKRSIYDPAAEWTGNMIKFMKELLPKLQE 200

Human   204 YYRP--------------------GPAGSGGCG--------------------STIGPLP----- 223
            ||:.                    |||.:|..|                    |...|||     
  Fly   201 YYQQNHDKSSSNGTTSGSLTAAGNGPASNGSTGTSSINSVTGSSASTNVIPVPSMASPLPPIHSP 265

Human   224 -----------------------------------------------------------HDVEVA 229
                                                                       .|...|
  Fly   266 ANGQQAAPGGGVNAGSVMPTTGSLGGVVGGPGSSVVGGAAGAGAAVPPGSTISGIGSQFEDSRNA 330

Human   230 IRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPG---EDELLKLLLPLLLRYSGEFVQSA 291
            ::.|.|..:|:.:|:::.:|||.|||.|:|:..:|:|..   ::.|.||:|...|:|..:||||.
  Fly   331 LKYWKYCHQLSKYMYEESLLDRQEFLNWILDLLDKMRTQASFDEPLKKLVLSFALQYMHDFVQSE 395

Human   292 YLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHR 356
            .|.|::||..:::||..|       :.|:..|:...|......|.|.    .....:.:.||.||
  Fly   396 RLCRKMAYIVSKKLAQLL-------NTVVEQQTIKELDEPKLQQDPY----ELALQEQMSCPHHR 449

Human   357 PLVFGLSCILQTILLCCPSALVWHYSLTDSRIKT---GSPLDHLPIAPSNLPMPEGNSAFTQQVR 418
            .:|..||.|||.|.:.||:||||. .:...|..:   ||||||||:|||.||||........::|
  Fly   450 DIVLYLSTILQIITIECPTALVWS-GIAAHRAPSSLLGSPLDHLPLAPSVLPMPTRCPRTNHEIR 513

Human   419 AKLREIEQQIKERGQAVEVRWSFDKCQEATAG-FTIGRVLHTLEVLDSHSFERSDFSNSLDSLCN 482
            .:||..|..|..|.|..|.||...|...|... :|  .||.||:.||:|.|:|.:.:||:|:|..
  Fly   514 RQLRAAESDIVLRTQHAEQRWFAAKWLSAGKNQYT--SVLATLDHLDTHCFDRMEHNNSIDTLYA 576

Human   483 RIFGLGPS--------------KDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQ 533
            :||   ||              :..:|...|.| .|.:|||||||.:|.|.|||||||.||:|||
  Fly   577 QIF---PSPTVSRRREEDQVEPRPPYEPKQDKD-TVRILCEWAVSGQRWGEHRAMVVAILLDKRQ 637

Human   534 AEIEAERCG-ESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTD-PRSESERVEFFNL 596
            .::.:.... :|...|:|.|:|||:......|:||.||:.|||..||:|.: ..|..:|.||.||
  Fly   638 IDVTSTPADQQSSDKDDKDSLASGAGLIDGLPVFQHVLMHFLDHDAPVLDEHVSSPQQRTEFTNL 702

Human   597 VLLFCELIRHDVFSHNMYTCTLISRGDLAFGA------------PGPRPPSP-------FDDPAD 642
            |.||..||||||||||.|..||||||||...:            ..|.||:|       |||...
  Fly   703 VQLFSALIRHDVFSHNAYMHTLISRGDLLLESVLVIKSGTTATKTSPPPPAPPPTTTHGFDDDGF 767

Human   643 ----DPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEK 703
                |.:|.|.:.|              ::|.....|.:::::            :|:...:|:.
  Fly   768 GGGLDFKHNEFDDS--------------NVDDDLDKLVQNIKE------------KGQQHEAPDS 806

Human   704 PDVEKEVKPPPKEKIE--GTLGVLYDQPRHVQYATHFPIPQEE----SCSHECNQRLVVLFGVGK 762
            |    ::.||...:..  |::.      ||..|..||||||::    |.|.|.|||.::||||||
  Fly   807 P----KIGPPGDGETNPGGSIS------RHYVYTKHFPIPQDDPSMSSYSSESNQRYILLFGVGK 861

Human   763 QRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAE 827
            :||:.:||:||::|:|.|:..:|.:.:.                  ...|..::.:|.|.  ..|
  Fly   862 ERDEKKHAVKKMSKEIGKLFTKKFSIDV------------------AAAGHVKKHSRNEF--NFE 906

Human   828 DIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDF 892
            ...:|.|.::::|||.||||.:.|||||:..||||.:.:||:.:||.|:|||||.:|:|..|::.
  Fly   907 ATTSKCQQMAYFDQHVVTAQCAANVLEQLNGFALGNNNYLPVQEHVAFLFDLMELALNIYSLLEL 971

Human   893 AIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKH 957
            ...||.||..||.:|.||.|:||.||||||.|.||::||.||:||:|:.:|...||||:|..::|
  Fly   972 CDSLLKELPEVEHQLQLKKSNLVRSYTTSLALYIVSILRRYHSCLLLSPEQTLSVFEGVCRTIRH 1036

Human   958 GMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDF-----CSKVKNTIYCNVE----PSES 1013
            ..|.|:.:||||||:|||.||:.||..|:.|  |..:::     |.|....|:...|    |.:.
  Fly  1037 VSNPSECTSAERCIIAYLSDLHESCVLLQGK--EQSTEYYQQLQCIKRFKDIFNTPEQLDLPPQG 1099

Human  1014 NMRWAPEFMIDTLENPAAHTFTYTGLGK-------SLSENPANRYSFVCNALMHVCVGHHDPDRV 1071
               :.|..:.:....|...       ||       :|.|:|||.||||.|||:.|| ...|.:|:
  Fly  1100 ---YNPLLLQELFMAPRRG-------GKLDPHWLGTLHESPANVYSFVSNALIAVC-RETDNERL 1153

Human  1072 NDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILI 1136
            ||:|:.|||||..|..||.||:..|::||..|.:..  :..|...||:..|..|::||.||.||:
  Fly  1154 NDVALACAELTASCNVLSEEWIYALQSLCSGSKSPR--YPHLGGQVDIGQLKTHNALAVFVCILV 1216

Human  1137 ARQCLLLEDLIRCAAIPSLLNAACS-----EQDSEPGARLTCRILLHLFKTPQL----------- 1185
            ||.|..|.|.:...|:|:|..:..:     ..|:|.||||||.::|.||||.::           
  Fly  1217 ARHCFSLADFVSKFALPTLARSVSAGGAELSVDAEAGARLTCHLVLKLFKTLEIPQPGMYSVSTS 1281

Human  1186 -NPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGD-AELK-----GSGFTVT 1243
             ||..:.||  ...||.|||||||..:...|...||.|||||:.::.| |.||     ||| |.:
  Fly  1282 PNPLHAVGN--DFSIRLSCDRHLLVGAHKTIPIAAVLAVLKAILIVVDNAALKTPLASGSG-TSS 1343

Human  1244 GGTEELPEEEGGGGSGGRRQG--------------------------------GRNIS------- 1269
            ||.       ||....|:|.|                                |.:::       
  Fly  1344 GGL-------GGAFGSGKRSGFNTPVHPGSTPKSNEQRPADLSQILGTSDLQLGSSLTSEPEALQ 1401

Human  1270 ------VETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPH 1328
                  :|..||..:|:.||:.||.||.|.|||||:..:..:.:.|.:|::.||||::.:||||.
  Fly  1402 QPSVGGMEQISLLEFAQAVLKQICAQEHVLERCLKNAEQLCDMIIDEMLTAKQAQRVLHMICYPE 1466

Human  1329 RLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNN--EMNSLLENIAKATIEVFQ 1391
            ... |...|..||..|.|||:||.|||:|.|.|:||||.:|:.:|  |:|..|:.:|:|.|:||.
  Fly  1467 PEF-NIISELDQRSMIVRILENLGQWTLRISWLDLQLMYRQSLSNNAELNVWLDTVARAAIDVFH 1530

Human  1392 QSAETGSSSGSTASNMPSSSKT--KPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKG 1454
            .....          :|.:.|.  ||      :...||||||||||..:|||.:|:.||:.||..
  Fly  1531 MEEVV----------LPGAVKATHKP------KPSTWLVAPLIAKLTPAVQGRILRVAGQVLESM 1579

Human  1455 QHL-----------GSSSRKERDRQKQKSMSL-------------LSQQPFLSLVLTCLKGQDEQ 1495
            .:.           ||...:|:......|.|.             |..||||.|:|||||||||.
  Fly  1580 NYFSKVSKSDCNSSGSGDEREKSNSCHSSNSYGLGGVPARNKKMPLDYQPFLGLILTCLKGQDEY 1644

Human  1496 REGLLTSLYSQVHQIVNNWRD-DQY--LDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEW 1557
            :|.||.|||:|:.|.:.::.: |..  :|:.:.::.:.:||:||.:||||||:.:|:::..||:|
  Fly  1645 KENLLVSLYAQLSQCLQSFAELDTIGGIDEPQAREEILDALQLRFSLVGGMFEAIQKNSTPTTDW 1709

Human  1558 AMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQK 1622
            |:||.:::..|.||:..|.||||||:|||:.|::.||.:|           ::|.||||.|||:|
  Fly  1710 AILLAQLVCQGVVDLSCNRELFTTVVDMLATLVHSTLVSD-----------DERHYMNLMKKLKK 1763

Human  1623 ELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISP 1687
            |:||:.:.|:..:||||||.||..:||.||..|  :|||||||...|    |:.|::|.||:||.
  Fly  1764 EIGEKNNASIRVIRQLLPLYKQPTEVIACEHSG--MDTKGNKICDID----KKQLRISDKQRISV 1822

Human  1688 WDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEP- 1751
            ||:.||.|..|||||.|||.|:::|:....||..|.|.||||...:|.:||.|||||||||.|| 
  Fly  1823 WDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYYEPLPLPPEDIEPV 1887

Human  1752 PAPTLLEPEKKAPEPPKTDK-PGAAPPSTEERKKKSTKGKKRSQPATKT---------------- 1799
            |....::.|.||..|...|: |.|....|...:.|.|..:||.....||                
  Fly  1888 PEKICIKDEMKADTPSSVDQSPSAVVGGTGRGRGKGTTTRKRKPKNPKTPPVVNTQQQQPQLAQQ 1952

Human  1800 ---------------------------EDYGMGPGRSGPYGVTVPPDLLHH-PNPGSITHLN--- 1833
                                       :...|.|.:.|...:.:|.::... |||.::...|   
  Fly  1953 PQQPQNVQQQQLQQQQQQQQHMQQQHMQQQQMQPNQMGQMPMNMPMNMQQFAPNPNNMMQQNAML 2017

Human  1834 -----YRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSY 1893
                 .:...:|.....|.|..||....|...:....|    .|...|..|..|.|    :...:
  Fly  2018 QQQQQQQMQQMGNNPMQQQLNVGGGNGQPNPQMNFMQQ----GPGGGGAGPQGMPG----QQQQW 2074

Human  1894 KTSVYRQQQPAVP-------------------------QGQRLRQQLQQSQGMLGQSSVHQMTPS 1933
            ..:. :||||..|                         ..|.|.|.|:|.|....|:   |..|.
  Fly  2075 HNAP-QQQQPPQPYHNQYAPHQQNMQSNRIERPPLNANSKQALSQMLRQRQPFQQQA---QQGPG 2135

Human  1934 SSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGY 1998
            ..:.....|   |..|    ||..||...|.|   :....|..:|..||..|.....:||:|...
  Fly  2136 GGFNPMQQQ---PQAS----QQQPGPQQQMNP---NQMRQQQMNPQQNPQSVAAFNAMQQQPQQN 2190

Human  1999 VHQQ----------------------APTY-------GHGLTSTQRFSHQTLQQTPMISTMTPMS 2034
            ..||                      ||..       |.|::.......|..|.  |:..:.|.:
  Fly  2191 AQQQQMNPNQQQQQQFMRGGNMRPGMAPNQMNQMNMGGQGMSQNPMMQQQIPQN--MVGMVNPNA 2253

Human  2035 AQ---------------GVQAGVRSTAILPE------------QQQQQQQQQQQ------QQQQQ 2066
            .|               ||..||......|.            |||.|||.|||      |.|.|
  Fly  2254 NQMMQSGGAQGGNGVGVGVGVGVGGAGNNPNMGMGGMPQQGMIQQQPQQQPQQQVQFQNFQNQYQ 2318

Human  2067 QQQQQQQQQQ-----------YHIRQQQQQQ-------------------------ILRQQQQQQ 2095
            |||||..|||           ....||||||                         .:.||||||
  Fly  2319 QQQQQGMQQQGGGAGVGVGVGMAPNQQQQQQANMMGNFNPQMQQGNRNNPDFMAAAAVAQQQQQQ 2383

Human  2096 QQQQQ---------------------------------------------------------QQQ 2103
            ||||:                                                         |||
  Fly  2384 QQQQRVVPGGMMAGNRNQYMNQAPNVTMSTMMGPGPGGVVGQVPPYARQQSAGGGKPGVLNTQQQ 2448

Human  2104 QQQQQQQQQQQQHQQQQQQ---------QAAPPQ---------------PQPQSQPQFQRQGLQQ 2144
            .|||||||||.:||..|.|         ..|.||               ||            ||
  Fly  2449 FQQQQQQQQQLRHQMMQLQGMGGGAGGGMGAGPQQGGGAVGGGAGGGMVPQ------------QQ 2501

Human  2145 TQQQQQTAALVRQLQQQ--LSNTQPQP 2169
            :..||||..||.|||:|  :...|.||
  Fly  2502 SMNQQQTPNLVAQLQRQNMMGQQQYQP 2528

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MED12NP_005111.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 12..35 18/22 (82%)
Med12 103..161 CDD:286572 27/57 (47%)
Med12-LCEWAV 286..757 CDD:288959 184/519 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..344 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 627..669 11/64 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 690..717 5/26 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1241..1266 8/56 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1394..1415 2/22 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1450..1474 6/34 (18%)
Interaction with CTNNB1 and GLI3. /evidence=ECO:0000269|PubMed:17000779 1616..2051 156/569 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1738..1829 34/136 (25%)
Med12-PQL 1820..2019 CDD:288958 53/261 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1919..1938 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1967..1989 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2115..2149 11/57 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2158..2177 6/14 (43%)
ktoNP_524786.1 Med12 99..157 CDD:286572 27/57 (47%)
Med12-LCEWAV 390..856 CDD:288959 184/519 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141342
Domainoid 1 1.000 714 1.000 Domainoid score I117
eggNOG 1 0.900 - - E1_KOG3598
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1250 1.000 Inparanoid score I178
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45902
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004348
OrthoInspector 1 1.000 - - otm42165
orthoMCL 1 0.900 - - OOG6_105637
Panther 1 1.100 - - LDO PTHR46007
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X4125
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.760

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