DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZBTB5 and CG6654

DIOPT Version :9

Sequence 1:	NP_055687.1	Gene:	ZBTB5 / 9925	HGNCID:	23836	Length:	677	Species:	Homo sapiens
Sequence 2:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	451	Identity:	99/451 - (21%)
Similarity:	157/451 - (34%)	Gaps:	129/451 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   272 VPSQSDNSAGNMAQLSMASRATQVETSFDQEAAPEKSSFQCENPEVGLGEKEHMRVVVKS----- 331
            :|.:.|:.......::...:|.|. ||::    |::.:...:...|...:.|....::||
  Fly    84 LPEEPDSKVSISCPVATTDQAVQT-TSWE----PDRCTASVQTDAVTTTDAEQNTSLIKSTISVD 143

Human   332 -------EPLSSPEPQDEVSDVTS---QAEGSESVEVEGVVVSAEKIDLSPESSDRSFSDPQSST 386
                   |......|.:.|...||   |.:|:...|.|.|..                   |::.
  Fly   144 LDYEGEGEVFDYELPDEPVEKTTSLILQVQGNLKDEKEVVFT-------------------QTNV 189

Human   387 DRVGDIHILE-------------VTNNLEHKSTFSISNFLNKSRGNNFTANQNNDDNIP-NTTSD 437
            ...||.|.||             |.|..|..:..:......||.....|..:|:....| .:..:
  Fly   190 IYEGDDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKEE 254

Human   438 CR-LESEAPYLLSPEAG--------------PAGGPSSAPGSHVENPFSEPADSHFVRPMQEVMG 487
            .| ||.|.    .|::.              ||..||.|          ||:........|..:.
  Fly   255 ARELEKEQ----VPQSAKRTSRRRGVVKQDVPATPPSDA----------EPSPKQHRLGTQRKLS 305

Human   488 LPCVQT----SGYQGGE-----QFGMDFSRSGLGLHSSFSRVMIGSPRGGASNFPYYRRIAPKMP 543
            .|...|    |...|..     ::..|...:|..:..|   :||...:.|..|..|......|:
  Fly   306 APRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKS---LMIHRRQKGCINRNYKCNECEKV- 366

Human   544 VVTSVRSSQIPENSTSSQLMMNGATSSFENGHPSQPGPPQLTRASADVLSKCKKALSEHNVLVVE 608
               .|....:.|:..|     :||.:..|.|                :....|:|||:|   :|:
  Fly   367 ---FVSPDHLAEHQAS-----HGAHNCPECG----------------IRCDSKEALSKH---MVQ 404

Human   609 GAR---KYACKICCKTFLTLTDCKKHIRVHTGEKPYACLKCGKRFSQSS----HLYKHSKT 662
            |.:   :..|.||.|.|..|:..:.|:|:||||||:.|..|||.|:|::    |..:||:|
  Fly   405 GHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSET 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZBTB5	NP_055687.1	BTB	14..119	CDD:279045
		BTB	25..119	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..252
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..312		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..387		12/70 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..474		7/40 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	552..585		6/32 (19%)
		C2H2 Zn finger	615..635	CDD:275368	8/19 (42%)
		zf-H2C2_2	627..652	CDD:290200	13/24 (54%)
		C2H2 Zn finger	643..662	CDD:275368	9/22 (41%)
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	6/25 (24%)
		COG5048	<357..570	CDD:227381	40/137 (29%)
		C2H2 Zn finger	360..380	CDD:275368	4/28 (14%)
		C2H2 Zn finger	385..406	CDD:275370	8/39 (21%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	13/23 (57%)
		C2H2 Zn finger	442..490	CDD:275368	10/24 (42%)
		C2H2 Zn finger	470..487	CDD:275368
		zf-H2C2_2	482..507	CDD:290200
		C2H2 Zn finger	498..518	CDD:275368
		zf-H2C2_2	510..534	CDD:290200
		C2H2 Zn finger	526..546	CDD:275368
		zf-H2C2_2	539..563	CDD:290200
		C2H2 Zn finger	554..574	CDD:275368
		C2H2 Zn finger	582..602	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000