Protein Alignment CDC25A and stg

DIOPT Version :10

• Sequence 1: NP_001780.2
• Gene: CDC25A / 993
• HGNCID: 1725
• Length: 524
• Species: Homo sapiens
• Sequence 2: NP_524547.1
• Gene: stg / 43466
• FlyBaseID: FBgn0003525
• Length: 479
• Species: Drosophila melanogaster
• Alignment Length: 467
• Identity: 146/467 - (31%)
• Similarity: 222/467 - (47%)
• Gaps: 74/467 - (15%)

Human    97 NLENPMRRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLH 161
            |:.|......|: .|:.|...|.:.....|:|.:.....|.|...:::    ::...|...|.|.
  Fly    17 NISNNTSSSSSI-NKMSGSRRARRSLELMSMDQEELSFYDDDVVPQDQ----QRSASPELMGLLS 76

Human   162 SHGLQEGKDLFTQRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGEN 226
            ..|..:...:..| ....||..:||:.    .|.....:|...|...:..|..||.:::|.:.|:
  Fly    77 PEGSPQRFQIVRQ-PKILPAMGVSSDH----TPARSFRIFNSLSSTCSMESSMDDEYMELFEMES 136

Human   227 LKNEEET----PSCMASLWT------------APLVMRTTNLDNRCKLFDSPSLCSSST------ 269
              ..::|    ||.:.||.:            |.|.||..:: .||......:..|::|
  Fly   137 --QSQQTALGFPSGLNSLISGQIKEQPAAKSPAGLSMRRPSV-RRCLSMTESNTNSTTTPPPKTP 198

Human   270 ---RSVLKRPERSQEESPPGST-----KRRKSMSGASPKES------------TNPEKAHETLHQ 314
               |...||||      ||.|.     :.::....|..||:            ::|....:.:..
  Fly   199 ETARDCFKRPE------PPASANCSPIQSKRHRCAAVEKENCPAPSPLSQVTISHPPPLRKCMSL 257

Human   315 SLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKE 379
            :.:...|.....||  .|:| :|||||||.|....:.|:|:|||.||.|.:|.:|.|:|::.:..
  Fly   258 NDAEIMSALARSEN--RNEP-ELIGDFSKAYALPLMEGRHRDLKSISSETVARLLKGEFSDKVAS 319

Human   380 FVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLL--------KKPIVPTDGKRVIVVFHCEFSSE 436
            :.|||||||||:|||||:||.||:..|::.|..|        ::....:..||.|::||||||||
  Fly   320 YRIIDCRYPYEFEGGHIEGAKNLYTTEQILDEFLTVQQTELQQQQNAESGHKRNIIIFHCEFSSE 384

Human   437 RGPRMCRYVR--ERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKEDLK 499
            |||:|.|::|  :|:|..|.||.|||||:|:|..||||||......|||.:||.|....:.|..:
  Fly   385 RGPKMSRFLRNLDRERNTNAYPALHYPEIYLLHNGYKEFFESHVELCEPHAYRTMLDPAYNEAYR 449

Human   500 KFRTKSRTWAGE 511
            .||.||::|.|:
  Fly   450 HFRAKSKSWNGD 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDC25A	NP_001780.2	Phosphodegron	74..84
		M-inducer_phosp	86..328	CDD:461962	53/272 (19%)
		KEN box	141..143		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..317		14/78 (18%)
		Cdc25	357..475	CDD:238788	64/127 (50%)
stg	NP_524547.1	Cdc25	297..425	CDD:238788	64/127 (50%)