DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF14 and Kif14

DIOPT Version :9

Sequence 1:	NP_055690.1	Gene:	KIF14 / 9928	HGNCID:	19181	Length:	1648	Species:	Homo sapiens
Sequence 2:	XP_006529793.2	Gene:	Kif14 / 381293	MGIID:	1098226	Length:	1717	Species:	Mus musculus

Alignment Length:	1703	Identity:	1189/1703 - (69%)
Similarity:	1364/1703 - (80%)	Gaps:	84/1703 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSLHSTHNRNNSGDILDIPSSQNSSSLNALTHSSRLKLHLKSDMSECENDDPLLRSAGKVRDINR 65
            ||:|::|:|:|.|. |::.|||..|:.:.|.|||||:||||:|||||||.||.:.:..|..|||.
Mouse     1 MSVHTSHSRHNIGS-LEVSSSQKISASSGLVHSSRLELHLKADMSECENHDPFVNAGSKTIDINS 64

Human    66 TYVISASRKTADMPLTPNPVGRLALQRRTT-RNKESSLLVSELEDTTEKTAETRLTLQRR-AKTD 128
            ||||||.:||.:.|:|.:| .||:||||.| .::|||||.|||.:  .:||:|.|.|||| .:.|
Mouse    65 TYVISACKKTRETPVTSDP-RRLSLQRRATCGDRESSLLGSELGN--RRTADTSLRLQRRHGRAD 126

Human   129 SAEKWKTAEIDSVKMTLN-VGGETENNGVSKESRTNVRIVNNAKNSFVASSVPLDEDPQVIEMMA 192
            ...||:         ||| |||...::..|:.|||..:.|||  ::.|.|||...:|.....:
Mouse   127 YVGKWE---------TLNPVGGNPGSDSASQASRTEAKGVNN--DTRVLSSVVSVKDSNDTGL-- 178

Human   193 DKKYKETFSAPSRANENVALKYSSNRPPIASLSQTEVVRSGHLTTKPTQSKLDIKVLGTGNLYHR 257
             .:.|:.......:||.|.:|.:::|.|:.|..|||.:|||||..:.|:||.|..|.|..|.:..
Mouse   179 -TRCKDPGPPVGASNEKVTVKDTNSRAPVGSQRQTEAMRSGHLVVQLTESKSDTPVSGGRNSHRG 242

Human   258 SIGKEIAKTSNKFGSLEKRTPTKCTTEHKLT---------------------------------- 288
            :.||:.||....|||.:.|||.||..||:.|
Mouse   243 NAGKDTAKQVGTFGSSDTRTPVKCVLEHRWTPRHDPPPPKSPALSTPKNNGKDIPKHGSTFRSAS 307

Human   289 ------TKC----------SLPQLKSPAPSILKNRMSNLQVKQRPKSSFLANKQERSAENTILPE 337
                  .||          .||..||||.|.||||:::.:||.|||||..|||:|.|.|:|:.||
Mouse   308 SESRTPVKCVPEHRWTPRHDLPPPKSPALSTLKNRIASPRVKPRPKSSLFANKRESSRESTLPPE 372

Human   338 EETVVQNTSAGKDPLKVENSQVTVAVRVRPFTKREKIEKASQVVFMSGKEITVEHPDTKQVYNFI 402
            |.::||.|....|.|||||||||||||||||:||||.||||||||.:|:||||||||.||||:||
Mouse   373 ENSLVQKTFTEPDSLKVENSQVTVAVRVRPFSKREKTEKASQVVFTNGEEITVEHPDMKQVYSFI 437

Human   403 YDVSFWSFDECHPHYASQTTVYEKLAAPLLERAFEGFNTCLFAYGQTGSGKSYTMMGFSEEPGII 467
            |||||||||||||.|||||||||.||||||:|||||:||||||||||||||||||||.:||||||
Mouse   438 YDVSFWSFDECHPGYASQTTVYETLAAPLLDRAFEGYNTCLFAYGQTGSGKSYTMMGLNEEPGII 502

Human   468 PRFCEDLFSQVARKQTQEVSYHIEMSFFEVYNEKIHDLLVCKDENGQRKQPLRVREHPVYGPYVE 532
            ||||||||:|:|:|||.|||||:|||||||||||||||||||.||||||||||.|||||.|||||
Mouse   503 PRFCEDLFAQIAKKQTSEVSYHLEMSFFEVYNEKIHDLLVCKGENGQRKQPLRAREHPVSGPYVE 567

Human   533 ALSMNIVSSYADIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITS 597
            .||||:||||:|||||||||||||||||||||||||||||||||||||||||.||||||||||||
Mouse   568 GLSMNVVSSYSDIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEVVEGEEHDHRITS 632

Human   598 RINLIDLAGSERCSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQANQRSVFIPYRESVLTWLL 662
            ||||:||||||||||||::|.|||||||||||||||||||||||||||.:.||||||||.|||||
Mouse   633 RINLVDLAGSERCSTAHSSGQRLKEGVSINKSLLTLGKVISALSEQANGKRVFIPYRESTLTWLL 697

Human   663 KESLGGNSKTAMIATISPAASNIEETLSTLRYANQARLIVNIAKVNEDMNAKLIRELKAEIAKLK 727
            |||||||||||||||:|||||||||||||||||.|||||||||||||||||||||||||||.|||
Mouse   698 KESLGGNSKTAMIATVSPAASNIEETLSTLRYATQARLIVNIAKVNEDMNAKLIRELKAEIEKLK 762

Human   728 AAQRNSRNIDPERYRLCRQEITSLRMKLHQQERDMAEMQRVWKEKFEQAEKRKLQETKELQKAGI 792
            ||||::|||||||||||||||||||||||||||||||:||||||||||||||||||||||||||:
Mouse   763 AAQRSNRNIDPERYRLCRQEITSLRMKLHQQERDMAEIQRVWKEKFEQAEKRKLQETKELQKAGV 827

Human   793 MFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHDIQLSGVLIADDHCTIKNFGG 857
            .||||||||||||||||||||||||||:|||.|||||:.|:|||||||||||||||||||:||||
Mouse   828 TFQMDNHLPNLVNLNEDPQLSEMLLYMVKEGVTTVGKHTPSSSHDIQLSGVLIADDHCTIRNFGG 892

Human   858 TVSIIPVGEAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRPSGRDT-PISEGP 921
            ||||:|.|||||||||.||.|.|||.|||||:|||||||||||||||||||:.|.|:. ..||||
Mouse   893 TVSIVPAGEAKTYVNGTHISEPTVLHHGDRVVLGGDHYFRFNHPVEVQKGKKLSSRNNLTTSEGP 957

Human   922 KDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMMQGIQIAKEMAQQELSSQKAAYESKIKALEAE 986
            |||||||||||.||||:||||||:|||||||||||||||||||||||||||||.||.||:|||||
Mouse   958 KDFEFAKNELLTAQRSRLEAEIKDAQLKAKEEMMQGIQIAKEMAQQELSSQKAVYERKIQALEAE 1022

Human   987 LREESQRKKMQEINNQKANHKIEELEKAKQHLEQEIYVNKKRLEMETLATKQALEDHSIRHARIL 1051
            ||||||||:::|:|||||:|||||||:||||||||:||||:||||||||||||||||.|||||||
Mouse  1023 LREESQRKRLEELNNQKASHKIEELERAKQHLEQEVYVNKRRLEMETLATKQALEDHRIRHARIL 1087

Human  1052 EALETEKQKIAKEVQILQQNRNNRDKTFTVQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDIS 1116
            ||||.||||||:|||:||:||.|||||||:|..|:|||||.|||||||||.|.|..|:|||||.|
Mouse  1088 EALEIEKQKIAEEVQMLQENRGNRDKTFTIQPNWNSMKLSTMIQEANAISDKFKKCYIFGRHDAS 1152

Human  1117 DKSSSDTSIRVRNLKLGISTFWSLEKFESKLAAMKELYESNGSNRGEDAFCDPEDEWEPDITDAP 1181
            ||..||||:|||||:|||||||||||||||||||||||||||.:|.||.||||.||||||||..|
Mouse  1153 DKGRSDTSVRVRNLQLGISTFWSLEKFESKLAAMKELYESNGGDRDEDVFCDPADEWEPDITSTP 1217

Human  1182 VSSLSRRRSRSLMKNRRISGCLHDIQVHPIKNLHSSHSSGLMDKSSTIYSNSAESFLPGICKELI 1246
            |||||||||||||||||:|||||||  |||:::.||||||||:|.|||||||:||||||||||||
Mouse  1218 VSSLSRRRSRSLMKNRRVSGCLHDI--HPIQSMQSSHSSGLMEKPSTIYSNSSESFLPGICKELI 1280

Human  1247 GSSLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEESQDNLFSSDRAIQSLTIQTA 1311
            |||:||.|||:|||:||||||||:.|:::||:.|||||||||||||||||| ||||.|:||||.|
Mouse  1281 GSSIDFLGQSFDEEKTIADSLINNLLRLHNGVIAISKAHEEQDEESQDNLF-SDRAAQALTIQVA 1344

Human  1312 CAFEQLVVLMKHWLSDLLPCTNIARLEDELRQEVKKLGGYLQLFLQGCCLDISSMIKEAQKNAIQ 1376
            |||||||||.||||.|.||||..|||||||||::|||||||||||||||.|||||:||||...::
Mouse  1345 CAFEQLVVLFKHWLGDFLPCTGSARLEDELRQDIKKLGGYLQLFLQGCCSDISSMVKEAQNKVMK 1409

Human  1377 IVQQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAVCDGVGLGMKILLDSGLEKAKELQH 1441
            |:||||:.||||||||||||..||| ::|.:|.| |||.|:.|||..|||.|||||||.|::|:.
Mouse  1410 IIQQAVQCVGQLAVLKGSKLCVLEN-SSKVSSTQ-EFMAALQDGVTSGMKSLLDSGLETAQDLRQ 1472

Human  1442 ELFRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRRQVQEENFEYQDFKRMVNRAPEFLKL 1506
            :|.||..:.||||:||.:.:..:.||||..||.:.||||.|.||.:  .|...::::.|.|||||
Mouse  1473 DLSRQSAREEVTKQMKASTVEWVGSLENAVAEWRTKSFRTQAQEGS--RQQVSKLLSLASEFLKL 1535

Human  1507 KHCLEKAIEIIISALKGCHSDINLLQTCVESIRNLASDFYSDFSVPSTSVGSYESRVTHIVHQEL 1571
            |.||::.:|:|:|||:||.||::.|::|.|:|.:||...:||||..|.|.||..:.:.....:||
Mouse  1536 KSCLQQTVEMIVSALRGCPSDLHCLRSCTETICSLARKLHSDFSAHSASAGSCGNELPRADCEEL 1600

Human  1572 ESLAKSLLFCFESEESPDLLKPWETYNQNTKEEHQQSKSSGIDGSKNKGVPKRVYELHG-SSPAV 1635
            ||||||||.|||..|||.|.||||:.:.|:|||  |.||...|..|:.  |:|..|.|| ::|||
Mouse  1601 ESLAKSLLLCFECGESPGLSKPWESCSSNSKEE--QCKSDRADCGKSG--PRRACEPHGDATPAV 1661

Human  1636 SSEECTPSRIQWV 1648
            ||.:|||:||||:
Mouse  1662 SSGDCTPNRIQWL 1674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF14	NP_055690.1	Required for PRC1-binding	1..356		165/407 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		12/25 (48%)
		Required for microtubule-binding with high affinity. /evidence=ECO:0000250\|UniProtKB:L0N7N1	356..737		342/380 (90%)
		KISc_KIF1A_KIF1B	357..708	CDD:276816	315/350 (90%)
		KISc	358..708	CDD:214526	314/349 (90%)
		Kinesin_assoc	705..823	CDD:292801	110/117 (94%)
		FHA	803..900	CDD:238017	83/96 (86%)
		Required for CIT-binding	901..1648		531/748 (71%)
		YlqD	962..>1022	CDD:287979	50/59 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1600..1648		25/48 (52%)
Kif14	XP_006529793.2	AF-4	<161..>384	CDD:368289	76/225 (34%)
		KISc_KIF1A_KIF1B	392..743	CDD:276816	315/350 (90%)
		Kinesin_assoc	740..859	CDD:374417	111/118 (94%)
		FHA	838..935	CDD:238017	83/96 (86%)
		SMC_prok_B	<937..>1109	CDD:274008	144/171 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83960883
Domainoid	1	1.000	1037	1.000	Domainoid score	I1538
eggNOG	1	0.900	-	-		E2759_KOG0245
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8916
Inparanoid	1	1.050	2237	1.000	Inparanoid score	I1223
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41382
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	1	1.000	-	-		FOG0006888
OrthoInspector	1	1.000	-	-		oto128158
orthoMCL	1	0.900	-	-		OOG6_108291
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4992
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.310