DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment OXSR1 and hpo

DIOPT Version :9

Sequence 1:	XP_011532633.1	Gene:	OXSR1 / 9943	HGNCID:	8508	Length:	580	Species:	Homo sapiens
Sequence 2:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster

Alignment Length:	486	Identity:	152/486 - (31%)
Similarity:	218/486 - (44%)	Gaps:	96/486 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    77 GSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDEL 141
            |.|:...|   |.|..||..:|..|.|...::.:.|::|||..|.||..|.:|.||.|:..:.:|
  Fly    49 GEGSYGSV---YKAVHKESSSIVAIKLVPVESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDL 110

Human   142 WLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNIL 206
            |:.|:....|||.||::       .:...|.|..|||||.:.|:||.|||...:||||:||.|||
  Fly   111 WICMEYCGAGSVSDIMR-------LRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANIL 168

Human   207 LGEDGSVQIADFGVSAFLATGGDITRNKV-RKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITA 270
            |..:|..::|||||:      |.:|.... |.|.:|||.||||||:|:: |||..|||||.||||
  Fly   169 LNTEGYAKLADFGVA------GQLTDTMAKRNTVIGTPFWMAPEVIEEI-GYDCVADIWSLGITA 226

Human   271 IELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTA 335
            :|:|.|..||.:..||:.:.:..|..|||....       .::...|...:|.||.|:|:.|.||
  Fly   227 LEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREP-------DRWSTEFIDFVSKCLVKEPDDRATA 284

Human   336 AELLRHKFFQKAKNKEFLQEKTLQRAPTISERAKKVRRVPG----SSGRLHKTEDGGWEW--SDD 394
            .|||.|:|.:.||::..| :..|:....|.|:.:..|...|    |..:...|::.|.:.  :|:
  Fly   285 TELLEHEFIRNAKHRSIL-KPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHITDN 348

Human   395 EFDEESEEGKAAISQLRSPRVKESISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQV 459
            .|.|                              || |||  |||:...:....|       :..
  Fly   349 AFME------------------------------DP-GTL--VPEKFGEYQQSSA-------SDA 373

Human   460 SLPPTAEPAKTAQALSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISA 524
            ::...||.......|..|.              |||..|          .....|...:...:..
  Fly   374 TMIAHAEQGVDEGTLGPGG--------------LRNLSK----------AAAPAAASSAASPLDM 414

Human   525 GLVDGRDLVIVAANLQKIVEEPQSNRSVTFK 555
            ..||...:|.:.:||..:|....|:.|.|.|
  Fly   415 PAVDSGTMVELESNLGTMVINSDSDDSTTAK 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OXSR1	XP_011532633.1	STKc_OSR1_SPAK	77..344	CDD:270787	109/267 (41%)
OXSR1	XP_011532633.1	S_TKc	77..344	CDD:214567	109/267 (41%)
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	109/267 (41%)
		S_TKc	42..293	CDD:214567	109/267 (41%)
		Mst1_SARAH	608..655	CDD:288481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910