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Protein Alignment MFN2 and Marf

DIOPT Version :9

Sequence 1:	NP_001121132.1	Gene:	MFN2 / 9927	HGNCID:	16877	Length:	757	Species:	Homo sapiens
Sequence 2:	NP_572320.2	Gene:	Marf / 31581	FlyBaseID:	FBgn0029870	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	752	Identity:	354/752 - (47%)
Similarity:	508/752 - (67%)	Gaps:	32/752 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    27 SPLKHFVTAKKKINGIFEQLGAYIQESATFLEDTYRNAELDPVTTEEQVLDVKGYLSKVRGISEV 91
            |||:.||.||||||.|:.::..|:.|:.||:...:..||:  |...|:.| .:.|:.||..|.||
  Fly    71 SPLQIFVRAKKKINDIYGEIEEYVHETTTFINALHAEAEI--VDKAEREL-FESYVYKVAAIREV 132

Human    92 LARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVEGTDGHEAFLLTEGSEEKRS 156
            |.|.|||||||||||||||:||||||.:|:||||||||||||.:|||::|.||:|:|||||||.:
  Fly   133 LQRDHMKVAFFGRTSNGKSSVINAMLREKILPSGIGHTTNCFCQVEGSNGGEAYLMTEGSEEKLN 197

Human   157 AKTVNQLAHALHQDKQLHAGSLVSVMWPNSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCLDAD 221
            ...:.|||:||.|:| |...|||.:.||..:|.||:||:|.:||||:||:..||.|||..||:||
  Fly   198 VVNIKQLANALCQEK-LCESSLVRIFWPRERCSLLRDDVVFVDSPGVDVSANLDDWIDNHCLNAD 261

Human   222 VFVLVANSESTLMQTEKHFFHKVSERLSRPNIFILNNRWDASASEPEYME----EVRRQHMERCT 282
            |||||.|:|||:.:.||.|||.||::||:||||||||||||||:|||..|    :|:.||.|||.
  Fly   262 VFVLVLNAESTMTRAEKQFFHTVSQKLSKPNIFILNNRWDASANEPECQESELAKVKSQHTERCI 326

Human   283 SFLVDELGVVDRSQAGDRIFFVSAKEVLNARIQKAQGMPEGGGALAEGFQVRMFEFQNFERRFEE 347
            .||..||.|.:..:|.:|:|||||:|.|.|||::|:|.|...||:|||||:|.||||:|||:|||
  Fly   327 DFLTKELKVSNEKEAAERVFFVSARETLQARIEEAKGNPPHMGAIAEGFQIRYFEFQDFERKFEE 391

Human   348 CISQSAVKTKFEQHTVRAKQIAEAVRLIMDSLHMAAREQQVYCEEMREERQ----DRLKFIDKQL 408
            |||||||||||:||:.|.|.::..::.::|:::    |:......::::::    :|::..:.|:
  Fly   392 CISQSAVKTKFQQHSSRGKSVSGDMKSMLDNIY----ERITIFRNLKQDQKNLLTERIQGTETQM 452

Human   409 ELLAQDYKLRIKQITEEVERQVSTAMAEEIRRLSVLVDDYQMDFHPSPVVLKVYKNELHRHIEEG 473
            ..:.::.|::|..:.||||.:||.|:.|||.||.||:|::.|.|||..:||.:||.||:.|:|.|
  Fly   453 MQVTREMKMKIHNMVEEVEEKVSKALNEEIWRLGVLIDEFNMPFHPERLVLNIYKKELNAHVESG 517

Human   474 LGRNMSDRCSTAITNSLQTMQQDMIDGLKPLLPVS--VRSQIDMLVPRQCFSLNYDLNCDKLCAD 536
            ||.|:..|.|.|:..::::.|.:|.|.:..|:|..  :.:...|:|..|.|.:.|.|||..||||
  Fly   518 LGSNLRARLSMALAMNVESAQTEMTDRMHALVPNEQLLATSTKMVVRTQPFEMLYSLNCQNLCAD 582

Human   537 FQEDIEFHFSLGWTMLVNRFLG-----PKNSRRALMGYNDQV--------QRPIPLTPANPSMPP 588
            ||||:||.||.|...::.||.|     .|..:.||:.....:        ..|:..||......|
  Fly   583 FQEDLEFKFSWGIAAMIQRFTGKVRERSKKGQPALVNRQSSIGHSVSTPTTTPVEATPVCLLPAP 647

Human   589 LPQGSLTQEEFMVSMVTGLASLTSRTSMGILVVGGVVWKAVGWRLIALSFGLYGLLYVYERLTWT 653
            :..| :|.|:..:.....::|:.|:.::|.|||.||:.|.:|||::.....|||.:|:||||:||
  Fly   648 VVAG-ITPEQLSLISRFAVSSIGSQGTVGGLVVAGVMLKTIGWRVLVGVGALYGCIYLYERLSWT 711

Human   654 TKAKERAFKRQFVEHASEKLQLVISYTGSNCSHQVQQELSGTFAHLCQQVDVTRENLEQEIAAMN 718
            ..||||.||.|:|.||::||::::..|.:|||||||||||.|||.||:.||....::..|:..::
  Fly   712 NSAKERTFKSQYVRHATKKLKMIVDLTSANCSHQVQQELSSTFARLCRTVDTATTDMNDELKTLD 776

Human   719 KKIEVLDSLQSKAKLLRNKAGWLDSELNMFTHQYLQP 755
            .::.:|::.|.:.|||||||.::.:||::|.|.|:.|
  Fly   777 SQLNILEANQKQLKLLRNKANYIQNELDIFEHNYISP 813

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.