Protein Alignment KIF14 and kif14

DIOPT Version :10

• Sequence 1: NP_055690.1
• Gene: KIF14 / 9928
• HGNCID: 19181
• Length: 1648
• Species: Homo sapiens
• Sequence 2: XP_004913798.2
• Gene: kif14 / 100493263
• XenbaseID: XB-GENE-981231
• Length: 1609
• Species: Xenopus tropicalis
• Alignment Length: 1714
• Identity: 861/1714 - (50%)
• Similarity: 1130/1714 - (65%)
• Gaps: 196/1714 - (11%)

Human    14 DILDIPSSQN--SSSLNALTH--SSRLKLHLKSDMSECENDDPLLRSAGKVRDINRTYVISASRK 74
            |:..:.::||  .|..||:.:  :|.:|....:|....:...  |.|:.|.:::|.||||||.:|
 Frog    13 DVYGVLAAQNRPHSKPNAVNNIIASPVKKGTFADGIGVKQQK--LLSSNKSKEVNTTYVISACKK 75

Human    75 TADMPLTPNPVGRLALQRRTTRNKESSLLVSELEDTTEK--TAETRLTLQRRAKTDSAEKWKTAE 137
            :.....|..|..:|.|||| .|:.:.|....|..:|..|  ..:.|||||||.:|
 Frog    76 SQASLKTSRPGSKLILQRR-ERSSKGSPHAEEGTETINKQDCTDRRLTLQRRLRT---------- 129

Human   138 IDSVKMTLNVGGETEN---NGVSKE-----------SRTNVRIVNNAKNSFVASSVPLDEDPQVI 188
                       |.|||   |.:::|           ..|...:...:|.:...||..:..
 Frog   130 -----------GSTENARPNKITEEVLQHCLPMEHLDITPGSLAGPSKFTVKMSSKDIKS----- 178

Human   189 EMMADKKYKETFSAPSRANENVALKYSSNRPPIASLSQTEVVRSGHLTTKPTQSKLDIKV---LG 250
            |||     .:.|:|       |:.|.|   ||.:.||..|.:.    |....:||...||   :|
 Frog   179 EMM-----NKDFNA-------VSGKMS---PPKSELSSAEPLN----TQVEGRSKEADKVGPIVG 224

Human   251 T----GNLYHRSIGKEIAKTSNKFGSLEKRTPTKCTTEHKLTTKCSLPQLKSP------------ 299
            |    ||....|:||.         ..||:||        :|.|..|.|.:.|
 Frog   225 TLGIKGNDKGSSLGKP---------GQEKKTP--------VTKKNGLDQQRMPQLGATSLSRSSS 272

Human   300 -----APSILKNR-MSNLQVKQRPKS----SFLANKQERSAE-----NTILPEEETVVQNTSAGK 349
                 :|.:...| ::.|...|:..|    |..:.:.|:||:     :.|.|:.:|...|.:..:
 Frog   273 TRNIRSPQVTPKRVVATLPASQKKNSSTPGSVYSGRSEKSADVCLSSDEIQPKGDTAFSNFNLEE 337

Human   350 DPLKVENSQVTVAVRVRPFTKREKIEKASQVVFMSGKEITVEHPDTKQVYNFIYDVSFWSFDECH 414
            :..|.||..||||||||||:|||..|||.|||||:|:|.||:|||:||.|.|.||.|||||::..
 Frog   338 EHFKAENCAVTVAVRVRPFSKREVNEKAVQVVFMNGQETTVQHPDSKQNYIFCYDFSFWSFEKSQ 402

Human   415 PHYASQTTVYEKLAAPLLERAFEGFNTCLFAYGQTGSGKSYTMMGFSEEPGIIPRFCEDLFSQVA 479
            |.:..|.:||||||.||||.:..|:|||||||||||||||||||||..|||||||||.||||::.
 Frog   403 PSFVGQASVYEKLAVPLLEWSLLGYNTCLFAYGQTGSGKSYTMMGFDGEPGIIPRFCSDLFSRIQ 467

Human   480 RKQTQEVSYHIEMSFFEVYNEKIHDLLVCKDENGQRKQPLRVREHPVYGPYVEALSMNIVSSYAD 544
            ....|::|:|:|:|:||||||||||||:.|.||||:||||:|||||:.|||||.||||:|||:.|
 Frog   468 ATMKQKLSFHLEISYFEVYNEKIHDLLIFKAENGQKKQPLKVREHPLTGPYVEDLSMNVVSSFQD 532

Human   545 IQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSER 609
            ||||||||||||||||||||||||||||||||||||||||:|:|:||||||||||||:|||||||
 Frog   533 IQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEYVDGQEHDHRITSRINLVDLAGSER 597

Human   610 CSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQANQR-SVFIPYRESVLTWLLKESLGGNSKTA 673
            ||||.|:|:||||||||||||||||||||||||.:..| ..|||||||||||||||||||||||:
 Frog   598 CSTAQTSGERLKEGVSINKSLLTLGKVISALSENSQTRKKTFIPYRESVLTWLLKESLGGNSKTS 662

Human   674 MIATISPAASNIEETLSTLRYANQARLIVNIAKVNEDMNAKLIRELKAEIAKLKAAQRNSRNIDP 738
            |||||||||:|:||||||||||.|||||:|:||||||:|||:||||||||.|:||:|.:::|.|.
 Frog   663 MIATISPAATNMEETLSTLRYAKQARLIINVAKVNEDLNAKIIRELKAEIEKMKASQLSAKNKDS 727

Human   739 ERYRLCRQEITSLRMKLHQQERDMAEMQRVWKEKFEQAEKRKLQETKELQKAGIMFQMDNHLPNL 803
            |:||.|.||:|||::||.||||:|:|::|.||:|.||||:||..|.:|||||||.|:|||.||||
 Frog   728 EKYRQCHQEVTSLKLKLCQQEREMSELRRAWKDKLEQAEQRKKVEMQELQKAGITFKMDNRLPNL 792

Human   804 VNLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHDIQLSGVLIADDHCTIKNFGGTVSIIPVGEAK 868
            ||||||||||||||||||||.|||||||..|||||||||.|||:|||.|.|....|.|.|.|:||
 Frog   793 VNLNEDPQLSEMLLYMIKEGQTTVGKYKAGSSHDIQLSGALIAEDHCIITNNENIVCIKPFGDAK 857

Human   869 TYVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRPSGRDTPISEGPKDFEFAKNELLM 933
            |||||..|...|:|.||||:|||||||||.|||:||.:    ....|.:|:||||:||||||||.
 Frog   858 TYVNGNQISGSTILHHGDRLILGGDHYFRVNHPMEVNR----LNATTQVSDGPKDYEFAKNELLS 918

Human   934 AQRSQLEAEIKEAQLKAKEEMMQGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQE 998
            ||||||..||:||:|:||||||:|||||||||||||:|||.|||.||:.|||:|::|||.|::||
 Frog   919 AQRSQLAEEIEEARLRAKEEMMEGIQIAKEMAQQELTSQKFAYEEKIRDLEAQLKKESQHKELQE 983

Human   999 INNQKANHKIEELEKAKQHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAK 1063
            :|:|:|..:|:|||:.|.||:||:..|||||||||||||||||||::|||:||:|||.|||||||
 Frog   984 MNSQRATTRIQELEEMKIHLQQEVQFNKKRLEMETLATKQALEDHNVRHAKILQALEAEKQKIAK 1048

Human  1064 EVQILQQNRNNRDKTFTVQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDISDKSSSDTS---I 1125
            |||:||:.||::|:...||.||::||||:||||||:||||||.:.||.|||::||.:..|:   |
 Frog  1049 EVQMLQRERNSQDRAMAVQPTWNNMKLSVMIQEANSISSKLKKHTVFSRHDVTDKENLPTNPVQI 1113

Human  1126 RVRNLKLGISTFWSLEKFESKLAAMKELYESNGSNRGEDAFCDPEDEWEPDITDAPVSSLSRRRS 1190
            :|:||||||.|:|||||||.||||||:|||::||.:.:|.|.||.||||||:::..||..|||
 Frog  1114 QVKNLKLGIVTYWSLEKFEYKLAAMKDLYENHGSTKDDDVFYDPGDEWEPDLSNTSVSRFSRR-- 1176

Human  1191 RSLMKNRRISGCLHDIQVHPIKNLHSSHSSGLMDK-------SSTIYSNSAESFLPGICKELIGS 1248
            :||||||||||||::|:||||::|.|.|:||||:|       ||::.||.::|.||||||:||.|
 Frog  1177 KSLMKNRRISGCLYEIRVHPIQSLQSGHASGLMNKSSSFLSCSSSVSSNPSDSHLPGICKDLIAS 1241

Human  1249 SLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEESQDNLFSSDRAIQSLTIQTACA 1313
            |||:.|:|:.:|..:|||:|:|..:...|:..:|:|:|:|.|:|.|.||.::|..||.::|...|
 Frog  1242 SLDYLGRSHVDESNMADSMIDSVKRACIGVRTVSQAYEQQKEDSTDMLFLANREAQSHSVQLTSA 1306

Human  1314 FEQLVVLMKHWLSDLLPCTNIARLEDELRQEVKKLGGYLQLFLQGCCLDISSMIKEAQKNAIQIV 1378
            |:|||||.|||...|.....:.:..|.:...::||||||||.||||..||:||:.||:..:..|.
 Frog  1307 FQQLVVLNKHWPRLLPEIQEMTKPADNVSLYIRKLGGYLQLLLQGCTSDIASMVTEARDKSFHIA 1371

Human  1379 QQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAVCDGVGLGMKILLDSGLEKAKELQHEL 1443
            :|.::.:||||.|..::|||||........:|:.|..:|.:|:..|::.:::|.|:...::...:
 Frog  1372 EQILQNIGQLAALTNTELHFLEEELKDEKDLQKLFSRSVSEGLRFGLQSIMESVLKATHDIYTHI 1436

Human  1444 FRQCTKNEVTKEMKTNAMGLIRSLE-----------NIFAESKIKSFRRQVQEENFEYQDFKRMV 1497
            .|...::|...|:||||:.|...|:           ||..:..:.|.|..:   ....::.:.::
 Frog  1437 QRFIVQDEHLTEIKTNAIRLTTFLQKCLANCVKLDLNILLKDSVFSIRSSL---TIGLRNLRSIM 1498

Human  1498 NRAPEFLKLKHCLEKAIEIIISALKGCHSDINLLQTCVESIRNLASDFYSDFSVPSTSVGSYESR 1562
            :|    |:|         .::|||:|..:|:.:|.:....|...:|....:..:.|..|
 Frog  1499 DR----LRL---------AVVSALEGADADVPILLSLKHDIVECSSQINRNLLLLSPQV------ 1544

Human  1563 VTHIVHQELESLAKSLLFCFESEESPDLLKPWETYNQNTKEE---HQQSKSSGIDGSKNKGVPKR 1624
               |..|:||:|.:||:.|...|:   :..|     :.:||:   |.:|:....:.::|
 Frog  1545 ---IGLQDLEALTQSLMQCLCREQ---VAGP-----RRSKEQVAGHGRSREKMDEHARN------ 1592

Human  1625 VYELHGSSPAVSSEECTPSRIQWV 1648
               ||    .......:||.||||
 Frog  1593 ---LH----TWQHNTFSPSAIQWV 1609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF14	NP_055690.1	Required for PRC1-binding	1..356		98/395 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		4/14 (29%)
		Required for microtubule-binding with high affinity. /evidence=ECO:0000250|UniProtKB:L0N7N1	356..737		294/381 (77%)
		KISc_KIF1A_KIF1B	357..708	CDD:276816	273/351 (78%)
		Kinesin_assoc	705..823	CDD:465047	84/117 (72%)
		FHA_KIF14	794..901	CDD:438759	80/106 (75%)
		Required for CIT-binding	901..1648		349/770 (45%)
		Smc	<927..>1077	CDD:440809	107/149 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1600..1648		11/50 (22%)
kif14	XP_004913798.2	KISc_KIF1A_KIF1B	347..697	CDD:276816	273/349 (78%)
		Kinesin_assoc	694..812	CDD:465047	84/117 (72%)
		FHA_KIF14	783..890	CDD:438759	80/106 (75%)
		Smc	<912..>1063	CDD:440809	108/150 (72%)