Protein Alignment MED12 and med12

DIOPT Version :10

• Sequence 1: NP_005111.2
• Gene: MED12 / 9968
• HGNCID: 11957
• Length: 2177
• Species: Homo sapiens
• Sequence 2: XP_012824460.1
• Gene: med12 / 100495585
• XenbaseID: XB-GENE-985871
• Length: 2221
• Species: Xenopus tropicalis
• Alignment Length: 2228
• Identity: 1698/2228 - (76%)
• Similarity: 1876/2228 - (84%)
• Gaps: 101/2228 - (4%)

Human     1 MAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFN 65
            ||||||||||||||||||||||||||||.|||||||||||||||||||||||.|||||||||:||
 Frog    44 MAAFGILSYEHRPLKRPRLGPPDVYPQDAKQKEDELTALNVKQGFNNQPAVSADEHGSAKNVNFN 108

Human    66 PAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLA 130
            |||||||||||::||||||||||||||||||||||||.|||.|:||:|||||:|||||||||.||
 Frog   109 PAKISSNFSSIMSEKLRCNTLPDTGRRKPQVNQKDNFMLVTVRTQSSINTWFSDLAGTKPLTHLA 173

Human   131 KKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHV-DPFMEWTQIITKYL 194
            ||||||.|||||||:||:::||||||||||||||||||||:||||||||| ||.:|||||||:||
 Frog   174 KKVPIFGKKEEVFGFLARFSVPVMRAAWLIKMTCAYYAAITETKVKKRHVMDPIIEWTQIITRYL 238

Human   195 WEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVL 259
            ||||||:|:||||   ..|||.|..||:|.:||||::||:|.||||:||||||||||||||||||
 Frog   239 WEQLQKIADYYRP---ALGGCSSPSGPMPPEVEVALKQWEYNEKLALFMFQDGMLDRHEFLTWVL 300

Human   260 ECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQS 324
            |||||||.|||||||||||||||||...|||||||||||||||||||..|:|..||..|:::||:
 Frog   301 ECFEKIRQGEDELLKLLLPLLLRYSNSLVQSAYLSRRLAYFCTRRLAQLLEGSGSHPGHLMTAQT 365

Human   325 TSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIK 389
            .:.||..|||.||:.|.||:||||||.|||||||||||||:||:|:|||||||||||||||:|||
 Frog   366 GTALPPAPAPPPPSGSAPSSPFSDLLQCPQHRPLVFGLSCMLQSIVLCCPSALVWHYSLTDNRIK 430

Human   390 TGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIG 454
            |||||||||||||:||||.|:||||||||.|||::||||||||::|||||||||||||||||.||
 Frog   431 TGSPLDHLPIAPSSLPMPGGSSAFTQQVRRKLRDMEQQIKERGRSVEVRWSFDKCQEATAGFPIG 495

Human   455 RVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGR 519
            |||||||||||||||:|||||:||||.|||||||..|||||||.||||||:|||||||||||.|.
 Frog   496 RVLHTLEVLDSHSFEKSDFSNNLDSLYNRIFGLGLGKDGHEISPDDDAVVTLLCEWAVSCKRYGH 560

Human   520 HRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSA-PIFQDVLLQFLDTQAPMLTD 583
            |||:|||||||||||||||||||:|||.|||||::||||||.|| |:||:|||||||||||||||
 Frog   561 HRALVVAKLLEKRQAEIEAERCGDSEAVDEKGSVSSGSLSALSAPPVFQEVLLQFLDTQAPMLTD 625

Human   584 PRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKE 648
            |.:|||||||:||||||||||||||||||||.|||||||||......|||.||::||:||.:.||
 Frog   626 PANESERVEFYNLVLLFCELIRHDVFSHNMYMCTLISRGDLGIDPHAPRPRSPYEDPSDDTDRKE 690

Human   649 AEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPP 713
            .|.:||.||||..|||:||||..|..|||||||.:|.:|||.|.|||: ||.||  |.:::::..
 Frog   691 GEANSSIKLEDTTLSETMDIDHGSGALFEDMEKSEFPMFSPAMRCEGR-SPGPE--DGDRDIRRT 752

Human   714 PKE-KIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKD 777
            .|. ..||.|..|||||||:|||||||||||||||||||||||||:|||:|||||||.||:||:|
 Frog   753 VKGLNGEGPLSALYDQPRHIQYATHFPIPQEESCSHECNQRLVVLYGVGRQRDDARHIIKRITRD 817

Human   778 ILKVLNRKGTAETDQL--------------APIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAED 828
            ||||||||.|:||.::              .|.:.|:|     .|.::||:|||.:||||||||:
 Frog   818 ILKVLNRKSTSETGKVVVMGKVKQIEKQVNVPKLTLSP-----CGTDEGQRRRRAKPEAFPTAEE 877

Human   829 IFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFA 893
            ||.:||.|||:|||||||||||||||||||||||:|||||||||:|||||||||||:||||||||
 Frog   878 IFCRFQQLSHFDQHQVTAQVSRNVLEQITSFALGLSYHLPLVQHIQFIFDLMEYSLNISGLIDFA 942

Human   894 IQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHG 958
            |||||||||||||||||||.||||||..|||||||||||||.||||||:|.||||||||||||||
 Frog   943 IQLLNELSVVEAELLLKSSSLVGSYTMGLCLCIVAVLRHYHTCLILNQEQTAQVFEGLCGVVKHG 1007

Human   959 MNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMI 1023
            ||||||||||||||||||||||||||||:||||||||||||||||||||||||:|||.|..|||:
 Frog  1008 MNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSDSNMLWEQEFML 1072

Human  1024 DTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSL 1088
            ||:.||:.|:.....|||.||::|.||||||||||:|||.|.||.|||||||||||||||.||:|
 Frog  1073 DTIINPSGHSVNCGMLGKLLSDSPTNRYSFVCNALVHVCAGDHDTDRVNDIAILCAELTGSCKAL 1137

Human  1089 SAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIP 1153
            |:|||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||
 Frog  1138 SSEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILVARQCLLLEDLIRCAAIP 1202

Human  1154 SLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDG 1218
            |||||||||||||.|||||||||||||||||||||:.||:|||||||||||||||||||||||||
 Frog  1203 SLLNAACSEQDSEAGARLTCRILLHLFKTPQLNPCEPDGSKPTVGIRSSCDRHLLAASQNRIVDG 1267

Human  1219 AVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVL 1283
            |||||||||||||||||:||||:...||:...||:    ...||.|||.:|:||||||.||||||
 Frog  1268 AVFAVLKAVFVLGDAELRGSGFSHPTGTDNASEED----IATRRAGGRPVSIETASLDEYAKYVL 1328

Human  1284 RSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRIL 1348
            |||||||||||||::||||||||||||||||||||||||||||||||.|.|.|:||||||||.||
 Frog  1329 RSICQQEWVGERCVRSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLNDTEQGDNPQRQRIKHIL 1393

Human  1349 QNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAE--------TGSSSGSTAS 1405
            |||||||||||:|||||||||||:|||||||||||||||||||||||        :.:.|.:|:|
 Frog  1394 QNLDQWTMRQSALELQLMIKQTPSNEMNSLLENIAKATIEVFQQSAENACAAPANSAALSNATSS 1458

Human  1406 NMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQ 1470
            |.|.:||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||
 Frog  1459 NAPPNSKTKPVLSSLERSGAWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQ 1523

Human  1471 KSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKL 1535
            ||||||||||||||||||||||||||||||||||.||.|||:|||:|||.||||..||:|:.|||
 Frog  1524 KSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYGQVQQIVSNWREDQYQDDCKTPQLLHDVLKL 1588

Human  1536 RLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSS 1600
            |||||||||||||||||||||||:|||:||.||||||||||||||||||||||||||||||||||
 Frog  1589 RLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSS 1653

Human  1601 ISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKI 1665
            ||||||||||||||||.|||:||||:|||:|||||||||||||||||||||||||||||||||||
 Frog  1654 ISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKI 1718

Human  1666 AGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHL 1730
            ||||||||||||||||||||||||||||:|.||||||||||||||||||:|.|||||||||||||
 Frog  1719 AGFDSIFKKEGLQVSTKQKISPWDLFEGIKQSAPLSWGWFGTVRVDRRVSRMEEQQRLLLYHTHL 1783

Human  1731 RPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPG-AAPPSTEERKK--KSTKGKKR 1792
            :|:||:||||.|||||||||||.||..||:||..|..|.||.| ....:|::|||  |..:.|||
 Frog  1784 KPKPRSYYLENLPLPPEDEEPPTPTSTEPDKKLSEALKVDKSGVGGTTNTDDRKKPSKPKREKKR 1848

Human  1793 SQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVD- 1856
            :...:|.|::.:||||.||||: ||.||||....| ::.|.|  .:..:|.||||||.||||:|
 Frog  1849 NMAPSKVEEFPLGPGRPGPYGM-VPTDLLHTQAAG-MSRLPY--ATQNMYAQNQPLPPGGPRLDN 1909

Human  1857 PYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQQ--SQ 1919
            .|||.|:.|.|:|.||.|...:|  ..|:|    .|||..:|| .||.:||||.||||||.  :|
 Frog  1910 SYRPTRMAMVKVPARPQYVSGVP--QAGMM----DSYKPVMYR-PQPPIPQGQLLRQQLQAKLAQ 1967

Human  1920 GMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGP--AGTMVPPSYSSQPYQSTHPSTNP 1982
            ||:.| .|.||:.:.|||....||||.|.||:.||||..|  ||.:|||.||:|.|..:.|.:..
 Frog  1968 GMMPQ-PVRQMSQTPSYGSMQPQGYTSYGSHMTLQQHPPPSQAGALVPPPYSTQQYPGSLPPSGG 2031

Human  1983 TLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAI 2047
            .|:||.|.:||||||||||||..:.|..::.|||.||.:.||.|:.:|..::.|.|...:| ..:
 Frog  2032 ALLDPVRQMQQRPSGYVHQQASGFSHSASAGQRFPHQQITQTGMMPSMGHLTTQPVTGAIR-PQL 2095

Human  2048 LPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQ 2112
            ||||||||||||                  ::|   |||||| ||||||||||||||||||||||
 Frog  2096 LPEQQQQQQQQQ------------------YLR---QQQILR-QQQQQQQQQQQQQQQQQQQQQQ 2138

Human  2113 QQQHQQQQQQQAAP----------PQPQPQSQP--------QFQRQGLQQTQQQQQTAALVRQLQ 2159
            |||:|...||||.|          ||||.|.||        ||||||||||||||||||||||||
 Frog  2139 QQQNQAPPQQQAPPQPPPQQVPTVPQPQTQGQPPGLGMQTLQFQRQGLQQTQQQQQTAALVRQLQ 2203

Human  2160 QQLSNTQPQPSTNIFGRY 2177
            ||||:||||.::|.||||
 Frog  2204 QQLSSTQPQQNSNPFGRY 2221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED12	NP_005111.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	12..35		21/22 (95%)
		Med12	106..161	CDD:462818	44/54 (81%)
		Med12-LCEWAV	286..757	CDD:463472	361/472 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..344		10/20 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	627..669		23/41 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	690..717		10/27 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1241..1266		7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1394..1415		10/28 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1450..1474		23/23 (100%)
		Interaction with CTNNB1 and GLI3. /evidence=ECO:0000269|PubMed:17000779	1616..2051		268/442 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1738..1829		50/93 (54%)
		Med12-PQL	1819..2022	CDD:463471	103/207 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1919..1938		9/18 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1967..1989		8/21 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2115..2149		26/51 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2158..2177		13/18 (72%)
med12	XP_012824460.1	Med12	148..204	CDD:462818	45/55 (82%)
		Med12-LCEWAV	329..797	CDD:463472	361/470 (77%)
		Med12-PQL	1874..2070	CDD:463471	103/206 (50%)