DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF14 and CIN8

DIOPT Version :9

Sequence 1:	NP_055690.1	Gene:	KIF14 / 9928	HGNCID:	19181	Length:	1648	Species:	Homo sapiens
Sequence 2:	NP_010853.2	Gene:	CIN8 / 856648	SGDID:	S000000787	Length:	1000	Species:	Saccharomyces cerevisiae

Alignment Length:	1157	Identity:	274/1157 - (23%)
Similarity:	460/1157 - (39%)	Gaps:	363/1157 - (31%)

- Green bases have known domain annotations that are detailed below.

Human   326 QERSAENTILPEEETVVQNTSAGKDPLKVENSQVTVAVRVRPFTKREKIEKASQVV----FMSGK 386
            |:||: |:|...     .|:..|...:..|...:|||||.|...:||...|:|.||    ....|
Yeast    10 QDRSS-NSISKN-----GNSQVGCHTVPNEELNITVAVRCRGRNEREISMKSSVVVNVPDITGSK 68

Human   387 EITVEHPD----TKQVYNFIYDVSFWSFDECHPHYASQTTVYEKLAAPLLERAFEGFNTCLFAYG 447
            ||::....    |.|:     :...::.|:.....|||..:::::|.||.:...:|:|..:..||
Yeast    69 EISINTTGDTGITAQM-----NAKRYTVDKVFGPGASQDLIFDEVAGPLFQDFIKGYNCTVLVYG 128

Human   448 QTGSGKSYTMMG--------FSEEPGIIPRFCEDLFSQVARKQTQEVSYHIEMSFFEVYNEKIHD 504
            .|.:||:|||.|        .|:..|||||....||..:   :.|:..|.::.||.|:|||::.|
Yeast   129 MTSTGKTYTMTGDEKLYNGELSDAAGIIPRVLLKLFDTL---ELQQNDYVVKCSFIELYNEELKD 190

Human   505 LLVCKDEN----------GQ--------------------------------------------- 514
            ||   |.|          ||
Yeast   191 LL---DSNSNGSSNTGFDGQFMKKLRIFDSSTANNTTSNSASSSRSNSRNSSPRSLNDLTPKAAL 252

Human   515 -RKQPLRVREHP-------------------------------------------------VYGP 529
             ||: ||.:..|                                                 ..|.
Yeast   253 LRKR-LRTKSLPNTIKQQYQQQQAVNSRNNSSSNSGSTTNNASSNTNTNNGQRSSMAPNDQTNGI 316

Human   530 YVEALSMNIVSSYADIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHR 594
            |::.|....:::..:..:.|:.|.|.|..|:|.|||.|||||::||:      |.:.:.::...|
Yeast   317 YIQNLQEFHITNAMEGLNLLQKGLKHRQVASTKMNDFSSRSHTIFTI------TLYKKHQDELFR 375

Human   595 ITSRINLIDLAGSERCSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQANQRSVFIPYRESVLT 659
            | |::||:||||||..:.:.....|.||..|||:||||||:||:||.:    :|..||:|||.||
Yeast   376 I-SKMNLVDLAGSENINRSGALNQRAKEAGSINQSLLTLGRVINALVD----KSGHIPFRESKLT 435

Human   660 WLLKESLGGNSKTAMIATISPAASNIEETLSTLRYANQARLIVNIAKVNE-DMNAKLIRELKAEI 723
            .||::|||||:|||:|||||||....|||.|||.||::|:.|.|..::.. .|...|::.:..|:
Yeast   436 RLLQDSLGGNTKTALIATISPAKVTSEETCSTLEYASKAKNIKNKPQLGSFIMKDILVKNITMEL 500

Human   724 AKLKA-------------AQRNSRNI--DPERYR----LCRQEITSLRMKLHQQERDMAEMQRVW 769
            ||:|:             :|.:.:|:  |.|.|:    .|::||.||..|.....:|..:.:...
Yeast   501 AKIKSDLLSTKSKEGIYMSQDHYKNLNSDLESYKNEVQECKREIESLTSKNALLVKDKLKSKETI 565

Human   770 KEKFEQAEKRKLQETKELQKAGIMFQMDNHLPNLVNL----NEDPQLSEMLLYMIKEGTTTVGKY 830
            :.:..|.|  .|:.|.:..:|    |:|......:.:    |:..:|:|::...:.:       |
Yeast   566 QSQNCQIE--SLKTTIDHLRA----QLDKQHKTEIEISDFNNKLQKLTEVMQMALHD-------Y 617

Human   831 KPNSSHDIQLSGVLIADDHCT--IKNFGGTVSIIPVGEAKTYVNGKHILEITVLRHGDRVILGGD 893
            |   ..::.|:...  :.|.|  ||....|:                .|::..::  ...||
Yeast   618 K---KRELDLNQKF--EMHITKEIKKLKSTL----------------FLQLNTMQ--QESIL--- 656

Human   894 HYFRFNHPVEVQKGKRPSGRDTPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMMQGI 958
                               ::|.|.   .:.:..|||:|...|:..|          |.|:|.
Yeast   657 -------------------QETNIQ---PNLDMIKNEVLTLMRTMQE----------KAELMY-- 687

Human   959 QIAKEMAQQELSSQKAAYESKIKALE-----------------AELREESQRKKMQEINNQ--KA 1004
               |:..::.|:.....:...|:.::                 :::.||:...| |.:.|.  |.
Yeast   688 ---KDCVKKILNESPKFFNVVIEKIDIIRVDFQKFYKNIAENLSDISEENNNMK-QYLKNHFFKN 748

Human  1005 NHKIEELEKAKQHLEQEIYVNKKRLEMETLATKQALEDHSIRHAR-ILEALETEKQK-IAKEVQI 1067
            ||:    |...:|::......:||........|:.|.||...:.: |::.|.|.... |.:|:.:
Yeast   749 NHQ----ELLNRHVDSTYENIEKRTNEFVENFKKVLNDHLDENKKLIMQNLTTATSAVIDQEMDL 809

Human  1068 LQQNRNNRDKTFTVQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDISDKSSSDTSIRVRNLKL 1132
            .:..|...:.:|.:.....||.....    |::::.|...          ||:.|||....|..:
Yeast   810 FEPKRVKWENSFDLINDCDSMNNEFY----NSMAATLSQI----------KSTVDTSSNSMNESI 860

Human  1133 GISTFWSLEKFESKLAAMKELYESNGSNRGEDAFCDPEDEWEPDITDAPVSSLSRRRSRSLMKNR 1197
            .:.. ..:|:.|:.::.:|...:.|             |::|..|..
Yeast   861 SVMK-GQVEESENAISLLKNNTKFN-------------DQFEQLINK------------------ 893

Human  1198 RISGCLHDIQVHPIKN-LHSSHS--SGLMDKSSTI------YSN----SAESFLPGICKELIGSS 1249
                  |::....||| :.|:||  :.:.|..:||      |.|    :.:..:..|.||:
Yeast   894 ------HNMLKDNIKNSITSTHSHITNVDDIYNTIENIMKNYGNKENATKDEMIENILKEI---- 948

Human  1250 LDFFGQSYDEERTIADSLINSFLKIYNGLFAI--SKAHEEQDE----ESQDN 1295
                 .:..::..:..|.|||     |.:.::  .|.|..:||    |:.||
Yeast   949 -----PNLSKKMPLRLSNINS-----NSVQSVISPKKHAIEDENKSSENVDN 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF14	NP_055690.1	Required for PRC1-binding	1..356		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Required for microtubule-binding with high affinity. /evidence=ECO:0000250\|UniProtKB:L0N7N1	356..737		154/517 (30%)
		KISc_KIF1A_KIF1B	357..708	CDD:276816	146/471 (31%)
		KISc	358..708	CDD:214526	146/470 (31%)
		Kinesin_assoc	705..823	CDD:292801	28/141 (20%)
		FHA	803..900	CDD:238017	14/102 (14%)
		Required for CIT-binding	901..1648		81/435 (19%)
		YlqD	962..>1022	CDD:287979	13/78 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1600..1648
CIN8	NP_010853.2	KISc_BimC_Eg5	34..486	CDD:276815	146/474 (31%)
		Smc	<493..>772	CDD:224117	63/359 (18%)
		CCDC158	677..>928	CDD:318193	58/322 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910