Protein Alignment IQSEC1 and SYT1

DIOPT Version :10

• Sequence 1: NP_001363867.1
• Gene: IQSEC1 / 9922
• HGNCID: 29112
• Length: 1222
• Species: Homo sapiens
• Sequence 2: NP_015420.1
• Gene: SYT1 / 856210
• SGDID: S000006299
• Length: 1226
• Species: Saccharomyces cerevisiae
• Alignment Length: 712
• Identity: 147/712 - (20%)
• Similarity: 253/712 - (35%)
• Gaps: 195/712 - (27%)

Human   197 SRSLSESYELSSDLQDKQVEMLERKYGGRLVT----------RHAARTIQTAFRQYQMNKNFERL 251
            ::|:|...:|.. ||....:....|.||..|:          .:.:..:|.|..|...|.:.::|
Yeast     2 NQSISSLIKLKF-LQSHSNDKNGNKKGGSNVSTGIDKLRESESYRSPFLQLAEIQEHTNNDDDKL 65

Human   252 -----RSSMSENRMSRRIVLSNM-RMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLG-ALVSPECG 309
                 ..:...:::||  :...| |:..:|.               |....||:.. .||:....
Yeast    66 DVKECEPTKKHSKLSR--IRRKMGRLDLNFR---------------SANEKGSEDDEILVAQHLR 113

Human   310 DLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTE 374
            :..:|..:  |..|.:..|:|.::......:| :|..|..|.:...|.|   ||.:....|.:..
Yeast   114 NGQDPEEM--PFKSENNIDSIEKVPKPDGERV-TLTSSGSDNVKRNSKH---APFIPVKPALEKF 172

Human   375 PQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLP----LSQAGDRPSSTESDLRLRAGGAAP 435
            |.:.....|:||..|.|....|        .|.|.||    :|.:....|||          ||.
Yeast   173 PSSNRLSRDYRKSQEPTLFNGD--------RLVPTLPTVSRISTSSSVGSST----------AAS 219

Human   436 DYWALAHKEDKADTDTSCRS-------------TPSLERQEQRLRVEHLPLLTIEPPSDSSVDLS 487
            .|:..:.:...|.:.:|..|             ||.:|..:|:   :.:...........:||:.
Yeast   220 RYFNPSKRAVVASSSSSSSSIKFNSLHAIPLDATPQIELAKQQ---DEISKRRFGRRRSRTVDVF 281

Human   488 DRSERGSLKRQ------SAYERSLGG-------QQGSPKHGP------------HSGAPKSLPRE 527
            |...:.:..:.      |::.|::..       |......||            ..||..|.|..
Yeast   282 DYINKNNTAKNKPPLSPSSFIRTIDEKNTNSLMQDPMGSRGPLLPDDANIISNDTDGAEASHPDH 346

Human   528 EPELRPRPPRPLDSHLAINGSANRQSKSESD---------YSDGDNDSINSTSNSNDTINCSS-- 581
            :...|.|.    .|...:.|...::...|.:         :..|.....|:.||:|.||...|
Yeast   347 QVLSRSRS----QSTSFVQGKGGKRKSIEDEGYHNKLGLPHGSGPTSVYNNKSNANSTITGMSRR 407

Human   582 --------------ESSSRDSLREQTLSKQTYHKEARNSWD----------SPAFSNDVIRKRHY 622
                          .|||..|.|:|.|.:|   ::.:...|          :|.||:..
Yeast   408 SSSIVNALSSFVNLRSSSLSSSRQQHLQQQ---QQLQQKLDVSLEDLPPVPAPEFSDSC------ 463

Human   623 RIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCV 687
                          ..:||:.     .|.|             :.||..|..:..:|.::.|:.:
Yeast   464 --------------KDFLIKL-----APYG-------------KFIGIILTEKDDEFKKNCLNYL 496

Human   688 VDE-MDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFS------QRYCICNPGVVRQFRNPDT 745
            :.. .:|....||.||||....:.:..|.|:::|||.|||      |:......|:...:.|.|.
Yeast   497 LTNCFEFKNDPLDIALRKLLMFLELPKETQQIDRLIMAFSFAYYKAQKSYSKKKGIECPWSNADQ 561

Human   746 IFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRG--VDDGEDIPREMLMGIYERIRKRE 805
            ::.:||::::|:||.::||.|  .||...||:..:..  ...|.:||..:|...||.:..:|
Yeast   562 VYFIAFSLLMLHTDYFNPNNK--SKMTKHDFVDLVHNDKYSGGNEIPMAVLTYFYENVTAKE 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IQSEC1	NP_001363867.1	Sec7	618..806	CDD:460178	47/197 (24%)
		IQ_SEC7_PH	838..967	CDD:465120
SYT1	NP_015420.1	Sec7	443..622	CDD:214569	51/219 (23%)