DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MED12 and srb8

DIOPT Version :10

Sequence 1:NP_005111.2 Gene:MED12 / 9968 HGNCID:11957 Length:2177 Species:Homo sapiens
Sequence 2:NP_001417945.1 Gene:srb8 / 2543467 PomBaseID:SPAC688.08 Length:1148 Species:Schizosaccharomyces pombe


Alignment Length:1356 Identity:248/1356 - (18%)
Similarity:410/1356 - (30%) Gaps:486/1356 - (35%)


- Green bases have known domain annotations that are detailed below.


Human    10 EHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFS 74
            |:..|.:.::..||      |...||..        :..|.::||  ..:|...::|...|...|
pombe    32 EYLTLLQSKVSAPD------KNFRDETV--------DGAPFLAGD--AISKGHRYSPPVRSDRAS 80

Human    75 S--IIAEKL-RCNTLPDTGRRKPQVNQKDNFWLV------------TARSQSAINTWFTDLAGTK 124
            :  ::.:.| :.:||.:..|....:..:.|..::            ...|:|..:.|...|:...
pombe    81 AQGLLQQHLEKSSTLENLKRYSSTLLGRQNDAVIDEPFAPFRPPPRVTLSESRRDRWLQGLSDPM 145

Human   125 -PLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETK--VKKRHVDPFMEW 186
             ||:.|.|.:|.....|::...|.|:.||..||.|.|:  |   |.::|.:  ::|.......||
pombe   146 VPLSSLIKTIPHGLWGEDILRMLVKFRVPFTRAIWFIR--C---AGVNEARSFLRKVQTTDITEW 205

Human   187 TQ------------IITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKL 239
            .:            .|:.:|...:...|:                              |||..|
pombe   206 VKNWTDVAAGFLISFISSFLNADIYSFAD------------------------------DYTYLL 240

Human   240 AMF--MFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPL--LLRYSGEFVQSAYLSRRLAYF 300
            .:|  :..:.::....||..::..     .|:..|....|..  |..:|...:|..::.|:    
pombe   241 KLFGRLLAEELVSPKHFLLRIVSF-----SGDSSLKSFSLHFFALQFFSTSLIQYTHICRK---- 296

Human   301 CTRRL--------------ALQLDGVSSHSSHVISAQSTSTL-----PTTPAPQPPT-----SST 341
            |...:              .|:...:|...||.:...:...:     ||......||     ...
pombe   297 CVITILQSYQQLIVDQPANLLKFSLLSKKVSHFLFTLAQKNIESFFFPTEWDKLKPTIILLWKDF 361

Human   342 PSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPM 406
            |:  :|.||...|.|                 .|..::.|....|.|:      .|.|. |.|..
pombe   362 PN--YSTLLSIMQER-----------------NSKAMYMYKPVTSSIR------FLQII-SCLSF 400

Human   407 PEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERS 471
            |.|.....:.: .||..:     ..|..:.:.|    |....:.|:..|......:.|:.:|:|:
pombe   401 PVGWRTLAKDL-FKLLPV-----YTGVPLLLHW----CINCRSIFSGDRNFIVSSIFDNANFDRN 455

Human   472 ---DFSNS-------------------LDSL--CN---------RIFGLGPSKDGHEISSDDDAV 503
               |.:.|                   ||.|  |.         |:..||..::....||..|..
pombe   456 LIVDLTLSFVLKLHPLEYNECVAAAQLLDHLAACGYFFFSKYIARLASLGYLRESMLNSSFMDDQ 520

Human   504 VSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGE------------SEAADEKGSIASG 556
            ..:|.:..:  .|..:.....:..:|.|....::...|.|            ....:|..:|.:.
pombe   521 RKILVQLPI--LRMSQQLKNKIYYILSKGNYFVDWSICDEYVKRFKEDHFSFMFKKEENYAIITL 583

Human   557 SL----SAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCT 617
            ||    |.|.:.:::|.|:...                ...:::..:..:||..::...:..:|.
pombe   584 SLVKIASTPMSKLYEDYLVMLF----------------AFHYSMFQVMTKLIADNLVHFSFQSCA 632

Human   618 LISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDP---SSSVLFEDM 679
            ||....:                           ||...|:....|....:.|   |..:|..:|
pombe   633 LIFLYKI---------------------------SSYFVLDAKLFSSICSVVPKTESQKLLLNEM 670

Human   680 EKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEE 744
            .|    ||...:      :.|.:.|||                .:|.:|             ..|
pombe   671 GK----LFQVEL------NFSYDSPDV----------------NLLIEQ-------------FYE 696

Human   745 SCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGG 809
            ..|:|.|.            |||....|..|     |.|||...|                ||  
pombe   697 ITSYESNY------------DDAFVEYKDAT-----VANRKDFIE----------------FL-- 726

Human   810 EDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQ 874
                                   |.:::...:|  ||.:..:.|..:...||.   |.|      
pombe   727 -----------------------FHNITVSSKH--TAVIFTSDLLMVLKIALN---HPP------ 757

Human   875 FIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLIL 939
             .||                    :|:......|||..:..       .|....:|:.| .|.:|
pombe   758 -YFD--------------------DLATTTFSSLLKRDECT-------ILSFFKILQFY-GCKLL 793

Human   940 NQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYT--------------SCSHLKN--- 987
            :.||       :..||.......|.::..:....||.|..|              .|...:.   
pombe   794 SVDQ-------IWAVVSDVYEAQDNNTTLKQFFNYLLDESTWPEGYLEERHWRSILCKEARKHDS 851

Human   988 --KFGELFSDFCSK---VKNTIY-------CN----VEPSESNMRWAPE-FMIDTLENPAAHTFT 1035
              |..:|....|::   :..||:       ||    |.|.:..:|...| ||||..:....    
pombe   852 GLKLFKLGIKLCTRNEQIMKTIWSFIHVHDCNVISEVIPDQRFLRTLTEHFMIDLRQLDIV---- 912

Human  1036 YTGLGK---SLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTG------YCKSLSAE 1091
             |.|.|   :|.|..|..|:.....|        |.|.:       :|||.      ..:||...
pombe   913 -TCLKKALVTLDEFSAPLYATWLTTL--------DDDEL-------SELTDDVVQKKVLESLDNY 961

Human  1092 WLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSL---ATFVAILIARQCLLLEDL------- 1146
            ..|:.|.:.....|....|..||.      .|..:.|   |.|:..||.....::|.:       
pombe   962 KSGIWKLVLSGLPNCKTVFEHLLL------FSLEERLDLPAAFLQDLIGASAYVMEQVPDSWFLE 1020

Human  1147 -IRCAAIPSL-----LNAACSEQDSEPGARLT--CRILLHLF----KTPQLNPCQS 1190
             :.|....||     |:......||...:|||  |.::||:.    .|.||...:|
pombe  1021 KLPCPLTQSLQSFSHLSNHIEVLDSTRQSRLTFLCHLILHMHGFVELTDQLATLES 1076

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MED12NP_005111.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 12..35 4/22 (18%)
Med12 106..161 CDD:462818 17/55 (31%)
Med12-LCEWAV 286..757 CDD:463472 89/546 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..344 5/30 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 627..669 4/41 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 690..717 4/26 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1241..1266
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1394..1415
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1450..1474
Interaction with CTNNB1 and GLI3. /evidence=ECO:0000269|PubMed:17000779 1616..2051
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1738..1829
Med12-PQL 1819..2022 CDD:463471
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1919..1938
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1967..1989
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2115..2149
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2158..2177
srb8NP_001417945.1 Med12 127..183 CDD:462818 17/55 (31%)
Blue background indicates that the domain is not in the aligned region.

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