|
Human 18 RLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFN--------PAKISSNFS 74
|:|..|||.|:..|:||.||...:|:|: ..|....:......|.|.| ..:..|..:
Worm 8 RMGTADVYKQNKNQEEDMLTTERLKKGY-QMPLTQYELQSLVFNASENKLIRLEKAQKRSQSMIA 71
Human 75 SIIAEKLRCNTLPDTGRRKPQVNQKDNF----WLVTARSQSAINTWFTDLAGTKPLTQLAKKVPI 135
|:|.:|...:...|..|:.|: .|...| | .|..|....:|:.||...||.||::::|.
Worm 72 SVIHKKGEFHMNYDRERKIPK-EQLPCFAPHNW---KRILSDRVKFFSALARGTPLQQLSQRIPG 132
Human 136 FSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVD-PFMEWTQIITK---YLWE 196
|.:||.:|...:.|.:...||.|.:|:.|......|....||..:| ..:|.:|...| :|..
Worm 133 FRRKELLFLEFSDYNISYDRAIWCVKLLCILGFNSSSKTQKKTLLDVATLELSQACNKTTIWLVT 197
Human 197 QLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLEC 261
||.| |...|:.. ..|.:.|:|......:||.||:||:.|||..:.|.
Worm 198 QLYK----------------SFRNPIKR--REATKTWNYLTGFMKYMFDDGVLDKQEFLNDLTEV 244
Human 262 FEKIRPGEDELLKLLLPLLLRYSGEFVQ----SAYLSRRL----------------------AYF 300
|.::...::.....:|...::|...||: |..|:||. ||:
Worm 245 FNQLFLQKNFKNPSVLSTFMKYYVYFVEDLSSSLVLARRSSTLLCQALGFLFEMAQDKRKIDAYY 309
Human 301 CT--------------------------------------------------------------- 302
.:
Worm 310 DSANKTFIKKEFENEDGEIYEFEDYDDFIDMLDEIPDVPYFDETDKTPEAQAEELIKQHEKRKAG 374
Human 303 --------RRLAL---------------------------------------------------- 307
||..|
Worm 375 SLKKSERRRRRGLSKNRPKKMPQNPSNEASLDHDKVQIKQEPMDYDEYGGQQSDNSMDYDSFSHQ 439
Human 308 ----------------------------------------------------------------- 307
Worm 440 YDPSYEPLPFKPLHTDIPKKLTDDEEFKYMKIGKRSVTPERISGRYGSMTYPFWIQQGGVGIDPP 504
Human 308 --------------------QLDGVSSHS-SHVIS------------------------------ 321
|:|..||.| |..:|
Worm 505 KDEVLDFSNPTPTETVNTQPQIDFESSPSASPALSVDKENECEKKEDESKTKEKNKDKEKDKEKE 569
Human 322 ----------------------------------------------------------------- 321
Worm 570 KSVDEHTNDLDVPINPDDAEMADANDKTDASEKQKLVEEEPTGKENEDDTSSKTAKTSTSAEKSE 634
Human 322 ----------------AQSTS--------TLP-------TTPAPQPPTSSTPSTPF--------- 346
|.||| |:| .|..|:..|..|...|.
Worm 635 APSIVDSNDKIDKEPNASSTSNDETSKDDTVPMESDPPAATEKPKESTEITTEEPLEVDKAPEVD 699
Human 347 -------SDLLM----------------------------------------------------- 351
.|:::
Worm 700 KSEKEHEDDIMIIESNKKADEDDCVVIAVVDPDQEQTPESEKKKDGEEERDKNKDTDVADNEPEK 764
Human 352 ---------------------------------------------------CPQHRPLVFGLSCI 365
|.|....:..||.:
Worm 765 IYTDEELAEIKIRKEKEMKIATLASHIKEKMVSDKKWKEKTSHAGWRTLDQCSQFSEALHLLSSM 829
Human 366 LQTILLCCPSALVWHYSLTDSRIK------------TGSPLDHLPIAPSNLPMPEGNSAFTQQVR 418
:|.:....|.:.||: |..:: .|||||:||.....||:.|| .::|.
Worm 830 VQYMACVTPESFVWN----DLSVQQEERRHRILPQLCGSPLDYLPCELHKLPVMEG----VEEVV 886
Human 419 AKLREIEQQIKERGQAVEVRWSFDKCQEATAGF--TIGRVLHT----LEVLDSHSFERSDFSNSL 477
..||....:|..|.||.|.||. ..|.| :.||::.| :.::|:...|: .|::
Worm 887 DCLRLRHCEIVRRSQAAEDRWL------PNAAFLQSFGRIIDTCVDVIGIMDNIDVEK---PNAI 942
Human 478 DSLCNRIFGLGPSKDGHEISSDDDAVVS--LLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAER 540
.:...|:|.. .|.....:|::. |:.:|.::.:|.|..||..:|||| |
Worm 943 TNAGLRLFAF------REKFEKQEALLKTMLMFKWCITEEREGSFRATYIAKLL----------R 991
Human 541 CGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIR 605
.|..: :.:.:|....: .|:..:|:.|:.| ...|:..:..|.:.|.:..|::|
Worm 992 FGMDQ--NPENTIGGWQV--------MDLFFKFMSTEGP---KHGSKMYQAHFDSTVAIMIEMMR 1043
Human 606 HDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDP 670
..:||.......|....||.:.||
Worm 1044 EKIFSITDILRELEKDSDLDYNAP----------------------------------------- 1067
Human 671 SSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEV----KPPPKEKIEGTLGVLYDQPRH 731
|.|...| ..:|...|....||.||..|.| :..||....|....|.::...
Worm 1068 ----LMERQRK-------QKIPKISKRHRKPETPDDTKLVHFTTEYTPKRLFMGKKMDLLERMII 1121
Human 732 VQYATHFPIPQ--EESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLA 794
: :|| .:..:.|...|.::|||:....:......:.|.|.|.|....:...|.|:.:
Worm 1122 I-------LPQLDVDEDTDEYRLRRLLLFGLKPAANVYFRRARAIYKSITKEFTTRLYIEFDRSS 1179
Human 795 PIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSF 859
.:...: :|..:|| .:|:..:|:..:::|||.:..::..|.::.|..|
Worm 1180 KVTTAH------------KKINQNR------LDDLLRQFRAQTYHDQHLILERIVYNFIDGIGGF 1226
Human 860 ALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNE-LSVVEAELLLKSSDLVGS--YTTS 921
.......:|..:....|.::.|:|:.|:.:.|| .:::|. |..|:.::.....|::.. ||.:
Worm 1227 LKKNCDDVPAPEVANIICEMYEFSMDITSIFDF-FEMVNPYLKAVDDKIAHFRMDVLPDMYYTET 1290
Human 922 LCLCIVAVLRHY-------HACLILNQ------------DQMAQ---------VFEGLCGVVKHG 958
..:.:...::|: .||.|:|| |.|.. ||.....:...|
Worm 1291 AFIFVSFFMKHWQRFLLHPRACAIVNQCFVLIQDMIRADDHMITCWGRTVAIFVFHARKAIANAG 1355
Human 959 MNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVK-----NTIYCNVEPSESNMRWA 1018
:...:..:.: ::.:.::.:..|:....|....||.. || .|:..: |.::.:|.
Worm 1356 LQNEEFLAED----SHFWRVFPNAQHVDLDVGYFNEDFAG-VKLQLRGGTLRYD---SYNDFKWL 1412
Human 1019 PEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTG 1083
...|...|:. |...:.|..|||||..|.|.......:.||:|::|..||.:|.
Worm 1413 VSNMKPNLKK------------KPHLKRPNTRYSFVVRAFMEARQHGRNFDRINELANYCANITA 1465
Human 1084 YCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQC-----LLL 1143
....||..|:|.:|.||..|.:....|.::...:|:||.|.|.||.||:..|..:.. ||.
Worm 1466 NDPPLSEYWIGAIKGLCFLSLDAPYPFKEMSQQIDISDCSTHYSLTTFITCLAGKSAFYIPRLLA 1530
Human 1144 E----------------------DLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLN 1186
| |:.|..|..:..:...|| :|||..|...|:..|.
Worm 1531 ELTKHVFPLMLRHDGRLTSQKTHDVKRKVASKTTESRTLSE--AEPGVCLCLLIICGLC------ 1587
Human 1187 PCQSDG-----------NKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVL--------GD 1232
|..|. .|......::.|..::.......:|.|:|..|..:..| .|
Worm 1588 -CVGDEPFGLSVHYRGIEKKKKRFNNTADERIMHLFHWFEMDHAMFRTLGHISQLLEALQSRCRD 1651
Human 1233 AEL-KGSGFTVTG---GTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVG 1293
|.| ....|.:.. ..:||..|: :..|.|...|| ||.|...||:|:||.
Worm 1652 ANLVLPKNFPIKNPPKHQQELHREK----APYRPQYLFNI----------AKTVQFVICEQDWVT 1702
Human 1294 ERCLKSL----CEDSNDLQDPVLSSAQAQRLMQLIC-------YPHRLLDNEDGENPQRQRIKRI 1347
.|..:.. .|..| ||.:..:...|:::::.. ..|:|. |..:..::..:.::
Worm 1703 LRMFRFFQTRKMEAFN--QDKLKQNCLGQQILRMALRRRTERENVHKLF--EAHKISKKATVDKV 1763
Human 1348 LQNLDQWTMRQSSLELQLMIKQ-TPNNE----------MNSLLENIAKATIEVFQQSAETGSSSG 1401
|..::.|..|.:..:|.||||: :|:.. .::|:..|.|...::| .|:.
Worm 1764 LSFMNLWNFRATLFDLMLMIKEISPDGNSRHAQQGAIAADALMSEIGKCCRDMF-------LSAY 1821
Human 1402 STASNMP-SSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQ----------GHVLKAAGEELEKGQ 1455
.|...|| :.:.|...||.:.: .||:|||:...|..:. |.| ||....|...
Worm 1822 KTKIKMPIAKTLTDFRLSDINK--FWLIAPLVRMCPKPINIPPQYANTTVGTV--AAKFLREAAL 1882
Human 1456 HLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQ--DEQREGLLTSLYSQV-------HQIV 1511
.:.:.....::|..|.|.: :|:.||::::||||:.: .:.::..|.|||:|: |...
Worm 1883 LMDTPPTTPKERLLQCSWA-MSKVPFINMILTCLQCEKMQQSKDVFLQSLYTQLQRETLRDHHRR 1946
Human 1512 NNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNN 1576
:||.:.:...|| ...|:.|:|.::..:.::|...| |.:|:.:::..|.::.....
Worm 1947 SNWTNRREHRDC---------TIFRITLIGYIYKEILKATHVET-WGLLIFQLMFHGIINPVREK 2001
Human 1577 ELFTTVLDMLSVLINGTLAADMSSISQ----GSMEENKRAYMNLAKKLQKELGERQSD-SLEKVR 1636
.::.|..|||..::..|| .|..|::| ||:......|..|.||::||:.||.:| :...:.
Worm 2002 LIYETCFDMLHHMVLWTL-VDGDSMNQHDRYGSIRVRWPQYAGLMKKIRKEMQERFTDQTRNSLH 2065
Human 1637 QLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLF-EGLK----- 1695
:.||:.|.....|: :||...:....||:|...|. ||||
Worm 2066 RFLPIGKMQMSTIS---------------------YKKYQKRPKVNQKMSKKFLAGEGLKNGKYS 2109
Human 1696 --PSAP----------------LSWGW----FGTVRVDRRVARGEEQQRLLLYHTHLRP--RPRA 1736
|... :..|| |.|.|:|:.....:...|..::|||:.. ||:.
Worm 2110 FLPEEKAKTNAFEHTDHLGDLIVKGGWKFRMFQTTRLDKVAKNVQNVLRSNMHHTHVLEFNRPQL 2174
Human 1737 ---------YYLEP----------LPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEER 1782
.:|.| .|:|..||| .|....|.||:|.|..:..| :.|:.
Worm 2175 LMSDNMFDDIFLAPPDIEITKIIEQPVPVIDEE-EAKKRAEEEKEAAEKKEESK------NAEDE 2232
Human 1783 K-------KKSTK--------------GKKRSQPATKTEDY-----GMGPGRSGPYGVTVPPDL- 1820
| ||.|| .|::.:.|:|.:|. .:....|.....|..|:.
Worm 2233 KNKNNAENKKDTKEGEKGKSKDKEKDGEKEKCKDASKKDDVTSEKNELEKRASDAAAATNAPETN 2297
Human 1821 ----LHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGP-------RVDPYRPVRLPMQ-KLP---- 1869
...|.|..:|.....:|..|...:|.....||| |.|..:......| ..|
Worm 2298 KDMDTSTPKPAPVTRSPATRGRGGGRKRNSGARGGGPRAKRANSRADTAQAAAATTQWNAPIANT 2362
Human 1870 TRPTYPGVLPTTMTGVMGLEP-----SSYKTSVY------RQQQ--------------------- 1902
:.|...|.....| .|.:| ||.:|.|: |:::
Worm 2363 SNPAAGGNFHAAM---RGNQPPMSNGSSDETKVHIRNLLNRKKEEKRNSLADASAAAAAANSNAM 2424
Human 1903 ----------PAVPQGQRLRQ--QLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQ 1955
|.:|.|..::. ..||.||| ..|||..|.|...|...|....:||
Worm 2425 GNTSSMPPSGPPMPMGSSMQSAGATQQLQGM----QKHQMGGSMSGMNQNMGGMNQSMSH----- 2480
Human 1956 HTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQT 2020
..|| ||.||:....|.: ...|..|..||..|....|:...|.:|
Worm 2481 -------QAPP-----PYSSTNEMNRPLM---------NQYGGPHFAAPNPGPLNRSSGPVSSET 2524
Human 2021 LQQT-------------PMISTMTPMSAQGVQAGVR----------------------------- 2043
.||. .::.......|:..:|..|
Worm 2525 RQQIMEQQMREKLAAHHQLVEQQKQRDAREREAREREAREHQERMQREAYMKEQQLLERKRAIEE 2589
Human 2044 STAILPEQQQQ-----------------------------------------------QQQQQQQ 2061
:..|:.|||:: |::.:::
Worm 2590 NNRIMEEQQREREMEAARKEAARRAAEEAYAAEQQRLELLRRQEEERLRKEAEERMRIQRENEER 2654
Human 2062 QQQQQ-----------------------------------QQQQQQQQQQYHIRQQQQQQILRQQ 2091
.:|:| :|::::|:|:..:|:.::.::.||:
Worm 2655 VRQEQMRLEAEERERIRRAEEERIQKELEDKVRREKEEAARQEKERQEQEARMREAREAELSRQR 2719
Human 2092 QQQQQQQQQQQQQQQQQQQQQQQQHQQQQ----------QQQAAPP---QPQPQSQPQFQRQGLQ 2143
.:||::.||.....||.|..||.....|| ||...|| ||..||..|..:.|.|
Worm 2720 MEQQRRSQQNPYMNQQGQYSQQPPPSYQQSSYPNNYQPGQQGNQPPNYQQPSHQSMQQGHQAGYQ 2784
Human 2144 QTQQQQQTAALVRQLQQQLSNTQPQPSTNIFG 2175
||..|.| ..:|||.:..|..|..:..|
Worm 2785 QTSNQMQ-----MNMQQQQNRQQGGPQQSFSG 2811
| 
