Protein Alignment IQSEC1 and siz

DIOPT Version :10

• Sequence 1: NP_001363867.1
• Gene: IQSEC1 / 9922
• HGNCID: 29112
• Length: 1222
• Species: Homo sapiens
• Sequence 2: NP_730594.1
• Gene: siz / 40327
• FlyBaseID: FBgn0026179
• Length: 1325
• Species: Drosophila melanogaster
• Alignment Length: 1340
• Identity: 427/1340 - (31%)
• Similarity: 581/1340 - (43%)
• Gaps: 397/1340 - (29%)

Human    70 PGPGPGPQPLG---------AIP------------------ELGGRRDKSEGESSRSVRSSLD-- 105
            |||...|.||.         |:|                  ||...||:...|.| ::|..||
  Fly    53 PGPVSLPLPLSINMPHHHVHAMPYNVDELLRENNALHAKIKELSLERDRLLCEVS-NLRLELDMS 116

Human   106 --------------------TGSSLSTDRYSVEG--EAPSSETGTSLDSPS----AYPQGPLVPG 144
                                :||:    :|.:.|  :..|:...|..||.|    .|.|....||
  Fly   117 ELKRLPVDLDDNFPQKSLERSGST----QYELAGAQQPGSANASTCTDSGSVGGYVYLQNHYAPG 177

Human   145 SSLS-----------------------------------PDHYEHTSVGAY-------------- 160
            :..|                                   ..|...|..|.|
  Fly   178 AHSSSAAINYPAQQHPQMVYQIQQYPTCHQQQQQQHLQQQQHLHQTGAGHYMQVTATGGGQYHHH 242

Human   161 --------------------------GLYSGPPG----QQQRTRRPKLQHSTSILRKQAEEEAIK 195
                                      ||.||...    .||:.::.:..|..:.:|...  :.:|
  Fly   243 HMLHGHGHHAHHHGGAVVIAGSGVGTGLGSGATSVIMQHQQQQQQQQNMHKKNSIRNGG--DVLK 305

Human   196 RSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRS-SMSENR 259
            |:|:.| :||||.||.:||:|:||||||| :..|:||.|||.|||.|.|.|.|..:.: :.:|.|
  Fly   306 RTRAQS-AYELSQDLLEKQIELLERKYGG-VRARNAAVTIQRAFRHYMMVKKFASITAMAKAEKR 368

Human   260 MSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEP--TTLKSPAP 322
            :|||:|::...:..:.||... .|:|....:..:|....|      .:.....:|  |.:..||.
  Fly   369 LSRRMVVTASSLGLAEEGASS-SSAYGSATESQLTEQQQQ------QQAQQQQQPRVTIMAGPAG 426

Human   323 SSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKL 387
            ::                                     :|.|..     |.|..:|...:.|:|
  Fly   427 AA-------------------------------------SPGLSR-----TPPTRSLSMRERRQL 449

Human   388 DEMTASYSDVTLYIDEEELSPPLPLSQAGDRP----SSTESDLRLRA-------GGAAPDYWALA 441
            |                  ..|:|.||:|..|    |||.|...|.:       ..|.|.|:...
  Fly   450 D------------------CSPIPRSQSGASPASISSSTVSTSALASHPHVNLLHAAEPHYYNAQ 496

Human   442 HKEDKADTDTSCRSTPS----LERQEQRLRVE------HLPLLTIEPPSDSSVDLSDRSERGSLK 496
            .....|...||...:|.    ....:..|...      |.|    ..|..|:..:..|.:.||
  Fly   497 ALPQGAAYYTSYHGSPHDLSYASSADTSLNASWVNTSGHSP----HTPYYSAAQIYMRPKGGS-- 555

Human   497 RQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPE----------------LRPRPPRPLDSHLAI 545
              :....|..|..||...|..||:.|.:|.|.|:                .|..||.|  |.|..
  Fly   556 --TTPTPSCSGSTGSGSGGSGSGSSKKVPPEVPKRTSSITAQQQTQLLLLQRQTPPPP--SLLRT 616

Human   546 NGSANRQSKSE--SDYSDGDNDSINST------------SNSNDT------INCSSE-------- 582
            ||.........  |..|.|.:.|:.|.            |||..|      :|.|.:
  Fly   617 NGLCKTAENGSLTSVQSSGSDSSVTSAERNLNSDLGSDRSNSPHTWKRGTALNSSQQFSTHSADS 681

Human   583 ------------------------------------------SSSRDSLREQTLSKQTYHKEARN 605
                                                      .||..|..:....:|..|::.:.
  Fly   682 AGAVSGGGVGVAGGAGVYAAQMQAAVAAATAAGGMPPADDHAISSHTSAAQYEQHEQQQHEQQQL 746

Human   606 SWDSPAFS-------NDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGL 663
            ...:.|..       ::.||||.||:||||||||||||:.|||.|||:.:||.|||.||:.||||
  Fly   747 QAAAAAAGVAQNYKMSETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGL 811

Human   664 SRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQR 728
            |||||||:|||.|.|||..||.|...|:|.|..::|.|||||||:.|:.|||||:|||:|.||||
  Fly   812 SRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQR 876

Human   729 YCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREM 793
            ||.||..:|.:.|:.||||:||||||:||||:::||:||||:|::|||||||||:||..||.::|
  Fly   877 YCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDM 941

Human   794 LMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPD 858
            |||||:|::..|.|...|||:||.||:..||||||          .|:||||||||||||:|:||
  Fly   942 LMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKP----------NLALPHRRLVCYCRLYEIPD 996

Human   859 PNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTS 923
            .||.::.|:||||:||||||||:||||.|||.||||:||.||.|.|..|.|.:...||..|:|:.
  Fly   997 VNKKERPGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQLSQ 1061

Human   924 SVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQK-------------- 974
            .|.|   |:||.|||.|..||.||.:||:|||:|:.|||..|||:|||:||
  Fly  1062 KVDG---KILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARNRAPGNAENRD 1123

Human   975 -GVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEA---GKRGRRSSA 1035
             ||....:..|...:....:|..:....|:|    :.|||||||:||.|:.|.   .|..||.|.
  Fly  1124 SGVADVEVCPCPYQQGSQASGEQAPNSADNS----QQLKRSALSNSLLDMHEQFGNEKPQRRGSV 1184

Human  1036 GSLESNVEGSIISSPHMRRRATSTRECPSRPHQTMPNSSSLLGSLFGSKRGKPPPQAHLPSAPAL 1100
            |||:|.:..|..|:    ..::::||          |::::..:...:...|  .:.::|...|:
  Fly  1185 GSLDSGMSISFQST----TTSSASRE----------NAAAIAAAANAAAAAK--MRFNMPPTAAI 1233

Human  1101 PPPHPPVVLP---------HLQHSVAGHHLGPPEGLPQAA 1131
            ..|......|         .:|.|.|.:.|...:.|.|.|
  Fly  1234 ATPSNVYAAPGMQAYTHANFVQQSQAAYMLQQQQMLQQQA 1273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IQSEC1	NP_001363867.1	Sec7	618..806	CDD:460178	123/187 (66%)
		IQ_SEC7_PH	838..967	CDD:465120	77/128 (60%)
siz	NP_730594.1	Sec7	766..954	CDD:460178	123/187 (66%)
		PH_IQSEC	981..1108	CDD:270128	80/129 (62%)