DRSC/TRiP Functional Genomics Resources

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Protein Alignment KIF14 and Klp98A

DIOPT Version :9

Sequence 1:NP_055690.1 Gene:KIF14 / 9928 HGNCID:19181 Length:1648 Species:Homo sapiens
Sequence 2:NP_524532.2 Gene:Klp98A / 43310 FlyBaseID:FBgn0004387 Length:1265 Species:Drosophila melanogaster


Alignment Length:1341 Identity:403/1341 - (30%)
Similarity:603/1341 - (44%) Gaps:329/1341 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   357 SQVTVAVRVRPFTKREKIEKASQVVFMSGKEITVEHPDTKQV--------YNFIYDVSFWSFDEC 413
            |.:.||||||||..||....|..::.|..|:..:..|..:.:        ::|.:|.|:||||..
  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAE 66

Human   414 HPHYASQTTVYEKLAAPLLERAFEGFNTCLFAYGQTGSGKSYTMMGFSEEPGIIPRFCEDLFSQV 478
            .||:|:|..||..|...:::.|:||:|.|:||||||||||::||||....||:|||.||:||:::
  Fly    67 DPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELFARM 131

Human   479 ARKQTQEVSYHIEMSFFEVYNEKIHDLLVCKDENGQRKQPLRVREHPVYGPYVEALSMNIVSSYA 543
            ...|.....|....|:.|:|||::.|||..:...    ..||||||...|||||.||.:.||.:.
  Fly   132 RVGQESGTGYRTHASYLEIYNERVKDLLAAQSTG----HGLRVREHRSLGPYVENLSQHAVSDFD 192

Human   544 DIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSE 608
            :||..:..||.||.||:|.|||.|||||::||:...|.    |...:......|:|:|:||||||
  Fly   193 EIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQA----VFMNDMPSETVSKIHLVDLAGSE 253

Human   609 RCSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQ------------------ANQRSVFIPYRE 655
            |.:.....|.|||||..|||||:|||.|||||:||                  |::|.::||||:
  Fly   254 RANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRD 318

Human   656 SVLTWLLKESLGGNSKTAMIATISPAASNIEETLSTLRYANQARLIVNIAKVNEDMNAKLIRELK 720
            |:||||||:||||||||.|||.:|||..|..||||||||||:|:.|:|...||||.|.||||||:
  Fly   319 SILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELR 383

Human   721 AEIAKLKAAQRNS-RNIDPERYRLCRQEITSLRMKLHQQERDMAE--MQRVWKEKFEQAEKRKLQ 782
            .||.|||:..... .::.|           ||::....|:::..|  :...|.||::.|:. .||
  Fly   384 EEINKLKSMLAGDIHSLQP-----------SLKVLADLQKKEAQEKVLTEEWTEKWKVAQS-ILQ 436

Human   783 ETKE--LQKAGIMFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHDIQLSGVLI 845
            |.|.  |:|:|:...:|:.:|:|:.::.| ..:.:.||.:|||.|.:|....:.:.||:|:|..|
  Fly   437 EQKSLGLRKSGVGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGI 500

Human   846 ADDHCTIKNFGGTVSIIPVGEAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQK---- 906
            ...||:|...||.|::.|...|:.:||...|.|...:..||.::||..:.||||:|.|..|    
  Fly   501 RAQHCSIFLKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKD 565

Human   907 --------------------------------------------GKRPSGRDTP--ISEGPKDFE 925
                                                        .:||..||.|  ..|..|..:
  Fly   566 LSRSQLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILD 630

Human   926 FAKNEL--LMAQRSQLEAEIK-------EAQLKAKEEMMQGIQI----------AKEMAQQELSS 971
            ..:|.|  |..:|.|:..:.|       |..::.::|.|.|:|:          .|:|...|.::
  Fly   631 TIENALKQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNN 695

Human   972 QKAAYE---SKIKALEAEL----REESQ--RKKMQEINN----QKANHKIEE------------- 1010
            :|...:   .:|.|.:.:|    |:.|:  .|::||:.:    .:...||||             
  Fly   696 EKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLNDELLLQVS 760

Human  1011 --LEK-AKQHLEQEIYVNKKRLEM--ETLATKQALEDHSIRHARILEALETEKQKIAK------E 1064
              |:. |.|.::..:..|.:.:..  |.:|.|:          |||.|..|   ||||      |
  Fly   761 DSLDLFAAQFIKDTVRRNNEEIRKLDEQIAEKE----------RILNASTT---KIAKVDETMLE 812

Human  1065 VQI-LQQNRNNRDKTFTVQTTWSSMKLSMMIQEAN-AISSKLKTYYVFGRHDISDKSSSDTSIRV 1127
            :|. |::.|..|.::........:.|.:|.:|..| ::|:...|      ::..|.|.|||    
  Fly   813 IQAQLERLRLERAESEAESQAMRAKKQNMKLQLGNKSMSTSTST------NEADDVSKSDT---- 867

Human  1128 RNLKLGISTFWSLEKFESKLAAMKELYESNGSNRG-EDAFCDPEDEWEPDITDAPVSSLSRRRSR 1191
                  ..|..:....:|.|:.:.....:.|.... .:..||.|||.| |.....:|..|...||
  Fly   868 ------YETCDTFHTAQSNLSLVSSPTITEGQQSPLSNCSCDAEDEAE-DTRKDDLSGSSEETSR 925

Human  1192 SLMKNRRISGCLHDIQVHPIKNLHSSHSSGLMDKSSTI-YSNSAESFLP---------GICKELI 1246
            :         |.            :..|||....|..| .|.||.|..|         |:|    
  Fly   926 T---------CT------------AGPSSGSGSGSVGIGGSGSAPSCTPSSQAIMSDSGVC---- 965

Human  1247 GSSLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEESQDNL-FSSDRA-----IQS 1305
               ||...|:.         |.|..|..|..  |:..:.|:....|...| ..||.|     :.|
  Fly   966 ---LDSRNQAI---------LQNGHLNNYKQ--AVRTSDEDTGSCSSCELGRHSDVARPYCPLHS 1016

Human  1306 LTIQTACAFEQLVVLMKHWLSDLLPCTNIARLEDELRQEVKKLGGYLQLFLQGCCLDISSMIKEA 1370
            |..:.|.   |..::||:..:||    |.|:|::.:..                       :::.
  Fly  1017 LRRKIAA---QKALIMKNLETDL----NKAQLDEHIAD-----------------------LQDL 1051

Human  1371 QKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAVCDGVGLGMKILLD--SGL 1433
            |:..||:.|:.::                        |||:....|.|         ..|  ||:
  Fly  1052 QRRYIQMEQEMLQ------------------------SVQDLEAHAQC---------CADERSGM 1083

Human  1434 EKAKELQHELFRQCTKNEVTKEMKTNAM---GLIRSLENI--FAESK----IKSF--RRQVQEEN 1487
            |:..||...:.|....:..:.|..|:.:   .:.||..::  |.|.:    |.||  |...::.:
  Fly  1084 ERQYELASSIMRSSVMSPTSMEESTSQIYSPSMTRSCPSMREFPEGEHFITIPSFVMRGAGKQTH 1148

Human  1488 FEYQ------DFK-RMVNRAPEFLKLKHCLEKAIEIIISAL 1521
            :||:      |.| .::.|...|.:|..|::......||||
  Fly  1149 YEYEVRIALPDGKLNILRRYSRFRELHLCMKHCYGAKISAL 1189

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KIF14NP_055690.1 Required for PRC1-binding 1..356
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
Required for microtubule-binding with high affinity. /evidence=ECO:0000250|UniProtKB:L0N7N1 356..737 191/406 (47%)
KISc_KIF1A_KIF1B 357..708 CDD:276816 175/376 (47%)
KISc 358..708 CDD:214526 174/375 (46%)
Kinesin_assoc 705..823 CDD:292801 39/122 (32%)
FHA 803..900 CDD:238017 33/96 (34%)
Required for CIT-binding 901..1648 160/766 (21%)
YlqD 962..>1022 CDD:287979 19/88 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1600..1648
Klp98ANP_524532.2 KISc_KIF1A_KIF1B 2..371 CDD:276816 175/376 (47%)
KISc 3..371 CDD:214526 174/375 (46%)
Kinesin_assoc 370..478 CDD:292801 39/120 (33%)
FHA 456..555 CDD:238017 34/99 (34%)
PX_KIF16B_SNX23 1131..1259 CDD:132784 16/59 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0245
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D123768at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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