Protein Alignment IQSEC1 and GEA2

DIOPT Version :10

• Sequence 1: NP_001363867.1
• Gene: IQSEC1 / 9922
• HGNCID: 29112
• Length: 1222
• Species: Homo sapiens
• Sequence 2: NP_010892.1
• Gene: GEA2 / 856691
• SGDID: S000000748
• Length: 1459
• Species: Saccharomyces cerevisiae
• Alignment Length: 1062
• Identity: 215/1062 - (20%)
• Similarity: 366/1062 - (34%)
• Gaps: 359/1062 - (33%)

Human   204 YELSSDLQDKQV---------EMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENR 259
            :|.|..|.|..|         .:::..||..|........:||.......|:..|.||::.....
Yeast   154 FEGSQQLSDDSVLLKVVFLLRSIVDSPYGDLLSNSIIYDVLQTILSLACNNRRSEVLRNAAQSTM 218

Human   260 MSRRI-VLSNMRMQFSFEGPEKVHSSYFEGKQVSVTND---GSQLGALV-SPECGDLSEPTTLKS 319
            ::..: :.|.::   :.| |..|:..|...:  |.|||   ...:|..| |.|.|...:|..:|
Yeast   219 IAVTVKIFSKLK---TIE-PVNVNQIYINDE--SYTNDVLKADTIGTNVESKEEGSQEDPIGMK- 276

Human   320 PAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEE----APALDAARARDTEPQTAL- 379
                       ...|:|.|.         ||.:....:|:|:    |..||..: :.|...:.:
Yeast   277 -----------VNNEEAISE---------DDGIEEEHIHSEKSTNGAEQLDIVQ-KTTRSNSRIQ 320

Human   380 -HGMDHRKL-----------------DEMTASYSDVTLYIDEEELSPPLPLSQAGDR-------- 418
             :..|:..|                 :|:..|||  |.....|.:...|.:|  |||
Yeast   321 AYADDNYGLPVVRQYLNLLLSLIAPENELKHSYS--TRIFGLELIQTALEIS--GDRLQLYPRLF 381

Human   419 ---------------PSSTE-------------------SDLRLRAGGAAPDYWALAHKEDKADT 449
                           .::|:                   ::|:|:........:::...:..|:.
Yeast   382 TLISDPIFKSILFIIQNTTKLSLLQATLQLFTTLVVILGNNLQLQIELTLTRIFSILLDDGTANN 446

Human   450 DTS-CRSTPSLERQEQRLRVEHLPLLTIEPPS---------DSSVDLSDRSER--GSLKRQSAYE 502
            .:| .::.||:.::   |.:|.:.:|....||         |.::|.:|.|..  .:|.:.:..|
Yeast   447 SSSENKNKPSIIKE---LLIEQISILWTRSPSFFTSTFINFDCNLDRADVSINFLKALTKLALPE 508

Human   503 RSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSI 567
            .:|...:..|.                             :.:.|..:..........|.|.:..
Yeast   509 SALTTTESVPP-----------------------------ICLEGLVSLVDDMFDHMKDIDREEF 544

Human   568 NSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKK 632
            ....|..:.:      ..||                              ||..:....|.||:|
Yeast   545 GRQKNEMEIL------KKRD------------------------------RKTEFIECTNAFNEK 573

Human   633 PEKGVQYLIERGFV-PDTPVGVAHFLLQRKG-LSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFST 695
            |:||:..|||:||: .|:...:|.||..... ::::.||..|.:..|.   .:|:..:...|||.
Yeast   574 PKKGIPMLIEKGFIASDSDKDIAEFLFNNNNRMNKKTIGLLLCHPDKV---SLLNEYIRLFDFSG 635

Human   696 MELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNP----------------- 743
            :.:|||:|......|:.||:|::||:|||||..||      ..|..:|
Yeast   636 LRVDEAIRILLTKFRLPGESQQIERIIEAFSSAYC------ENQDYDPSKISDNAEDDISTVQPD 694

Human   744 -DTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELK 807
             |::|||:::||:||||:::|.||  ..|..||:..||:|..:.:|.|...|..||..||.:|:.
Yeast   695 ADSVFILSYSIIMLNTDLHNPQVK--EHMSFEDYSGNLKGCCNHKDFPFWYLDRIYCSIRDKEIV 757

Human   808 TNEDH--------------------VSQVQK-----VEKLI--------------VGKKPIGSL- 832
            ..|:|                    :::::|     ::||.              ||...:.:|
Yeast   758 MPEEHHGNEKWFEDAWNNLISSTTVITEIKKDTQSVMDKLTPLELLNFDRAIFKQVGPSIVSTLF 822

Human   833 ---------HPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKK 888
                     |.....:.||.....:  ...|:..|               ||||:|
Yeast   823 NIYVVASDDHISTRMITSLDKCSYI--SAFFDFKD---------------LFNDIL--------- 861

Human   889 KNSV----------------TYSFRQSFSLYGMQVLL---FE--NQYYP---NGIRLTSSVPGAD 929
             ||:                |.:|.     ||...|:   ||  |...|   :.:|...|..| .
Yeast   862 -NSIAKGTTLINSSHDDELSTLAFE-----YGPMPLVQIKFEDTNTEIPVSTDAVRFGRSFKG-Q 919

Human   930 IKVLINFN-APNPQDRKKFTDDLRESIAEV---------------QEMEKHRIESELEKQKGVVR 978
            :..::.|. ....:|.|.|:.:|..:|..:               .:::|....|.|.|
Yeast   920 LNTVVFFRIIRRNKDPKIFSKELWLNIVNIILTLYEDLILSPDIFPDLQKRLKLSNLPK------ 978

Human   979 PSMSQCSSLKKESGNGTLSRACLDDSYASG-EGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNV 1042
            || .:.|..|.:...|.||...   ||..| |......:.||.:.:.........:|....|||:
Yeast   979 PS-PEISINKSKESKGLLSTFA---SYLKGDEEPTEEEIKSSKKAMECIKSSNIAASVFGNESNI 1039

Human  1043 EGSII----SSPHMRRRATSTR 1060
            ...:|    .|....:.|.::|
Yeast  1040 TADLIKTLLDSAKTEKNADNSR 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IQSEC1	NP_001363867.1	Sec7	618..806	CDD:460178	71/207 (34%)
		IQ_SEC7_PH	838..967	CDD:465120	30/168 (18%)
GEA2	NP_010892.1	Sec7_N	350..489	CDD:463703	23/145 (16%)
		Sec7	559..756	CDD:460178	71/207 (34%)